The main interest of the Abramson lab (est. Jan 2011) is to understand how immunological tolerance to self is established and how breakdown of this process results in autoimmunity. Specifically, the lab studies the role of the thymus gland and of the autoimmune regulator (AIRE) gene in these processes, but also investigates their non-conventional and emerging roles within the immune system. Furthermore, the lab is interested in translating their findings from basic research into designing novel approaches for immune-based therapies.
To address the above goals, the lab utilizes a broad and diverse arsenal of tools and expertise ranging from classical immunology, molecular biology, multiomics, microscopy, in-vivo gene editing, generation and analysis of genetically manipulated mouse models, as well as studies on human patients.