Publications
Cardenas P. D., Sonawane P. D., Heinig U., Jozwiak A., Panda S., Abebie B., Kazachkova Y., Pliner M., Unger T., Wolf D., Ofner I., Vilaprinyo E., Meir S., Davydov O., Gal-On A., Burdman S., Giri A., Zamir D., Scherf T., Szymanski J., Rogachev I. & Aharoni A.
(2019).
Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases.
Nature Communications.
10.
Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y.
(2019).
RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.
Oncogene.
38:(13)2432-2434.
Meltzer H., Marom E., Alyagor I., Mayseless O., Berkun V., Segal-Gilboa N., Unger T., Luginbuhl D. & Schuldiner O.
(2019).
Tissue-specific (ts) CRISPR as an efficient strategy for in vivo screening in Drosophila.
Nature Communications.
10.
Dalaloyan A., Martorana A., Barak Y., Gataulin D., Reuveny E., Howe A., Elbaum M., Albeck S., Unger T., Frydman V., Abdelkader E. H., Otting G. & Goldfarb D.
(2019).
Tracking Conformational Changes in Calmodulin in vitro, in Cell Extract, and in Cells by Electron Paramagnetic Resonance Distance Measurements.
ChemPhysChem.
20:(14)1860-1868.
Karbat I., Altman-Gueta H., Fine S., Szanto T., Hamer-Rogotner S., Dym O., Frolow F., Gordon D., Panyi G., Gurevitz M. & Reuveny E.
(2019).
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels.
Proceedings of the National Academy of Sciences of the United States of America.
116:(37)18700-18709.
Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Ben Nissan G., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J.
(2019).
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
PLoS Computational Biology.
15:(8)
Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N.
(2019).
Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.
Cell Chemical Biology.
26:(1)98 - 108.e5.
Baron S., Peleg Y., Grunwald J., Morgenstern D., Elad N., Peretz M., Albeck S., Levin Y., Welch J. T., Deweerd K. A., Schwarz A., Burstein Y., Diskin R., Shakked Z. & Zimhony O.
(2018).
Expression of a recombinant, 4 '-Phosphopantetheinylated, active M-tuberculosis fatty acid synthase I in E-coli.
PLoS One.
13:(9)
Kahlon S., Shreibman D., Unger T., Ben-Yehuda D. & Elias S.
(2018).
The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.
Blood Cancer Journal.
8.
Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J.
(2018).
Highly active enzymes by automated combinatorial backbone assembly and sequence design.
Nature Communications.
9.
Kantaev R., Riven I., Goldenzweig A., Barak Y., Dym O., Peleg Y., Albeck S., Fleishman S. J. & Haran G.
(2018).
Manipulating the Folding Landscape of a Multi-Domain Protein.
Journal of Physical Chemistry B.
122:(49)11030-11038.
Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J.
(2018).
Ultrahigh specificity in a network of computationally designed protein-interaction pairs.
Nature Communications.
9.
Karniel A., Mrusek D., Steinchen W., Dym O., Bange G. & Bibi E.
(2018).
Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.
Journal of Molecular Biology.
Elad N., Baron S., Peleg Y., Albeck S., Grunwald J., Raviv G., Shakked Z., Zimhony O. & Diskin R.
(2018).
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution.
Nature Communications.
9.
Ben-Nissan G., Vimer S., Warszawski S., Katz A., Yona M., Unger T., Peleg Y., Morgenstern D., Cohen-Dvashi H., Diskin R., Fleishman S. J. & Sharon M.
(2018).
Rapid characterization of secreted recombinant proteins by native mass spectrometry.
Communications biology.
1.
Bandyopadhyay B. & Peleg Y.
(2018).
Facilitating circular permutation using Restriction Free (RF) cloning.
Protein Engineering Design & Selection.
31:(3)65-68.
Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J.
(2018).
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Molecular Cell.
72:(1)178-+.
Sonawane P. D., Heinig U., Panda S., Gilboa N. S., Yona M., Kumar S. P., Alkan N., Unger T., Bocobza S., Pliner M., Malitsky S., Tkachev M., Meir S., Rogachev I. & Aharoni A.
(2018).
Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum.
Proceedings of the National Academy of Sciences of the United States of America.
115:(23)E5419-E5428.
Cohen-Khait R., Dym O., Hamer-Rogotner S. & Schreiber G.
(2017).
Promiscuous Protein Binding as a Function of Protein Stability.
