Publications

2021

Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects
Repudi S, Steinberg DJ, Elazar N, Breton VL, Aquilino MS, Saleem A, Abu-Swai S, Vainshtein A, Eshed-Eisenbach Y, Vijayaragavan B, Behar O, Hanna JJ, Peles E, Carlen PL, Aqeilan RI. (2021) BRAIN 144,
A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement
Rebelo AP, Cortese A, Abraham A, Eshed-Eisenbach Y, Shner G, Vainshtein A, Buglo E, Camarena V, Gaidosh G, Shiekhattar R, Abreu L, Courel S, Burns DK, Bacon C, Feely S, Castro D, Peles E, Reilly MM. Shy ME., Zuchner S. (2021) BRAIN 144, 1197-1213
TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells
Chang KJ, Agrawal I, Vainshtein A, Ho WY, Xin W, Tucker-Kellogg G, Susuki K, Peles E, Ling SC, Chan JR. (2021) eLIFE 10, e64456
Differential contribution of Cadm1-Cadm3 cell adhesion molecules to peripheral myelinated axons
Sukhanov N, Vainshtein A, Eshed-Eisenbach Y, Peles E. (2021) JOURNAL OF NEUROSCIENCE 41, 1393-1400
Mechanisms of node of Ranvier assembly
Rasband MN and Peles E. (2021) NATURE REVIEW NEUROSCIENCE 22, 7–20

2020

Schwann-cell-derived CMTM6 restricts radial axonal growth
Nimrod E and Peles E (2020) NATURE COMMUNICATION 11, 5044
Accumulation of Neurofascin at Nodes of Ranvier Is Regulated by a Paranodal Switch
Zhang Y, Yuen S, Peles E, Salzer JL (2020) JOURNAL OF NEUROSCIENCE 40, 5709-5723
N-Wasp Regulates Oligodendrocyte Myelination
Katanov C, Novak N, Vainshtein A, Golani O, Dupree JL, Peles E. (2020) JOURNAL OF NEUROSCIENCE 40, 6103-6111
Precise spatiotemporal control of nodal Na+ channel clustering by Bone Morphogenetic Protein-1/Tolloid-like proteinases
Eshed-Eisenbach Y, Devaux J, Vainshtein A, Golani O, Lee SJ, Feinberg K, Sukhanov N, Greenspan DS, Susuki K, Rasband MN, Peles E (2020) NEURON 106, 806-815
The clustering of voltage-gated sodium channels in various excitable membranes
Eshed-Eisenbach Y, Peles E. (2020) DEVELOPMENTAL NEUROBIOLOGY 80, 1-11

2019

Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
Djannatian M, Timmler S, Arends M, Luckner M, Weil MT, Alexopoulos I, Snaidero N, Schmid B, Misgeld T, Möbius W, Schifferer M, Peles E, Simons M. (2019) NATURE COMMUNICATION 10,
Coordinated internodal and paranodal adhesion controls accurate myelination by oligodendrocytes.
Elazar N, Vainshtein A, Rechav K, Tsoory M, Eshed-Eisenbach Y, Peles E. (2019) JOURNAL OF CELL BIOLOGY 218, 2887-2895
Axoglial adhesion by Cadm4 regulates CNS myelination
Elazar N, Vainshtein A, Golan N, Vijayaragavan B, Schaeren-Wiemers N, Eshed-Eisenbach Y, Peles E (2019) NEURON 101, 224-231
Loss of Cntnap2 causes axonal excitability deficits, developmental delay in cortical myelination, and abnormal stereotyped motor behavior
Scott R, Sánchez-Aguilera A, van Elst K, Lim L, Dehorter N, Bae SE, Bartolini G, Peles E, Kas MJH, Bruining H, Marín O. (2019) CEREBRAL CORTEX 29, 586-597

