Publications

2023

Neural basis for fasting activation of the hypothalamic–pituitary–adrenal axis

Douglass A. M., Resch J. M., Madara J. C., Kucukdereli H., Yizhar O., Grama A., Yamagata M., Yang Z. & Lowell B. B. (2023) Nature. 620, 7972, p. 154-162

A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits

Wietek J., Nozownik A., Pulin M., Saraf-Sinik I., Matosevich N., Malan D., Brown B. J., Dine J., Levy R., Litvin A., Regev N., Subramaniam S., Bitton E., Benjamin A., Copits B. A., Sasse P., Rost B. R., Schmitz D., Soba P., Nir Y., Wiegert J. S. & Yizhar O. (2023) BioRxiv.

Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice

Printz Y., Patil P., Mahn M., Benjamin A., Litvin A., Levy R., Bringmann M. & Yizhar O. (2023) Nature Communications. 14, 1667.

2022

Exercise increases information content and affects long-term stability of hippocampal place codes

Rechavi Y., Rubin A., Yizhar O. & Ziv Y. (2022) Cell reports (Cambridge). 41, 8, 111695.

Localized chemogenetic silencing of inhibitory neurons: a novel mouse model of focal cortical epileptic activity

Goldenberg A. M., Schmidt S., Mitelman R., Levy D. R., Prigge M., Katz Y., Yizhar O., Beck H. & Lampl I. (2022) Cerebral cortex (New York, N.Y. 1991). bhac245.

Optogenetics for light control of biological systems

Emiliani V., Entcheva E., Hedrich R., Hegemann P., Konrad K. R., Lüscher, C., Mahn M., Pan Z., Sims R. R., Vierock J. & Yizhar O. (2022) Nature Reviews Methods Primers. 2, 1, 55.

Molecular Optimization of Rhodopsin-Based Tools for Neuroscience Applications

Fenno L. E., Levy R. & Yizhar O. (2022) Rhodopsin . Vol. 2501. p. 289-310

Optogenetics at the presynapse

Rost B. R., Wietek J., Yizhar O. & Schmitz D. (2022) Nature Neuroscience. 25, 8, p. 984-998

Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels

Rozenberg A., Kaczmarczyk I., Matzov D., Vierock J., Nagata T., Sugiura M., Katayama K., Kawasaki Y., Konno M., Nagasaka Y., Aoyama M., Das I., Pahima E., Church J., Adam S., Borin V. A., Chazan A., Augustin S., Wietek J., Dine J., Peleg Y., Kawanabe A., Fujiwara Y., Yizhar O., Sheves M., Schapiro I., Furutani Y., Kandori H., Inoue K., Hegemann P., Beja O. & Shalev-Benami M. (2022) Nature Structural & Molecular Biology. 29, 6, p. 592-603

A Glowing Protein Helps Scientists Visualize Brain Cell Activity

Bouccara S. & Yizhar O. (2022) Frontiers for young minds. 10, 620308.

Neurophotonic tools for microscopic measurements and manipulation: status report

Abdelfattah A. S., Ahuja S., Akkin T., Allu S. R., Brake J., Boas D. A., Buckley E. M., Campbell R. E., Chen A. I., Cheng X., Čižmár T., Costantini I., De Vittorio M., Devor A., Doran P. R., El Khatib M., Emiliani V., Fomin-Thunemann N., Fainman Y., Ferri C. G. L., Fernandez-Alfonso T., Gilad A., Han X., Harris A., Hillman E. M. C., Hochgeschwender U., Holt M. G., Ji N., Kılıç K., Lake E. M. R., Li L., Li T., Mächler P., Miller E. W., Mesquita R. C., Nadella K. M. N. S., Nägerl U. V., Nasu Y., Nimmerjahn A., Ondráčková P., Pavone F. S., Perez Campos C., Peterka D. S., Pisano F., Pisanello F., Puppo F., Sabatini B. L., Sadegh S., Sakadzic S., Shoham S., Shroff S. N., Silver R. A., Sims R. R., Smith S. L., Srinivasan V. J., Thunemann M., Tian L., Tian L., Troxler T., Valera A., Vaziri A., Vinogradov S. A., Vitale F., Wang L. V., Uhlířová H., Xu C., Yang C., Yang M., Yellen G., Yizhar O. & Zhao Y. (2022) Neurophotonics (Print). 9, S1, p. 13001 013001.

2021

Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons

Printz Y., Patil P., Mahn M., Benjamin A., Litvin A., Levy R., Bringmann M. & Yizhar O. (2021) BioRxiv.

