Publications
Prashant D. Sonawane; Uwe Heinig; Sayantan Panda; Netta Segal Gilboa; Meital Yona; S. Pradeep Kumar; Noam Alkan; Tamar Unger; Samuel Bocobza; Margarita Pliner; Sergey Malitsky; Maria Tkachev; Sagit Meir; Ilana Rogachev; Asaph Aharoni
(2018).
Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum.
Proceedings of the National Academy of Sciences of the United States of America.
115:(23)E5419-E5428.
Olga Khersonsky; Rosalie Lipsh; Ziv Avizemer; Yacov Ashani; Moshe Goldsmith; Haim Leader; Orly Dym; Shelly Rogotner; Devin L. Trudeau; Jaime Prilusky; Pep Amengual-Rigo; Victor Guallar; Dan S. Tawfik; Sarel J. Fleishman
(2018).
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Molecular Cell.
72:(1)178-+.
Gili Ben-Nissan; Shay Vimer; Shira Warszawski; Aliza Katz; Meital Yona; Tamar Unger; Yoav Peleg; David Morgenstern; Hadas Cohen-Dvashi; Ron Diskin; Sarel J Fleishman; Michal Sharon
(2018).
Rapid characterization of secreted recombinant proteins by native mass spectrometry.
Communications biology.
1.
Shira Kahlon; Dorin Shreibman; Tamar Unger; Dina Ben-Yehuda; Shlomo Elias
(2018).
The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.
Blood Cancer Journal.
8.
Szilvia Baron; Yoav Peleg; Jacob Grunwald; David Morgenstern; Nadav Elad; Moshe Peretz; Shire Albeck; Yishai Levin; John T. Welch; Kim A. Deweerd; Alon Schwarz; Yigal Burstein; Ron Diskin; Zippora Shakked; Oren Zimhony
(2018).
Expression of a recombinant, 4 '-Phosphopantetheinylated, active M-tuberculosis fatty acid synthase I in E-coli.
PLoS One.
13:(9)
Gideon Lapidoth; Olga Khersonsky; Rosalie Lipsh; Orly Dym; Shira Albeck; Shelly Rogotner; Sarel J. Fleishman
(2018).
Highly active enzymes by automated combinatorial backbone assembly and sequence design.
Nature Communications.
9.
Amihai Karniel; Devid Mrusek; Wieland Steinchen; Orly Dym; Gert Bange; Eitan Bibi
(2018).
Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.
Journal of Molecular Biology.
Raisa Kantaev; Inbal Riven; Adi Goldenzweig; Yoav Barak; Orly Dym; Yoav Peleg; Shira Albeck; Sarel J. Fleishman; Gilad Haran
(2018).
Manipulating the Folding Landscape of a Multi-Domain Protein.
Journal of Physical Chemistry B.
122:(49)11030-11038.
Boudhayan Bandyopadhyay; Yoav Peleg
(2018).
Facilitating circular permutation using Restriction Free (RF) cloning.
Protein Engineering Design & Selection.
31:(3)65-68.
Nadav Elad; Szilvia Baron; Yoav Peleg; Shira Albeck; Jacob Grunwald; Gal Raviv; Zippora Shakked; Oren Zimhony; Ron Diskin
(2018).
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution.
Nature Communications.
9.
Ravit Netzer; Dina Listov; Rosalie Lipsh; Orly Dym; Shira Albeck; Orli Knop; Colin Kleanthous; Sarel J. Fleishman
(2018).
Ultrahigh specificity in a network of computationally designed protein-interaction pairs.
Nature Communications.
9.
Elad Milrot; Eyal Shimoni; Tali Dadosh; Katya Rechav; Tamar Unger; Etten, James L. Van Etten; Abraham Minsky
(2017).
Structural studies demonstrating a bacteriophage-like replication cycle of the eukaryote-infecting Paramecium bursaria chlorella virus-1.
PLoS Pathogens.
13:(8)
Ruth Cohen-Khait; Orly Dym; Shelly Hamer-Rogotner; Gideon Schreiber
(2017).
Promiscuous Protein Binding as a Function of Protein Stability.
Structure (London, England : 1993).
25:(12)1867-+.
Gideon Schreiber; R. Cohen-Khait; Orly Dym
(2017).
Promiscuous protein assembly as a function of interface plasticity and protein stability.
FEBS Journal.
284:12-12.
Zohar Pode; Ronny Peri-Naor; Joseph M. Georgeson; Tal Ilani; Vladimir Kiss; Tamar Unger; Barak Markus; Haim M. Barr; Leila Motiei; David Margulies
(2017).
Protein recognition by a pattern-generating fluorescent molecular probe.
Nature Nanotechnology.
12:(12)1161-1168.
Zohar Erez; Ida Steinberger-Levy; Maya Shamir; Shany Doron; Avihail, Avigail Stokar Avihail; Yoav Peleg; Sarah Melamed; Azita Leavitt; Alon Savidor; Shira Albeck; Gil Amitai; Rotem Sorek
(2017).
Communication between viruses guides lysis-lysogeny decisions.
Nature.
541:(7638)
Yoav Peleg; Vadivel Prabahar; Dominika Bednarczyk; Tamar Unger
(2017).
Harnessing the Profinity eXact™ System for Expression and Purification of Heterologous Proteins in E. coli.
Heterologous Gene Expression in E.coli: Methods and Protocols.
33-43.
