phospholipid vesicle

Single Molecule Protein Dynamics

Single-molecule fluorescence spectroscopy is a powerful method to study the dynamics of proteins. We use it to elucidate a variety of important biophysical challenges, such as:

  • Mapping the heterogeneous folding landscapses of large and complex proteins and identifying intermediate states and folding pathways.
  • Deciphering the impact of conformational dynamics on the function of enzymes and protein machines.

We are looking for post-doctoral fellows and Ph.D. students to join this ERC-funded project!

plasmonic particles

Coupling Quantum Emitters & Surface Plasmons

We are interested in the way molecules and other quantum emitters interact with plasmonic excitations. To that end we use single-molecule Raman spectroscopy and other ultrasensitive optical methods. We also empoly state-of-the-art nanolithography and electron microscopy techniques.

We are looking for a post-doctoral fellow to join this project!

3D topology of T-cell membrane

Super-Resolution Microscopy of the Cell Membrane

By localizing single fluorescent molecules one-by-one we can obtain exciting information on biological systems at spatial resolutions that far exceed the diffraction limit:

  • We use stochastic super-resolution microscopy to locate the positions of important receptors on the membranes of immune cells.
  • We perform single-particle tracking experiments to measure hydrodynamic pair correlations in the motion of  proteins within membranes.

Looking for a challenging Ph.D. project? We are interested in YOU!