1. Mathias Mahn; Lihi Gibor; Pritish Patil; Katayun Cohen-Kashi Malina; Shir Oring; Yoav Printz; Rivka Levy; Ilan Lampl; Ofer Yizhar (2018). High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins.  Nature Communications. 9.  Abstract

    Here we develop a set of soma-targeted chloride-conducting channelrhodopsins that allow highly-efficient silencing of somatic action potentials in vitro and in vivo. Constructs available on Addgene.

  2. Ofer Yizhar; Oded Klavir (2018). Reciprocal amygdala-prefrontal interactions in learning.  Current Opinion in Neurobiology. 52:149-155.  Abstract
  3. Dana Rubi Levy, Tal Tamir, Maya Kaufman, Aharon Weissbrod, Elad Schneidman and Ofer Yizhar (2018). Dynamics of social representation in the mouse prefrontal cortex.  bioRxiv. 321182.  Abstract

    Our latest preprint, in which we characterize the responses of neurons in the mouse prefrontal cortex to socially-relevant odors. We also compare the prefrontal representation of social and non-social odors in wild-type mice and in Cntnap2 knockout mice, a genetic model of autism and related neurodevelopmental disorders.

  4. Dana Rubi Levy; Ofer Yizhar (2018). Stress and sociability.  Nature Neuroscience. 21:(3)304-306.
  5. Angelo Forli; Dania Vecchia; Noemi Binini et al. (2018). Two-Photon Bidirectional Control and Imaging of Neuronal Excitability with High Spatial Resolution In Vivo.  Cell Reports. 22:(11)3087-3098.  Abstract

    Here we show that  blue-absorbing channelrhodopsins can be combined with red-shifted calcium indicators for simultaneous two-photon holographic stimulation/silencing of single neurons in vivo.

    [All authors]


  1. J. Simon Wiegert; Mathias Mahn; Matthias Prigge; Yoav Printz; Ofer Yizhar (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints.  Neuron. 95:(3)504-529.  Abstract

    A detailed analysis of the tools used to silence neurons and their applications in systems neuroscience.

  2. Oded Klavir; Matthias Prigge; Ayelet Sarel; Rony Paz; Ofer Yizhar (2017). Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex.  Nature Neuroscience. 20:(6)836-844.  Abstract

    Previewed by Stujenske and Likhtik on Nature Neuroscience

  3. Tatiana Tkatch; Elisa Greotti; Gytis Baranauskas et al. (2017). Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins.  Proceedings of the National Academy of Sciences of the United States of America. 114:(26)E5167-E5176.  Abstract [All authors]
  4. Satoshi P. Tsunoda; Matthias Prigge; Rei Abe-Yoshizumi; Keiichi Inoue; Yuko Kozaki; Toru Ishizuka; Hiromu Yawo; Ofer Yizhar; Hideki Kandori (2017). Functional characterization of sodium-pumping rhodopsins with different pumping properties.  PLoS One. 12:(7)  Abstract
  5. Marco Venniro; Daniele Caprioli; Michelle Zhang et al. (2017). The Anterior Insular Cortex -> Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management.  Neuron. 96:(2)414-+.  Abstract [All authors]
  6. M. J. A. G. Henckens; Y. Printz; U. Shamgar et al. (2017). CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery.  Molecular Psychiatry. 22:(12)1691-1700.  Abstract [All authors]
  7. Thomas Lissek; Michelle Adams; John Adelman et al. (2017). Building Bridges through Science.  Neuron. 96:(4)730-735.  Abstract [All authors]
  8. Stefanie Hardung; Robert Epple; Zoe Jaeckel; David Eriksson; Cem Uran; Verena Senn; Lihi Gibor; Ofer Yizhar; Ilka Diester (2017). A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition.  Current Biology. 27:(4)549-555.  Abstract


  1. Mathias Mahn; Matthias Prigge; Shiri Ron; Rivka Levy; Ofer Yizhar (2016). Biophysical constraints of optogenetic inhibition at presynaptic terminals.  Nature Neuroscience. 19:(4)554-6.  Abstract
  2. Alice Ting; Rosalind Segal; Matteo Carandini; Valentina Emiliani; Ofer Yizhar; Botond Roska; Na Ji; David J. Anderson (2016). Opportunities for Technology and Tool Development.  Neuron. 92:(3)564-566.  Abstract
  3. Yair Shemesh; Oren Forkosh; Mathias Mahn et al. (2016). Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.  Nature Neuroscience. 19:(11)1489-1496.  Abstract [All authors]


  1. Niv Scott; Matthias Prigge; Ofer Yizhar; Tali Kimchi (2015). A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion.  Nature. 525:(7570)519-522.  Abstract


  1. Mathias Mahn; Shiri Ron; Ofer Yizhar (2014). Viral Vector-Based Techniques for Optogenetic Modulation In Vivo.  VIRAL VECTOR APPROACHES IN NEUROBIOLOGY AND BRAIN DISEASES. 289-310.  Abstract
  2. T. B. Oram; A. Ahissar; Ofer Yizhar (2014). Changes in motor-sensory exploratory behavior induced by optogenetic inhibition of thalamic activity.  Journal of Molecular Neuroscience. 53:S96-S96.  Abstract


  1. Yonatan Katz; Ofer Yizhar; Jochen Staiger; Ilan Lampl (2013). Optopatcher-An electrode holder for simultaneous intracellular patch-clamp recording and optical manipulation.  Journal of Neuroscience Methods. 214:(1)113-117.  Abstract
  2. Boaz Barak; Eitan Okun; Yoav Ben-Simon et al. (2013). Neuron-Specific Expression of Tomosyn1 in the Mouse Hippocampal Dentate Gyrus Impairs Spatial Learning and Memory.  NeuroMolecular Medicine. 15:(2)351-363.  Abstract [All authors]


  1. Joanna Mattis; Kay M. Tye; Emily A. Ferenczi et al. (2012). Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.  Nature Methods. 9:(2)159-172.  Abstract [All authors]
  2. Ofer Yizhar (2012). Optogenetic Insights into Social Behavior Function.  Biological Psychiatry. 71:(12)1075-1080.  Abstract
  3. Ofer Yizhar; L. Fenno; Matthias Prigge; P. Hegemann; K. Deisseroth (2012). Neocortical excitation/inhibition balance in information processing and social dysfunction.  Journal of Molecular Neuroscience. 48:S128-S129.  Abstract


  1. Ilana B. Witten; Elizabeth E. Steinberg; Soo Yeun Lee et al. (2011). Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement.  Neuron. 72:(5)721-733.  Abstract [All authors]
  2. Ofer Yizhar; Lief E. Fenno; Matthias Prigge et al. (2011). Neocortical excitation/inhibition balance in information processing and social dysfunction.  Nature. 477:(7363)171-178.  Abstract [All authors]
  3. Feng Zhang; Johannes Vierock; Ofer Yizhar et al. (2011). The Microbial Opsin Family of Optogenetic Tools.  Cell. 147:(7)1446-1457.  Abstract [All authors]