2018

Molecular pathogenesis of human CD59 deficiency
Karbian N, Eshed-Eisenbach Y, Tabib A, Hoizman H, Morgan BP, Schueler-Furman O, Peles E, Mevorach D. (2018) NEUROLOGY GENETICS 4, e280
Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability
Dawes JM, Weir GA, Middleton SJ, Patel R, Chisholm KI, Pettingill P, Peck LJ, Sheridan J, Shakir A, Jacobson L, Gutierrez-Mecinas M, Galino J, Walcher J, Kühnemund J, Kuehn H, Sanna MD, Lang B, Clark AJ, Themistocleous AC, Iwagaki N, West SJ, Werynska K, Carroll L, Trendafilova T, Menassa DA, Giannoccaro MP, Coutinho E, Cervellini I, Tewari D, Buckley C, Leite MI, Wildner H, Zeilhofer HU, Peles E, Todd AJ, McMahon SB, Dickenson AH, Lewin GR, Vincent A, Bennett DL. (2018) NEURON 97, 806-822
Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier
Bang ML, Vainshtein A Yang HJ, Eshed-Eisenbach Y, Devaux J, Werner HB, Peles E. (2018) GLIA 66, 801–812

2017

Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton.
Brivio V, Faivre-Sarrailh C, Peles E, Sherman DL, Brophy PJ. (2017) CURRENT BIOLOGY 27, 1068-1073
The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier
Amor, V., Zhang, C., Vainshtein, A., Zhang, A., Zollinger, D.R., Eshed-Eisenbach, Y., Brophy, P.J., Rasband, M.N., and Peles, E. (2017) eLIFE 6, e21392

2016

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination
Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan JR. (2016) NEURON 91, 824-836
Auto-antibodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy
Doppler K, Appeltshauser L, Villmann C, Martin C, Peles E, Krämer HH, Haarmann A, Buttmann M, Sommer C. (2016) BRAIN 139, 2617-2630
Specific inhibition of secreted NRG1 types I-II by heparin enhances Schwann cell myelination
Eshed-Eisenbach Y, Gordon A, Sukhanov N, Peles E (2016) GLIA 64, 1227-1234
G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination.
Yang HJ, Vainshtein A, Maik-Rachline G, Peles E. (2016) NATURE COMMUNICATION 7, 10884
Expression of Cntnap2 (Caspr2) in multiple levels of sensory systems
Gordon A, Salomon D, Barak N, Pen Y, Tsoory M, Kimchi T, Peles E (2016) MOLECULAR AND CELLULAR NEUROSCIENCE 70, 42-53

2015

The nodes of Ranvier: molecular assembly and maintenance
Rasband MN, and Peles E. (2015) COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY 8, a020495
Comprehensive analysis of the 16p11.2 deletion and null Cntnap2 mouse models of autism spectrum disorder
Brunner D, Kabitzke P, He D, Cox K, Thiede L, Hanania T, Sabath E, Alexandrov V, Saxe M, Peles E, Mills A, Spooren W, Ghosh A, Feliciano P, Benedetti M, Luo Clayton A, Biemans B (2015) PLOS ONE 10, e0134572
Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder
Lossos A, Elazar N, Lerer I, Schueler-Furman O, Fellig Y, Glick B, Zimmerman BE, Azulay H, Dotan S, Goldberg S, Gomori JM, Ponger P, Newman JP, Marreed H, Steck AJ, Schaeren-Wiemers N, Mor N, Harel M, Geiger T, Eshed-Eisenbach Y, Meiner V, Peles E (2015) BRAIN 138, 2521-2536
The myelin proteolipid plasmolipin forms oligomers and induces liquid-ordered membranes in the Golgi complex
Yaffe Y, Hugger I, Yassaf IN, Shepshelovitch J, Sklan EH, Elkabetz Y, Yeheskel A, Pasmanik-Chor M, Benzing C, Macmillan A, Gaus K, Eshed-Eisenbach Y, Peles E, Hirschberg K (2015) JOURNAL OF CELL SCIENCE 28, 2293-2302
Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons
Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P (2015) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112, 6176-6181
Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes
Chen N, Koopmans F, Gordon A, Paliukhovich I, Klaassen RV, van der Schors RC, Peles E, Verhage M, Smit AB, Li KW. (2015) BIOCHIMIA ET BIOPHYSICA ACTA 1854, 827-833
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
Penagarikano O, Lazaro MT, Lu XH, Gordon A, Dong HM, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH, (2015) SCIENCE TRANSLATIONAL MEDICINE 7,
Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin
Colombelli C, Palmisano M, Eshed-Eisenbach Y, Zambroni D, Pavoni E, Ferri C, Saccucci S, Nicole S, Soininen R, McKee KK, Yurchenco PD, Peles E, Wrabetz L, Feltri ML, (2015) JOURNAL OF CELL BIOLOGY 208, 313-329

