Publications

Meltzer H., Marom E., Alyagor I., Mayseless O., Berkun V., Segal-Gilboa N., Unger T., Luginbuhl D. & Schuldiner O. (). Tissue-specific (ts) CRISPR as an efficient strategy for in vivo screening in Drosophila.  Nature Communications. 10.
Ofir-Birin Y., Ben Ami Pilo H., Camacho A. C., Rudik A., Rivkin A., Revach O., Nir N., Tamin T. B., Karam P. A., Kiper E., Peleg Y., Nevo R., Solomon A., Havkin-Solomon T., Rojas A., Rotkopf R., Porat Z., Avni D., Schwartz E., Zillinger T., Hartmann G., Di Pizio A., Ben Quashie N., Dikstein R., Gerlic M., Torrecilhas A. C., Levy C., Hoen E. N. M. N., Bowie A. G. & Regev-Rudzki N. (). Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration.  Nature Communications. 12:(1)
Peleg Y. & Unger T. (). Resolving bottlenecks for recombinant protein expression in E. coli.  . 173-186.
Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y. (). Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms.  Biochemistry. 49:(9)1943-1953.
Tal L., Friedlander G., Gilboa N. S., Unger T., Gilad S. & Eshed Y. (). Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein.  Plant Cell. 29:(4)681-696.
Sela-Passwell N. A., Kikkeri R., Dym O., Rozenberg H., Margalit R., Arad-Yellin R., Eisenstein M., Brenner O., Shoham T., Danon T., Shanzer A. & Sagi I. (). Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.  Nature Medicine. 18:(1)143-147.
Rezenman S., Knafo M., Tsigalnitski I., Barad S., Jona G., Levi D., Dym O., Reich Z. & Kapon R. (). gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution.  PLoS ONE. 18:(6)e0286696.
Addadi L., Aizenberg J., Albeck S., Berman A., Leiserowitz L. & Weiner S. (). Controlled occlusion of proteins: A tool for modulating the properties of skeletal elements.  Molecular Crystals and Liquid Crystals. 248:(1)185-198.
Giannoulis A., Feintuch A., Unger T., Amir S. & Goldfarb D. (). Monitoring the Conformation of the Sba1/Hsp90 Complex in the Presence of Nucleotides with Mn(II)-Based Double Electron\u2013Electron Resonance.  Journal of Physical Chemistry Letters. 12:(51)12235-12241.
Shpilka T., Welter E., Borovsky N., Amar N., Shimron F., Peleg Y. & Elazar Z. (). Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast.  Proceedings of the National Academy of Sciences of the United States of America. 112:(5)1434-1439.
Baron S., Peleg Y., Grunwald J., Morgenstern D., Elad N., Peretz M., Albeck S., Levin Y., Welch J. T., Deweerd K. A., Schwarz A., Burstein Y., Diskin R., Shakked Z. & Zimhony O. (). Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli.  PLoS ONE. (9)
Chaturvedi A. K., Dym O., Levin Y. & Fluhr R. (). PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE1A redox states alleviate photoinhibition during changes in light intensity.  Plant Physiology. 194:(2)1059-1074.
Erijman A., Shifman J. M. & Peleg Y. (). A single-tube assembly of DNA using the transfer-PCR (TPCR) platform.  . 89-101.
Cardenas P. D., Sonawane P. D., Heinig U., Jozwiak A., Panda S., Abebie B., Kazachkova Y., Pliner M., Unger T., Wolf D., Ofner I., Vilaprinyo E., Meir S., Davydov O., Gal-On A., Burdman S., Giri A., Zamir D., Scherf T., Szymanski J., Rogachev I. & Aharoni A. (). Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases.  Nature Communications. 10.
Saikia C., Altman-Gueta H., Dym O., Karbat I. & Reuveny E. (). Conkunitzin-C2 from Conus consors induces an incomplete block of the Shaker K+ channel using a unique mode of action.  Biophysical Journal. 121:(3(1))500a-500a.