Structure (London, England : 1993).
25:(12)1867-+.
Pode Z., Peri-Naor R., Georgeson J. M., Ilani T., Kiss V., Unger T., Markus B., Barr H. M., Motiei L. & Margulies D.
(2017).
Protein recognition by a pattern-generating fluorescent molecular probe.
Nature Nanotechnology.
12:(12)1161-1168.
Erez Z., Steinberger-Levy I., Shamir M., Doron S., Stokar Avihail A. A., Peleg Y., Melamed S., Leavitt A., Savidor A., Albeck S., Amitai G. & Sorek R.
(2017).
Communication between viruses guides lysis-lysogeny decisions.
Nature.
541:(7638)
Sonawane P. D., Pollier J., Panda S., Szymanski J., Massalha H., Yona M., Unger T., Malitsky S., Arendt P., Pauwels L., Almekias-Siegl E., Rogachev I., Meir S., Cardenas P. D., Masri A., Petrikov M., Schaller H., Schaffer A. A., Kamble A., Giri A. P., Goossens A. & Aharoni A.
(2017).
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.
Nature Plants.
3:(1)
Sonawane P. D., Pollier J., Panda S., Szymanski J., Massalha H., Yona M., Unger T., Malitsky S., Arendt P., Pauwels L., Almekias-Siegl E., Rogachev I., Meir S., Cardenas P. D., Masri A., Petrikov M., Schaller H., Schaffer A. A., Kamble A., Giri A. P., Goossens A. & Aharoni A.
(2017).
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism (vol 3, 16205, 2016).
Nature Plants.
3:(7)
Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M.
(2017).
Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.
Analytical Chemistry.
89:(8)4708-4715.
Tal L., Friedlander G., Gilboa N. S., Unger T., Gilad S. & Eshed Y.
(2017).
Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein.
Plant Cell.
29:(4)681-696.
Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J.
(2017).
Principles for computational design of binding antibodies.
Proceedings of the National Academy of Sciences of the United States of America.
114:(41)10900-10905.
Milrot E., Shimoni E., Dadosh T., Rechav K., Unger T., Van Etten E. J. L. & Minsky A.
(2017).
Structural studies demonstrating a bacteriophage-like replication cycle of the eukaryote-infecting Paramecium bursaria chlorella virus-1.
PLoS Pathogens.
13:(8)
Bandyopadhyay B., Goldenzweig A., Unger T., Adato O., Fleishman S. J., Unger R. & Horovitz A.
(2017).
Local energetic frustration affects the dependence of green fluorescent protein folding on the chaperonin GroEL.
Journal of Biological Chemistry.
292:(50)20583-20591.
Peleg Y., Prabahar V., Bednarczyk D. & Unger T.
(2017).
Harnessing the Profinity eXact™ System for Expression and Purification of Heterologous Proteins in E. coli.
.
33-43.
Dym O., Song W., Felder C., Roth E., Shnyrov V., Ashani Y., Xu Y., Joosten R. P., Weiner L., Sussman J. & Silman I.
(2016).
The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Science.
25:(6)1096-1114.
Yosef E., Katz A., Peleg Y., Mehlman T. & Karlish S. J.
(2016).
Do Src Kinase and Caveolin Interact Directly with Na,K-ATPase?.
Journal of Biological Chemistry.
291:(22)11736-11750.
Bednarczyk D., Dym O., Prabahar V., Peleg Y., Pike D. H. & Noy D.
(2016).
Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.
Angewandte Chemie-International Edition.
55:(24)6901-6905.
Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J.
(2016).
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.
Molecular Cell.
63:(2)337-346.
Wong E., Cohen T., Romi E., Levin M., Peleg Y., Arad U., Yaron A., Milla M. E. & Sagi I.
(2016).
Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo.
Scientific Reports.
6.
Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D.
(2016).
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
Cell.
164:(3)476-486.
Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Garcia Arroyo A. A. & Sagi I.
(2015).
Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.
Structure.
23:(1)104-115.
Sun L., Xiong Y., Bashan A., Zimmerman E., Daube S. S., Peleg Y., Albeck S., Unger T., Yonath H., Krupkin M., Matzov D. & Yonath A.
(2015).
A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis.
ChemBioChem.
16:(10)1415-1419.
Wong E., Maretzky T., Peleg Y., Blobel C. P. & Sagi I.
(2015).
The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.
The journal of Biological chemistry.