2014

Kv7.2 regulates the function of peripheral sensory neurons
King CH, Lancaster E, Salomon D, Peles E, Scherer SS, (2014) JOURNAL OF COMPARATIVE NEUROLOGY 522, 3262-3280
Direct genesis of functional rodent and human Schwann cells from skin mesenchymal precursors
Krause MP, Dworski S, Feinberg K, Jones K, Johnston APW, Paul S, Paris M, Peles E, Bagli D, Forrest CR, Kaplan DR, Miller FD, (2014) STEM CELL REPORTS 3,
Loss of glial Neurofascin155 delays developmental synapse elimination at the neuromuscular junction
Roche SL, Sherman DL, Dissanayake K, Soucy G, Desmazieres A, Lamont DJ, Peles E, Julien JP, Wishart TM, Ribchester RR, Brophy PJ, Gillingwater TH, (2014) JOURNAL OF NEUROSCIENCE 34, 12904-12918
Caspr and Caspr2 are required for both radial and longitudinal organization of myelinated axons
Gordon A, Adamsky K, Vainshtein A, Frechter S, Dupree JL, Rosenbluth J, Peles E, (2014) JOURNAL OF NEUROSCIENCE 34, 14820-14826
Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse apinal cord
Ashrafi S, Betley JN, Comer JD, Brenner-Morton S, Bar V, Shimoda Y, Watanabe K, Peles E, Jessell TM, Kaltschmidt JA, (2014) NEURON 81, 120-129
Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM
Amor V, Feinberg K, Eshed-Eisenbach Y, Vainshtein A, Frechter S, Grumet M, Rosenbluth J, Peles E, (2014) JOURNAL OF NEUROSCIENCE 34, 5089-5098
Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission
Karayannis T, Au E, Patel JC, Kruglikov I, Markx S, Delorme R, Heron D, Salomon D, Glessner J, Restituito S, Gordon A, Rodriguez-Murillo L, Roy NC, Gogos JA, Rudy B, Rice ME, Karayiorgou M, Hakonarson H, Keren B, Huguet G, Bourgeron T, Hoeffer C, Tsien RW, Peles E, Fishell G, (2014) NATURE 511, 236-+

2013

Three mechanisms assemble central nervous system nodes of Ranvier
Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN (2013) NEURON 78, 469-481
An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease
Kinter J, Lazzati T, Schmid D, Zeis T, Erne B, Lutzelschwab R, Steck AJ, Pareyson D, Peles E, Schaeren-Wiemers N, (2013) NEUROBIOLOGY OF DISEASE 49, 221-231
Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy
Golan N, Kartvelishvily E, Spiegel I, Salomon D, Sabanay H, Rechav K, Vainshtein A, Frechter S, Maik-Rachline G, Eshed-Eisenbach Y, Momoi T, Peles E, (2013) JOURNAL OF NEUROSCIENCE 33, 10950-10961
The making of a node: a co-production of neurons and glia
Eshed-Eisenbach Y, Peles E, (2013) CURRENT OPINION IN NEUROBIOLOGY 23, 1049-1056

2012

Neurofascin as a target for autoantibodies in peripheral neuropathies
Ng JKM, Malotka J, Kawakami N, Derfuss T, Khademi M, Olsson T, Linington C, Odaka M, Tackenberg B, Pruss H, Schwab JM, Harms L, Harms H, Sommer C, Rasband MN, Eshed-Eisenbach Y, Peles E, Hohlfeld R, Yuki N, Dornmair K, Meinl E, (2012) NEUROLOGY 79, 2241-2248
The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves
Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, Ohno S, Terada N, Mobius W, Rosenbluth J, Brose N, Peles E, (2012) JOURNAL OF CELL BIOLOGY 196, 337-344
Dependence of paranodal junctional gap width on transverse bands
Rosenbluth J, Petzold C, Peles E (2012) JOURNAL OF COMPARATIVE NEUROLOGY 520, 2774-2784
Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves
Terada N, Saitoh Y, Ohno N, Komada M, Saitoh S, Peles E, Ohno S, (2012) MOLECULAR AND CELLULAR BIOLOGY 32, 199-205