Itkin M., Heinig U., Tzfadia O., Bhide A. J., Shinde B. A., Cardenas P. D., Bocobza S. E., Unger T., Malitsky S., Finkers R., Tikunov Y., Bovy A., Chikate Y. R., Singh P., Rogachev I., Beekwilder J., Giri A. P. & Aharoni A. (). Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes.  Science. 341:(6142)175-179.
Yagound B., Dogantzis K. A., Zayed A., Lim J., Broekhuyse P., Remnant E. J., Beekman M., Allsopp M. H., Aamidor S. E., Dim O., Buchmann G. & Oldroyd B. P. (). A Single Gene Causes Thelytokous Parthenogenesis, the Defining Feature of the Cape Honeybee Apis mellifera capensis.  Current Biology. 30:(12)2248-2259.
Zeev-Ben-Mordehai T., Paz A., Peleg Y., Toker L., Wolf S. G., Rydberg E. H., Sussman J. & Silman I. (). Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization.  Protein Expression and Purification. 63:(2)147-157.
Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 63:(2)337-346.
Khmelnitsky L., Milo A., Dym O. & Fass D. (). Diversity of CysD domains in gel-forming mucins.  FEBS Journal.
Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J. (). Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators.  Journal of Medicinal Chemistry. 54:(10)3575-3580.
Graslund S., Peleg Y., Albeck S., Unger T., Dym O., Prilusky J. & Sussman J. L. (). Protein production and purification.  Nature Methods. 5:(2)135-146.
Singh A., Erijman A., Noronha A., Kumar H., Peleg Y., Yarden Y. & Shifman J. M. (). Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anti-cancer activities in lung adenocarcinoma.  Journal of Biological Chemistry. 297:(6)
Unger T. & Peleg Y. (). Recombinant protein expression in the baculovirus-infected insect cell system.  . 187-199.
Dym O., Mevarech M. & Sussman J. L. (). Structural features that stabilize halophilic malate dehydrogenase from an archaebacterium.  Science. 267:(5202)1344-1346.
Sonawane P. D., Pollier J., Panda S., Szymanski J., Massalha H., Yona M., Unger T., Malitsky S., Arendt P., Pauwels L., Almekias-Siegl E., Rogachev I., Meir S., Cardenas P. D., Masri A., Petrikov M., Schaller H., Schaffer A. A., Kamble A., Giri A. P., Goossens A. & Aharoni A. (). Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.  Nature Plants. 3.
RöThlisberger D., Khersonsky O., Wollacott A. M., Jiang L., Dechancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. S. & Baker D. (). Kemp elimination catalysts by computational enzyme design.  Nature. 453:(7192)190-195.
Khersonsky O., Goldsmith M., Zaretsky I., Hamer-Rogotner S., Dym O., Unger T., Yona M., Fridmann-Sirkis Y. & Fleishman S. J. (). Stable Mammalian Serum Albumins Designed for Bacterial Expression.  Journal of Molecular Biology. 435:(17)
Albeck S., Aizenberg J., Addadi L. & Weiner S. (). Interactions of Various Skeletal Intracrystalline Components with Calcite Crystals.  Journal of the American Chemical Society. 115:(25)11691-11697.
Gould N. L., Scherer G. R., Carvalho S., Shurrush K., Kayyal H., Edry E., Elkobi A., David O., Foqara M., Thakar D., Pavesi T., Sharma V., Walker M., Maitland M., Dym O., Albeck S., Peleg Y., Germain N., Babaev I., Sharir H., Lalzar M., Shklyar B., Hazut N., Khamaisy M., LéVesque M., Lajoie G., Avoli M., Amitai G., Lefker B., Subramanyam C., Shilton B., Barr H. & Rosenblum K. (). Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer\u2019s disease phenotype in mice.  Journal of Clinical Investigation. 133:(19)
Xu Y., Li M., Greenblatt H., Chen W., Paz A., Dym O., Peleg Y., Chen T., Shen X., He J., Jiang H., Silman I. & Sussman J. (). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.  Acta Crystallographica Section D: Biological Crystallography. 68:(1)13-25.
