Publications

2024

Tuft cells and fibroblasts promote thymus regeneration through ILC2-mediated type 2 immune response

Nevo S., Frenkel N., Kadouri N., Gome T., Rosenthal N., Givony T., Avin A., Peligero Cruz C., Kedmi M., Lindzen M., Ben Dor S., Damari G., Porat Z., Haffner-Krausz R., Keren-Shaul H., Yarden Y., Munitz A., Leshkowitz D., Goldfarb Y. & Abramson J. (2024) Science Immunology. 9, 91, eabq6930.

Segmented filamentous bacteria-induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover

Brabec T., Schwarzer M., Kováčová K., Dobešová M., Schierová D., Březina J., Pacáková I., Šrůtková D., Ben-Nun O., Goldfarb Y., Šplíchalová I., Kolář M., Abramson J., Filipp D. & Dobeš J. (2024) Journal of Experimental Medicine. 221, 1, e20230194.

The emerging family of RORγt+ antigen-presenting cells

Abramson J., Dobeš J., Lyu M. & Sonnenberg G. F. (2024) Nature Reviews Immunology. 24, p. 64-77

Computational optimization of antibody humanness and stability by systematic energy-based ranking

Tennenhouse A., Khmelnitsky L., Khalaila R., Yeshaya N., Noronha A., Lindzen M., Makowski E. K., Zaretsky I., Sirkis Y. F., Galon-Wolfenson Y., Tessier P. M., Abramson J., Yarden Y., Fass D. & Fleishman S. J. (2024) Nature Biomedical Engineering. 8, p. 30-44

2023

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

Gruper Y., Wolff A. S. B., Glanz L., Spoutil F., Marthinussen M. C., Osickova A., Herzig Y., Goldfarb Y., Aranaz-Novaliches G., Dobeš J., Kadouri N., Ben-Nun O., Binyamin A., Lavi B., Givony T., Khalaila R., Gome T., Wald T., Mrazkova B., Sochen C., Besnard M., Ben-Dor S., Feldmesser E., Orlova E. M., Hegedűs C., Lampé I., Papp T., Felszeghy S., Sedlacek R., Davidovich E., Tal N., Shouval D. S., Shamir R., Guillonneau C., Szondy Z., Lundin K. E. A., Osicka R., Prochazka J., Husebye E. S. & Abramson J. (2023) Nature. 624, 7992, p. 653-662

A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1

Oftedal B. E., Berger A. H., Bruserud Ø., Goldfarb Y., Sulen A., Breivik L., Hellesen A., Ben-Dor S., Haffner-Krausz R., Knappskog P. M., Johansson S., Wolff A. S., Bratland E., Abramson J. & Husebye E. S. (2023) The Journal of Clinical Investigation. 133, 21, e169704.

Thymic mimetic cells function beyond self-tolerance

Givony T., Leshkowitz D., Del Castillo D., Nevo S., Kadouri N., Dassa B., Gruper Y., Khalaila R., Ben-Nun O., Gome T., Dobeš J., Ben-Dor S., Kedmi M., Keren-Shaul H., Heffner-Krausz R., Porat Z., Golani O., Addadi Y., Brenner O., Lo D. D., Goldfarb Y. & Abramson J. (2023) Nature. 622, 7981, p. 164–172

2022

Transcriptional regulation of the thymus master regulator Foxn1

Kadouri N., Giladi T., Katz S., Hey J., Ben-Dor S., Damari G., Dassa B., Dobes J., Dieter W., Bähr M., Paulsen M., Haffner-Krausz R., Mall M. A., Plass C., Kafka Y. & Abramson J. (2022) Science Immunology. 7, 74, eabn8144.

Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans

Dobeš J., Ben-Nun O., Binyamin A., Stoler-Barak L., Oftedal B. E., Goldfarb Y., Kadouri N., Gruper Y., Givony T., Zalayat I., Kováčová K., Böhmová H., Valter E., Shulman Z., Filipp D., Husebye E. S. & Abramson J. (2022) Nature Immunology. 23, 7, p. 1098-1108

The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance

Heinlein M., Gandolfo L. C., Zhao K., Teh C. E., Nguyen N., Baell J. B., Goldfarb Y., Abramson J., Wichmann J., Voss A. K., Strasser A., Smyth G. K., Thomas T. & Gray D. H. D. (2022) Science Immunology. 7, 67, eabb6032.

2021

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation

Goldfarb Y., Givony T., Dobeš J., Kadouri N., Zalayat I., Peligero-Cruz C., Damari G., Dassa B., Ben-Dor S., Gruper Y., Oftedal B. E., Bratland E., Erichsen M. M., Berger A., Avin A., Nevo S., Haljasorg U., Kuperman Y., Ulman A., Porat Z., Haffner-Krausz R., Atasoy U., Leshkowitz D., Husebye E. S. & Abramson J. (2021) Journal of Experimental Medicine. 218, 11, e20201076.

2020

IL18 signaling promotes homing of mature Tregs into the thymus

Peligero-Cruz C., Givony T., Sebe-Pedros A., Dobes J., Kadouri N., Nevo S., Roncato F., Alon R., Goldfarb Y. & Abramson J. (2020) eLife. 9, e58213.

Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells

Delacher M., Barra M. M., Herzig Y., Eichelbaum K., Rafiee M., Richards D. M., Traeger U., Hofer A., Kazakov A., Braband K. L., Gonzalez M., Woehrl L., Schambeck K., Imbusch C. D., Abramson J., Krijgsveld J. & Feuerer M. (2020) iScience. 23, 5, 101127.

Thymic epithelial cell heterogeneity: TEC by TEC

Kadouri N., Nevo S., Goldfarb Y. & Abramson J. (2020) Nature Reviews Immunology. 20, 4, p. 239-253

2019

Tuft cells: From the mucosa to the thymus

Nevo S., Kadouri N. & Abramson J. (2019) Immunology Letters. 210, p. 1-9

Rbpj expression in regulatory T cells is critical for restraining T(H)2 responses

Delacher M., Schmidl C., Herzig Y., Breloer M., Hartmann W., Brunk F., Kaegebein D., Traeger U., Hofer A., Bittner S., Weichenhan D., Imbusch C. D., Hotz-Wagenblatt A., Hielscher T., Breiling A., Federico G., Groene H., Schmid R. M., Rehli M., Abramson J. & Feuerer M. (2019) Nature Communications. 10, 1621.

Immunological tolerance-t cells

Goldfarb Y., Peligero-Cruz C. & Abramson J. (2019) The Autoimmune Diseases . 6 ed. p. 65-90

2018

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Bornstein C., Nevo S., Giladi A., Kadouri N., Pouzolles M., Gerbe F., David E., Machado A., Chuprin A., Toth B., Goldberg O., Itzkovitz S., Taylor N., Jay P., Zimmermann V. S., Abramson J. & Amit I. (2018) Nature. 559, 7715, p. 622-626

2017

Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations

Avin A., Levy M., Porat Z. & Abramson J. (2017) Nature Communications. 8,

Thymospheres Are Formed by Mesenchymal Cells with the Potential to Generate Adipocytes, but Not Epithelial Cells

Sheridan J. M., Keown A., Policheni A., Roesley S. N., Rivlin N., Kadouri N., Ritchie M. E., Jain R., Abramson J., Heng T. S. & Gray D. H. (2017) Cell Reports. 21, 4, p. 934-942

Thymic epithelial cells

Abramson J. & Anderson G. (2017) Annual Review of Immunology. 35, p. 85-118

Transcriptional programs that control expression of the autoimmune regulator gene Aire

Herzig Y., Nevo S., Bornstein C., Brezis M. R., Ben-Hur S., Shkedy A., Eisenberg-Bord M., Levi B., Delacher M., Goldfarb Y., David E., Weinberger L., Viukov S., Ben-Dor S., Giraud M., Hanna J. H., Breiling A., Lyko F., Amit I., Feuerer M. & Abramson J. (2017) Nature Immunology. 18, 2, p. 161-172

2016

Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells

Danan-Gotthold M., Guyon C., Giraud M., Levanon E. Y. & Abramson J. (2016) GENOME BIOLOGY. 17, 1, 219.

Autoimmune regulator and self-tolerance - molecular and clinical aspects

Abramson J. & Husebye E. S. (2016) Immunological Reviews. 271, 1, p. 127-140

HDAC3 Is a Master Regulator of mTEC Development

Goldfarb Y., Kadouri N., Levi B., Sela A., Herzig Y., Cohen R. N., Hollenberg A. N. & Abramson J. (2016) Cell Reports. 15, 3, p. 651-665

AIRE: From promiscuous molecular partnerships to promiscuous gene expression

Abramson J. & Goldfarb Y. (2016) European Journal of Immunology. 46, 1, p. 22-33

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

Satoh R., Kakugawa K., Yasuda T., Yoshida H., Sibilia M., Katsura Y., Levi B., Abramson J., Koseki Y., Koseki H., van Ewijk E. W., Hollander G. A. & Kawamoto H. (2016) PLoS Genetics. 12, 1, e1005776.

2015

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

Chuprin A., Sagi I., Avin A., Goldfarb Y., Herzig Y., Levi B., Jacob A., Sela A., Katz S., Grossman M., Guyon C., Rathaus M., Cohen H. Y., Sagi I., Giraud M., McBurney M. W., Husebye E. S. & Abramson J. (2015) Nature Immunology. 16, 7, p. 737-745

Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases

Oftedal B., Hellesen A., Erichsen M., Bratland E., Vardi A., Perheentupa J., Kemp E., Fiskerstrand T., Viken M., Weetman A., Fleishman S., Banka S., Newman W., Sewell W., Sozaeva L., Zayats T., Haugarvoll K., Orlova E., Haavik J., Johansson S., Knappskog P., Lovas K., Wolff A., Abramson J. & Husebye E. (2015) Immunity. 42, 6, p. 1185-1196

Treg Cell Differentiation: From Thymus to Peripheral Tissue

Richards D. M., Delacher M., Goldfarb Y., Kägebein D., Hofer A. C., Abramson J. & Feuerer M. (2015) Regulatory T Cells in Health and Disease, 2015 . Liston A.(eds.). p. 175-205