2011

Investigations of Caspr2, an autoantigen of encephalitis and neuromyotonia
Lancaster E, Huijbers MGM, Bar V, Boronat A, Wong A, Martinez-Hernandez E, Wilson C, Jacobs D, Lai M, Walker RW, Graus F, Bataller L, Illa I, Markx S, Strauss KA, Peles E, Scherer SS, Dalmau J, (2011) ANNALS OF NEUROLOGY 69, 303-311
N-WASP is required for membrane wrapping and myelination by Schwann cells
Novak N, Bar V, Sabanay H, Frechter S, Jaegle M, Snapper SB, Meijer D, Peles E (2011) JOURNAL OF CELL BIOLOGY 192, 243-250
The neurexin superfamily of Caenorhabditis elegans
Haklai-Topper L, Soutschek J, Sabanay H, Scheel J, Hobert O, Peles E, (2011) GENE EXPRESSION PATTERNS 11, 144-150
Schwann cell spectrins modulate peripheral nerve myelination
Susuki K, Raphael AR, Ogawa Y, Stankewich MC, Peles E, Talbot WS, Rasband MN, (2011) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, 8009-8014
Paranodal permeability in "Myelin Mutants"
Shroff S, Mierzwa A, Scherer SS, Peles E, Arevalo JC, Chao MV, Rosenbluth J, (2011) GLIA 59, 1447-1457
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
Penagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong HM, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DH, (2011) CELL 147, 235-246

2010

Cellular form of prion protein Inhibits reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated Inhibition of neurite outgrowth
Devanathan V, Jakovcevski I, Santuccione A, Li S, Lee HJ, Peles E, Leshchyns'ka I, Sytnyk V, Schachner M (2010) JOURNAL OF NEUROSCIENCE 30, 9292-9305
Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A, (2010) BRAIN 133, 2734-2748
Localization of the paranodal protein Caspr in the mammalian retina
O'Brien BJ, Hirano AA, Buttermore ED, Bhat MA, Peles E, (2010) MOLECULAR VISION 16, 1854-1863
ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons
Ogawa Y, Oses-Prieto J, Kim MY, Horresh I, Peles E, Burlingame AL, Trimmer JS, Meijer D, Rasband MN, (2010) JOURNAL OF NEUROSCIENCE 30, 1038-1048
A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier
Feinberg K, Eshed-Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, Dupree JL, Grumet M, Brophy PJ, Shrager P, Peles E, (2010) NEURON 65, 490-502
Organization of Myelinated Axons by Caspr and Caspr2 Requires the Cytoskeletal Adapter Protein 4.1B
Horresh I, Bar V, Kissil JL, Peles E, (2010) JOURNAL OF NEUROSCIENCE 30, 2480-2489

2009

Differential clustering of Caspr by oligodendrocytes and Schwann cells
Eisenbach M, Kartvelishvily E, Eshed-Eisenbach Y, Watkins T, Sorensen A, Thomson C, Ranscht B, Barnett SC, Brophy P, Peles E, (2009) JOURNAL OF NEUROSCIENCE RESEARCH 87, 3492-3501
The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development
Grossmann KS, Wende H, Paul FE, Cheret C, Garratt AN, Zurborg S, Feinberg K, Besser D, Schulz H, Peles E, Selbach M, Birchmeier W, Birchmeier C, (2009) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, 16704-16709
A novel method for isolating Schwann cells using the extracellular domain of Necl1
Spiegel I, Peles E, (2009) JOURNAL OF NEUROSCIENCE RESEARCH 87, 3288-3296
A novel Caspr mutation causes the shambling mouse phenotype by disrupting axoglial interactions of myelinated nerves
Sun XY, Takagishi Y, Okabe E, Chishima Y, Kanou Y, Murase S, Mizumura K, Inaba M, Komatsu Y, Hayashi Y, Peles E, Oda S, Murata Y, (2009) JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 68, 1207-1218

2008

Thrombin receptor PAR-1 on myelin at the node of Ranvier: a new anatomy and physiology of conduction block
Shavit E, Beilin O, Korczyn AD, Sylantiev C, Aronovich R, Drory VE, Gurwitz D, Horresh I, Bar-Shavit R, Peles E, Chapman J, (2008) BRAIN 131, 1113-1122
Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
Ogawa Y, Horresh I, Trimmer JS, Bredt DS, Peles E, Rasband MN, (2008) JOURNAL OF NEUROSCIENCE 28, 5731-5739
Identification of Tmem10/Opalin as an oligodendrocyte enriched gene using expression profiling combined with genetic cell ablation
Golan N, Adamsky K, Kartvelishvily E, Brockschnieder D, Mobius W, Spiegel I, Roth AD, Thomson CE, Rechavi G, Peles E, (2008) GLIA 56, 1176-1186
Molecular domains of myelinated axons in the peripheral nervous system
Salzer JL, Brophy PJ, Peles E, (2008) GLIA 56, 1532-1540
Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons
Horresh I, Poliak S, Grant S, Bredt D, Rasband MN, Peles E, (2008) JOURNAL OF NEUROSCIENCE 28, 14213-14222