Prashant D. Sonawane; Jacob Pollier; Sayantan Panda; Jedrzej Szymanski; Hassan Massalha; Meital Yona; Tamar Unger; Sergey Malitsky; Philipp Arendt; Laurens Pauwels; Efrat Almekias-Siegl; Ilana Rogachev; Sagit Meir; Pablo D. Cardenas; Athar Masri; Marina Petrikov; Hubert Schaller; Arthur A. Schaffer; Avinash Kamble; Ashok P. Giri; Alain Goossens; Asaph Aharoni
(2017).
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.
Nature Plants.
3:(1)
Prashant D. Sonawane; Jacob Pollier; Sayantan Panda; Jedrzej Szymanski; Hassan Massalha; Meital Yona; Tamar Unger; Sergey Malitsky; Philipp Arendt; Laurens Pauwels; Efrat Almekias-Siegl; Ilana Rogachev; Sagit Meir; Pablo D. Cardenas; Athar Masri; Marina Petrikov; Hubert Schaller; Arthur A. Schaffer; Avinash Kamble; Ashok P. Giri; Alain Goossens; Asaph Aharoni
(2017).
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism (vol 3, 16205, 2016).
Nature Plants.
3:(7)
Gill Ben-Nissan; Mikhail E. Belov; David Morgenstern; Yishai Levin; Orly Dym; Galina Arkind; Garth Lipson; Alexander A. Makarov; Michal Sharon
(2017).
Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.
Analytical Chemistry.
89:(8)4708-4715.
Dror Baran; M. Gabriele Pszolla; Gideon D. Lapidoth; Christoffer Norn; Orly Dym; Tamar Unger; Shira Albeck; Michael D. Tyka; Sarel J. Fleishman
(2017).
Principles for computational design of binding antibodies.
Proceedings of the National Academy of Sciences of the United States of America.
114:(41)10900-10905.
Lior Tal; Gilgi Friedlander; Netta Segal Gilboa; Tamar Unger; Shlomit Gilad; Yuval Eshed
(2017).
Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein.
Plant Cell.
29:(4)681-696.
Boudhayan Bandyopadhyay; Adi Goldenzweig; Tamar Unger; Orit Adato; Sarel J Fleishman; Ron Unger; Amnon Horovitz
(2017).
Local energetic frustration affects the dependence of green fluorescent protein folding on the chaperonin GroEL.
Journal of Biological Chemistry.
292:(50)20583-20591.
Robert G Smock; Itamar Yadid; Orly Dym; Jane Clarke; Dan Tawfik
(2016).
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
Cell.
164:(3)476-486.
Orly Dym; Wanling Song; Clifford Felder; Esther Roth; Valery Shnyrov; Yacov Ashani; Yechun Xu; Robbie P. Joosten; Lev Weiner; Joel Sussman; Israel Silman
(2016).
The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Science.
25:(6)1096-1114.
Dominika Bednarczyk; Orly Dym; Vadivel Prabahar; Yoav Peleg; Douglas H. Pike; Dror Noy
(2016).
Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.
Angewandte Chemie-International Edition.
55:(24)6901-6905.
Eliyahu Yosef; Adriana Katz; Yoav Peleg; Tevie Mehlman; Steven J.D Karlish
(2016).
Do Src Kinase and Caveolin Interact Directly with Na,K-ATPase?.
Journal of Biological Chemistry.
291:(22)11736-11750.
Adi Goldenzweig; Moshe Goldsmith; Shannon E. Hill; Or Gertman; Paola Laurino; Yacov Ashani; Orly Dym; Tamar Unger; Shira Albeck; Jaime Prilusky; Raquel L. Lieberman; Amir Aharoni; Israel Silman; Joel Sussman; Dan Tawfik; Sarel J. Fleishman
(2016).
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.
Molecular Cell.
63:(2)337-346.
Eitan Wong; Tal Cohen; Erez Romi; Maxim Levin; Yoav Peleg; Uri Arad; Avraham Yaron; Marcos E. Milla; Irit Sagi
(2016).
Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo.
Scientific Reports.
6.
Tomer Shpilka; Evelyn Welter; Noam Borovsky; Nira Amar; Frida Shimron; Yoav Peleg; Zvulun Elazar
(2015).
Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast.
Proceedings of the National Academy of Sciences of the United States of America.
112:(5)1434-1439.
Yael Udi; Moran Grossman; Inna Solomonov; Orly Dym; Haim Rozenberg; Vanessa Moreno; Philippe Cuniasse; Vincent Dive; Arroyo, Alicia Garcia Arroyo; Irit Sagi
(2015).
Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.
Structure.
23:(1)104-115.
Liping Sun; Yunjing Xiong; Anat Bashan; Ella Zimmerman; Shirley Shulman Daube; Yoav Peleg; Shira Albeck; Tamar Unger; Hagith Yonath; Miri Krupkin; Donna Matzov; Ada Yonath
(2015).
A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis.
ChemBioChem.
16:(10)1415-1419.
E Wong; Thorsten Maretzky; Yoav Peleg; Carl P. Blobel; Irit Sagi
(2015).
The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.
The journal of Biological chemistry.
290:12135-12146.
Oren Zimhony; Alon Schwarz; Gurevich, Maria Raitses Gurevich; Yoav Peleg; Orly Dym; Shira Albeck; Yigal Burstein; Zippora Shakked
(2015).
AcpM, the Meromycolate Extension Acyl Carrier Protein of Mycobacterium tuberculosis, Is Activated by the 4 '-Phosphopantetheinyl Transferase PptT, a Potential Target of the Multistep Mycolic Acid Biosynthesis.
Biochemistry.
54:(14)2360-2371.
Yael Nissinkorn; Naama Lahav-Mankovski; Aharon Rabinkov; Shira Albeck; Leila Motiei; David Margulies
(2015).
