Publications
Milrot, E; Shimoni, E; Dadosh, T; Rechav, K; Unger, T; Van Etten, Jl; Minsky, A
(2017).
Structural Studies Demonstrating a Bacteriophage-Like Replication Cycle of the Eukaryote-Infecting Paramecium Bursaria Chlorella Virus-1.
Plos Pathogens.
13.
Erez, Z; Steinberger-Levy, I; Shamir, M; Doron, S; Stokar-Avihail, A; Peleg, Y; Melamed, S; Leavitt, A; Savidor, A; Albeck, S; Amitai, G; Sorek, R
(2017).
Communication Between Viruses Guides Lysis-Lysogeny Decisions.
Nature.
541.
Sonawane, Pd; Pollier, J; Panda, S; Szymanski, J; Massalha, H; Yona, M; Unger, T; Malitsky, S; Arendt, P; Pauwels, L; Almekias-Siegl, E; Rogachev, I; Meir, S; Cardenas, Pd; Masri, A; Petrikov, M; Schaller, H; Schaffer, Aa; Kamble, A; Giri, Ap; Goossens, A; Aharoni, A
(2017).
Plant Cholesterol Biosynthetic Pathway Overlaps With Phytosterol Metabolism.
Nature Plants.
3.
Tal, L; Friedlander, G; Gilboa, Ns; Unger, T; Gilad, S; Eshed, Y
(2017).
Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein.
Plant Cell.
29:681-696.
Wong, E; Cohen, T; Romi, E; Levin, M; Peleg, Y; Arad, U; Yaron, A; Milla, Me; Sagi, I
(2016).
Harnessing the Natural Inhibitory Domain to Control TNF Alpha Converting Enzyme (Tace) Activity in Vivo.
Scientific Reports.
6.
Smock, Robert G; Yadid, Itamar; Dym, Orly; Clarke, Jane; Tawfik, Dan S
(2016).
De Novo Evolutionary Emergence of a Symmetrical Protein is Shaped by Folding Constraints.
Cell.
164:476-486.
Yosef, E; Katz, A; Peleg, Y; Mehlman, T; Karlish, Sjd
(2016).
Do Src Kinase and Caveolin Interact Directly With na,k-Atpase?.
Journal of Biological Chemistry.
291:11736-11750.
Dym, O; Song, Wl; Felder, C; Roth, E; Shnyrov, V; Ashani, Y; Xu, Yc; Joosten, Rp; Weiner, L; Sussman, Jl; Silman, I
(2016).
The Impact of Crystallization Conditions on Structure-Based Drug Design: a Case Study on the Methylene Blue/Acetylcholinesterase Complex.
Protein Science.
25:1096-1114.
Goldenzweig, A; Goldsmith, M; Hill, Se; Gertman, O; Laurino, P; Ashani, Y; Dym, O; Unger, T; Albeck, S; Prilusky, J; Lieberman, Rl; Aharoni, A; Silman, I; Sussman, Jl; Tawfik, Ds; Fleishman, Sj
(2016).
Automated Structure- and Sequence-Based Design of Proteins For High Bacterial Expression and Stability.
Molecular Cell.
63:337-346.
Nissinkorn, Yael; Lahav-Mankovski, Naama; Rabinkov, Aharon; Albeck, Shira; Motiei, Leila; Margulies, David
(2015).
Sensing Protein Surfaces With Targeted Fluorescent Receptors.
Chemistry (Weinheim an Der Bergstrasse, Germany).
21:15873.
Nissinkorn, Yael; Lahav-Mankovski, Naama; Rabinkov, Aharon; Albeck, Shira; Motiei, Leila; Margulies, David
(2015).
Sensing Protein Surfaces With Targeted Fluorescent Receptors.
Chemistry (Weinheim an Der Bergstrasse, Germany).
21:15981-7.
Zimhony, O; Schwarz, A; Raitses-Gurevich, M; Peleg, Y; Dym, O; Albeck, S; Burstein, Y; Shakked, Z
(2015).
Acpm, the Meromycolate Extension Acyl Carrier Protein of Mycobacterium Tuberculosis, is Activated by the 4 '-Phosphopantetheinyl Transferase Pptt, a Potential Target of the Multistep Mycolic Acid Biosynthesis.
Biochemistry.
54:2360-2371.
Udi, Y; Grossman, M; Solomonov, I; Dym, O; Rozenberg, H; Moreno, V; Cuniasse, P; Dive, V; Arroyo, Ag; Sagi, I
(2015).
Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.
Structure.
23:104-115.
Shpilka, T; Welter, E; Borovsky, N; Amar, N; Shimron, F; Peleg, Y; Elazar, Z
(2015).