Peleg Y., Vincentelli R., Collins B. M., Chen K., Livingstone E. K., Weeratunga S., Leneva N., Guo Q., Remans K., Perez K., Bjerga G. E., Larsen Ø., VaněK O., SkořEpa O., Jacquemin S., Poterszman A., Kjaer S., Christodoulou E., Albeck S., Dym O., Ainbinder E., Unger T., Schuetz A., Matthes S., Bader M., De Marco A., Storici P., Semrau M. S., Stolt-Bergner P., Aigner C., Suppmann S., Goldenzweig A. & Fleishman S. J. (). Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.  Journal of Molecular Biology. 433:(13)
Yeshaya N., Gupta P. K., Dym O., Morgenstern D., Major D. T. & Fass D. (). VWD domain stabilization by autocatalytic Asp-Pro cleavage.  Protein Science. 33:(3)
Wong E., Maretzky T., Peleg Y., Blobel C. P. & Sagi I. (). The functional maturation of a disintegrin and metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site.  The journal of Biological chemistry. 290:(19)12135-12146.
Gabizon R., Shraga A., Gehrtz P., Livnah E., Shorer Y., Gurwicz N., Avram L., Unger T., Aharoni H., Albeck S., Brandis A., Shulman Z., Katz B., Herishanu Y. & London N. (). Efficient targeted degradation via reversible and irreversible covalent PROTACs.  Journal of the American Chemical Society. 142:(27)11734-11742.
Goldsmith M., Barad S., Peleg Y., Albeck S., Dym O., Brandis A., Mehlman T. & Reich Z. (). The identification and characterization of an oxalyl-CoA synthetase from grass pea ( Lathyrus sativus L.).  RSC Chemical Biology. 3:(3)320-333.
Jiang W., Wang X. W., Unger T., Forgues M., Kim J. W., Hussain S. P., Bowman E., Spillare E. A., Lipsky M. M., Meck J. M., Cavalli L. R., Haddad B. R. & Harris C. C. (). Cooperation of tumor-derived HBx mutants and p53-249ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.  International Journal of Cancer. 127:(5)1011-1020.
Mohan V., Gaffney J. P., Solomonov I., Levin M., Klepfish M., Akbareian S., GrüNwald B., Dym O., Eisenstein M., Yu K. H., Kelsen D. P., KrüGer A., Edwards D. R. & Sagi I. (). Conformation-specific inhibitory anti-mmp-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill.  Cancers. 13:(7)
Reichmann D., Rahat O., Albeck S., Meged R., Dym O. & Schreiber G. (). The modular architecture of protein-protein binding interfaces.  Proceedings of the National Academy of Sciences of the United States of America. 102:(1)57-62.
Khersonsky O., Kiss G., RöThlisberger D., Dym O., Albeck S., Houk K. N., Baker D. & Tawfik D. S. (). Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.  Proceedings of the National Academy of Sciences of the United States of America. 109:(26)10358-10363.
Dym O., Aggarwal N., Ashani Y., Leader H., Albeck S., Unger T., Hamer-Rogotner S., Silman I., Tawfik D. S. & Sussman J. L. (). The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.  Acta Crystallographica Section D: Structural Biology. 79:(Pt 11)992-1009.
Chill J., Nivasch R., Levy R., Albeck S., Schreiber G. & Anglister J. (). The human interferon receptor: NMR-based modeling, mapping of the IFN-α2 binding site, and observed ligand-induced tightening.  Biochemistry. 41:(11)3575-3585.