Sensing Protein Surfaces with Targeted Fluorescent Receptors.
Chemistry (Weinheim an der Bergstrasse, Germany).
21:(45)15873-15873.
Yael Nissinkorn; Naama Lahav-Mankovski; Aharon Rabinkov; Shira Albeck; Leila Motiei; David Margulies
(2015).
Sensing Protein Surfaces with Targeted Fluorescent Receptors.
Chemistry (Weinheim an der Bergstrasse, Germany).
21:(45)15981-7.
Yonathan Arfi; Melina Shamshoum; Ilana Rogachev; Yoav Peleg; Ed Bayer
(2014).
Integration of bacterial lytic polysaccharide monooxygenases into designer cellulosomes promotes enhanced cellulose degradation.
Proceedings of the National Academy of Sciences of the United States of America.
111:(25)9109-9114.
Ariel Erijman; Julia M. Shifman; Yoav Peleg
(2014).
A Single-Tube Assembly of DNA Using the Transfer-PCR (TPCR) Platform.
Dna Cloning And Assembly Methods.
89-101.
Yoav Peleg; Tamar Unger
(2014).
Application of the Restriction-Free (RF) Cloning for Multicomponents Assembly.
Dna Cloning And Assembly Methods.
73-87.
Maxim Itkin; U. Heinig; Oren Tzfadia; A. J. Bhide; Belkrishna Ankush Shinde; P. D. Cardenas; S. E. Bocobza; Tamar Unger; Sergey Malitsky; R. Finkers; Y. Tikunov; A. Bovy; Yujana Rohidas Chikate; P. Singh; Ilana Rogachev; J. Beekwilder; A. P. Giri; Asaph Aharoni
(2013).
Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes.
Science.
341:(6142)175-179.
Tanmay A. M. Bharat; David Zbaida; Miriam Eisenstein; Ziv Frankenstein; Tevie Mehlman; Lev Weiner; Carlos Oscar S. Sorzano; Yoav Barak; Shira Albeck; John A. G. Briggs; Sharon G. Wolf; Michael Elbaum
(2013).
Variable Internal Flexibility Characterizes the Helical Capsid Formed by Agrobacterium VirE2 Protein on Single-Stranded DNA.
Structure.
21:(7)1158-1167.
Yael Vazana; Yoav Barak; Tamar Unger; Yoav Peleg; Melina Shamshoum; Tuval Ben-Yehezkel; Yair Mazor; Ehud Shapiro; Raphael Lamed; Ed Bayer
(2013).
A synthetic biology approach for evaluating the functional contribution of designer cellulosome components to deconstruction of cellulosic substrates.
Biotechnology for Biofuels.
6.
Elisha Krieg; Shira Albeck; Haim Weissman; Eyal Shimoni; Boris Rybtchinski
(2013).
Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane.
PLoS One.
8:(5)
Hila Sberro; Azita Leavitt; Ruth Kiro; Eugene Koh; Yoav Peleg; Udi Qimron; Rotem Sorek
(2013).
Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning.
Molecular Cell.
50:(1)136-148.
Vladimir Sobolev; Marvin Edelman; Orly Dym; Tamar Unger; Shira Albeck; Menny Kirma; Gad Galili
(2013).
Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.
Acta Crystallographica Section F-Structural Biology And Crystallization Communications.
69:84-89.
Olga Khersonsky; Gert Kiss; Daniela Roethlisberger; Orly Dym; Shira Albeck; Kendall N. Houk; David Baker; Dan Tawfik
(2012).
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proceedings of the National Academy of Sciences of the United States of America.
109:(26)10358-10363.
S. Hama; H. Soran; Shira Albeck; V. Charlton-Menys; R. Yadav; Y. Liu; M. France; D. Tawfiq; P. Durrington
(2012).
High Paraoxonase-1 Hdl is More Effective Than Low Paraoxonase-1 Hdl in Impeding Ldl Oxidation in Vitro.
Atherosclerosis.
223:(2)529-529.
Yoav Peleg; Tamar Unger
(2012).
Resolving Bottlenecks for Recombinant Protein Expression in E. coli.
Chemical Genomics And Proteomics: Reviews And Protocols.
173-186.
Yechun Xu; Min-Jun Li; Harry Greenblatt; Wuyan Chen; Aviv Paz; Orly Dym; Yoav Peleg; Tiantian Chen; Xu Shen; Jianhua He; Hualiang Jiang; Israel Silman; Joel Sussman
(2012).
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.
Acta Crystallographica Section D-Biological Crystallography.
68:13-25.
Nett A. Sela-Passwell; Raghavendra Kikkeri; Orly Dym; Haim Rozenberg; Raanan Margalit; Rina Arad-Yellin; Miriam Eisenstein; Ori Brenner; Tsipi Shoham; Tamar Danon; Abraham Shanzer; Irit Sagi
(2012).
Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.
Nature Medicine.
18:(1)143-147.
Tamar Unger; Yoav Peleg
(2012).
Recombinant Protein Expression in the Baculovirus-Infected Insect Cell System.
Chemical Genomics And Proteomics: Reviews And Protocols.
187-199.
Ariel Erijman; Ada Dantes; Reut Bernheim; Julia M. Shifman; Yoav Peleg
(2011).
Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering.
Journal of Structural Biology.
175:(2)171-177.
Min-Jun Li; Harry M. Greenblatt; Orly Dym; Shira Albeck; Adi Pais; Chidambaram Gunanathan; David Milstein; Hadassa Degani; Joel Sussman
(2011).
Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators.