Fatty Acid Synthase is Preferentially Degraded by Autophagy Upon Nitrogen Starvation in Yeast.
Proceedings of the National Academy of Sciences of the United States of America.
112:1434-1439.
Wong, E; Maretzky, T; Peleg, Y; Blobel, Cp; Sagi, I
(2015).
The Functional Maturation of a Disintegrin and Metalloproteinase (Adam) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (pc) Cleavage Site.
The Journal of Biological Chemistry.
290:12135-12146.
Arfi, Y; Shamshoum, M; Rogachev, I; Peleg, Y; Bayer, Ea
(2014).
Integration of Bacterial Lytic Polysaccharide Monooxygenases Into Designer Cellulosomes Promotes Enhanced Cellulose Degradation.
Proceedings of the National Academy of Sciences of the United States of America.
111:9109-9114.
Erijman, A; Shifman, Jm; Peleg, Y
(2014).
A Single-Tube Assembly of DNA Using the Transfer-Pcr (Tpcr) Platform.
DNA Cloning and Assembly Methods.
1116:89-101.
Peleg, Y; Unger, T
(2014).
Application of the Restriction-Free (rf) Cloning For Multicomponents Assembly.
DNA Cloning and Assembly Methods.
1116:73-87.
Sberro, H; Leavitt, A; Kiro, R; Koh, E; Peleg, Y; Qimron, U; Sorek, R
(2013).
Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning.
Molecular Cell.
50:136-148.
Krieg, E; Albeck, S; Weissman, H; Shimoni, E; Rybtchinski, B
(2013).
Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane.
PLoS ONE.
8.
Itkin, M; Heinig, U; Tzfadia, O; Bhide, Aj; Shinde, B; Cardenas, Pd; Bocobza, Se; Unger, T; Malitsky, S; Finkers, R; Tikunov, Y; Bovy, A; Chikate, Y; Singh, P; Rogachev, I; Beekwilder, J; Giri, Ap; Aharoni, A
(2013).
Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops is Mediated by Clustered Genes.
Science.
341:175-179.
Sobolev, V; Edelman, M; Dym, O; Unger, T; Albeck, S; Kirma, M; Galili, G
(2013).
Structure of Ald1, a Plant-Specific Homologue of the Universal Diaminopimelate Aminotransferase Enzyme of Lysine Biosynthesis.
Acta Crystallographica Section f-Structural Biology and Crystallization Communications.
69:84-89.
Vazana, Y; Barak, Y; Unger, T; Peleg, Y; Shamshoum, M; Ben-Yehezkel, T; Mazor, Y; Shapiro, E; Lamed, R; Bayer, Ea
(2013).
A Synthetic Biology Approach For Evaluating the Functional Contribution of Designer Cellulosome Components to Deconstruction of Cellulosic Substrates.
Biotechnology For Biofuels.
6.
Bharat, Tam; Zbaida, D; Eisenstein, M; Frankenstein, Z; Mehlman, T; Weiner, L; Sorzano, Cos; Barak, Y; Albeck, S; Briggs, Jag; Wolf, Sg; Elbaum, M
(2013).
Variable Internal Flexibility Characterizes the Helical Capsid Formed by Agrobacterium Vire2 Protein on Single-Stranded DNA.
Structure.
21:1158-1167.
Sela-Passwell, Na; Kikkeri, R; Dym, O; Rozenberg, H; Margalit, R; Arad-Yellin, R; Eisenstein, M; Brenner, O; Shoham, T; Danon, T; Shanzer, A; Sagi, I
(2012).
Antibodies Targeting the Catalytic Zinc Complex of Activated Matrix Metalloproteinases Show Therapeutic Potential.
Nature Medicine.
18:143-147.
Hama, S; Soran, H; Albeck, S; Charlton-Menys, V; Yadav, R; Liu, Y; France, M; Tawfiq, D; Durrington, P
(2012).
High Paraoxonase-1 Hdl is More Effective Than Low Paraoxonase-1 Hdl in Impeding Ldl Oxidation in Vitro.
Atherosclerosis.
223:529.
Peleg, Y; Unger, T
(2012).
Resolving Bottlenecks For Recombinant Protein Expression in E. Coli.
Chemical Genomics and Proteomics: Reviews and Protocols.
800:173-186.
Xu, Yc; Li, Mj; Greenblatt, H; Chen, Wy; Paz, A; Dym, O; Peleg, Y; Chen, Tt; Shen, X; He, Jh; Jiang, Hl; Silman, I; Sussman, Jl
(2012).
Flexibility of the Flap in the Active Site of Bace1 as Revealed by Crystal Structures and Molecular Dynamics Simulations.
Acta Crystallographica Section D-Biological Crystallography.
68:13-25.
