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Lectures & Events

Tuesday 03 September
Helen and Milton A. Kimmelman Building 11:00
Learning to Love CO2: Carboxylation, Catalysis, and Desalination Prof. Ji-Woong Lee [Info]

Learning to Love CO2: Carboxylation, Catalysis, and Desalination

Currently, more than 40 gigatonnes of CO2 are released annually into the atmosphere as a result of fossil fuel combustion, causing ocean acidification and climate unpredictability. Anthropogenic CO2 emission is seemingly hard to diminish in the near future and, therefore, CO2 -capture and sequestration or CO2 -functionalization can be viable solutions to address this issue. To use CO2 as a chemical feedstock, namely as a C1 building block, it is essential to equip the process with a nucleophilic catalyst or a highly active reagent, as exemplified by Grignard carboxylation reactions and some recent progress in metal-catalyzed reactions. In this seminar, I will display how we can utilize CO2 not only as a chemical feedstock and a catalyst but also as a stimulus for a desalination process. The obtained knowledge in CO2 activation and desalination will be beneficial in supramolecular chemistry, biology, CO2functionalization catalysis and CO2 sequestration processes. Department of Chemistry, University of Copenhagen
Sunday 15 September
Perlman Chemical Sciences Building 11:00
Chemical and Biological Physics Dept Special Seminar Prof. Randall Goldsmith [Info]

Chemical and Biological Physics Dept Special Seminar

University of Wisconsin
Sunday 22 September
Gerhard M.J. Schmidt Lecture Hall 11:00
Ben May Center for Chemical Theory and Computation, Inaugural lecture Prof Daan Frenkel [Info]

Ben May Center for Chemical Theory and Computation, Inaugural lecture

University of Cambridge
Monday 23 September
Gerhard M.J. Schmidt Lecture Hall 11:00
Ribosomal decoding, tRNA modifications and human disease Prof. Eric Westhof [Info]

Ribosomal decoding, tRNA modifications and human disease

Decoding during ribosomal translation occurs through complex and interdependent molecular recognition networks between mRNA, tRNA, and rRNA. Among those, the stability of codon-anticodon triplets, the fold of the tRNA anticodon hairpin, the modified nucleotides, and the interactions with rRNA bases at the decoding site cosntitute key contributors. On the basis of biochemical and genetic data in the literature, coupled with many crystal structures of fully active ribosomes, nucleotide modifications at positions 34 and 37 of the anticodon loop are now understood molecularly. Both pre-organize the anticodon loop for efficient mRNA binding. The modifications at 37 stabilize AU-rich codon-anticodon pairs and maintain the coding frame. The modifications at 34 help to avoid miscoding and allow to decode purine-ending codons in split codon boxes by promoting base pairing that can be accommodated within the structural constraints of the ribosomal grip at the decoding site. Depending on the codon box, the tRNA modifications allow for diversity in codon usage depending on genomic GC content as well as on the number and types of isoacceptor tRNAs. Although universal, the genetic code is not translated identically and differences exist not only between organisms in the three kingdoms of life but also between cellular types. To decipher diversely but efficiently the genetic code, cells developed sophisticated arrays between tRNA pools and tRNA modifications, anchored in the cellular metabolic enzymatic pathways and guaranteeing protein homeostasis. Examples of mutations leading to specific human diseases in some of those enzymes will be described. Institut de Biologie Mol├ęculaire et Cellulaire Centre National de la Recherche Scientifique
Monday 28 October
Gerhard M.J. Schmidt Lecture Hall 11:00
Chemistry colloquium Prof. Eiichi Nakamura [Info]

Chemistry colloquium

University of Tokyo
Monday 25 November
Gerhard M.J. Schmidt Lecture Hall 11:00
Chemistry colloquium Dr. Ron Diskin [Info]

Chemistry colloquium

Dept. of Structural Biology, WIS
Monday 09 December
Gerhard M.J. Schmidt Lecture Hall 11:00
Chemistry colloquium Dr. Emmanuel Levy [Info]

Chemistry colloquium

Dept. of Structural Biology, WIS
Monday 16 December
Gerhard M.J. Schmidt Lecture Hall 11:00
Chemistry colloquium Prof. Thuc-Quyen Nguyen [Info]

Chemistry colloquium

University of California, Santa Barbara