Journal of Medicinal Chemistry.
54:(10)3575-3580.
Shmuel Cohen; Shira Albeck; Eitan Ben-Dov; Rivka Cahan; Michael Firer; Arieh Zaritsky; Orly Dym
(2011).
Cyt1Aa Toxin: Crystal Structure Reveals Implications for Its Membrane-Perforating Function.
Journal of Molecular Biology.
413:(4)804-814.
Olga Khersonsky; Daniela Roethlisberger; Andrew M. Wollacott; Paul Murphy; Orly Dym; Shira Albeck; Gert Kiss; K. N. Houk; David Baker; Dan Tawfik
(2011).
Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution.
Journal of Molecular Biology.
407:(3)391-412.
Neeraj Kumar Mishra; Yoav Peleg; Erica Cirri; Talya Belogus; Yael Lifshitz; Dennis R. Voelker; Hans-Juergen Apell; Haim Garty; Steven J.D Karlish
(2011).
FXYD Proteins Stabilize Na,K-ATPase AMPLIFICATION OF SPECIFIC PHOSPHATIDYLSERINE-PROTEIN INTERACTIONS.
Journal of Biological Chemistry.
286:(11)9699-9712.
Didier Busso; Yoav Peleg; Tatjana Heidebrecht; Christophe Romier; Yossi Jacobovitch; Ada Dantes; Loubna Salim; Edouard Troesch; Anja Schuetz; Udo Heinemann; Gert E. Folkers; Arie Geerlof; Matthias Wilmanns; Andrea Polewacz; Claudia Quedenau; Konrad Buessow; Rachel Adamson; Elena Blagova; Julia Walton; Jared L. Cartwright; Louise E. Bird; Raymond J. Owens; Nick S. Berrow; Keith S. Wilson; Joel Sussman; Anastassis Perrakis; Patrick H. N. Celie
(2011).
Expression Of Protein Complexes Using Multiple Escherichia Coli Protein Co-Expression Systems: A Benchmarking Study.
Journal of Structural Biology.
175:(2)159-170.
Olga Khersonsky; Daniela Roethlisberger; Andrew M. Wollacott; Paul Murphy; Orly Dym; Shira Albeck; Gert Kiss; K. N. Houk; David Baker; Dan Tawfik
(2011).
Optimization of the in silico designed Kemp eliminase KE70 by computational design and directed evolution: Insights from MD.
Abstracts of Papers of the American Chemical Society.
241.
Orit Siton; Yaron Ideses; Shira Albeck; Tamar Unger; Alexander D. Bershadsky; Nir Gov; Anne Bernheim-Groswasser
(2011).
Cortactin Releases the Brakes in Actin-Based Motility by Enhancing WASP-VCA Detachment from Arp2/3 Branches.
Current Biology.
21:(24)2092-2097.
Rodrigo Carlessi; Vered Levin-Salomon; Sara Ciprut; Shani Bialik; Hanna Berissi; Shira Albeck; Yoav Peleg; Adi Kimchi
(2011).
GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling.
EMBO Reports.
12:(9)917-923.
John Karanicolas; Jacob E. Com; Irwin Chen; Lukasz A. Joachimiak; Orly Dym; Sun H. Peck; Shira Albeck; Tamar Unger; Wenxin Hu; Gaohua Liu; Scott Delbecq; Gaetano T. Montelione; Clint P. Spiegel; David R. Liu; David Baker
(2011).
A De Novo Protein Binding Pair By Computational Design and Directed Evolution.
Molecular Cell.
42:(2)250-260.
Tamar Unger; Yossi Jacobovitch; Ada Dantes; Reut Bernheim; Yoav Peleg
(2010).
Applications of the Restriction Free (RF) cloning procedure for molecular manipulations and protein expression.
Journal of Structural Biology.
172:(1)34-44.
Olga Khersonsky; Daniela Rothlisberger; Orly Dym; Shira Albeck; Colin J. Jackson; David Baker; Dan Tawfik
(2010).
Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
Journal of Molecular Biology.
396:(4)1025-1042.
Weidong Jiang; Xin Wei Wang; Tamar Unger; Marshonna Forgues; Jin Woo Kim; S. Perwez Hussain; Elise Bowman; Elisa A. Spillare; Michael M. Lipsky; Jeanne M. Meck; Luciane R. Cavalli; Bassem R. Haddad; Curtis C. Harris
(2010).
Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.
International Journal of Cancer.
127:(5)1011-1020.
Elvira Vitu; Sunghwan Kim; Carolyn S. Sevier; Omer Lutzky; Nimrod Heldman; Moran Bentzur; Tamar Unger; Meital Yona; Chris A. Kaiser; Deborah Fass
(2010).
Oxidative Activity of Yeast Ero1p on Protein Disulfide Isomerase and Related Oxidoreductases of the Endoplasmic Reticulum.
Journal of Biological Chemistry.
285:(24)18155-18165.
Tamar Unger; Orly Dym; Shira Albeck; Yossi Jacobovitch; Reut Bernehim; David Marom; Odelia Pisanty; Adina Breiman
(2010).
Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain.
Journal of Structural and Functional Genomics.
11:(2)113-23.
Edi Goihberg; Moshe Peretz; Shoshana Tel-Or; Orly Dym; Linda Shimon; Felix Frolow; Yigal Burstein
(2010).
Biochemical and Structural Properties of Chimeras Constructed by Exchange of Cofactor-Binding Domains in Alcohol Dehydrogenases from Thermophilic and Mesophilic Microorganisms.
Biochemistry.
49:(9)1943-1953.