290:12135-12146.
Zimhony O., Schwarz A., Raitses Gurevich G. M., Peleg Y., Dym O., Albeck S., Burstein Y. & Shakked Z.
(2015).
AcpM, the Meromycolate Extension Acyl Carrier Protein of Mycobacterium tuberculosis, Is Activated by the 4 '-Phosphopantetheinyl Transferase PptT, a Potential Target of the Multistep Mycolic Acid Biosynthesis.
Biochemistry.
54:(14)2360-2371.
Nissinkorn Y., Lahav-Mankovski N., Rabinkov A., Albeck S., Motiei L. & Margulies D.
(2015).
Sensing Protein Surfaces with Targeted Fluorescent Receptors.
Chemistry (Weinheim an der Bergstrasse, Germany).
21:(45)15873-15873.
Nissinkorn Y., Lahav-Mankovski N., Rabinkov A., Albeck S., Motiei L. & Margulies D.
(2015).
Sensing Protein Surfaces with Targeted Fluorescent Receptors.
Chemistry (Weinheim an der Bergstrasse, Germany).
21:(45)15981-7.
Shpilka T., Welter E., Borovsky N., Amar N., Shimron F., Peleg Y. & Elazar Z.
(2015).
Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast.
Proceedings of the National Academy of Sciences of the United States of America.
112:(5)1434-1439.
Erijman A., Shifman J. M. & Peleg Y.
(2014).
A Single-Tube Assembly of DNA Using the Transfer-PCR (TPCR) Platform.
.
89-101.
Peleg Y. & Unger T.
(2014).
Application of the Restriction-Free (RF) Cloning for Multicomponents Assembly.
.
73-87.
Arfi Y., Shamshoum M., Rogachev I., Peleg Y. & Bayer E.
(2014).
Integration of bacterial lytic polysaccharide monooxygenases into designer cellulosomes promotes enhanced cellulose degradation.
Proceedings of the National Academy of Sciences of the United States of America.
111:(25)9109-9114.
Itkin M., Heinig U., Tzfadia O., Bhide A. J., Shinde B. A., Cardenas P. D., Bocobza S. E., Unger T., Malitsky S., Finkers R., Tikunov Y., Bovy A., Chikate Y. R., Singh P., Rogachev I., Beekwilder J., Giri A. P. & Aharoni A.
(2013).
Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes.
Science.
341:(6142)175-179.
Bharat T. A. M., Zbaida D., Eisenstein M., Frankenstein Z., Mehlman T., Weiner L., Sorzano C. O. S., Barak Y., Albeck S., Briggs J. A. G., Wolf S. G. & Elbaum M.
(2013).
Variable Internal Flexibility Characterizes the Helical Capsid Formed by Agrobacterium VirE2 Protein on Single-Stranded DNA.
Structure.
21:(7)1158-1167.
Vazana Y., Barak Y., Unger T., Peleg Y., Shamshoum M., Ben-Yehezkel T., Mazor Y., Shapiro E., Lamed R. & Bayer E.
(2013).
A synthetic biology approach for evaluating the functional contribution of designer cellulosome components to deconstruction of cellulosic substrates.
Biotechnology for Biofuels.
6.
Krieg E., Albeck S., Weissman H., Shimoni E. & Rybtchinski B.
(2013).
Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane.
PLoS One.
8:(5)
Sberro H., Leavitt A., Kiro R., Koh E., Peleg Y., Qimron U. & Sorek R.
(2013).
Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning.
Molecular Cell.
50:(1)136-148.
Sobolev V., Edelman M., Dym O., Unger T., Albeck S., Kirma M. & Galili G.
(2013).
Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.
Acta Crystallographica Section F-Structural Biology And Crystallization Communications.
69:84-89.
Hama S., Soran H., Albeck S., Charlton-Menys V., Yadav R., Liu Y., France M., Tawfiq D. & Durrington P.
(2012).
High Paraoxonase-1 Hdl is More Effective Than Low Paraoxonase-1 Hdl in Impeding Ldl Oxidation in Vitro.
Atherosclerosis.
223:(2)529-529.
Peleg Y. & Unger T.
(2012).
Resolving Bottlenecks for Recombinant Protein Expression in E. coli.
.
173-186.
Xu Y., Li M., Greenblatt H., Chen W., Paz A., Dym O., Peleg Y., Chen T., Shen X., He J., Jiang H., Silman I. & Sussman J.
