Spatial transcriptomics of mammalian tissues

Human evolution and disease

We study interactions between peripheral circadian clocks and exercise physiology, hypoxia signaling and metabolic pathways

We study the functional roles of epigenetics during cell-fate decisions

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.

Combining data analysis and experimental methods for understanding tissue function from single cells

Proprioception and the the musculoskeletal system in development and disease

We develop algorithms and utilize single cell genomics for studying the organization and function of immune cells in a tissue

Understanding epithelial, stem and immune cell interactions in the gut

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

Decipher expression of molecular pathways and their function in cells, disease models and samples from patients.

Why do some people succumb to infection - while others don't?