Khersonsky, O; Kiss, G; Rothlisberger, D; Dym, O; Albeck, S; Houk, Kn; Baker, D; Tawfik, Ds
(2012).
Bridging the Gaps in Design Methodologies by Evolutionary Optimization of the Stability and Proficiency of Designed Kemp Eliminase Ke59.
Proceedings of the National Academy of Sciences of the United States of America.
109:10358-10363.
Unger, T; Peleg, Y
(2012).
Recombinant Protein Expression in the Baculovirus-Infected Insect Cell System.
Chemical Genomics and Proteomics: Reviews and Protocols.
800:187-199.
Mishra, Nk; Peleg, Y; Cirri, E; Belogus, T; Lifshitz, Y; Voelker, Dr; Apell, Hj; Garty, H; Karlish, Sjd
(2011).
Fxyd Proteins Stabilize na,k-Atpase Amplification of Specific Phosphatidylserine-Protein Interactions.
Journal of Biological Chemistry.
286:9699-9712.
Cohen, S; Albeck, S; Ben-Dov, E; Cahan, R; Firer, M; Zaritsky, A; Dym, O
(2011).
Cyt1aa Toxin: Crystal Structure Reveals Implications For Its Membrane-Perforating Function.
Journal of Molecular Biology.
413:804-814.
Khersonsky, O; Rothlisberger, D; Wollacott, Am; Murphy, P; Dym, O; Albeck, S; Kiss, G; Houk, Kn; Baker, D; Tawfik, Ds
(2011).
Optimization of the in-Silico-Designed Kemp Eliminase Ke70 by Computational Design and Directed Evolution.
Journal of Molecular Biology.
407:391-412.
Siton, O; Ideses, Y; Albeck, S; Unger, T; Bershadsky, Ad; Gov, Ns; Bernheim-Groswasser, A
(2011).
Cortactin Releases the Brakes in Actin-Based Motility by Enhancing Wasp-Vca Detachment from Arp2/3 Branches.
Current Biology.
21:2092-2097.
Carlessi, R; Levin-Salomon, V; Ciprut, S; Bialik, S; Berissi, H; Albeck, S; Peleg, Y; Kimchi, A
(2011).
GTP Binding to the ROC Domain of DAP-Kinase Regulates Its Function Through Intramolecular Signalling.
Embo Reports.
12:917-923.
Karanicolas, J; Com, Je; Chen, I; Joachimiak, La; Dym, O; Peck, Sh; Albeck, S; Unger, T; Hu, Wx; Liu, Gh; Delbecq, S; Montelione, Gt; Spiegel, Cp; Liu, Dr; Baker, D
(2011).
A De Novo Protein Binding Pair by Computational Design and Directed Evolution.
Molecular Cell.
42:250-260.
Busso, D; Peleg, Y; Heidebrecht, T; Romier, C; Jacobovitch, Y; Dantes, A; Salim, L; Troesch, E; Schuetz, A; Heinemann, U; Folkers, Ge; Geerlof, A; Wilmanns, M; Polewacz, A; Quedenau, C; Bussow, K; Adamson, R; Blagova, E; Walton, J; Cartwright, Jl; Bird, Le; Owens, Rj; Berrow, Ns; Wilson, Ks; Sussman, Jl; Perrakis, A; Celie, Phn
(2011).
Expression of Protein Complexes Using Multiple Escherichia Coli Protein co-Expression Systems: a Benchmarking Study.
Journal of Structural Biology.
175:159-170.
Li, Mj; Greenblatt, Hm; Dym, O; Albeck, S; Pais, A; Gunanathan, C; Milstein, D; Degani, H; Sussman, Jl
(2011).
Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: the Basis For Designing a New Class of Selective Estrogen Receptor Modulators.
Journal of Medicinal Chemistry.
54:3575-3580.
Khersonsky, O; Rothlisberger, D; Wollacott, Am; Murphy, P; Dym, O; Albeck, S; Kiss, G; Houk, Kn; Baker, D; Tawfik, Ds
(2011).
Optimization of the in Silico Designed Kemp Eliminase Ke70 by Computational Design and Directed Evolution: Insights from md.
Abstracts of Papers of the American Chemical Society.
241.
Erijman, A; Dantes, A; Bernheim, R; Shifman, Jm; Peleg, Y
(2011).
Transfer-Pcr (Tpcr): a Highway For DNA Cloning and Protein Engineering.
Journal of Structural Biology.
175:171-177.
Unger, T; Jacobovitch, Y; Dantes, A; Bernheim, R; Peleg, Y
(2010).
Applications of the Restriction Free (rf) Cloning Procedure For Molecular Manipulations and Protein Expression.
Journal of Structural Biology.
