
lecture
Brain Sciences
Travelling waves or sequentially activated modules: mapping the granularity of cortical propagation
Dr. Mark Shein-Idelson
March 12, 2024
12:30
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13:30
: Numerous studies have identified travelling waves in the cortex and suggested they play important roles in brain processing. These waves are most often measured using macroscopic methods that do not allow assessing wave dynamics at the single neuron scale and analyzed using techniques that smear neuronal excitability boundaries. In my talk, I will present a new approach for discriminating travelling waves from modular activation. Using this approach I will show that Calcium dynamics in mouse cortex and spiking activity in turtle cortex are dominated by modular activation rather than by propagating waves. I will then show how sequentially activating two discrete brain areas can appear as travelling waves in EEG simulations and present an analytical model in which modular activation generates wave-like activity with variable directions, velocities, and spatial patterns. I will end by illustrating why a careful distinction between modular and wave excitability profiles across scales will be critical for understanding the nature of cortical computations.