Davidi D., Shamshoum M., Guo Z., Bar\U2010on Y. M., Prywes N., Oz A., Jablonska J., Flamholz A., Wernick D. G., Antonovsky N., Pins B., Shachar L., Hochhauser D., Peleg Y., Albeck S., Sharon I., Mueller\U2010cajar O. & Milo R. (). Highly active rubiscos discovered by systematic interrogation of natural sequence diversity.  The EMBO Journal. 39:(18)
Adams E. M., Pezzotti S., Ahlers J., RüTtermann M., Levin M., Goldenzweig A., Peleg Y., Fleishman S. J., Sagi I. & Havenith M. (). Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction.  JACS Au. 1:(7)1076-1085.
Gurfinkel N., Unger T., Givol D. & Mushinski J. F. (). Expression of the bcl‐2 gene in mouse B lymphocytic cell lines is differentiation stage specific.  European Journal of Immunology. 17:(4)567-570.
Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (). The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.  Biochemistry. 49:(29)6184-6192.
Sonawane P. D., Heinig U., Panda S., Gilboa N. S., Yona M., Kumar S. P., Alkan N., Unger T., Bocobza S., Pliner M., Malitsky S., Tkachev M., Meir S., Rogachev I. & Aharoni A. (). Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum.  Proceedings of the National Academy of Sciences of the United States of America. 115:(23)E5419-E5428.
Arfi Y., Shamshoum M., Rogachev I., Peleg Y. & Bayer E. (). Integration of bacterial lytic polysaccharide monooxygenases into designer cellulosomes promotes enhanced cellulose degradation.  Proceedings of the National Academy of Sciences of the United States of America. 111:(25)9109-9114.
Peleg Y., Prabahar V., Bednarczyk D. & Unger T. (). Harnessing the Profinity eXact™ System for Expression and Purification of Heterologous Proteins in E. coli.  . 33-43.
Albeck S. & Schreiber G. (). Biophysical characterization of the interaction of the β-lactamase TEM- 1 with its protein inhibitor BLIP.  Biochemistry. 38:(1)11-21.
Zimhony O., Schwarz A., Raitses-Gurevich M., Peleg Y., Dym O., Albeck S., Burstein Y. & Shakked Z. (). AcpM, the meromycolate extension Acyl carrier protein of mycobacterium tuberculosis, is activated by the 4\u2032-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.  Biochemistry. 54:(14)2360-2371.
Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D. (). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.  Cell. 164:(3)476-486.
Israeli H., Degtjarik O., Fierro F., Chunilal V., Gill A. K., Roth N. J., Botta J., Prabahar V., Peleg Y., Chan L. F., Ben-Zvi D., Mccormick P. J., Niv M. Y. & Shalev-Benami M. (). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.  Science (American Association for the Advancement of Science). 372:(6544)808-814.
Vitu E., Kim S., Sevier C. S., Lutzky O., Heldman N., Bentzur M., Unger T., Yona M., Kaiser C. A. & Fass D. (). Oxidative activity of yeast Ero1p on protein disulfide isomerase and related oxidoreductases of the endoplasmic reticulum.  Journal of Biological Chemistry. 285:(24)18155-18165.
Aricescu A. R., Assenberg R., Bill R. M., Busso D., Chang V. T., Davis S. J., Dubrovsky A., Gustafsson L., Hedfalk K., Heinemann U., Jones I. M., Ksiazek D., Lang C., Maskos K., Messerschmidt A., Macieira S., Peleg Y., Perrakis A., Poterszman A., Schneider G., Sixma T. K., Sussman J., Sutton G., Tarboureich N., Zeev-Ben-Mordehai T. & Jones E. Y. (). Eukaryotic expression: Developments for structural proteomics.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1114-1124.
Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (). Highly active enzymes by automated combinatorial backbone assembly and sequence design.  Nature Communications. 9.
Unger T., Jacobovitch Y., Dantes A., Bernheim R. & Peleg Y. (). Applications of the Restriction Free (RF) cloning procedure for molecular manipulations and protein expression.  Journal of Structural Biology. 172:(1)34-44.
Bandyopadhyay B. & Peleg Y. (). Application of Restriction Free (RF) Cloning in Circular Permutation.  . 149-163.