2007

Secreted gliomedin is a perinodal matrix component of peripheral nerves
Eshed Y, Feinberg K, Carey DJ, Peles E, (2007) JOURNAL OF CELL BIOLOGY 177, 551-562
A central role for Necl4 ( SynCAM4) in Schwann cell- axon interaction and myelination
Spiegel I, Adamsky K, Eshed Y, Milo R, Sabanay H, Sarig-Nadir O, Horresh I, Scherer SS, Rasband MN, Peles E, (2007) NATURE NEUROSCIENCE 10, 861-869
A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones
Parent AS, Mungenast AE, Lomniczi A, Sandau US, Peles E, Bosch MA, Ronnekleiv OK, Ojeda SR, (2007) JOURNAL OF NEUROENDOCRINOLOGY 19, 847-859
Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons
Sumita K, Sato Y, Iida J, Kawata A, Hamano M, Hirabayashi S, Ohno K, Peles E, Hata Y, (2007) JOURNAL OF NEUROCHEMISTRY 100, 154-166

2006

Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton
Ogawa Y, Schafer DP, Horresh I, Bar V, Hales K, Yang Y, Susuki K, Peles E, Stankewich MC, Rasband MN, (2006) JOURNAL OF NEUROSCIENCE 26, 5230-5239
A new player in CNS myelination
Spiegel I, Peles E (2006) NEURON 49, 777-778
Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology
Brockschnieder D, Sabanay H, Riethmacher D, Peles E (2006) JOURNAL OF NEUROSCIENCE 26, 757-762
Identification of novel cell-adhesion molecules in peripheral nerves using a signal-sequence trap
Spiegel I, Adamsky K, Eisenbach M, Eshed Y, Spiegel A, Mirsky R, Scherer SS, Peles E (2006) NEURON GLIA BIOLOGY 2, 27-38

2005

Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier
Eshed Y, Feinberg K, Poliak S, Sabanay H, Sarig-Nadir O, Spiegel I, Bermingham JR, Peles E (2005) NEURON 47, 215-229

2004

Mechanisms and roles of axon-Schwann cell interactions
Corfas G, Velardez MO, Ko CP, Ratner N, Peles E (2004) JOURNAL OF NEUROSCIENCE 24, 9250-9260
Altered expression of ion channel isoforms at the node of Ranvier in P0-deficient myelin mutants
Ulzheimer JC, Peles E, Levinson SR, Martini R (2004) MOLECULAR AND CELLULAR NEUROSCIENCE 25, 83-94

2003

Caspr regulates the processing of contactin and inhibits its binding to neurofascin
Gollan L, Salomon D, Salzer JL, Peles E (2003) JOURNAL OF CELL BIOLOGY 163, 1213-1218
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
Poliak S, Salomon D, Elhanany H, Sabanay H, Kiernan B, Pevny L, Stewart CL, Xu XR, Chiu SY, Shrager P, Furley AJW, Peles E (2003) JOURNAL OF CELL BIOLOGY 162, 1149-1160
The local differentiation of myelinated axons at nodes of Ranvier
Poliak S, Peles E (2003) NATURE REVIEWS NEUROSCIENCE 4, 968-980
Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylaited proteins
Adamsky K, Arnold K, Sabanay H, Peles E (2003) JOURNAL OF CELL SCIENCE 116, 1279-1289