Itamar Yadid; Noam Kirshenbaum; Michal Sharon; Orly Dym; Dan Tawfik
(2010).
Metamorphic proteins mediate evolutionary transitions of structure.
Proceedings of the National Academy of Sciences of the United States of America.
107:(16)7287-7292.
Moran Grossman; Dmitry Tworowski; Orly Dym; Meng-Huee Lee; Yaakov Levy; Gillian Murphy; Irit Sagi
(2010).
The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function.
Biochemistry.
49:(29)6184-6192.
Tzviya Zeev-Ben-Mordehai; Efstratios Mylonas; Aviv Paz; Yoav Peleg; Lilly Toker; Israel Silman; Dmitri I. Svergun; Joel Sussman
(2009).
The Quaternary Structure Of Amalgam, A Drosophila Neuronal Adhesion Protein, Explains Its Dual Adhesion Properties.
Biophysical Journal.
97:(8)2316-2326.
Tzviya Zeev-Ben-Mordehai; Aviv Paz; Yoav Peleg; Lilly Toker; Sharon G. Wolf; Edwin H. Rydberg; Joel Sussman; Israel Silman
(2009).
Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization.
Protein Expression and Purification.
63:(2)147-157.
Oz Sharabi; Yoav Peleg; Efrat Mashiach; Eyal Vardy; Yacov Ashani; Israel Silman; Joel Sussman; Julia M. Shifman
(2009).
Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.
Protein Engineering Design & Selection.
22:(10)641-648.
Orly Dym; Shira Albeck; Yoav Peleg; Alon Schwarz; Zippora Shakked; Yigal Burstein; Oren Zimhony
(2009).
Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis.
Journal of Molecular Biology.
393:(4)937-950.
Kalia Bernath Levin; Orly Dym; Shira Albeck; Shlomo Magdassi; Anthony H. Keeble; Colin Kleanthous; Dan Tawfik
(2009).
Following evolutionary paths to protein-protein interactions with high affinity and selectivity.
Nature Structural & Molecular Biology.
16:(10)1049-U67.
Elizabeta Bab-Dinitz; Shira Albeck; Yoav Peleg; Vlad Brumfeld; Kay E. Gottschalk; Steven J.D Karlish
(2009).
A C-Terminal Lobe of the beta Subunit of Na,K-ATPase and H,K-ATPase Resembles Cell Adhesion Molecules.
Biochemistry.
48:(36)8684-8691.
Noa Liberman; Orly Dym; Tamar Unger; Shira Albeck; Yoav Peleg; Yossi Jacobovitch; Anna Branzburg; Miriam Eisenstein; Lea Marash; Adi Kimchi
(2008).
The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage.
Journal of Molecular Biology.
383:(3)539-548.
Shmuel Cohen; Orly Dym; Shira Albeck; Eitan Ben-Dov; Rivka Cahan; Michael Firer; Arieh Zaritsky
(2008).
High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp israelensis.
Journal of Molecular Biology.
380:(5)820-827.
Sankar Manicka; Yoav Peleg; Tamar Unger; Shira Albeck; Orly Dym; Harry A. Greenblatt; Gleb Bourenkov; Victor Lamzin; Sankaran Krishnaswamy; Joel Sussman
(2008).
Crystal structure of yagE, a putative DHDPS-like protein from Escherichia coli K12.
Proteins-Structure Function And Bioinformatics.
71:(4)2102-2108.
Daniela Rothlisberger; Olga Khersonsky; Andrew M. Wollacott; Lin Jiang; Jason Dechancie; Jamie Betker; Jasmine L. Gallaher; Eric A. Althoff; Alexandre Zanghellini; Orly Dym; Shira Albeck; Kendall N. Houk; Dan Tawfik; David Baker
(2008).
Kemp elimination catalysts by computational enzyme design.
Nature.
453:(7192)190-U4.
Edi Goihberg; Orly Dym; Shoshana Tel-Or; Linda Shimon; Felix Frolow; Moshe Peretz; Hua Tang
(2008).
Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution.
Proteins-Structure Function And Bioinformatics.
72:(2)711-719.
Orly Dym; Shira Albeck; Tamar Unger; Jossef Jacobovitch; Anna Brainzburg; Yigal Michael; Daphna Frenkiel-Krispin; Sharon G. Wolf; Michael Elbaum
(2008).
Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.
Proceedings of the National Academy of Sciences of the United States of America.
105:(32)11170-11175.
Shimon Cohen; Orly Dym; Shira Albeck; E. Ben-Dov; R. Cahan; M. Firer; A. Zaritsky
(2008).
High-resolution crystal structure of activated Cyt2Ba from Bacillus thuringiensis subsp israelensis.
FEBS Journal.
275:161-161.
Shira Albeck; Orly Dym; Tamar Unger; Zohar Snapir; Zippy Bercovich; Chaim Kahana
(2008).
Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.
Protein Science.
17:(5)793-802.
Yoav Peleg; Tamar Unger
(2008).
Application of High-Throughput Methodologies to the Expression of Recombinant Proteins in E. coli.
Structural Proteomics: High-Throughput Methods.
197-208.