The social dilemma: prefrontal control of mammalian sociability

Yizhar O. & Levy D. R. (2021) Current Opinion in Neurobiology. 68, p. 67-75

Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

Forli A., Pisoni M., Printz Y., Yizhar O. & Fellin T. (2021) eLife. 10, 63359.

Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin

Mahn M., Saraf-Sinik I., Patil P., Pulin M., Bitton E., Karalis N., Bruentgens F., Palgi S., Gat A., Dine J., Wietek J., Davidi I., Levy R., Litvin A., Zhou F., Sauter K., Soba P., Schmitz D., Lüthi A., Rost B. R., Wiegert J. S. & Yizhar O. (2021) Neuron (Cambridge, Mass.). 109, 10, p. 1621-1635

2020

Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors

Anpilov S., Shemesh Y., Eren N., Harony-Nicolas H., Benjamin A., Dine J., Oliveira V. E. M., Forkosh O., Karamihalev S., Huttl R., Feldman N., Berger R., Dagan A., Chen G., Neumann I. D., Wagner S., Yizhar O. & Chen A. (2020) Neuron. 107, 4, p. 644-655

In situ electrochemical generation of nitric oxide for neuronal modulation

Park J., Jin K., Sahasrabudhe A., Chiang P., Maalouf J. H., Koehler F., Rosenfeld D., Rao S., Tanaka T., Khudiyev T., Schiffer Z. J., Fink Y., Yizhar O., Manthiram K. & Anikeeva P. (2020) Nature Nanotechnology. 15, 8, p. 690-697

Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices

El-Boustani S., Sermet B. S., Foustoukos G., Oram T. B., Yizhar O. & Petersen C. C. H. (2020) Nature Communications. 11, 1, 3342.

Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior

Barsy B., Kocsis K., Magyar A., Babiczky A., Szabo M., Veres J. M., Hillier D., Ulbert I., Yizhar O. & Matyas F. (2020) Nature Neuroscience. 23, 5, p. 625-637

In Vivo Optophysiology Reveals Lateral Inhibition among Layer 1 Interneurons

Patil P. & Yizhar O. (2020) Neuron. 106, 1, p. 14-16

Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

Hayat H., Regev N., Matosevich N., Sales A., Paredes-Rodriguez E., Krom A. J., Berg L., Li Y., Lavigne M., Kremer E. J., Yizhar O., Pickering A. E. & Nirl Y. (2020) Science Advances. 6, 15, 4232.

Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

Scheggia D., Manago F., Maltese F., Bruni S., Nigro M., Dautan D., Latuske P., Contarini G., Gomez-Gonzalo M., Requie L. M., Ferretti V., Castellani G., Mauro D., Bonavia A., Carmignoto G., Yizhar O. & Papaleo F. (2020) Nature Neuroscience. 23, 1, p. 47-60

Optogenetic Modulation of Neural Circuits

Mahn M., Klavir O. & Yizhar O. (2020) Handbook of Neurophotonics . Pavone F. S. & Shoham S.(eds.). p. 235-269

2019

Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex

Sermet B. S., Truschow P., Feyerabend M., Mayrhofer J. M., Oram T. B., Yizhar O., Staiger J. F. & Petersen C. C. H. (2019) eLife. 8, 52665.

Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

Reichenstein I., Eitan C., Diaz-Garcia S., Haim G., Magen I., Siany A., Hoye M. L., Rivkin N., Olender T., Toth B., Ravid R., Mandelbaum A. D., Yanowski E., Liang J., Rymer J. K., Levy R., Beck G., Ainbinder E., Farhan S. M. K., Lennox K. A., Bode N. M., Behlke M. A., Moller T., Saxena S., Moreno C. A. M., Costaguta G., van Eijk K. R., Phatnani H., Al-Chalabi A., Basak A. N., van den Berg L. H., Hardiman O., Landers J. E., Mora J. S., Morrison K. E., Shaw P. J., Veldink J. H., Pfaff S. L., Yizhar O., Gross C., Brown R. H., Ravits J. M., Harms M. B., Miller T. M. & Hornstein E. (2019) Science Translational Medicine. 11, 523, 5264.

Dynamics of social representation in the mouse prefrontal cortex

Levy D. R., Tamir T., Kaufman M., Parabucki A., Weissbrod A., Schneidman E. & Yizhar O. (2019) Nature Neuroscience. 22, 12, p. 2013-2022

Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics

Yizhar O. & Wiegert J. S. (2019) Trends in Pharmacological Sciences. 40, 6, p. 362-364

2018

High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins

Mahn M., Gibor L., Patil P., Malina K. C., Oring S., Printz Y., Levy R., Lampl I. & Yizhar O. (2018) Nature Communications. 9, 4125.