172:34-44.
Jiang, Wd; Wang, Xw; Unger, T; Forgues, M; Kim, Jw; Hussain, Sp; Bowman, E; Spillare, Ea; Lipsky, Mm; Meck, Jm; Cavalli, Lr; Haddad, Br; Harris, Cc
(2010).
Cooperation of Tumor-Derived Hbx Mutants and P53-249(Ser) Mutant in Regulating Cell Proliferation, Anchorage-Independent Growth and Aneuploidy in a Telomerase-Immortalized Normal Human Hepatocyte-Derived Cell Line.
International Journal of Cancer.
127:1011-1020.
Grossman, M; Tworowski, D; Dym, O; Lee, Mh; Levy, Y; Murphy, G; Sagi, I
(2010).
The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor Timp-1 Controls Its Binding Interface and Affects Its Function.
Biochemistry.
49:6184-6192.
Yadid, I; Kirshenbaum, N; Sharon, M; Dym, O; Tawfik, Ds
(2010).
Metamorphic Proteins Mediate Evolutionary Transitions of Structure.
Proceedings of the National Academy of Sciences of the United States of America.
107:7287-7292.
Goihberg, E; Peretz, M; Tel-Or, S; Dym, O; Shimon, L; Frolow, F; Burstein, Y
(2010).
Biochemical and Structural Properties of Chimeras Constructed by Exchange of Cofactor-Binding Domains in Alcohol Dehydrogenases from Thermophilic and Mesophilic Microorganisms.
Biochemistry.
49:1943-1953.
Khersonsky, O; Rothlisberger, D; Dym, O; Albeck, S; Jackson, Cj; Baker, D; Tawfik, Ds
(2010).
Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the Ke07 Series.
Journal of Molecular Biology.
396:1025-1042.
Vitu, E; Kim, S; Sevier, Cs; Lutzky, O; Heldman, N; Bentzur, M; Unger, T; Yona, M; Kaiser, Ca; Fass, D
(2010).
Oxidative Activity of Yeast Ero1p on Protein Disulfide Isomerase and Related Oxidoreductases of the Endoplasmic Reticulum.
Journal of Biological Chemistry.
285:18155-18165.
Levin, Kb; Dym, O; Albeck, S; Magdassi, S; Keeble, Ah; Kleanthous, C; Tawfik, Ds
(2009).
Following Evolutionary Paths to Protein-Protein Interactions With High Affinity and Selectivity.
Nature Structural & Molecular Biology.
16:1049-U67.
Sharabi, O; Peleg, Y; Mashiach, E; Vardy, E; Ashani, Y; Silman, I; Sussman, Jl; Shifman, Jm
(2009).
Design, Expression and Characterization of Mutants of Fasciculin Optimized For Interaction With Its Target, Acetylcholinesterase.
Protein Engineering Design & Selection.
22:641-648.
Dym, O; Albeck, S; Peleg, Y; Schwarz, A; Shakked, Z; Burstein, Y; Zimhony, O
(2009).
Structure-Function Analysis of the Acyl Carrier Protein Synthase (Acps) from Mycobacterium Tuberculosis.
Journal of Molecular Biology.
393:937-950.
Zeev-Ben-Mordehai, T; Mylonas, E; Paz, A; Peleg, Y; Toker, L; Silman, I; Svergun, Di; Sussman, Jl
(2009).
The Quaternary Structure of Amalgam, a Drosophila Neuronal Adhesion Protein, Explains Its Dual Adhesion Properties.
Biophysical Journal.
97:2316-2326.
Bab-Dinitz, E; Albeck, S; Peleg, Y; Brumfeld, V; Gottschalk, Ke; Karlish, Sjd
(2009).
A c-Terminal Lobe of the Beta Subunit of na,k-Atpase and h,k-Atpase Resembles Cell Adhesion Molecules.
Biochemistry.
48:8684-8691.
Zeev-Ben-Mordehai, T; Paz, A; Peleg, Y; Toker, L; Wolf, Sg; Rydberg, Eh; Sussman, Jl; Silman, I
(2009).
Amalgam, an Axon Guidance Drosophila Adhesion Protein Belonging to the Immunoglobulin Superfamily: Over-Expression, Purification and Biophysical Characterization.
Protein Expression and Purification.
63:147-157.
Liberman, N; Dym, O; Unger, T; Albeck, S; Peleg, Y; Jacobovitch, Y; Branzburg, A; Eisenstein, M; Marash, L; Kimchi, A
(2008).
The Crystal Structure of the c-Terminal DAP5/P97 Domain Sheds Light on the Molecular Basis For Its Processing by Caspase Cleavage.
Journal of Molecular Biology.
383:539-548.