(2012).
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.
Acta Crystallographica Section D-Biological Crystallography.
68:13-25.
Sela-Passwell N. A., Kikkeri R., Dym O., Rozenberg H., Margalit R., Arad-Yellin R., Eisenstein M., Brenner O., Shoham T., Danon T., Shanzer A. & Sagi I.
(2012).
Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.
Nature Medicine.
18:(1)143-147.
Unger T. & Peleg Y.
(2012).
Recombinant Protein Expression in the Baculovirus-Infected Insect Cell System.
.
187-199.
Khersonsky O., Kiss G., Roethlisberger D., Dym O., Albeck S., Houk K. N., Baker D. & Tawfik D.
(2012).
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proceedings of the National Academy of Sciences of the United States of America.
109:(26)10358-10363.
Khersonsky O., Roethlisberger D., Wollacott A. M., Murphy P., Dym O., Albeck S., Kiss G., Houk K. N., Baker D. & Tawfik D.
(2011).
Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution.
Journal of Molecular Biology.
407:(3)391-412.
Mishra N. K., Peleg Y., Cirri E., Belogus T., Lifshitz Y., Voelker D. R., Apell H., Garty H. & Karlish S. J.
(2011).
FXYD Proteins Stabilize Na,K-ATPase AMPLIFICATION OF SPECIFIC PHOSPHATIDYLSERINE-PROTEIN INTERACTIONS.
Journal of Biological Chemistry.
286:(11)9699-9712.
Busso D., Peleg Y., Heidebrecht T., Romier C., Jacobovitch Y., Dantes A., Salim L., Troesch E., Schuetz A., Heinemann U., Folkers G. E., Geerlof A., Wilmanns M., Polewacz A., Quedenau C., Buessow K., Adamson R., Blagova E., Walton J., Cartwright J. L., Bird L. E., Owens R. J., Berrow N. S., Wilson K. S., Sussman J., Perrakis A. & Celie P. H. N.
(2011).
Expression Of Protein Complexes Using Multiple Escherichia Coli Protein Co-Expression Systems: A Benchmarking Study.
Journal of Structural Biology.
175:(2)159-170.
Siton O., Ideses Y., Albeck S., Unger T., Bershadsky A. D., Gov N. & Bernheim-Groswasser A.
(2011).
Cortactin Releases the Brakes in Actin-Based Motility by Enhancing WASP-VCA Detachment from Arp2/3 Branches.
Current Biology.
21:(24)2092-2097.
Carlessi R., Levin-Salomon V., Ciprut S., Bialik S., Berissi H., Albeck S., Peleg Y. & Kimchi A.
(2011).
GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling.
EMBO Reports.
12:(9)917-923.
Karanicolas J., Com J. E., Chen I., Joachimiak L. A., Dym O., Peck S. H., Albeck S., Unger T., Hu W., Liu G., Delbecq S., Montelione G. T., Spiegel C. P., Liu D. R. & Baker D.
(2011).
A De Novo Protein Binding Pair By Computational Design and Directed Evolution.
Molecular Cell.
42:(2)250-260.
Erijman A., Dantes A., Bernheim R., Shifman J. M. & Peleg Y.
(2011).
Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering.
Journal of Structural Biology.
175:(2)171-177.
Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J.
(2011).
Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators.
Journal of Medicinal Chemistry.
54:(10)3575-3580.
Cohen S., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A. & Dym O.
(2011).
Cyt1Aa Toxin: Crystal Structure Reveals Implications for Its Membrane-Perforating Function.
Journal of Molecular Biology.
413:(4)804-814.
Khersonsky O., Rothlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D.
(2010).
Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
Journal of Molecular Biology.
396:(4)1025-1042.
Jiang W., Wang X. W., Unger T., Forgues M., Kim J. W., Hussain S. P., Bowman E., Spillare E. A., Lipsky M. M., Meck J. M., Cavalli L. R., Haddad B. R. & Harris C. C.
(2010).
Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.
International Journal of Cancer.
127:(5)1011-1020.
Vitu E., Kim S., Sevier C. S., Lutzky O., Heldman N., Bentzur M., Unger T., Yona M., Kaiser C. A. & Fass D.
(2010).
Oxidative Activity of Yeast Ero1p on Protein Disulfide Isomerase and Related Oxidoreductases of the Endoplasmic Reticulum.
Journal of Biological Chemistry.