Reciprocal amygdala-prefrontal interactions in learning

Yizhar O. & Klavir O. (2018) Current Opinion in Neurobiology. 52, p. 149-155

Two-Photon Bidirectional Control and Imaging of Neuronal Excitability with High Spatial Resolution In Vivo

Forli A., Vecchia D., Binini N., Succol F., Bovetti S., Moretti C., Nespoli F., Mahn M., Baker C. A., Bolton M. M., Yizhar O. & Fellin T. (2018) Cell Reports. 22, 11, p. 3087-3098

Stress and sociability

Levy D. R. & Yizhar O. (2018) Nature Neuroscience. 21, 3, p. 304-306

2017

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery

Henckens M. J. A. G., Printz Y., Shamgar U., Dine J., Lebow M., Drori Y., Kuehne C., Kolarz A., Eder M., Deussing J. M., Justice N. J., Yizhar O. & Chen A. (2017) Molecular Psychiatry. 22, 12, p. 1691-1700

Building Bridges through Science

Lissek T., Adams M., Adelman J., Ahissar E., Akaaboune M., Akil H., a'Absi M., Arain F., Carlos Arango-Lasprilla J., Atasoy D., Avila J., Badawi A., Bading H., Baig A. M., Baleriola J., Belmonte C., Bertocchi I., Betz H., Blakemore C., Blanke O., Boehm-Sturm P., Bonhoeffer T., Bonifazi P., Brose N., Campolongo P., Celikel T., Chang C. C., Chang T., Citri A., Cline H. T., Cortes J. M., Cullen K., Dean K., M. Delgado-Garcia J., Desroches M., Disterhoft J. F., Dowling J. E., Draguhn A., El-Khamisy S. F., El Manira A., Enam S. A., Encinas J. M., Erramuzpe A., Esteban J. A., Farinas I., Fischer E., Fukunaga I., Gabilondo I., Ganten D., Gidon A., Carlos Gomez-Esteban J., Greengard P., Grinevich V., Gruart A., Guillemin R., Hariri A. R., Hassan B., Hausser M., Hayashi Y., Hussain N. K., Jabbar A. A., Jaber M., Jahn R., Janahi E. M., Kabbaj M., Kettenmann H., Kindt M., Knafo S., Koehr G., Komai S., Krugers H., Kuhn B., Lakhdar Ghazal N., Larkum M. E., London M., Lutz B., Matute C., Martinez-Millan L., Maroun M., McGaugh J., Moustafa A. A., Nasim A., Nave K., Neher E., Nikolich K., Outeiro T., Palmer L. M., Penagarikano O., Perez-Otano I., Pfaff D. W., Poucet B., Rahman A., Ramos-Cabrer P., Rashidy-Pour A., Roberts R. J., Rodrigues S., Sanes J. R., Schaefer A. T., Segal M., Segev I., Shafqat S., Siddiqui N. A., Soreq H., Soriano-Garcia E., Spanagel R., Sprengel R., Stuart G., Sudhof T. C., Tonnesen J., Trevino M., Uthman B. M., Venter J. C., Verkhratsky A., Weiss C., Wiesel T. N., Yaksi E., Yizhar O., Young L. J., Young P., Zawia N. H., Zugaza J. L. & Hasan M. T. (2017) Neuron. 96, 4, p. 730-735

Cell type-specific targeting strategies for optogenetics

Yizhar O. & Adamantidis A. (2017) Neuromethods:A Roadmap . p. 25-42

The Anterior Insular Cortex -> Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management

Venniro M., Caprioli D., Zhang M., Whitaker L. R., Zhang S., Warren B. L., Cifani C., Marchant N. J., Yizhar O., Bossert J. M., Chiamulera C., Morales M. & Shaham Y. (2017) Neuron. 96, 2, p. 414-427

Silencing Neurons: Tools, Applications, and Experimental Constraints

Wiegert J. S., Mahn M., Prigge M., Printz Y. & Yizhar O. (2017) Neuron. 95, 3, p. 504-529

Functional characterization of sodium-pumping rhodopsins with different pumping properties

Tsunoda S. P., Prigge M., Abe-Yoshizumi R., Inoue K., Kozaki Y., Ishizuka T., Yawo H., Yizhar O. & Kandori H. (2017) PLoS ONE. 12, 7, 0179232.

Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins

Tkatch T., Greotti E., Baranauskas G., Pendin D., Roy S., Nita L. I., Wettmarshausen J., Prigge M., Yizhar O., Shirihai O. S., Fishman D., Hershfinkel M., Fleidervish I. A., Perocchi F., Pozzan T. & Sekler I. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114, 26, p. E5167-E5176

Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex

Klavir O., Prigge M., Sarel A., Paz R. & Yizhar O. (2017) Nature Neuroscience. 20, 6, p. 836-844

A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition

Hardung S., Epple R., Jaeckel Z., Eriksson D., Uran C., Senn V., Gibor L., Yizhar O. & Diester I. (2017) Current Biology. 27, 4, p. 549-555

2016

Opportunities for Technology and Tool Development

Ting A., Segal R., Carandini M., Emiliani V., Yizhar O., Roska B., Ji N. & Anderson D. J. (2016) Neuron. 92, 3, p. 564-566

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Shemesh Y., Forkosh O., Mahn M., Anpilov S., Sztainberg Y., Manashirov S., Shlapobersky T., Elliott E., Tabouy L., Ezra G., Adler E. S., Ben-Efraim Y. J., Gil S., Kuperman Y., Haramati S., Dine J., Deussing J. M., Eder M., Schneidman E., Yizhar O. & Chen A. (2016) Nature Neuroscience. 19, 11, p. 1489-1496

Biophysical constraints of optogenetic inhibition at presynaptic terminals.

Mahn M., Prigge M., Ron S., Levy R. & Yizhar O. (2016) Nature Neuroscience. 19, 4, p. 554-556

2015

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

Yamamoto K., Tanei Z. i., Hashimoto T., Wakabayashi T., Okuno H., Naka Y., Yizhar O., Fenno L. E., Fukayama M., Bito H., Cirrito J. R., Holtzman D. M., Deisseroth K. & Iwatsubo T. (2015) Cell Reports. 11, 6, p. 859-865

Towards understanding the neural mechanism of behavioral phenotypes seen in psychiatric disorders

Nakai N., Yizhar O. & Takumi T. (2015) Optogenetics : Light-Sensing Proteins and their Applications . Koizumi A., Kandori H. & Yawo H.(eds.). p. 331-339

A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion

Scott N., Prigge M., Yizhar O. & Kimchi T. (2015) Nature. 525, 7570, p. 519-522 26375004.

2014

Viral Vector-Based Techniques for Optogenetic Modulation In Vivo

Mahn M., Ron S. & Yizhar O. (2014) VIRAL VECTOR APPROACHES IN NEUROBIOLOGY AND BRAIN DISEASES . p. 289-310 (trueNeuromethods).

2013

Neuron-Specific Expression of Tomosyn1 in the Mouse Hippocampal Dentate Gyrus Impairs Spatial Learning and Memory

Barak B., Okun E., Ben-Simon Y., Lavi A., Shapira R., Madar R., Wang Y., Norman E., Sheinin A., Pita M. A., Yizhar O., Mughal M. R., Stuenkel E., van Praag P. H., Mattson M. P. & Ashery U. (2013) NeuroMolecular Medicine. 15, 2, p. 351-363

Optopatcher-An electrode holder for simultaneous intracellular patch-clamp recording and optical manipulation

Katz Y., Yizhar O., Staiger J. & Lampl I. (2013) Journal of Neuroscience Methods. 214, 1, p. 113-117

2012

Optogenetic Insights into Social Behavior Function

Yizhar O. (2012) Biological Psychiatry. 71, 12, p. 1075-1080

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

Mattis J., Tye K. M., Ferenczi E. A., Ramakrishnan C., O'Shea D. J., Prakash R., Gunaydin L. A., Hyun M., Fenno L. E., Gradinaru V., Yizhar O. & Deisseroth K. (2012) Nature Methods. 9, 2, p. 159-172

2011

Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement

Witten I. B., Steinberg E. E., Lee S. Y., Davidson T. J., Zalocusky K. A., Brodsky M., Yizhar O., Cho S. L., Gong S., Ramakrishnan C., Stuber G. D., Tye K. M., Janak P. H. & Deisseroth K. (2011) Neuron. 72, 5, p. 721-733

The Microbial Opsin Family of Optogenetic Tools

Zhang F., Vierock J., Yizhar O., Fenno L. E., Tsunoda S., Kianianmomeni A., Prigge M., Berndt A., Cushman J., Polle J., Magnuson J., Hegemann P. & Deisseroth K. (2011) Cell. 147, 7, p. 1446-1457

Neocortical excitation/inhibition balance in information processing and social dysfunction

Yizhar O., Fenno L. E., Prigge M., Schneider F., Davidson T. J., O'Shea D. J., Sohal V. S., Goshen I., Finkelstein J., Paz J. T., Stehfest K., Fudim R., Ramakrishnan C., Huguenard J. R., Hegemann P. & Deisseroth K. (2011) Nature. 477, 7363, p. 171-178