Research

Single Molecule Protein Dynamics

Single-molecule fluorescence spectroscopy is a powerful method to study the dynamics of proteins. We use it to elucidate a variety of important biophysical challenges, such as:

Mapping the heterogeneous folding landscapses of large and complex proteins and identifying intermediate states and folding pathways.
Deciphering the impact of conformational dynamics on the function of enzymes and protein machines.

We are looking for post-doctoral fellows and Ph.D. students to join this ERC-funded project!

Coupling Quantum Emitters & Surface Plasmons

We are interested in the way molecules and other quantum emitters interact with plasmonic excitations. To that end we use single-molecule Raman spectroscopy and other ultrasensitive optical methods. We also empoly state-of-the-art nanolithography and electron microscopy techniques.

We are looking for a post-doctoral fellow to join this project!

Super-Resolution Microscopy of the Cell Membrane

By localizing single fluorescent molecules one-by-one we can obtain exciting information on biological systems at spatial resolutions that far exceed the diffraction limit:

We use stochastic super-resolution microscopy to locate the positions of important receptors on the membranes of immune cells.
We perform single-particle tracking experiments to measure hydrodynamic pair correlations in the motion of proteins within membranes.

Looking for a challenging Ph.D. project? We are interested in YOU!