lecture
Biomolecular Sciences

The ESCRT machinery: an evolutionary conserved, a multi-purpose membrane remodeling deviceounced

Prof. Natalie Elia
January 16, 2025
15:00 - 16:00

The ESCRT membrane remodeling complex, found across all life forms, exhibits a versatility that transcends evolutionary boundaries. From orchestrating the constriction of micron-wide tubes in cell division to facilitating the budding of 50 nm vesicles in receptor degradation, ESCRTs perform diverse functions in animal cells. In recent years, ESCRT homologs were identified in prokaryotes, highlighting a role for this protein machinery in the ancient world.  We seek to understand the mechanistic principles underlying the functional diversity of the ESCRT system across evolution. Specifically, we focus on understanding how the ESCRT complex orchestrate in cells to constrict and cut membranes in eukaryotes, focusing on its role in cell division, and in prokaryotes, focusing on the recently discovered Asgard archaea. By combining high-resolution imaging with biochemical and structural studies we aim to unlock the secrets of this fundamental membrane remodeling machinery and its potential role in evolution.