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Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p
Localization:
Intensity:
Fold change:
Significance:
-
C’ GFP library in SD
below threshold17.1 -
N' NOP1pr-GFP in SD
cytosol,punctate50.3316 -
N' TEF2pr-mCherry in SD
cytosol36.3945 -
N' NATIVEpr-GFP in SD
cytosol23.8982 -
N' TEF2pr-VC and Cyto-VN in SD
#N/A0 -
C’ GFP library in SD+DTT
cytosol17.851.04No -
C’ GFP library in SD+H2O2
cytosol16.470.96No -
C’ GFP library in Starvation Media
cytosol18.161.06No -
C’ GFP library on the background of Pup2-DaMP
below threshold -
C’ GFP library on the background of CCT mutant
below threshold17.43221.01897No