Katzir N., Rechavi G., Cohen J., Unger T., Simoni F., Segal S., Cohen D. & Givol D. (). 'Retroposon' insertion into the cellular oncogene c-myc in canine transmissible venereal tumor.  Proceedings of the National Academy of Sciences of the United States of America. 82:(4)1054-1058.
Heyne M., Shirian J., Cohen I., Peleg Y., Radisky E. S., Papo N. & Shifman J. M. (). Climbing up and down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein-Protein Complexes.  Journal of the American Chemical Society. 143:(41)17261-17275.
Sberro H., Leavitt A., Kiro R., Koh E., Peleg Y., Qimron U. & Sorek R. (). Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning.  Molecular Cell. 50:(1)136-148.
Falini G., Albeck S., Weiner S. & Addadi L. (). Control of aragonite or calcite polymorphism by mollusk shell macromolecules.  Science. 271:(5245)67-69.
SchüTz A., Bernhard F., Berrow N., Buyel J. F., Ferreira-Da-Silva F., Haustraete J., Van Den Heuvel J., Hoffmann J. E., De Marco A., Peleg Y., Suppmann S., Unger T., Vanhoucke M., Witt S. & Remans K. (). A concise guide to choosing suitable gene expression systems for recombinant protein production.  STAR Protocols. 4:(4)
Cohen S., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A. & Dym O. (). Cyt1Aa toxin: Crystal structure reveals implications for its membrane-perforating function.  Journal of Molecular Biology. 413:(4)804-814.
Erijman A., Dantes A., Bernheim R., Shifman J. M. & Peleg Y. (). Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering.  Journal of Structural Biology. 175:(2)171-177.
KolářOvá L., ZahradníK J., HuličIak M., Mikulecký P., Peleg Y., Shemesh M., Schreiber G. & Schneider B. (). De novo developed protein binders mimicking Interferon lambda signaling.  The FEBS journal. 289:(9)2672-2684.
Albeck S., Alzari P., Andreini C., Banci L., Berry I. M., Bertini I., Cambillau C., Canard B., Carter L., Cohen S. X., Diprose J. M., Dym O., Esnouf R. M., Felder C., Ferron F., Guillemot F., Hamer R., Ben Jelloul J. M., Laskowski R. A., Laurent T., Longhi S., Lopez R., Luchinat C., Malet H., Mochel T., Morris R. J., Moulinier L., Oinn T., Pajon A., Peleg Y., Perrakis A., Poch O., Prilusky J., Rachedi A., Ripp R., Rosato A., Silman I., Stuart D. I., Sussman J., Thierry J. -., Thompson J. D., Thornton J. M., Unger T., Vaughan B., Vranken W., Watson J. D., Whamond G. & Henrick K. (). SPINE bioinformatics and data-management aspects of high-throughput structural biology.  Acta Crystallographica Section D-Structural Biology. 62:(10)1184-1195.
Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (). Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.  Structure. 23:(1)104-115.
Wong E., Cohen T., Romi E., Levin M., Peleg Y., Arad U., Yaron A., Milla M. E. & Sagi I. (). Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo.  Scientific Reports. 6.
Bednarczyk D., Dym O., Prabahar V., Peleg Y., Pike D. H. & Noy D. (). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.  Angewandte Chemie-International Edition. 55:(24)6901-6905.
Pokorna S., Khersonsky O., Lipsh-Sokolik R., Goldenzweig A., Nielsen R., Ashani Y., Peleg Y., Unger T., Albeck S., Dym O., Tirosh A., Tarayra R., Hocquemiller M., Laufer R., Ben-Dor S., Silman I., Sussman J. L., Fleishman S. J. & Futerman A. H. (). Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.  FEBS Journal. 290:(13)3383-3399.
Nissinkorn Y., Lahav-Mankovski N., Rabinkov A., Albeck S., Motiei L. & Margulies D. (). Sensing Protein Surfaces with Targeted Fluorescent Receptors.  Chemistry (Weinheim an der Bergstrasse, Germany). 21:(45)15981-15987.