Susanne Graslund; Paer Nordlund; Johan Weigelt; James Bray; B. Martin Hallberg; Opher Gileadi; Stefan Knapp; Udo Oppermann; Cheryl Arrowsmith; Raymond Hui; Jinrong Ming; Sirano Dhe-Paganon; Hee-Won Park; Alexei Savchenko; Adelinda Yee; Aled Edwards; Renaud Vincentelli; Christian Cambillau; Rosalind Kim; S.H. Kim; Z. Rao; Y. Shi; T.C. Terwilliger; C.Y. Kim; L.W. Hung; G.S. Waldo; Yoav Peleg; S. Albeck; Tamar Unger; Orly Dym; J. Prilusky; J.L. Sussman; R.C. Stevens; S.A. Lesley; I.A. Wilson; J. Joachimiak; F. Collart; I. Dementieva; M.I. Donnelly; W.H. Eschenfeldt; Y. Kim; L. Stols; R. Wu; M. Zhou; S.K. Burley; J.S. Emtage; J.M. Sauder; D. Thompson; K. Bain; J. Luz; T. Gheyi; F. Zhang; S. Atwell; S.C. Almo; J.B. Bonanno; A. Fiser; S. Swaminathan; F.W. Studier; M.R. Chance; A. Sali; T.B. Acton; R. Xiao; L. Zhao; L.C. Ma; J.F. Hunt; L. Tong; K. Cunningham; M. Inouye; S. Anderson; H. Janjua; R. Shastry; C.K. Ho; D. Wang; H. Wang; M. Jiang; G.T. Montelione; D.I. Stuart; R.J. Owens; S. Daenke; A. SchüTz; U. Heinemann; S. Yokoyama; K. BüSsow; K.C. Gunsalus
(2008).
Protein production and purification.
Nature Methods.
5:(2)135-146.
Daphna Frenkiel-Krispin; Sharon G. Wolf; Shira Albeck; Tamar Unger; Yoav Peleg; Jossef Jacobovitch; Yigal Michael; Shirley Daube; Michal Sharon; Carol V. Robinson; Dmitri I. Svergun; Deborah Fass; Tzvi Tzfira; Michael Elbaum
(2007).
Plant transformation by Agrobacterium tumefaciens - Modulation of single-stranded DNA-VirE2 complex assembly by VirE1.
Journal of Biological Chemistry.
282:(6)3458-3464.
Yoseph Shaaltiel; Daniel Bartfeld; Sharon Hashmueli; Gideon Baum; Einat Brill-Almon; Gad Galili; Orly Dym; Swetlana A. Boldin-Adamsky; Israel Silman; Joel Sussman; Anthony H. Futerman; David Aviezer
(2007).
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
Plant Biotechnology Journal.
5:(5)579-590.
Edi Goihberg; Orly Dym; Shoshana Tel-Or; Inna Levin; Moshe Peretz; Yigal Burstein
(2007).
A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase.
Proteins-Structure Function And Bioinformatics.
66:(1)196-204.
D. Reichmann; Merav Cohen; Renne Abramovich; Orly Dym; D. Lim; N. C. J. Strynadka; Gideon Schreiber
(2007).
Binding hot spots in the TEM1-BLIP interface in light of its modular architecture.
Journal of Molecular Biology.
365:(3)663-679.
Nick S. Berrow; K. Buessow; B. Coutard; J. Diprose; M. Ekberg; G. E. Folkers; Noam Levy; V. Lieu; R. J. Owens; Yoav Peleg; C. Pinaglia; S. Quevillon-Cheruel; L. Salim; C. Scheich; R. Vincentelli; Didier Busso
(2006).
Recombinant protein expression and solubility screening in Escherichia coli: a comparative study.
Acta Crystallographica Section D-Biological Crystallography.
62:1218-1226.
Ian M. Berry; Orly Dym; R. M. Esnouf; K. Harlos; R. Meged; A. Perrakis; Joel Sussman; T. S. Walter; J. Wilson; Albrecht Messerschmidt
(2006).
Spine High-Throughput Crystallization, Crystal Imaging And Recognition Techniques: Current State, Performance Analysis, New Technologies And Future Aspects.
Acta Crystallographica Section D-Biological Crystallography.
62:1137-1149.
Christophe Romier; Jelloul, Marouane Ben Jelloul; Shira Albeck; Gretel Buchwald; Didier Busso; Patrick H. N. Celie; Evangelos Christodoulou; Marco, Valeria De Marco; Gerwen, Suzan Van Gerwen; Puck Knipscheer; Joyce H. Lebbink; Valerie Notenboom; Arnaud Poterszman; Natacha Rochel; Serge X. Cohen; Tamar Unger; Joel Sussman; Dino Moras; Titia K. Sixma; Anastassis Perrakis
(2006).
Co-Expression Of Protein Complexes In Prokaryotic And Eukaryotic Hosts: Experimental Procedures, Database Tracking And Case Studies.
Acta Crystallographica Section D-Biological Crystallography.
62:1232-1242.
Pedro M. Alzari; H. Berglund; N. S. Berrow; E. Blagova; D. Busso; C. Cambillau; V. Campanacci; E. Christodoulou; S. Eiler; M. J. Fogg; G. Folkers; A. Geerlof; D. Hart; A. Haouz; M. D. Herman; S. Macieira; P. Nordlund; A. Perrakis; S. Quevillon-Cheruel; F. Tarandeau; H. Van Tilbeurgh; Tamar Unger; M.P.A. Luna-Vargas; M. Velarde; M. Willmanns; Raymond J. Owens
(2006).
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.
Acta Crystallographica Section D-Biological Crystallography.
62:1103-1113.