285:(24)18155-18165.
Unger T., Dym O., Albeck S., Jacobovitch Y., Bernehim R., Marom D., Pisanty O. & Breiman A.
(2010).
Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain.
Journal of Structural and Functional Genomics.
11:(2)113-23.
Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y.
(2010).
Biochemical and Structural Properties of Chimeras Constructed by Exchange of Cofactor-Binding Domains in Alcohol Dehydrogenases from Thermophilic and Mesophilic Microorganisms.
Biochemistry.
49:(9)1943-1953.
Yadid I., Kirshenbaum N., Sharon M., Dym O. & Tawfik D.
(2010).
Metamorphic proteins mediate evolutionary transitions of structure.
Proceedings of the National Academy of Sciences of the United States of America.
107:(16)7287-7292.
Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I.
(2010).
The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function.
Biochemistry.
49:(29)6184-6192.
Unger T., Jacobovitch Y., Dantes A., Bernheim R. & Peleg Y.
(2010).
Applications of the Restriction Free (RF) cloning procedure for molecular manipulations and protein expression.
Journal of Structural Biology.
172:(1)34-44.
Zeev-Ben-Mordehai T., Paz A., Peleg Y., Toker L., Wolf S. G., Rydberg E. H., Sussman J. & Silman I.
(2009).
Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization.
Protein Expression and Purification.
63:(2)147-157.
Sharabi O., Peleg Y., Mashiach E., Vardy E., Ashani Y., Silman I., Sussman J. & Shifman J. M.
(2009).
Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.
Protein Engineering Design & Selection.
22:(10)641-648.
Dym O., Albeck S., Peleg Y., Schwarz A., Shakked Z., Burstein Y. & Zimhony O.
(2009).
Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis.
Journal of Molecular Biology.
393:(4)937-950.
Levin K. B., Dym O., Albeck S., Magdassi S., Keeble A. H., Kleanthous C. & Tawfik D.
(2009).
Following evolutionary paths to protein-protein interactions with high affinity and selectivity.
Nature Structural & Molecular Biology.
16:(10)1049-U67.
Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K. E. & Karlish S. J.
(2009).
A C-Terminal Lobe of the beta Subunit of Na,K-ATPase and H,K-ATPase Resembles Cell Adhesion Molecules.
Biochemistry.
48:(36)8684-8691.
Zeev-Ben-Mordehai T., Mylonas E., Paz A., Peleg Y., Toker L., Silman I., Svergun D. I. & Sussman J.
(2009).
The Quaternary Structure Of Amalgam, A Drosophila Neuronal Adhesion Protein, Explains Its Dual Adhesion Properties.
Biophysical Journal.
97:(8)2316-2326.
Cohen S., Dym O., Albeck S., Ben-Dov E., Cahan R., Firer M. & Zaritsky A.
(2008).
High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp israelensis.
Journal of Molecular Biology.
380:(5)820-827.
Manicka S., Peleg Y., Unger T., Albeck S., Dym O., Greenblatt H. A., Bourenkov G., Lamzin V., Krishnaswamy S. & Sussman J.
(2008).
Crystal structure of yagE, a putative DHDPS-like protein from Escherichia coli K12.
Proteins-Structure Function And Bioinformatics.
71:(4)2102-2108.
Rothlisberger D., Khersonsky O., Wollacott A. M., Jiang L., Dechancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. & Baker D.
(2008).
Kemp elimination catalysts by computational enzyme design.
Nature.
453:(7192)190-U4.
Goihberg E., Dym O., Tel-Or S., Shimon L., Frolow F., Peretz M. & Burstein Y.
(2008).
Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution.
Proteins-Structure Function And Bioinformatics.
72:(2)711-719.
Dym O., Albeck S., Unger T., Jacobovitch J., Brainzburg A., Michael Y., Frenkiel-Krispin D., Wolf S. G. & Elbaum M.
(2008).
Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.
Proceedings of the National Academy of Sciences of the United States of America.
105:(32)11170-11175.
Albeck S., Dym O., Unger T., Snapir Z., Bercovich Z. & Kahana C.
(2008).
Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.
Protein Science.
17:(5)793-802.
Peleg Y. & Unger T.
(2008).
Application of High-Throughput Methodologies to the Expression of Recombinant Proteins in E. coli.
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197-208.
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Protein production and purification.
Nature Methods.
5:(2)135-146.