Dym, O; Albeck, S; Unger, T; Jacobovitch, J; Brainzburg, A; Michael, Y; Frenkiel-Krispin, D; Wolf, Sg; Elbaum, M
(2008).
Crystal Structure of the Agrobacterium Virulence Complex Vire1-Vire2 Reveals a Flexible Protein That Can Accommodate Different Partners.
Proceedings of the National Academy of Sciences of the United States of America.
105:11170-11175.
Cohen, S; Dym, O; Albeck, S; Ben-Dov, E; Cahan, R; Firer, M; Zaritsky, A
(2008).
High-Resolution Crystal Structure of Activated Cyt2ba from Bacillus Thuringiensis Subsp Israelensis.
Febs Journal.
275:161.
Cohen, S; Dym, O; Albeck, S; Ben-Dov, E; Cahan, R; Firer, M; Zaritsky, A
(2008).
High-Resolution Crystal Structure of Activated Cyt2ba Monomer from Bacillus Thuringiensis Subsp Israelensis.
Journal of Molecular Biology.
380:820-827.
Manicka, S; Peleg, Y; Unger, T; Albeck, S; Dym, O; Greenblatt, Ha; Bourenkov, G; Lamzin, V; Krishnaswamy, S; Sussman, Jl
(2008).
Crystal Structure of Yage, a Putative Dhdps-Like Protein from Escherichia Coli K12.
Proteins-Structure Function and Bioinformatics.
71:2102-2108.
Goihberg, E; Dym, O; Tel-Or, S; Shimon, L; Frolow, F; Peretz, M; Burstein, Y
(2008).
Thermal Stabilization of the Protozoan Entamoeba Histolytica Alcohol Dehydrogenase by a Single Proline Substitution.
Proteins-Structure Function and Bioinformatics.
72:711-719.
Rothlisberger, D; Khersonsky, O; Wollacott, Am; Jiang, L; Dechancie, J; Betker, J; Gallaher, Jl; Althoff, Ea; Zanghellini, A; Dym, O; Albeck, S; Houk, Kn; Tawfik, Ds; Baker, D
(2008).
Kemp Elimination Catalysts by Computational Enzyme Design.
Nature.
453:190-U4.
Albeck, S; Dym, O; Unger, T; Snapir, Z; Bercovich, Z; Kahana, C
(2008).
Crystallographic and Biochemical Studies Revealing the Structural Basis For Antizyme Inhibitor Function.
Protein Science.
17:793-802.
Reichmann, D; Cohen, M; Abramovich, R; Dym, O; Lim, D; Strynadka, Ncj; Schreiber, G
(2007).
Binding Hot Spots in the Tem1-Blip Interface in Light of Its Modular Architecture.
Journal of Molecular Biology.
365:663-679.
Frenkiel-Krispin, D; Wolf, Sg; Albeck, S; Unger, T; Peleg, Y; Jacobovitch, J; Michael, Y; Daube, S; Sharon, M; Robinson, Cv; Svergun, Di; Fass, D; Tzfira, T; Elbaum, M
(2007).
Plant Transformation by Agrobacterium Tumefaciens - Modulation of Single-Stranded DNA-Vire2 Complex Assembly by Vire1.
Journal of Biological Chemistry.
282:3458-3464.
Shaaltiel, Y; Bartfeld, D; Hashmueli, S; Baum, G; Brill-Almon, E; Galili, G; Dym, O; Boldin-Adamsky, Sa; Silman, I; Sussman, Jl; Futerman, Ah; Aviezer, D
(2007).
Production of Glucocerebrosidase With Terminal Mannose Glycans For Enzyme Replacement Therapy of Gaucher's Disease Using a Plant Cell System.
Plant Biotechnology Journal.
5:579-590.
Goihberg, E; Dym, O; Tel-Or, S; Levin, I; Peretz, M; Burstein, Y
(2007).
A Single Proline Substitution is Critical For the Thermostabilization of Clostridium Beijerinckii Alcohol Dehydrogenase.
Proteins-Structure Function and Bioinformatics.
66:196-204.
Reichmann, D; Cohen, M; Roisman, L; Potapov, V; Sobolev, V; Edelman, M; Dym, O; Schreiber, G
(2006).
Architecture and Design of Protein-Protein Binding Sites Using the Proteon (tm) Xpr36 Protein Interaction Array System.
Molecular & Cellular Proteomics.
5:S49.