Yifrach E., Holbrook\U2010smith D., BüRgi J., Othman A., Eisenstein M., Roermund C. W., Visser W., Tirosh A., Rudowitz M., Bibi C., Galor S., Weill U., Fadel A., Peleg Y., Erdmann R., Waterham H. R., Wanders R. J. A., Wilmanns M., Zamboni N., Schuldiner M. & Zalckvar E. (). Systematic multi\u2010level analysis of an organelle proteome reveals new peroxisomal functions.  Molecular Systems Biology. 18:(9)
Yadid I., Kirshenbaum N., Sharon M., Dym O. & Tawfik D. (). Metamorphic proteins mediate evolutionary transitions of structure.  Proceedings of the National Academy of Sciences of the United States of America. 107:(16)7287-7292.
Tarayrah-Ibraheim L., Maurice E. C., Hadary G., Ben-Hur S., Kolpakova A., Braun T., Peleg Y., Yacobi-Sharon K. & Arama E. (). DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.  Nature Communications. 12:(1)
Frenkiel-Krispin D., Wolf S. G., Albeck S., Unger T., Peleg Y., Jacobovitch J., Michael Y., Daube S., Sharon M., Robinson C. V., Svergun D. I., Fass D., Tzfira T. & Elbaum M. (). Plant transformation by Agrobacterium tumefaciens: Modulation of single-stranded DNA-VirE2 complex assembly by VirE.  Journal of Biological Chemistry. 282:(6)3458-3464.
Yosef E., Katz A., Peleg Y., Mehlman T. & Karlish S. J. (). Do Src kinase and caveolin interact directly with Na,K-ATPase?.  Journal of Biological Chemistry. 291:(22)11736-11750.
Ganor Y., Besser M., Ben-Zakay N., Unger T. & Levite M. (). Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.  Journal of Immunology. 170:(8)4362-4372.
Pode Z., Peri-Naor R., Georgeson J. M., Ilani T., Kiss V., Unger T., Markus B., Barr H. M., Motiei L. & Margulies D. (). Protein recognition by a pattern-generating fluorescent molecular probe.  Nature Nanotechnology. 12:(12)1161-1168.
Yifrach E., Rudowitz M., Cruz-Zaragoza L. D., Tirosh A., Gazi Z., Peleg Y., Kunze M., Eisenstein M., Schliebs W., Schuldiner M., Erdmann R. & Zalckvar E. (). Determining the targeting specificity of the selective peroxisomal targeting factor Pex9.  Biological Chemistry. 404:(2-3)121-133.
Siton O., Ideses Y., Albeck S., Unger T., Bershadsky A. D., Gov N. S. & Bernheim-Groswasser A. (). Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches.  Current Biology. 21:(24)2092-2097.
Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Nissan G. B., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (). Erratum: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces (PLoS Computational Biology(2019)15: 8(e1007207)Doi: 10.1371/journal.pcbi.1007207).  PLoS Computational Biology. 16:(10)
Selzer T., Albeck S. & Schreiber G. (). Rational design of faster associating and tighter binding protein complexes.  Nature Structural Biology. 7:(7)537-541.
Shaaltiel Y., Bartfeld D., Hashmueli S., Baum G., Brill-Almon E., Galili G., Dym O., Boldin-Adamsky S. A., Silman I., Sussman J. L., Futerman A. H. & Aviezer D. (). Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.  Plant Biotechnology Journal. 5:(5)579-590.
Oranges M., Giannoulis A., Vanyushkina A., Sirkis Y. F., Dalaloyan A., Unger T., Su X. C., Sharon M. & Goldfarb D. (). C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains.  Biophysical Journal.
Cohen S., Dym O., Albeck S., Ben-Dov E., Cahan R., Firer M. & Zaritsky A. (). High-Resolution Crystal Structure of Activated Cyt2Ba Monomer from Bacillus thuringiensis subsp. israelensis.  Journal of Molecular Biology. 380:(5)820-827.