Shira Albeck; P. Alzari; C. Andreini; L. Banci; I. M. Berry; I. Bertini; C. Cambillau; B. Canard; L. Carter; S. X. Cohen; J. M. Diprose; Orly Dym; R. M. Esnouf; Clifford Felder; F. Ferron; F. Guillemot; R. Hamer; Jelloul, M. Ben Jelloul; R. A. Laskowski; T. Laurent; S. Longhi; R. Lopez; C. Luchinat; H. Malet; T. Mochel; R. J. Morris; L. Moulinier; T. Oinn; A. Pajon; Yoav Peleg; A. Perrakis; O. Poch; Jaime Prilusky; A. Rachedi; R. Ripp; A. Rosato; Israel Silman; D. I. Stuart; Joel Sussman; J. -C. Thierry; J. D. Thompson; J. M. Thornton; Tamar Unger; B. Vaughan; W. Vranken; J. D. Watson; G. Whamond; K. Henrick
(2006).
Spine Bioinformatics And Data-Management Aspects Of High-Throughput Structural Biology.
Acta Crystallographica Section D-Structural Biology.
62:1184-1195.
A. R. Aricescu; R. Assenberg; R. M. Bill; D. Busso; V. T. Chang; S. J. Davis; A. Dubrovsky; L. Gustafsson; K. Hedfalk; U. Heinemann; I. M. Jones; D. Ksiazek; C. Lang; K. Maskos; A. Messerschmidt; S. Macieira; Yoav Peleg; A. Perrakis; A. Poterszman; G. Schneider; T. K. Sixma; Joel Sussman; G. Sutton; N. Tarboureich; T. Zeev-Ben-Mordehai; E. Yvonne Jones
(2006).
Eukaryotic Expression: Developments For Structural Proteomics.
Acta Crystallographica Section D-Biological Crystallography.
62:1114-1124.
Gad Asher; Orly Dym; Peter Tsvetkov; Julia Adler; Yosef Shaul
(2006).
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.
Biochemistry.
45:(20)6372-6378.
D. Reichmann; Merav Cohen; L. Roisman; Vladimir Potapov; Vladimir Sobolev; Marvin Edelman; Orly Dym; Gideon Schreiber
(2006).
Architecture and design of protein-protein binding sites using the ProteOn (TM) XPR36 protein interaction array system.
Molecular & Cellular Proteomics.
5:(10)S49-S49.
M. J. Fogg; P. Alzari; M. Bahar; I. Bertini; J. -M. Betton; W. P. Burmeister; C. Cambillau; B. Canard; M. Carrondo; M. Coll; S. Daenke; Orly Dym; M. -P. Egloff; F. J. Enguita; A. Geerlof; A. Haouz; T. A. Jones; Qingjun Ma; S. N. Manicka
(2006).
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.
Acta Crystallographica Section D-Biological Crystallography.
62:1196-1207.
D Reichmann; O Rahat; Shira Albeck; R Meged; Orly Dym; Gideon Schreiber
(2005).
The modular architecture of protein-protein binding interfaces.
Proceedings of the National Academy of Sciences of the United States of America.
102:(1)57-62.
Hs Shao; M Revach; Sandra Moshonov; Y Tzuman; Kfir Gazit; Shira Albeck; Tamar Unger; Rivka Dikstein
(2005).
Core promoter binding by histone-like TAF complexes.
Molecular and Cellular Biology.
25:(1)206-219.
Shira Albeck; Yigal Burstein; Orly Dym; Y Jacobovitch; Noam Levi; R Meged; Y Michael; Yoav Peleg; Jaime Prilusky; Gideon Schreiber; Israel Silman; Tamar Unger; Joel Sussman
(2005).
Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC).
Acta Crystallographica Section D-Biological Crystallography.
61:1364-1372.
Y Ganor; M Besser; N Ben-Zakay; Tamar Unger; M Levite
(2003).
Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.
Journal of Immunology.
170:(8)4362-4372.
Y Sandowski; N Raver; Ee Gussakovsky; S Shochat; Orly Dym; O Livnah; Menachem Rubinstein; R Krishna; A Gertler
(2002).
Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain.
Journal of Biological Chemistry.
277:(48)46304-46309.
Jh Chill; R Nivasch; Ran Levy; Shira Albeck; Gideon Schreiber; Jacob Anglister
(2002).
The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening.
Biochemistry.
41:(11)3575-3585.
Tamar Unger; Z Oren; Yechiel Shai
(2001).
The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: Implication to their mode of action.
Biochemistry.
40:(21)6388-6397.
T Selzer; Shira Albeck; Gideon Schreiber
(2000).
Rational design of faster associating and tighter binding protein complexes.
Nature Structural Biology.
7:(7)537-541.
Shira Albeck; R Unger; Gideon Schreiber
(2000).
Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges.
Journal of Molecular Biology.
298:(3)503-520.
Tamar Unger; T Juven-Gershon; E Moallem; Michael Berger; Rv Sionov; G Lozano; Moshe Oren; Y Haupt
(1999).
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
EMBO Journal.
18:(7)1805-1814.
Tamar Unger; Rv Sionov; E Moallem; Cl Yee; Pm Howley; Moshe Oren; Y Haupt
(1999).
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
Oncogene.
18:(21)3205-3212.
Shira Albeck; Gideon Schreiber
(1999).
Biophysical characterization of the interaction of the beta-lactamase TEM-1 with its protein inhibitor BLIP.
Biochemistry.
38:(1)11-21.
T Juven-Gershon; O Shifman; Tamar Unger; A Elkeles; Y Haupt; Moshe Oren
(1998).
The Mdm2 oncoprotein interacts with the cell fate regulator numb.
Molecular and Cellular Biology.
18:(7)3974-3982.
Yafa Levi; Shira Albeck; A Brack; Stephen Weiner; Lia Addadi
(1998).
Control over aragonite crystal nucleation and growth: An in vitro study of biomineralization.
Chemistry-A European Journal.
4:(3)389-396.
