Publications

2018

  1. Mahn M., Gibor L., Patil P., Malina K. C., Oring S., Printz Y., Levy R., Lampl I. & Yizhar O. (2018). High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins.  Nature Communications. 9.  Abstract

    Here we develop a set of soma-targeted chloride-conducting channelrhodopsins that allow highly-efficient silencing of somatic action potentials in vitro and in vivo. Constructs available on Addgene.

  2. Yizhar O. & Klavir O. (2018). Reciprocal amygdala-prefrontal interactions in learning.  Current Opinion in Neurobiology. 52:149-155.  Abstract
  3. Dana Rubi Levy, Tal Tamir, Maya Kaufman, Aharon Weissbrod, Elad Schneidman and Ofer Yizhar (2018). Dynamics of social representation in the mouse prefrontal cortex.  bioRxiv. 321182.  Abstract

    Our latest preprint, in which we characterize the responses of neurons in the mouse prefrontal cortex to socially-relevant odors. We also compare the prefrontal representation of social and non-social odors in wild-type mice and in Cntnap2 knockout mice, a genetic model of autism and related neurodevelopmental disorders.

  4. Levy D. R. & Yizhar O. (2018). Stress and sociability.  Nature Neuroscience. 21:(3)304-306.
  5. Forli A., Vecchia D., Binini N., Succol F., Bovetti S., Moretti C., Nespoli F., Mahn M., Baker C. A., Bolton M. M., Yizhar O. & Fellin T. (2018). Two-Photon Bidirectional Control and Imaging of Neuronal Excitability with High Spatial Resolution In Vivo.  Cell Reports. 22:(11)3087-3098.  Abstract

    Here we show that  blue-absorbing channelrhodopsins can be combined with red-shifted calcium indicators for simultaneous two-photon holographic stimulation/silencing of single neurons in vivo.

2017

  1. Wiegert J. S., Mahn M., Prigge M., Printz Y. & Yizhar O. (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints.  Neuron. 95:(3)504-529.  Abstract

    A detailed analysis of the tools used to silence neurons and their applications in systems neuroscience.

  2. Klavir O., Prigge M., Sarel A., Paz R. & Yizhar O. (2017). Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex.  Nature Neuroscience. 20:(6)836-844.  Abstract

    Previewed by Stujenske and Likhtik on Nature Neuroscience

  3. Tkatch T., Greotti E., Baranauskas G., Pendin D., Roy S., Nita L. I., Wettmarshausen J., Prigge M., Yizhar O., Shirihai O. S., Fishman D., Hershfinkel M., Fleidervish I. A., Perocchi F., Pozzan T. & Sekler I. (2017). Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins.  Proceedings of the National Academy of Sciences of the United States of America. 114:(26)E5167-E5176.  Abstract
  4. Tsunoda S. P., Prigge M., Abe-Yoshizumi R., Inoue K., Kozaki Y., Ishizuka T., Yawo H., Yizhar O. & Kandori H. (2017). Functional characterization of sodium-pumping rhodopsins with different pumping properties.  PLoS One. 12:(7)  Abstract
  5. Venniro M., Caprioli D., Zhang M., Whitaker L. R., Zhang S., Warren B. L., Cifani C., Marchant N. J., Yizhar O., Bossert J. M., Chiamulera C., Morales M. & Shaham Y. (2017). The Anterior Insular Cortex -> Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management.  Neuron. 96:(2)414-+.  Abstract
  6. Henckens M. J. A. G., Printz Y., Shamgar U., Dine J., Lebow M., Drori Y., Kuehne C., Kolarz A., Eder M., Deussing J. M., Justice N. J., Yizhar O. & Chen A. (2017). CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery.  Molecular Psychiatry. 22:(12)1691-1700.  Abstract
  7. Lissek T., Adams M., Adelman J., Ahissar E., Akaaboune M., Akil H., a'Absi M., Arain F., Carlos Arango-Lasprilla J., Atasoy D., Avila J., Badawi A., Bading H., Baig A. M., Baleriola J., Belmonte C., Bertocchi I., Betz H., Blakemore C., Blanke O., Boehm-Sturm P., Bonhoeffer T., Bonifazi P., Brose N., Campolongo P., Celikel T., Chang C. C., Chang T., Citri A., Cline H. T., Cortes J. M., Cullen K., Dean K., M. Delgado-Garcia J., Desroches M., Disterhoft J. F., Dowling J. E., Draguhn A., El-Khamisy S. F., El Manira A., Enam S. A., Encinas J. M., Erramuzpe A., Esteban J. A., Farinas I., Fischer E., Fukunaga I., Gabilondo I., Ganten D., Gidon A., Carlos Gomez-Esteban J., Greengard P., Grinevich V., Gruart A., Guillemin R., Hariri A. R., Hassan B., Hausser M., Hayashi Y., Hussain N. K., Jabbar A. A., Jaber M., Jahn R., Janahi E. M., Kabbaj M., Kettenmann H., Kindt M., Knafo S., Koehr G., Komai S., Krugers H., Kuhn B., Lakhdar Ghazal N., Larkum M. E., London M., Lutz B., Matute C., Martinez-Millan L., Maroun M., McGaugh J., Moustafa A. A., Nasim A., Nave K., Neher E., Nikolich K., Outeiro T., Palmer L. M., Penagarikano O., Perez-Otano I., Pfaff D. W., Poucet B., Rahman A., Ramos-Cabrer P., Rashidy-Pour A., Roberts R. J., Rodrigues S., Sanes J. R., Schaefer A. T., Segal M., Segev I., Shafqat S., Siddiqui N. A., Soreq H., Soriano-Garcia E., Spanagel R., Sprengel R., Stuart G., Sudhof T. C., Tonnesen J., Trevino M., Uthman B. M., Venter J. C., Verkhratsky A., Weiss C., Wiesel T. N., Yaksi E., Yizhar O., Young L. J., Young P., Zawia N. H., Zugaza J. L. & Hasan M. T. (2017). Building Bridges through Science.  Neuron. 96:(4)730-735.  Abstract
  8. Hardung S., Epple R., Jaeckel Z., Eriksson D., Uran C., Senn V., Gibor L., Yizhar O. & Diester I. (2017). A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition.  Current Biology. 27:(4)549-555.  Abstract

