Research

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Crystalline materials in nature

  • Biomineralization-formation of crystals and other aggregated phases in organisms
  • Crystallization in and from cell membranes
  • Cell interactions at interfaces
  • Antibody-Crystal interactions
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Protein interactions by NMR

  • The interaction of HIV-1 envelope glycoprotein with the HIV-1 co-receptor CCR5
  • The interaction of chemokines with CCR5
  • The use of transferred NOE to study intermolecular interactions in large protein complexes
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Structural virology & immunology - elucidating the molecular mechanisms of host / pathogen interactions

  • Structural basis for virus cell entry
  • Structural aspects of host immune response against pathogens
  • Novel therapeutic approaches inspired by structural information
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Integrated structural enzymology

  • Structures, mechanisms, and regulation of enzymes that catalyze disulfide bond formation
  • Novel structural techniques for studying extracellular matrix assembly
  • Development of potential cancer therapeutics targeting the cell microenvironment
  • Physiological functions of disulfide catalysts in the formation of complex biomaterials
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Molecular systems biophysics

  • Single-molecule spectroscopy
  • Protein interactions and dynamics
  • Bio-molecular networks
  • Benisti Itamar

    PI: Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann

    Phone: +972-8-934-2038

    Location: Helen and Milton A. Kimmelman Building

  • Benisti Itamar

    PI: Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann

    Phone: +972-8-934-2038

    Location: Helen and Milton A. Kimmelman Building

  • Benisti Itamar

    PI: Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann

    Phone: +972-8-934-2038

    Location: Helen and Milton A. Kimmelman Building

  • Benisti Itamar

    PI: Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann, Dr. Hagen Hofmann

    Phone: +972-8-934-2038

    Location: Helen and Milton A. Kimmelman Building

  • Noam Cohen

    PI: Dr. Hagen Hofmann

  • Artem Dubovetskyi

    PI: Dr. Hagen Hofmann

    Phone: +972-8-934-3269

    artem.dubovetskyi@weizmann.ac.il
  • Benjamin Lerner

    PI: Dr. Hagen Hofmann

    benjamin.lerner@weizmann.ac.il
  • Tanya Lasitza Male

    PI: Dr. Hagen Hofmann

    Phone: +972-8-934-6780

    tanya.lasitza-male@weizmann.ac.il
  • Dr. Gabriel Rosenblum

    PI: Dr. Hagen Hofmann

    Phone: +972-8-934-6785

    gabriel.rosenblum@weizmann.ac.il
  • David Gruia

    PI: Dr. Hagen Hofmann

    Phone: +972-8-934-6780

    david.gruia@weizmann.ac.il
  • PI: Dr. Hagen Hofmann

    Phone: +972-8-934-6780

    yair.harel@weizmann.ac.il
  • Dr. Felix Wiggers

    PI: Dr. Hagen Hofmann

    Phone: +972-8-934-6780

    felix.wiggers@weizmann.ac.il
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Cooperativity in protein structure, folding and function

  • Allostery in chaperonins
  • Mechanisms of action of chaperonins
  • Development of methods to study allostery
  • Correlated mutation analysis
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Structural systems biology - protein-protein interactions from atoms to cells

  • Proteins self-assembly and self-organization in cells
  • Evolution of the cellular protein machinery
  • Design and engineering of large protein assemblies
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Computational molecular biophysics - quantifying the self-assembly mechanisms of biomolecules

  • Understanding the mechanism of DNA search by proteins
  • Deciphering the effect of post-translational modifications on protein biophysics
  • Investigation of folding of multi-domain proteins
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Structural biology - structural studies of giant viruses

  • Structure of the giant Mimivirus
  • Infection cycle of the Mimivirus
  • Structure and infection cycle of the chlorella virus PBCV-1
  • Structure of the Pandora virus
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Biology - study of large protein complexes through nuclear magnetic resonance

  • Molecular chaperones combating neurodegenerative diseases
  • Protein folding and disaggregation
  • Structure, dynamics, and function of supramolecular complexes
  • Advanced Nuclear Magnetic Resonance techniques
  • Dar Gliksberg

    PI: Dr. Rina Rosenzweig

    dar.gliksberg@weizmann.ac.il
  • Dr. Sudipto Munshi

    PI: Dr. Rina Rosenzweig

    Phone: +972-8-934-3781

    sudipto.munshi@weizmann.ac.il
  • Leah Rose Shulman

    PI: Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig

    Phone: +972-8-934-3781

    leah-rose.shulman@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 651

  • Leah Rose Shulman

    PI: Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig

    Phone: +972-8-934-3781

    leah-rose.shulman@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 651

  • Leah Rose Shulman

    PI: Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig

    Phone: +972-8-934-3781

    leah-rose.shulman@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 651

  • Leah Rose Shulman

    PI: Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig

    Phone: +972-8-934-3781

    leah-rose.shulman@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 651

  • Atar Gilat

    PI: Dr. Rina Rosenzweig, Prof. Emmanuel Doram Levy, Prof. Emmanuel Doram Levy, Prof. Emmanuel Doram Levy

    atar.gilat@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building

  • Anna Harari

    PI: Prof. Deborah Fass, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig

    anna.harari@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 651

  • Anna Harari

    PI: Prof. Deborah Fass, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig

    anna.harari@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 651

  • Anna Harari

    PI: Prof. Deborah Fass, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig, Dr. Rina Rosenzweig

    anna.harari@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 651

  • Yuval Tarrab

    PI: Dr. Rina Rosenzweig

    Yuval-Tarrab@weizmann.ac.il
  • Guy Zoltsman

    PI: Dr. Rina Rosenzweig

    guy.zoltsman@weizmann.ac.il
  • Dr. Ofrah Nadya Faust

    PI: Dr. Rina Rosenzweig

    ofrah.faust@weizmann.ac.il
  • Dr. Meital Avraham

    PI: Dr. Rina Rosenzweig

    Phone: +972-8-934-3781

    meital.avayev@weizmann.ac.il
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Structural biology – structure-function studies of transcription factors and of enzymes from pathogenic bacteria

  • The tumor-suppressor protein p53 and its interaction with DNA
  • Cancer-related p53 mutants and their rescue by suppressor mutations and by small molecules
  • Fatty-acid synthesis enzymes from Mycobacterium tuberculosis as potential drug targets
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Structural Biology - Study of macromolecules through cryo-EM

> Structure and function of membrane proteins and their signaling pathways

> Specialized translation

> Single particle cryo-EM

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Biomineralization

  • Mineral formation in biology
  • Bone 3D structure
  • Tooth-mandible complex
  • Dr. Vlad Brumfeld

    PI: Prof. Stephen Weiner

  • Noy Shaked

    PI: Prof. Stephen Weiner, Prof. Lia Addadi

    Phone: +972-8-934-2547

    noy.shaked@weizmann.ac.il
  • Keren Kahil Guterman

    PI: Prof. Stephen Weiner, Prof. Lia Addadi

    Phone: +972-8-934-2547

    keren.kahil@weizmann.ac.il
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Translation of the genetic code: protein biosynthesis

  • Mechanisms of decoding and peptide bond formation
  • Antibiotics action and resistance
  • New generation of environmental friendly, species specific antibiotics
  • Origin of life
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