From Gene to 3D Protein Structure  
Details on Proteopedia:
The Israel Structural Proteomics Center (ISPC) at the Weizmann Institute of Science, directed by Prof Joel L. Sussman, was founded in 2002 with the support of the Israel Ministry of Science and the Divadol Foundation. It serves as an Israeli National Center for protein production, biochemical/biophysical studies and structure determination. It is within the Structural Proteomics Unit, headed by Prof Zvi Livneh, Dean of the Faculty of Biochemistry. The ISPC provides a service for the determination and analsysis of protein structures for scientists both at the Weizmann and at other academic institutions and biotech/pharma companies in Israel and abroad, as well as providing 'in house' training and consultation for students and staff. The ISPC was part of the European Union SPINE2, TeachSG and FESP projects. It is now one of the 6 core partners in the Integrated Structural Biology Infrastructure in Europe (INSTRUCT) project.

The ISPC has developed key new tools for studying protein structure/function:

  • Cloning & expression in bacteria, yeast, Baculovirus and HEK 293 cells
  • Purification & screening of folding conditions
  • HTP robotic crystallization
  • eMovie: A storyboard-based tool for making molecular movies
  • Visualization of 3D protein structures at the Jean Goldwurm 3D Visualization Theater
  • Proteopedia Joel: The collaborative 3D encyclopedia of proteins and other molecules

    Additional ISPC activities:
    SPINE Workshop on Micro-batch Protein Crystallization (Feb, 2005)
    INPEC Meeting 2005 (Nov, 2005)
    SESAME Meeting, Jordan (Dec, 2005)
    ISPC Retreat, Jerusalem (Jul, 2007)
    TeachSG BIOMics Workshop and Conference (Sep, 2009)
    SPINE2 Workshop on New Strategies for Cloning & Expression of Protein Complexes in E. coli & Insect Cells (Nov, 2009)
    Chinese Science Minister at the ISPC (May, 2010)
    2nd BIOMics Workshop and Conference (Nov, 2010)

    Several books have been edited by ISPC members: "Structural Proteomics and Its Impact on Life Sciences", "Computational Protein-Protein Interactions" and "From Molecules to Medicine".

    Joel Joel Joel