Liberman N., Dym O., Unger T., Albeck S., Peleg Y., Jacobovitch Y., Branzburg A., Eisenstein M., Marash L. & Kimchi A.
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The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage.
Journal of Molecular Biology.
383:(3)539-548.
Goihberg E., Dym O., Tel-Or S., Levin I., Peretz M. & Burstein Y.
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A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase.
Proteins-Structure Function And Bioinformatics.
66:(1)196-204.
Reichmann D., Cohen M., Abramovich R., Dym O., Lim D., Strynadka N. C. J. & Schreiber G.
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Binding hot spots in the TEM1-BLIP interface in light of its modular architecture.
Journal of Molecular Biology.
365:(3)663-679.
Frenkiel-Krispin D., Wolf S. G., Albeck S., Unger T., Peleg Y., Jacobovitch J., Michael Y., Daube S., Sharon M., Robinson C. V., Svergun D. I., Fass D., Tzfira T. & Elbaum M.
(2007).
Plant transformation by Agrobacterium tumefaciens - Modulation of single-stranded DNA-VirE2 complex assembly by VirE1.
Journal of Biological Chemistry.
282:(6)3458-3464.
Shaaltiel Y., Bartfeld D., Hashmueli S., Baum G., Brill-Almon E., Galili G., Dym O., Boldin-Adamsky S. A., Silman I., Sussman J., Futerman A. H. & Aviezer D.
(2007).
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
Plant Biotechnology Journal.
5:(5)579-590.
Romier C., Ben Jelloul J. M., Albeck S., Buchwald G., Busso D., Celie P. H. N., Christodoulou E., De Marco M. V., Van Gerwen G. S., Knipscheer P., Lebbink J. H., Notenboom V., Poterszman A., Rochel N., Cohen S. X., Unger T., Sussman J., Moras D., Sixma T. K. & Perrakis A.
(2006).
Co-Expression Of Protein Complexes In Prokaryotic And Eukaryotic Hosts: Experimental Procedures, Database Tracking And Case Studies.
Acta Crystallographica Section D-Biological Crystallography.
62:1232-1242.
Alzari P. M., Berglund H., Berrow N. S., Blagova E., Busso D., Cambillau C., Campanacci V., Christodoulou E., Eiler S., Fogg M. J., Folkers G., Geerlof A., Hart D., Haouz A., Herman M. D., Macieira S., Nordlund P., Perrakis A., Quevillon-Cheruel S., Tarandeau F., Van Tilbeurgh H., Unger T., Luna-Vargas M., Velarde M., Willmanns M. & Owens R. J.
(2006).
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.
Acta Crystallographica Section D-Biological Crystallography.
62:1103-1113.
Albeck S., Alzari P., Andreini C., Banci L., Berry I. M., Bertini I., Cambillau C., Canard B., Carter L., Cohen S. X., Diprose J. M., Dym O., Esnouf R. M., Felder C., Ferron F., Guillemot F., Hamer R., Ben Jelloul J. M., Laskowski R. A., Laurent T., Longhi S., Lopez R., Luchinat C., Malet H., Mochel T., Morris R. J., Moulinier L., Oinn T., Pajon A., Peleg Y., Perrakis A., Poch O., Prilusky J., Rachedi A., Ripp R., Rosato A., Silman I., Stuart D. I., Sussman J., Thierry J. -., Thompson J. D., Thornton J. M., Unger T., Vaughan B., Vranken W., Watson J. D., Whamond G. & Henrick K.
(2006).
Spine Bioinformatics And Data-Management Aspects Of High-Throughput Structural Biology.
Acta Crystallographica Section D-Structural Biology.
62:1184-1195.
Aricescu A. R., Assenberg R., Bill R. M., Busso D., Chang V. T., Davis S. J., Dubrovsky A., Gustafsson L., Hedfalk K., Heinemann U., Jones I. M., Ksiazek D., Lang C., Maskos K., Messerschmidt A., Macieira S., Peleg Y., Perrakis A., Poterszman A., Schneider G., Sixma T. K., Sussman J., Sutton G., Tarboureich N., Zeev-Ben-Mordehai T. & Jones E. Y.
(2006).
Eukaryotic Expression: Developments For Structural Proteomics.
Acta Crystallographica Section D-Biological Crystallography.
62:1114-1124.
Asher G., Dym O., Tsvetkov P., Adler J. & Shaul Y.
(2006).
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.