Fogg, Mj; Alzari, P; Bahar, M; Bertini, I; Betton, Jm; Burmeister, Wp; Cambillau, C; Canard, B; Carrondo, M; Coll, M; Daenke, S; Dym, O; Egloff, Mp; Enguita, Fj; Geerlof, A; Haouz, A; Jones, Ta; Ma, Qj; Manicka, Sn; Migliardi, M; Nordlund, P; Owens, Rj; Peleg, Y; Schneider, G; Schnell, R; Stuart, Di; Tarbouriech, N; Unge, T; Wilkinson, Aj; Wilmanns, M; Wilson, Ks; Zimhony, O; Grimes, Jm
(2006).
Application of the Use of High-Throughput Technologies to the Determination of Protein Structures of Bacterial and Viral Pathogens.
Acta Crystallographica Section D-Biological Crystallography.
62:1196-1207.
Fogg, Mj; Alzari, P; Bahar, M; Bertini, I; Betton, Jm; Burmeister, Wp; Cambillau, C; Canard, B; Carrondo, Ma; Coll, M; Daenke, S; Dym, O; Egloff, Mp; Enguita, Fj; Geerlof, A; Haouz, A; Jones, Ta; Qingjun, Mj; Manicka, Sn; Migliardi, M; Nordlund, P; Owens, Rj; Peleg, Y; Schneider, G; Schnell, R; Stuart, Di; Tarbouriech, N; Unge, T; Wilkinson, Aj; Wilmanns, M; Wilson, Ks; Zimhony, O; Grimes, Jm
(2006).
Application of the Use of High-Throughput Technologies to the Determination of Protein Structures of Bacterial and Viral Pathogens (Vol 62, pg 1196, 2006).
Acta Crystallographica Section D-Biological Crystallography.
62:1571.
Romier, C; Ben Jelloul, M; Albeck, S; Buchwald, G; Busso, D; Celie, Phn; Christodoulou, E; De Marco, V; Van Gerwen, S; Knipscheer, P; Lebbink, Jh; Notenboom, V; Poterszman, A; Rochel, N; Cohen, Sx; Unger, T; Sussman, Jl; Moras, D; Sixma, Tk; Perrakis, A
(2006).
Co-Expression of Protein Complexes in Prokaryotic and Eukaryotic Hosts: Experimental Procedures, Database Tracking and Case Studies.
Acta Crystallographica Section D-Biological Crystallography.
62:1232-1242.
Asher, G; Dym, O; Tsvetkov, P; Adler, J; Shaul, Y
(2006).
The Crystal Structure of Nad(p)h Quinone Oxidoreductase 1 in Complex With Its Potent Inhibitor Dicoumarol.
Biochemistry.
45:6372-6378.
Aricescu, Ar; Assenberg, R; Bill, Rm; Busso, D; Chang, Vt; Davis, Sj; Dubrovsky, A; Gustafsson, L; Hedfalk, K; Heinemann, U; Jones, Im; Ksiazek, D; Lang, C; Maskos, K; Messerschmidt, A; Macieira, S; Peleg, Y; Perrakis, A; Poterszman, A; Schneider, G; Sixma, Tk; Sussman, Jl; Sutton, G; Tarboureich, N; Zeev-Ben-Mordehai, T; Jones, Ey
(2006).
Eukaryotic Expression: Developments For Structural Proteomics.
Acta Crystallographica Section D-Biological Crystallography.
62:1114-1124.
Albeck, S; Alzari, P; Andreini, C; Banci, L; Berry, Im; Bertini, I; Cambillau, C; Canard, B; Carter, L; Cohen, Sx; Diprose, Jm; Dym, O; Esnouf, Rm; Felder, C; Ferron, F; Guillemot, F; Hamer, R; Ben Jelloul, M; Laskowski, Ra; Laurent, T; Longhi, S; Lopez, R; Luchinat, C; Malet, H; Mochel, T; Morris, Rj; Moulinier, L; Oinn, T; Pajon, A; Peleg, Y; Perrakis, A; Poch, O; Prilusky, J; Rachedi, A; Ripp, R; Rosato, A; Silman, I; Stuart, Di; Sussman, Jl; Thierry, Jc; Thompson, Jd; Thornton, Jm; Unger, T; Vaughan, B; Vranken, W; Watson, Jd; Whamond, G; Henrick, K
(2006).
Spine Bioinformatics and Data-Management Aspects of High-Throughput Structural Biology.
Acta Crystallographica Section D-Structural Biology.
62:1184-1195.
Berrow, Ns; Bussow, K; Coutard, B; Diprose, J; Ekberg, M; Folkers, Ge; Levy, N; Lieu, V; Owens, Rj; Peleg, Y; Pinaglia, C; Quevillon-Cheruel, S; Salim, L; Scheich, C; Vincentelli, R; Busso, D
(2006).
Recombinant Protein Expression and Solubility Screening in Escherichia Coli: a Comparative Study.
Acta Crystallographica Section D-Biological Crystallography.
62:1218-1226.