F Mor; Gl Boccaccio; Tamar Unger
(1998).
Expression of autoimmune disease-related antigens by cells of the immune system.
Journal of Neuroscience Research.
54:(2)254-262.
J Aizenberg; Shira Albeck; G Falini; Yafa Levi; Stephen Weiner; Lia Addadi
(1997).
Design strategies in mineralized biological materials.
Abstracts of Papers of the American Chemical Society.
213:768-INOR.
Shira Albeck; Lia Addadi; Stephen Weiner
(1996).
Regulation of calcite crystal morphology by intracrystalline acidic proteins and glycoproteins.
Connective Tissue Research.
35:(4-Jan)365-370.
Shira Albeck; Stephen Weiner; Lia Addadi
(1996).
Polysaccharides of intracrystalline glycoproteins modulate calcite crystal growth in vitro.
Chemistry-A European Journal.
2:(3)278-284.
G Falini; Shira Albeck; Stephen Weiner; Lia Addadi
(1996).
Control of aragonite or calcite polymorphism by mollusk shell macromolecules.
Science.
271:(5245)67-69.
H Tamary; Y Fromovich; L Shalmon; Ziv Reich; Orly Dym; N Lanir; B Brenner; Malka Paz; As Luder; O Blau; M Korostishevsky; R Zaizov; U Seligsohn
(1996).
Ala244Val is a common, probably ancient mutation causing factor VII deficiency in Moroccan and Iranian Jews.
Thrombosis and Haemostasis.
76:(3)283-291.
H Tamary; Y Fromovitch; L Shalmon; Ziv Reich; Orly Dym; N Lanir; B Brenner; Malka Paz; As Luder; O Blau; R Zaizov; U Seligsohn
(1995).
An Ala-244 Val Mutation in the Factor-Vii Gene is Common in Jews of Different Ethnic Backgrounds.
Thrombosis and Haemostasis.
73:(6)1440-1440.
Lia Addadi; J Aizenberg; Shira Albeck; G Falini; Stephen Weiner
(1995).
Structural control over the formation of calcium carbonate mineral phases in biomineralization.
Supramolecular Stereochemistry.
473:127-139.
Orly Dym; M Mevarech; Joel Sussman
(1995).
Structural Features That Stabilize Halophilic Malate-Dehydrogenase From An Archaebacterium.
Science.
267:(5202)1344-1346.
J Aizenberg; Shira Albeck; Stephen Weiner; Lia Addadi
(1994).
Crystal Protein Interactions Studied by Overgrowth of Calcite on Biogenic Skeletal Elements.
Journal of Crystal Growth.
142:(2-Jan)156-164.
Lia Addadi; J Aizenberg; Shira Albeck; A Berman; Leslie Leiserowitz; Stephen Weiner
(1994).
Controlled Occlusion of Proteins - a Tool For Modulating the Properties of Skeletal Elements.
Molecular Crystals And Liquid Crystals Science And Technology Section A-Molecular Crystals And Liquid Crystals.
248:185-198.
M Fiscella; N Zambrano; S J Ullrich; T Unger; D Lin; B Cho; W E Mercer; C W Anderson; E Appella
(1994).
The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.
Oncogene.
9:(11)3249-57.
Tamar Unger; J A Mietz; M Scheffner; C L Yee; P M Howley
(1993).
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.
Molecular and Cellular Biology.
13:(9)5186-94.
Shira Albeck; J Aizenberg; Lia Addadi; Stephen Weiner
(1993).
Interactions of Various Skeletal Intracrystalline Components With Calcite Crystals.
Journal of the American Chemical Society.
115:(25)11691-11697.
J A Mietz; T Unger; J M Huibregtse; P M Howley
(1992).
The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.
EMBO Journal.
11:(13)5013-20.
Tamar Unger; M M Nau; S Segal; J D Minna
(1992).
p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.
EMBO Journal.
11:(4)1383-90.
Tamar Unger; Yosef Shaul
(1990).
The x-Protein of the Hepatitis-b Virus Acts as a Transcription Factor When Targeted to Its Responsive Element.
EMBO Journal.
9:(6)1889-1895.
Ba Mock; David Givol; La Dhoostelaere; K Huppi; Mf Seldin; N Gurfinkel; Tamar Unger; M Potter; Jf Mushinski
(1988).
Mapping of the Bcl-2 Oncogene on Mouse Chromosome-1.
Cytogenetic and Genome Research.
47:(2-Jan)11-15.
N Gurfinkel; Tamar Unger; David Givol; Jf Mushinski
(1987).
Expression of the Bcl-2 Gene in Mouse b-Lymphocytic Cell-Lines is Differentiation Stage Specific.
European Journal of Immunology.
17:(4)567-570.
Tamar Unger; N Gurfinkel; R Zakuthouri; David Givol
(1987).
Structural-Analysis of the Mouse Protooncogene Bcl-2 and Its Differential Expression in B-Cell Lineage.
Israel Medical Association Journal.
23:(12)1270-1271.
N Katzir; G Rechavi; Jb Cohen; Tamar Unger; F Simoni; S Segal; Daniel Cohen; David Givol
(1985).
Retroposon Insertion Into the Cellular Oncogene c-Myc in Canine Transmissible Venereal Tumor.
Proceedings of the National Academy of Sciences of the United States of America.
82:(4)1054-1058.
Jb Cohen; Tamar Unger; G Rechavi; Eli Canaani; David Givol
(1983).
Rearrangement of the Oncogene c-Mos in Mouse Myeloma Nsi and Hybridomas.
Nature.
306:(5945)797-799.