Biochemistry.
45:(20)6372-6378.
Fogg M. J., Alzari P., Bahar M., Bertini I., Betton J. -., Burmeister W. P., Cambillau C., Canard B., Carrondo M., Coll M., Daenke S., Dym O., Egloff M. -., Enguita F. J., Geerlof A., Haouz A., Jones T. A., Ma Q. & Manicka S. N.
(2006).
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.
Acta Crystallographica Section D-Biological Crystallography.
62:1196-1207.
Berrow N. S., Buessow K., Coutard B., Diprose J., Ekberg M., Folkers G. E., Levy N., Lieu V., Owens R. J., Peleg Y., Pinaglia C., Quevillon-Cheruel S., Salim L., Scheich C., Vincentelli R. & Busso D.
(2006).
Recombinant protein expression and solubility screening in Escherichia coli: a comparative study.
Acta Crystallographica Section D-Biological Crystallography.
62:1218-1226.
Berry I. M., Dym O., Esnouf R. M., Harlos K., Meged R., Perrakis A., Sussman J., Walter T. S., Wilson J. & Messerschmidt A.
(2006).
Spine High-Throughput Crystallization, Crystal Imaging And Recognition Techniques: Current State, Performance Analysis, New Technologies And Future Aspects.
Acta Crystallographica Section D-Biological Crystallography.
62:1137-1149.
Shao H., Revach M., Moshonov S., Tzuman Y., Gazit K., Albeck S., Unger T. & Dikstein R.
(2005).
Core promoter binding by histone-like TAF complexes.
Molecular and Cellular Biology.
25:(1)206-219.
Albeck S., Burstein Y., Dym O., Jacobovitch Y., Levi N., Meged R., Michael Y., Peleg Y., Prilusky J., Schreiber G., Silman I., Unger T. & Sussman J.
(2005).
Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC).
Acta Crystallographica Section D-Biological Crystallography.
61:1364-1372.
Reichmann D., Rahat O., Albeck S., Meged R., Dym O. & Schreiber G.
(2005).
The modular architecture of protein-protein binding interfaces.
Proceedings of the National Academy of Sciences of the United States of America.
102:(1)57-62.
Ganor Y., Besser M., Ben-Zakay N., Unger T. & Levite M.
(2003).
Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.
Journal of Immunology.
170:(8)4362-4372.
Sandowski Y., Raver N., Gussakovsky E., Shochat S., Dym O., Livnah O., Rubinstein M., Krishna R. & Gertler A.
(2002).
Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain.
Journal of Biological Chemistry.
277:(48)46304-46309.
Chill J., Nivasch R., Levy R., Albeck S., Schreiber G. & Anglister J.
(2002).
The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening.
Biochemistry.
41:(11)3575-3585.
Unger T., Oren Z. & Shai Y.
(2001).
The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: Implication to their mode of action.
Biochemistry.
40:(21)6388-6397.
Selzer T., Albeck S. & Schreiber G.
(2000).
Rational design of faster associating and tighter binding protein complexes.
Nature Structural Biology.
7:(7)537-541.
Albeck S., Unger R. & Schreiber G.
(2000).
Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges.
Journal of Molecular Biology.
298:(3)503-520.
Unger T., Juven-Gershon T., Moallem E., Berger M., Sionov R., Lozano G., Oren M. & Haupt Y.
(1999).
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
EMBO Journal.
18:(7)1805-1814.
Unger T., Sionov R., Moallem E., Yee C., Howley P., Oren M. & Haupt Y.
(1999).
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
Oncogene.
18:(21)3205-3212.
Albeck S. & Schreiber G.
(1999).
Biophysical characterization of the interaction of the beta-lactamase TEM-1 with its protein inhibitor BLIP.
Biochemistry.
38:(1)11-21.
Juven-Gershon T., Shifman O., Unger T., Elkeles A., Haupt Y. & Oren M.
(1998).
The Mdm2 oncoprotein interacts with the cell fate regulator numb.
Molecular and Cellular Biology.
18:(7)3974-3982.
Levi Y., Albeck S., Brack A., Weiner S. & Addadi L.
(1998).
Control over aragonite crystal nucleation and growth: An in vitro study of biomineralization.
Chemistry-A European Journal.
4:(3)389-396.
Mor F., Boccaccio G. & Unger T.
(1998).
Expression of autoimmune disease-related antigens by cells of the immune system.
