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One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks
Localization:
Intensity:
Fold change:
Significance:
  • C’ GFP library in SD
    YLR450W
    nuclear periphery
    28.13
  • N' NOP1pr-GFP in SD
    YLR450W
    ER
    101.053
  • N' TEF2pr-mCherry in SD
    YLR450W
    ER,nuclear periphery
    110.354
  • N' NATIVEpr-GFP in SD
    YLR450W
    below threshold
    18.8535
  • N' TEF2pr-VC and Cyto-VN in SD
    YLR450W
    ER
    34.1714
  • C’ GFP library in SD+DTT 
    YLR450W
    nuclear periphery
    33.53
    1.19
    No
  • C’ GFP library in SD+H2O2
    YLR450W
    nuclear periphery
    37.45
    1.33
    Yes
  • C’ GFP library in Starvation Media
    YLR450W
    nuclear periphery
    41.34
    1.46
    Yes
  • C’ GFP library on the background of Pup2-DaMP
    noimage.png
    nuclear periphery
  • C’ GFP library on the background of CCT mutant
    noimage.png
    nuclear periphery
    22.7412
    0.808251
    No