Selected recent publications (see pubmed for full list)

*- Equal first-authors; # - Corresponding author


  • Gavish A, Tyler M, Greenwald A, ... , Tirosh I(2023) "Hallmarks of transcriptional intratumor heterogeneity across a thousand tumors". Nature [PDF] [3CA website]. Highlighted in Nature, Cancer Cell, and Nat. Rev. Genetics 
  • Puram S*,#, Mints M*, ... , Tirosh I(2023) "Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma". Nature Genetics 55(4):640-650 [PDF]. Highlighted in Nature Genetics


  • Chanoch-Myers R, Wider A, Suva ML, Tirosh I#(2022) "Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis". Genome medicine 14(1):106 [PDF]


  • Spitzer A*, Gritsch S*, ... , Ligon KL#, Cahill DP#, Suvà ML#, Tirosh I#(2021) "Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma". medRxiv [PDF]
  • Hara T*, Chanoch-Myers R*, ... , Suvà ML#, Tirosh I# (2021) "Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma". Cancer Cell. [PDF]. highlighted in Cancer Cell
  • Tyler M, Tirosh I# (2021) "Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis". Nature Commun12, 2592 [PDF]
  • Gonzalez Castro LN, Tirosh I#, Suvà ML# (2021) "Decoding Cancer Biology One Cell at a Time". Cancer Discov. 11(4):960-970. [PDF]
  • Mathewson ND*, Ashenberg O*, Tirosh I*, Gritsch S*, Perez EM*, Marx S*, Jerby-Arnon L, Chanoch-Myers R, ... , Reardon DA#, Regev A#, Suvà ML#, Wucherpfennig KW# (2021) "Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis". Cell 8674(21)00065-9 [PDF]


  • Kinker G*, Greenwald A*, ... , Tirosh I# (2020) "Pan-cancer single cell RNA-seq identifies recurring programs of cellular heterogeneity". Nature Genetics 52, 1208–1218 [PDF]
  • Izar B*, Tirosh I*, Stover EH* et al. (2020) "A single-cell landscape of high-grade serous ovarian cancer". Nature Med. [PDF]
  • Suva ML#, Tirosh I# (2020) "The Glioma Stem Cell Model in the Era of Single-Cell Genomics". Cancer Cell [PDF]


  • Neftel C*, Laffy J*, ... , Tirosh I#, Suva M# (2019) "An integrative model of cellular states, plasticity and genetics for glioblastoma". Cell 178:1–15. [PDF

  • Suvà ML#, Tirosh I# (2019). “Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges”. Mol Cell. 75(1):7-12. [PDF]

  • Keskin DB*, Anandappa AJ*, Sun J*, Tirosh I*, et al. (2019). “Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial”. Nature 565(7738):234-239. [PDF]

  • Tirosh I#, Suva ML# (2019). “Deciphering Human Tumor Biology by Single-Cell Expression Profiling”. Annual Reviews Cancer Biology Vol. 3. [PDF]


  • Filbin MG*, Tirosh I*, Hovestadt* et al. (2018). “Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq”. Science 360(6386): 331-335. [PDF]


  • Puram S*, Tirosh I*# et al. (2017). “Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer”. Cell 171(7):1611-1624. [PDF]    

  • Venteicher A*, Tirosh I*# et al.  (2017). “Decoupling genetic, developmental and micro-environmental programs in IDH-mutant gliomas through single-cell transcriptomics”. Science 355(6332). [PDF]


  • Tirosh I*, Venteicher A*, et al. (2016). "Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma." Nature 539(7628):309-313. [PDF]

  • Tirosh I*, Izar B* et al. (2016). "Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq." Science 352(6282): 189-196. [PDF]


  • Kowalczyk MS*., Tirosh I* et al. (2015). "Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells." Genome Res 25(12): 1860-1872. [PDF]


  • Patel AP*., Tirosh I* et al. (2014). "Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma." Science 344(6190): 1396-1401. [PDF]