Prof. Yehiel Zick
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Cross talk between insulin resistance, animal lectins and bone remodeling
We combine mouse models, cell biology and analysis of signaling pathways to focus on:
- Role of animal lectins (particularly galectin-8) as regulators of bone remodeling and insulin action
- Novel elements (Ndfip1; Otub2, TM7SF3) that modulate survival of pancreatic beta cells
- IRS (insulin receptor substrate) proteins, insulin resistance, and beta cell function