Journal of Neuroscience Research.
54:(2)254-262.
Albeck S., Weiner S. & Addadi L.
(1996).
Polysaccharides of intracrystalline glycoproteins modulate calcite crystal growth in vitro.
Chemistry-A European Journal.
2:(3)278-284.
Falini G., Albeck S., Weiner S. & Addadi L.
(1996).
Control of aragonite or calcite polymorphism by mollusk shell macromolecules.
Science.
271:(5245)67-69.
Albeck S., Addadi L. & Weiner S.
(1996).
Regulation of calcite crystal morphology by intracrystalline acidic proteins and glycoproteins.
Connective Tissue Research.
35:(4-Jan)365-370.
Tamary H., Fromovich Y., Shalmon L., Reich Z., Dym O., Lanir N., Brenner B., Paz M., Luder A., Blau O., Korostishevsky M., Zaizov R. & Seligsohn U.
(1996).
Ala244Val is a common, probably ancient mutation causing factor VII deficiency in Moroccan and Iranian Jews.
Thrombosis and Haemostasis.
76:(3)283-291.
Addadi L., Aizenberg J., Albeck S., Falini G. & Weiner S.
(1995).
Structural control over the formation of calcium carbonate mineral phases in biomineralization.
Supramolecular Stereochemistry.
473:127-139.
Dym O., Mevarech M. & Sussman J.
(1995).
Structural Features That Stabilize Halophilic Malate-Dehydrogenase From An Archaebacterium.
Science.
267:(5202)1344-1346.
Addadi L., Aizenberg J., Albeck S., Berman A., Leiserowitz L. & Weiner S.
(1994).
Controlled Occlusion of Proteins - a Tool For Modulating the Properties of Skeletal Elements.
Molecular Crystals And Liquid Crystals Science And Technology Section A-Molecular Crystals And Liquid Crystals.
248:185-198.
Fiscella M., Zambrano N., Ullrich S. J., Unger T., Lin D., Cho B., Mercer W. E., Anderson C. W. & Appella E.
(1994).
The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.
Oncogene.
9:(11)3249-57.
Aizenberg J., Albeck S., Weiner S. & Addadi L.
(1994).
Crystal Protein Interactions Studied by Overgrowth of Calcite on Biogenic Skeletal Elements.
Journal of Crystal Growth.
142:(2-Jan)156-164.
Unger T., Mietz J. A., Scheffner M., Yee C. L. & Howley P. M.
(1993).
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.
Molecular and Cellular Biology.
13:(9)5186-94.
Albeck S., Aizenberg J., Addadi L. & Weiner S.
(1993).
Interactions of Various Skeletal Intracrystalline Components With Calcite Crystals.
Journal of the American Chemical Society.
115:(25)11691-11697.
Unger T., Nau M. M., Segal S. & Minna J. D.
(1992).
p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.
EMBO Journal.
11:(4)1383-90.
Mietz J. A., Unger T., Huibregtse J. M. & Howley P. M.
(1992).
The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.
EMBO Journal.
11:(13)5013-20.
Unger T. & Shaul Y.
(1990).
The x-Protein of the Hepatitis-b Virus Acts as a Transcription Factor When Targeted to Its Responsive Element.
EMBO Journal.
9:(6)1889-1895.
Mock B., Givol D., Dhoostelaere L., Huppi K., Seldin M., Gurfinkel N., Unger T., Potter M. & Mushinski J.
(1988).
Mapping of the Bcl-2 Oncogene on Mouse Chromosome-1.
Cytogenetic and Genome Research.
47:(2-Jan)11-15.
Gurfinkel N., Unger T., Givol D. & Mushinski J.
(1987).
Expression of the Bcl-2 Gene in Mouse b-Lymphocytic Cell-Lines is Differentiation Stage Specific.
European Journal of Immunology.
17:(4)567-570.
Katzir N., Rechavi G., Cohen J., Unger T., Simoni F., Segal S., Cohen D. & Givol D.
(1985).
Retroposon Insertion Into the Cellular Oncogene c-Myc in Canine Transmissible Venereal Tumor.
Proceedings of the National Academy of Sciences of the United States of America.
82:(4)1054-1058.
Cohen J., Unger T., Rechavi G., Canaani E. & Givol D.
(1983).
Rearrangement of the Oncogene c-Mos in Mouse Myeloma Nsi and Hybridomas.
Nature.
306:(5945)797-799.