2002

Development of nodes of Ranvier
Girault JA, Peles E (2002) CURRENT OPINION NEUROBIOLOGY 12, 476-485
Clustering of neuronal potassium channels is independent of their interaction with PSD-95
Rasband MN, Park EW, Zhen D, Arbuckle MI, Poliak S, Peles E, Grant SG, Trimmer JS (2002) JOURNAL OF CELL BIOLOGY 159, 663-672
Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains
Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (2002) MOLECULAR AND CELLULAR NEUROSCIENCE 2, 283-297
Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1
Bulow HE, Berry KL, Topper LH, Peles E, Hobert O (2002) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99, 6346-6351
Genetic dysmyelination alters the molecular architecture of the nodal region
Arroyo EJ, Xu T, Grinspan J, Lambert S, Levinson SR, Brophy PJ, Peles E, Scherer SS (2002) THE JOURNAL OF NEUROSCIENCE 22, 1726-1737
Cellular junctions of myelinated nerves
Spiegel I, Peles E (2002) MOLECULAR MEMBRANE BIOLOGY 19, 95-101
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells
Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E (2002) JOURNAL OF CELL BIOLOGY 159, 361-372
Falkor, a novel cell growth regulator isolated by a functional genetic screen
Erez N, Milyavsky M, Goldfinger N, Peles E, Gudkov AV, Rotter V (2002) ONCOGENE 21, 6713-6721
Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr
Gollan L, Sabanay H, Poliak S, Berglund EO, Ranscht B, Peles E (2002) JOURNAL OF CELL BIOLOGY 157, 1247-1256
A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation
Ishibashi T, Dupree PJ, Ikenaka K, Hirahara Y, Honke K, Peles E, Popko B, Nishino H, Baba H (2002) JOURNAL OF NEUROSCIENCE 22, 6507-6514

2001

Internodal specializations of myelinated axons in the central nervous system
Arroyo EJ, Xu T, Poliak S, Watson M, Peles E, Scherer SS (2001) CELL AND TISSUE RESEARCH 305, 53-66
Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTP beta) to tenascin C
Adamsky K, Schilling J, Garwood J, Faissner A, Peles E (2001) ONCOGENE 20, 609-618
Molecular organization of the nodal region is not altered in spontaneously diabetic BB-wistar rats
Brown AA, Xu T, Arroyo EJ, Levinson SR, Brophy PJ, Peles E, Scherer SS (2001) JOURNAL OF NEUROSCIENCE RESEARCH 65, 139-149
Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve
Boyle MET, Berglund EO, Murai KK, Weber L, Peles E, Ranscht B (2001) NEURON 30, 385-397
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1
Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (2001) JOURNAL OF BIOLOGICAL CHEMISTRY 276, 12974-12982
Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
Poliak S, Gollan L, Salomon D, Berglund EO, Ohara R, Ranscht B, Peles E (2001) JOURNAL OF NEUROSCIENCE 21, 7568-7575

2000

Molecular domains of myelinated axons
Peles E, Salzer JL (2000) CURRENT OPINION IN NEUROBIOLOGY 10, 558-565
Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination
Rios JC, Melandez-Vasquez CV, Einheber S, Lustig M, Grumet M, Hemperly J, Peles E, Salzer JL (2000) JOURNAL OF NEUROSCIENCE 20, 8354-8364
Sodium channel Na(v)1.6 is localized at nodes of Ranvier, dendrites, and synapses
Caldwell JH, Schaller KL, Lasher RS, Peles E, Levinson SR (2000) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97, 5616-5620

1999

Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS
Rasband MN, Peles E, Trimmer JS, Levinson SR, Lux SE, Shrager P (1999) THE JOURNAL OF NEUROSCIENCE 19, 7516-7528
K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve
Rasband MN, Trimmer JS, Peles E, Levinson SR, Shrager P (1999) JOURNAL OF NEUROCYTOLOGY 28, 319-331
Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kv beta 2, and Caspr
Arroyo EJ, Xu YT, Zhou L, Messing A, Peles E, Chiu SY, Scherer SS (1999) JOURNAL OF NEUROCYTOLOGY 28, 333-347
Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels
Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E (1999) NEURON 24, 1037-1047

1998

Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta
Holland SJ, Peles E, Pawson T, Schlessinger J, (1998) CURRENT OPINION IN NEUROBIOLOGY 8, 117-127
Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: Implications for intercellular signaling
Peles E, Schlessinger J, Grumet M, (1998) TRENDS IN BIOCHEMICAL SCIENCES 23, 121-124

1997

The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination
Einheber S, Zanazzi G, Ching W, Scherer S, Milner TA, Peles E, Salzer JL (1997) JOURNAL OF CELL BIOLOGY 139, 1495-1506
Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions
Peles E, Joho K, Plowman GD, Schlessinger J (1997) CELL 88, 745-746
Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta
Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (1997) JOURNAL OF CELL BIOLOGY 136, 907-918
Identification of a novel contactin associated transmembrane receptor with multiple domains implicated in protein-protein interaction
Peles E, Nativ M, Lustig M, Grumet M, Schilling J, Martinez R, Plowman GD, Schlessinger J (1997) EUROPEAN MOLECULAR BIOLOGY ORGANIZATION JOURNAL 16, 978-988

