Stress Circuitry and Regulation

Ruat J, Genewsky AJ, Heinz DE, Kaltwasser SF, Canteras NS, Czisch M, Chen A, Wotjak CT.
Why do mice squeak? Toward a better understanding of defensive vocalization. iScience, 25(7):104657. doi: 10.1016/j.isci.2022.104657.

Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R, Flachskamm C, Ressle A, Roeh S, Huettl RE, Parl A, Eggert C, Novak B, Yan Y, Yeoh K, Holzapfel M, Hauger B, Harbich D, Schmid B, Di Giaimo R, Turck CW, Schmidt MV, Deussing JM, Eder M, Dine J, Theis FJ, Chen A.

Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron, doi: 10.1016/j.neuron.2022.05.001.

Ruat J, Hartmann A, Heinz DE, Nemcova P, Stoffel R, Deussing JM, Chen A, Wotjak CT.

CB1 receptors in corticotropin-releasing factor neurons selectively control the acoustic startle response in male mice. Genes Brain Behav., 2021;e12775. doi: 10.1111/gbb.12775.

Furman O, Tsoory M, Chen A.
Differential chronic social stress models in male and female mice. Eur J Neurosci. doi: 10.1111/ejn.15481

Ruat J, Heinz DE, Binder FP, Stark T, Neuner R, Hartmann A, Kaplick PM, Chen A, Czisch M, Wotjak CT.
Structural correlates of trauma-induced hyperarousal in mice. Prog Neuropsychopharmacol Biol Psychiatry. 111:110404. doi: 10.1016/j.pnpbp.2021.110404.

Dick ALW, Chen A.
The role of TET proteins in stress-induced neuroepigenetic and behavioural adaptations. Neurobiol Stress 15:100352. doi: 10.1016/j.ynstr.2021.100352. eCollection 2021 Nov.

Lee CR, Chen A, Tye KM.
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. Cell, 184 (6): 1500-1516. doi: 10.1016/j.cell.2021.02.028.

Lopez JP, Brivio E, Santambrogio A, De Donno C, Kos A, Peters M, Rost N, Czamara D, Brückl TM, Roeh S, Pöhlmann ML, Engelhardt C, Ressle A, Stoffel R, Tontsch A, Villamizar JM, Reincke M, Riester A, Sbiera S, Fassnacht M, Mayberg HS, Craighead WE, Dunlop BW, Nemeroff CB, Schmidt MV, Binder EB, Theis FJ, Beuschlein F, Andoniadou CL, Chen A.
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation. Science Advances, vol. 7, no. 5, eabe4497.