Berry, Im; Dym, O; Esnouf, Rm; Harlos, K; Meged, R; Perrakis, A; Sussman, Jl; Walter, TS; Wilson, J; Messerschmidt, A
(2006).
Spine High-Throughput Crystallization, Crystal Imaging and Recognition Techniques: Current State, Performance Analysis, New Technologies and Future Aspects.
Acta Crystallographica Section D-Biological Crystallography.
62:1137-1149.
Reichmann, D; Rahat, O; Albeck, S; Meged, R; Dym, O; Schreiber, G
(2005).
The Modular Architecture of Protein-Protein Binding Interfaces.
Proceedings of the National Academy of Sciences of the United States of America.
102:57-62.
Albeck, S; Burstein, Y; Dym, O; Jacobovitch, Y; Levi, N; Meged, R; Michael, Y; Peleg, Y; Prilusky, J; Schreiber, G; Silman, I; Unger, T; Sussman, Jl
(2005).
Three-Dimensional Structure Determination of Proteins Related to Human Health in Their Functional Context at the Israel Structural Proteomics Center (Ispc).
Acta Crystallographica Section D-Biological Crystallography.
61:1364-1372.
Shao, Hs; Revach, M; Moshonov, S; Tzuman, Y; Gazit, K; Albeck, S; Unger, T; Dikstein, R
(2005).
Core Promoter Binding by Histone-Like Taf Complexes.
Molecular and Cellular Biology.
25:206-219.
Ganor, Y; Besser, M; Ben-Zakay, N; Unger, T; Levite, M
(2003).
Human t Cells Express a Functional Ionotropic Glutamate Receptor Glur3, and Glutamate by Itself Triggers Integrin-Mediated Adhesion to Laminin and Fibronectin and Chemotactic Migration.
Journal of Immunology.
170:4362-4372.
Sandowski, Y; Raver, N; Gussakovsky, Ee; Shochat, S; Dym, O; Livnah, O; Rubinstein, M; Krishna, R; Gertler, A
(2002).
Subcloning, Expression, Purification, and Characterization of Recombinant Human Leptin-Binding Domain.
Journal of Biological Chemistry.
277:46304-46309.
Chill, Jh; Nivasch, R; Levy, R; Albeck, S; Schreiber, G; Anglister, J
(2002).
The Human Interferon Receptor: NMR-Based Modeling, Mapping of the IFN-Alpha 2 Binding Site, and Observed Ligand-Induced Tightening.
Biochemistry.
41:3575-3585.
Unger, T; Oren, Z; Shai, Y
(2001).
The Effect of Cyclization of Magainin 2 and Melittin Analogues on Structure, Function, and Model Membrane Interactions: Implication to Their Mode of Action.
Biochemistry.
40:6388-6397.
Selzer, T; Albeck, S; Schreiber, G
(2000).
Rational Design of Faster Associating and Tighter Binding Protein Complexes.
Nature Structural Biology.
7:537-541.
Albeck, S; Unger, R; Schreiber, G
(2000).
Evaluation of Direct and Cooperative Contributions Towards the Strength of Buried Hydrogen Bonds and Salt Bridges.
Journal of Molecular Biology.
298:503-520.
Unger, T; Sionov, Rv; Moallem, E; Yee, Cl; Howley, Pm; Oren, M; Haupt, Y
(1999).
Mutations in Serines 15 and 20 of Human P53 Impair Its Apoptotic Activity.
Oncogene.
18:3205-3212.
Albeck, S; Schreiber, G
(1999).
Biophysical Characterization of the Interaction of the Beta-Lactamase Tem-1 With Its Protein Inhibitor Blip.
Biochemistry.
38:11-21.
Unger, T; Juven-Gershon, T; Moallem, E; Berger, M; Sionov, Rv; Lozano, G; Oren, M; Haupt, Y
(1999).
Critical Role For Ser20 of Human P53 in the Negative Regulation of P53 by Mdm2.
EMBO Journal.
18:1805-1814.
Mor, F; Boccaccio, Gl; Unger, T
(1998).
Expression of Autoimmune Disease-Related Antigens by Cells of the Immune System.
Journal of Neuroscience Research.
54:254-262.
Levi, Y; Albeck, S; Brack, A; Weiner, S; Addadi, L
(1998).
Control Over Aragonite Crystal Nucleation and Growth: an in Vitro Study of Biomineralization.
Chemistry-a European Journal.
4:389-396.
Juven-Gershon, T; Shifman, O; Unger, T; Elkeles, A; Haupt, Y; Oren, M
(1998).
The Mdm2 Oncoprotein Interacts With the Cell Fate Regulator Numb.
Molecular and Cellular Biology.
18:3974-3982.