1995

Protein tyrosine kinase Pyk2 involved in Ca2+ induced regulation of ion channel and MAP kinase function
Lev, S., Moreno, H., Martinez, R., Canoll, P. D., Peles, E., Musacchio, J. M., Plowman, G. D., Rudy, B., Schlessinger, J. (1995) NATURE 376, 737-745
The carbonic anhydrase domain of receptor tyrosine phosphatase b is a functional ligand for the axonal cell recognition molecule contactin
Peles, E., Nativ, M., Campbell, P. L., Sakurai, T., Martinez, R., Lev, S., Clary, D. O., Schilling, J., Barnea, G., Plowman, G. D., Grumet, M., Schlessinger, J. (1995) CELL 82, 251-260

1994

ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.
Tzahar, E., Levkowitz, G., Karunagaran, D., Yi, L., Peles, E., Lavi, S., Chang, D., Liu, N., Yayon, A., Wen, D., Yarden, Y. (1994) JOURNAL OF BIOLOGICAL CHEMISTRY 269, 25226-25233

1993

Neu differentiation factor (Heregulin) induces expression of Intercellular adhesion molecule 1: implication for mammary tumors
Bacus, S. S., Gudkov, A. V., Zelnick, C. R., Chin, D., Stern, R., Stancovski, I., Peles, E., Ben-Baruch, N., Farbstein, H., Lupu, R., Wen, D., Sela, M., Yarden, Y. (1993) CANCER RESEARCH 53, 5251-5261
Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships
Peles, E., Ben-Levy, R., Tzahar, E., Naili, L., Wen, D., Yarden, Y. (1993) EUROPEAN MOLECULAR BIOLOGY ORGANIZATION JOURNAL 12, 961-971
Neu and its ligands: from an oncogene to neural factors
Peles E, Yarden Y. (1993) BIOESSAYS JOURNAL 15, 815-824

1992

Neu Differentiation Factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit
Wen, D., Peles, E., Cupples, R., Suggs, S. V., Bacus, S. S., Luo, Y., Trail, G., Hu, S., Silbiger, S. M., Ben-Levy, R., Luo, Y., arden, Y. (1992) CELL 69, 559-572
A point mutation confers high affinity ligand binding to the Neu receptor: Implications for the generation of site heterogenicity
Ben-Levy R, Peles E, Goldman-Michael R, Yarden Y. (1992) JOURNAL OF BIOLOGICAL CHEMISTRY 267, 17304-17313
Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation
Peles E, Lamprecht R, Ben-Levy R, Tzahar E, Yarden Y. (1992) JOURNAL OF BIOLOGICAL CHEMISTRY 267, 12266-12274
Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells
Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Ben-Levy, R., and Y. Yarden. (1992) CELL 69, 205-216
Signal transduction by the Neu/erbB-2 receptor: A potential target for anti-tumor therapy
Stancovski, I., Peles, E., Ben-Levy, R., Lemprecht, R., Kelman, Z., Goldman-Michael, R., Hurwitz, E., Bacus, S., Sela, M., Yarden, Y. (1992) JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 43, 95-103

1991

Oncogenic forms of the neu/HER-2 tyrosine kinase are permanently coupled to phospholipase C gamma
Peles E, Ben Levy R, Or E, Ullrich A, Yarden Y. (1991) EUROPEAN MOLECULAR BIOLOGY ORGANIZATION JOURNAL 10, 2077-2086
Biochemical analysis of the ligand for the Neu oncogenic receptor
Yarden Y, Peles E. (1991) BIOCHEMISTRY 30, 3543-3550

1990

Importance of the HpaI-P sequence for Herpes simplex virus-1 replication in the adrenal glands
Peles E, Rosen H, Darai G, Rosen-Wolff A, Becker Y. (1990) ARCHIVES OF VIROLOGY 113, 151-163
Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: A mechanism for receptor transregulation
Goldman, R., Ben-Levy, R., Peles, E., and Yarden, Y. (1990) BIOCHEMISTRY 29, 11024-11028