The objective of this study is to better understand the state and severity of infection during pregnancy and its effect on fetal development and neonatal outcome. The goal is to provide answers for the following questions:
- Are asymoptomaic women infected with SARS-Cov-2 at high risk for delivery complications or fetal developmental disorders?
- Does the time of infection affect outcome?
- Is there vertical transmission for early pregnancy infection?
- Is there evidence for fetal/placenta pathology?
- Is ACE2 expressed by the placenta relevant for pregnancy outcome after infection?
Preprints and publications
Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. Beharier O*, Plitman Mayo R*, Raz T, Nahum Sacks K, Schreiber L, Suissa-Cohen Y, Chen R, Gomez-Tolub R, Hadar E, Gabbay-Benziv R, Jaffe Moshkovich Y, Biron-Shental T, Shechter-Maor G, Farladansky-Gershnabel S, Yitzhak Sela H, Benyamini-Raischer H, Sela ND, Goldman-Wohl D, Shulman Z, Many A, Barr H, Yagel S#, Neeman M#, Kovo M#.
J Clin Invest. 2021 May 20:150319.
Waning of the Humoral Response to SARS-CoV-2 in Pregnancy is Variant-Dependent. Romina Plitman Mayo, Tal Raz, Bar Ben David, Gila Meir, Haim Barr, Leonardo solmesky, Rony Chen, Ana Idelson, Lucilla Zorzetti, Rinat Gabbay-Benziv, Yuval Yaffe Moshkovich, Tal Biron-Shental, Gil Shechter-Maor, Hen Yitzhak Sela, Itamar Glick, Hedi Benyamini Raischer, Raed Salim, Yariv Yogev, Ofer Beharier, Debra Goldman-Wohl, Ariel Many, Michal Kovo, Simcha Yagel, Michal Neeman
Boosting maternal and neonatal humoral immunity following SARS-CoV-2 infection using a single mRNA vaccine dose
Nevo L., Cahen-Peretz A., Vorontsov O. et_al. (2022) American Journal of Obstetrics and Gynecology.
Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Mt. Scopus, Jerusalem, Israel
Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001 Israel
Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food & Environment, The Hebrew University of Jerusalem P.O. Box 12, Rehovot 76100, Israel
Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva; affiliated to Sackler Faculty of Medicine, Tel Aviv University
The Hillel Yaffe Medical Center, Hadera, Israel, the Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel, affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Obstetrics and Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Israel
Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel affiliated with Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Department of Immunology, Weizmann Institute of Science, Rehovot 7610001 Israel
Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Supported by a research grant from the ISF KillCorona Program:
- Weizmann Institute of Science Michal Neeman
- Wolfson Medical Center/ TAU Michal Kovo
- Hadassah Medical Center/ HUJ Simcha Yagel
- Sourasky Medical Center/ TAU Ariel Many
Supported by a research grant from the Fondazione Henry Krenter