Research

Close

Prof. Lia Addadi

website of Prof. Lia Addadi, Opens in new window Send mail to Prof. Lia Addadi

Crystalline materials in nature

  • Biomineralization-formation of crystals and other aggregated phases in organisms
  • Crystallization in and from cell membranes
  • Cell interactions at interfaces
  • Antibody-Crystal interactions
Group members of Prof. Lia Addadi
Close

Dr. Ariel Afek

website of Dr. Ariel Afek, Opens in new window Send mail to Dr. Ariel Afek

High-throughput protein-DNA biophysics

  • The impact of DNA structure and sequence on transcription factors binding
  • The biophysical mechanism of mutagenesis
  • The effect of mechanical perturbations in the genome on DNA biochemistry
Group members of Dr. Ariel Afek
Close

Prof. Jacob Anglister

website of Prof. Jacob Anglister, Opens in new window Send mail to Prof. Jacob Anglister

Protein interactions by NMR

  • The interaction of HIV-1 envelope glycoprotein with the HIV-1 co-receptor CCR5
  • The interaction of chemokines with CCR5
  • The use of transferred NOE to study intermolecular interactions in large protein complexes
Group members of Prof. Jacob Anglister

  • Vladimir Kost

    PI: Prof. Jacob Anglister

    Phone: +972-8-934-3531

    vladimir.kost@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 550

  • Dr. Adi Moseri

    PI: Prof. Jacob Anglister

    adi.moseri@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 506

Close

Prof. Ron Diskin

website of Prof. Ron Diskin, Opens in new window Send mail to Prof. Ron Diskin

Structural virology & immunology - elucidating the molecular mechanisms of host / pathogen interactions

  • Structural basis for virus cell entry
  • Structural aspects of host immune response against pathogens
  • Novel therapeutic approaches inspired by structural information
Group members of Prof. Ron Diskin
Close

Prof. Deborah Fass

website of Prof. Deborah Fass, Opens in new window Send mail to Prof. Deborah Fass

Integrated structural enzymology

  • Structures, mechanisms, and regulation of enzymes that catalyze disulfide bond formation
  • Novel structural techniques for studying extracellular matrix assembly
  • Development of potential cancer therapeutics targeting the cell microenvironment
  • Physiological functions of disulfide catalysts in the formation of complex biomaterials
Group members of Prof. Deborah Fass
Close

Prof. Hagen Hofmann

website of Prof. Hagen Hofmann, Opens in new window Send mail to Prof. Hagen Hofmann

Molecular systems biophysics

  • Single-molecule spectroscopy
  • Protein interactions and dynamics
  • Bio-molecular networks
Group members of Prof. Hagen Hofmann
Close

Prof. Amnon Horovitz

website of Prof. Amnon Horovitz, Opens in new window Send mail to Prof. Amnon Horovitz

Cooperativity in protein structure, folding and function

  • Allostery in chaperonins
  • Mechanisms of action of chaperonins
  • Development of methods to study allostery
  • Correlated mutation analysis
Group members of Prof. Amnon Horovitz
Close

Prof. Emmanuel Doram Levy

website of Prof. Emmanuel Doram Levy, Opens in new window Send mail to Prof. Emmanuel Doram Levy

Structural systems biology - protein-protein interactions from atoms to cells

  • Proteins self-assembly and self-organization in cells
  • Evolution of the cellular protein machinery
  • Design and engineering of large protein assemblies
Group members of Prof. Emmanuel Doram Levy
Close

Prof. Koby Levy

website of Prof. Koby Levy, Opens in new window Send mail to Prof. Koby Levy

Computational molecular biophysics - quantifying the self-assembly mechanisms of biomolecules

  • Understanding the mechanism of DNA search by proteins
  • Deciphering the effect of post-translational modifications on protein biophysics
  • Investigation of folding of multi-domain proteins
Group members of Prof. Koby Levy
Close

Prof. Nir London

website of Prof. Nir London, Opens in new window Send mail to Prof. Nir London

Group members of Prof. Nir London
Close

Prof. David Margulies

website of Prof. David Margulies, Opens in new window Send mail to Prof. David Margulies

Group members of Prof. David Margulies
Close

Dr. Rina Rosenzweig

website of Dr. Rina Rosenzweig, Opens in new window Send mail to Dr. Rina Rosenzweig

Biology - study of large protein complexes through nuclear magnetic resonance

  • Molecular chaperones combating neurodegenerative diseases
  • Protein folding and disaggregation
  • Structure, dynamics, and function of supramolecular complexes
  • Advanced Nuclear Magnetic Resonance techniques
Group members of Dr. Rina Rosenzweig
Close

Prof. Zippora Shakked

website of Prof. Zippora Shakked, Opens in new window Send mail to Prof. Zippora Shakked

Structural biology – structure-function studies of transcription factors and of enzymes from pathogenic bacteria

  • The tumor-suppressor protein p53 and its interaction with DNA
  • Cancer-related p53 mutants and their rescue by suppressor mutations and by small molecules
  • Fatty-acid synthesis enzymes from Mycobacterium tuberculosis as potential drug targets
Group members of Prof. Zippora Shakked
Close

Dr. Moran Shalev-Benami

website of Dr. Moran Shalev-Benami, Opens in new window Send mail to Dr. Moran Shalev-Benami

Structural Biology - Study of macromolecules through cryo-EM

> Structure and function of membrane proteins and their signaling pathways

> Specialized translation

> Single particle cryo-EM

Group members of Dr. Moran Shalev-Benami
Close

Prof. Joel Sussman

website of Prof. Joel Sussman, Opens in new window Send mail to Prof. Joel Sussman

Structure/Function studies of Biomacromolecules

  • Proteins from the nervous system, including Acetylcholinesterase
  • Bioinformatic tools, including Proteopedia, FoldIndex and Dipole Moment Server
  • Proteins involved in decontamination of deadly poisons
Group members of Prof. Joel Sussman

  • Dr. Jacob Grunwald

    PI: Prof. Joel Sussman

    jacob.grunwald@weizmann.ac.il

    Location: Nella and Leon Benoziyo Building for Brain Research, 124

  • Dr. Michal Harel

    PI: Prof. Joel Sussman

    Phone: +972-8-934-2647

    michal.harel@weizmann.ac.il

    Location: Nella and Leon Benoziyo Building for Biological Sciences, 124

Close

Prof. Stephen Weiner

website of Prof. Stephen Weiner, Opens in new window Send mail to Prof. Stephen Weiner

Group members of Prof. Stephen Weiner

  • Dr. Joshua Milgram

    PI: Prof. Stephen Weiner

    joshua.milgram@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building

  • Noy Shaked

    PI: Prof. Stephen Weiner, Prof. Lia Addadi

    Phone: +972-8-934-3514

    noy.shaked@weizmann.ac.il

    Location: Helen and Milton A. Kimmelman Building, 568

Close

Prof. Ada Yonath

website of Prof. Ada Yonath, Opens in new window Send mail to Prof. Ada Yonath

Translation of the genetic code: protein biosynthesis

  • Mechanisms of decoding and peptide bond formation
  • Antibiotics action and resistance
  • New generation of environmental friendly, species specific antibiotics
  • Origin of life
Group members of Prof. Ada Yonath
Close