Ultrafast technology and multiphoton microscopy techniques

We are pursuing sereval research efforts under this topic.  One effort is aimed at utilizing spatiotemporal control of optical fields, and the phenomenon of temporal focusing to spatially control widefield multiphoton excitation patterns. We have utilized this to perform photoactivation of a single neuron deep inside scattering tissue. Dan's Photonics West 'hot topic' talk on this subject is available using this link.

A significant current effort involves the use of coherent nonlinear imaging as a microscopic spectroscopic tool for elucidating the properties of organic and inorganic nanocrystals and nanostructures. In particular, we are working on combining ideas from fluorescence imaging and coherent nonlinear microscopy to achieve superresolved nonlinear microscopy.

Last, we are working on developing new methods to characterize short ultrashort pulses using 'slow' detectors. 

Recent publications

  1. D. Raanan, M. S. Song, W. Tisdale, D. Oron, “Super-resolved second harmonic generation imaging by coherent image scanning microscopy”, Appl. Phys. Lett. 120, 071111 (2022).
  2. S. Shivkumar, D. Raanan, S. Metais, S. Suresh, N. Forget, R. Bartels, D. Oron, H. Rigneault, “Selective Detection in Impulsive Low-Frequency Raman Imaging Using Shaped Probe Pulses”, Phys. Rev. Applied 19, 054075 (2023).
  3. Q. Tang, B. Li, J. Wang, Y. Liu, I. Pinkas, H. Rigneault, D. Oron, L. Ren, “Electronic-Resonance Coherent Anti-Stokes Raman Scattering Spectroscopy and Microscopy”, ACS Photonics 11, 3467 (2024).
  4. A. Zhitnitsky, E. Benjamin, O. Bitton, D. Oron, “Super-resolved CARS by coherent image scanning”, Nature Commun. 15, 10073 (2024).
  5. Y. Soffer, D. Oron, “Single Pulse Coherent Anti-Stokes Raman Super-Resolved Image Scanning Microscopy”, ACS Photonics 12, 5697 (2025).