2016

  1. Mahn M., Prigge M., Ron S., Levy R. & Yizhar O. (2016). Biophysical constraints of optogenetic inhibition at presynaptic terminals.  Nature Neuroscience. 19:(4)554-6.  Abstract
  2. Ting A., Segal R., Carandini M., Emiliani V., Yizhar O., Roska B., Ji N. & Anderson D. J. (2016). Opportunities for Technology and Tool Development.  Neuron. 92:(3)564-566.  Abstract
  3. Shemesh Y., Forkosh O., Mahn M., Manashirov S., Anpilov S., Sztainberg Y., Shlapobersky T., Elliott E., Tabouy L., Ezra G., Adler E. S., Gil S., Ben-Efraim Y. J., Kuperman Y., Haramati S., Dine J., Deussing J. M., Eder M., Schneidman E., Yizhar O. & Chen A. (2016). Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.  Nature Neuroscience. 19:(11)1489-1496.  Abstract

2015

  1. Scott N., Prigge M., Yizhar O. & Kimchi T. (2015). A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion.  Nature. 525:(7570)519-522.  Abstract

2014

  1. Mahn M., Ron S. & Yizhar O. (2014). Viral Vector-Based Techniques for Optogenetic Modulation In Vivo.  VIRAL VECTOR APPROACHES IN NEUROBIOLOGY AND BRAIN DISEASES. 289-310.  Abstract

2013

  1. Barak B., Okun E., Ben-Simon Y., Lavi A., Shapira R., Madar R., Wang Y., Norman E., Sheinin A., Pita M. A., Yizhar O., Mughal M. R., Stuenkel E., van Praag P. H., Mattson M. P. & Ashery U. (2013). Neuron-Specific Expression of Tomosyn1 in the Mouse Hippocampal Dentate Gyrus Impairs Spatial Learning and Memory.  NeuroMolecular Medicine. 15:(2)351-363.  Abstract
  2. Katz Y., Yizhar O., Staiger J. & Lampl I. (2013). Optopatcher-An electrode holder for simultaneous intracellular patch-clamp recording and optical manipulation.  Journal of Neuroscience Methods. 214:(1)113-117.  Abstract

2012

  1. Mattis J., Tye K. M., Ferenczi E. A., Ramakrishnan C., O'Shea D. J., Prakash R., Gunaydin L. A., Hyun M., Fenno L. E., Gradinaru V., Yizhar O. & Deisseroth K. (2012). Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.  Nature Methods. 9:(2)159-172.  Abstract
  2. Yizhar O. (2012). Optogenetic Insights into Social Behavior Function.  Biological Psychiatry. 71:(12)1075-1080.  Abstract

2011

  1. Witten I. B., Steinberg E. E., Lee S. Y., Davidson T. J., Zalocusky K. A., Brodsky M., Yizhar O., Cho S. L., Gong S., Ramakrishnan C., Stuber G. D., Tye K. M., Janak P. H. & Deisseroth K. (2011). Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement.  Neuron. 72:(5)721-733.  Abstract
  2. Yizhar O., Fenno L. E., Prigge M., Schneider F., Davidson T. J., O'Shea D. J., Sohal V. S., Goshen I., Finkelstein J., Paz J. T., Stehfest K., Fudim R., Ramakrishnan C., Huguenard J. R., Hegemann P. & Deisseroth K. (2011). Neocortical excitation/inhibition balance in information processing and social dysfunction.  Nature. 477:(7363)171-178.  Abstract
  3. Zhang F., Vierock J., Yizhar O., Fenno L. E., Tsunoda S., Kianianmomeni A., Prigge M., Berndt A., Cushman J., Polle J., Magnuson J., Hegemann P. & Deisseroth K. (2011). The Microbial Opsin Family of Optogenetic Tools.  Cell. 147:(7)1446-1457.  Abstract