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Uri Alon lab Design Principles in Biology
Weizmann Institute of Science Department of Molecular Cell Biology

System Medicine 2022-2023

Lecture Notes and exercises 

Links for interactive python notebook tutorials

Colab notebooks:

  • Tutorial exercise 1 - introduction to sympy
  • Tutorial exercise 2 - expressing the glucose insulin model in python
  • Tutorial exercise 3 - exponential decay
  • Tutorial exercise 4 -  solving the steady state of the system
  • Tutorial exercise 5 - simulating GTT

Github repository 

The lecture notes are actually chapters from a new book we are working on. They are presented here in goolge doc format. Please comment if anything is unclear or if there are typos. This will help us make the book better.

Chapter 0: Introduction 

Chapter 1: The insulin circuit

Exercise set 1

Chapter 2: Dynamical compensation, mutant resistance, and type-2 diabetes

Chapter 2.5: Three laws of physiology

Chapter 3: The stress hormone axis as a two-gland oscillator

Chapter 3.5: The thyroid and its discontents

Chapter 4: Autoimmune diseases as a fragility of mutant surveillance

Exercise set 2

Chapter 5: Inflammation and fibrosis as a bistable system

Chapter 6: Basic facts aging

Exercise set 3

Chapter 7: Aging and saturated repair

Chapter 8: Age-related diseases

Chapter 9: Periodic Table of diseases

Chapter 10: Epilog - Simplicity in Systems Medicine 

Final Exercise

 

 

 

 

 

 

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28 Mar, 2023 | GMT+03:00