Aizenberg, J; Albeck, S; Falini, G; Levi, Y; Weiner, S; Addadi, L
(1997).
Design Strategies in Mineralized Biological Materials.
Abstracts of Papers of the American Chemical Society.
213:768-INOR.
Albeck, S; Addadi, L; Weiner, S
(1996).
Regulation of Calcite Crystal Morphology by Intracrystalline Acidic Proteins and Glycoproteins.
Connective Tissue Research.
35:365-370.
Albeck, S; Weiner, S; Addadi, L
(1996).
Polysaccharides of Intracrystalline Glycoproteins Modulate Calcite Crystal Growth in Vitro.
Chemistry-a European Journal.
2:278-284.
Falini, G; Albeck, S; Weiner, S; Addadi, L
(1996).
Control of Aragonite or Calcite Polymorphism by Mollusk Shell Macromolecules.
Science.
271:67-69.
Tamary, H; Fromovich, Y; Shalmon, L; Reich, Z; Dym, O; Lanir, N; Brenner, B; Paz, M; Luder, As; Blau, O; Korostishevsky, M; Zaizov, R; Seligsohn, U
(1996).
Ala244val is a Common, Probably Ancient Mutation Causing Factor Vii Deficiency in Moroccan and Iranian Jews.
Thrombosis and Haemostasis.
76:283-291.
Dym, O; Mevarech, M; Sussman, Jl
(1995).
Structural Features That Stabilize Halophilic Malate-Dehydrogenase from an Archaebacterium.
Science.
267:1344-1346.
Tamary, H; Fromovitch, Y; Shalmon, L; Reich, Z; Dym, O; Lanir, N; Brenner, B; Paz, M; Luder, As; Blau, O; Zaizov, R; Seligsohn, U
(1995).
An Ala-244 Val Mutation in the Factor-Vii Gene is Common in Jews of Different Ethnic Backgrounds.
Thrombosis and Haemostasis.
73:1440.
Addadi, L; Aizenberg, J; Albeck, S; Falini, G; Weiner, S
(1995).
Structural Control Over the Formation of Calcium Carbonate Mineral Phases in Biomineralization.
Supramolecular Stereochemistry.
473:127-139.
Addadi, L; Aizenberg, J; Albeck, S; Berman, A; Leiserowitz, L; Weiner, S
(1994).
Controlled Occlusion of Proteins - a Tool For Modulating the Properties of Skeletal Elements.
Molecular Crystals and Liquid Crystals Science and Technology Section a-Molecular Crystals and Liquid Crystals.
248:185-198.
Aizenberg, J; Albeck, S; Weiner, S; Addadi, L
(1994).
Crystal Protein Interactions Studied by Overgrowth of Calcite on Biogenic Skeletal Elements.
Journal of Crystal Growth.
142:156-164.
Albeck, S; Aizenberg, J; Addadi, L; Weiner, S
(1993).
Interactions of Various Skeletal Intracrystalline Components With Calcite Crystals.
Journal of the American Chemical Society.
115:11691-11697.
Unger, T; Shaul, Y
(1990).
The x-Protein of the Hepatitis-b Virus Acts as a Transcription Factor When Targeted to Its Responsive Element.
EMBO Journal.
9:1889-1895.
Mock, Ba; Givol, D; Dhoostelaere, La; Huppi, K; Seldin, Mf; Gurfinkel, N; Unger, T; Potter, M; Mushinski, Jf
(1988).
Mapping of the Bcl-2 Oncogene on Mouse Chromosome-1.
Cytogenetics and Cell Genetics.
47:11-15.
Gurfinkel, N; Unger, T; Givol, D; Mushinski, Jf
(1987).
Expression of the Bcl-2 Gene in Mouse b-Lymphocytic Cell-Lines is Differentiation Stage Specific.
European Journal of Immunology.
17:567-570.
Unger, T; Gurfinkel, N; Zakuthouri, R; Givol, D
(1987).
Structural-Analysis of the Mouse Protooncogene Bcl-2 and Its Differential Expression in B-Cell Lineage.
Israel Journal of Medical Sciences.
23:1270-1271.
Katzir, N; Rechavi, G; Cohen, Jb; Unger, T; Simoni, F; Segal, S; Cohen, D; Givol, D
(1985).
Retroposon Insertion Into the Cellular Oncogene c-Myc in Canine Transmissible Venereal Tumor.
Proceedings of the National Academy of Sciences of the United States of America.
82:1054-1058.
Cohen, Jb; Unger, T; Rechavi, G; Canaani, E; Givol, D
(1983).
Rearrangement of the Oncogene c-Mos in Mouse Myeloma Nsi and Hybridomas.
Nature.
306:797-799.