Kahlon S., Shreibman D., Unger T., Ben-Yehuda D. & Elias S. (). The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.  Blood Cancer Journal. 8:(5)
Allouche-Arnon H., Khersonsky O., Tirukoti N. D., Peleg Y., Dym O., Albeck S., Brandis A., Mehlman T., Avram L., Harris T., Yadav N. N., Fleishman S. J. & Bar-Shir A. (). Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.  Nature biotechnology. 40:(7)1143-1149.
Albeck S., Burstein Y., Dym O., Jacobovitch Y., Levi N., Meged R., Michael Y., Peleg Y., Prilusky J., Schreiber G., Silman I., Unger T. & Sussman J. (). Three-dimensional structure determination of proteins related to human health in their functional context at the Israel Structural Proteomics Center (ISPC).  Acta Crystallographica Section D: Biological Crystallography. 61:(10)1364-1372.
Reichmann D., Cohen M., Abramovich R., Dym O., Lim D., Strynadka N. C. J. & Schreiber G. (). Binding Hot Spots in the TEM1-BLIP Interface in Light of its Modular Architecture.  Journal of Molecular Biology. 365:(3)663-679.
Mishra N. K., Habeck M., Kirchner C., Haviv H., Peleg Y., Eisenstein M., Apell H. J. & Karlish S. J. D. (). Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase.  Journal of Biological Chemistry. 290:(48)28746-28759.
Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J. (). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 114:(41)10900-10905.
Goldsmith M., Barad S., Knafo M., Savidor A., Ben-Dor S., Brandis A., Mehlman T., Peleg Y., Albeck S., Dym O., Ben-Zeev E., Barbole R. S., Aharoni A. & Reich Z. (). Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea.  The journal of Biological chemistry. 298:(5)
Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K. E. & Karlish S. J. (). A C-terminal lobe of the β subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.  Biochemistry. 48:(36)8684-8691.
Goldsmith M., Avram L., Brandis A., Mehlman T., Ben-Dor S., Peleg Y., Ben-Zeev E., Barbole R. S. & Reich Z. (). LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea.  Nature Communications. 15.
Krieg E., Albeck S., Weissman H., Shimoni E. & Rybtchinski B. (). Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane.  PLoS ONE. 8:(5)
Saikia C., Dym O., Altman-Gueta H., Gordon D., Reuveny E. & Karbat I. (). A Molecular Lid Mechanism of K+ Channel Blocker Action Revealed by a Cone Peptide.  Journal of Molecular Biology. 433:(17)
Mock B., Givol D., Dhoostelaere L., Huppi K., Seldin M., Gurfinkel N., Unger T., Potter M. & Mushinski J. (). Mapping of the bcl-2 oncogene on mouse chromosome 1.  Cytogenetics and Cell Genetics. 47:(1-2)11-15.
Berrow N. S., Buessow K., Coutard B., Diprose J., Ekberg M., Folkers G. E., Levy N., Lieu V., Owens R. J., Peleg Y., Pinaglia C., Quevillon-Cheruel S., Salim L., Scheich C., Vincentelli R. & Busso D. (). Recombinant protein expression and solubility screening in Escherichia coli: A comparative study.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1218-1226.
Levi Y., Albeck S., Brack A., Weiner S. & Addadi L. (). Control over aragonite crystal nucleation and growth: An in vitro study of biomineralization.  Chemistry-A European Journal. 4:(3)389-396.
Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N. (). Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.  Cell Chemical Biology. 26:(1)98 - 108.
Rozenberg A., Kaczmarczyk I., Matzov D., Vierock J., Nagata T., Sugiura M., Katayama K., Kawasaki Y., Konno M., Nagasaka Y., Aoyama M., Das I., Pahima E., Church J., Adam S., Borin V. A., Chazan A., Augustin S., Wietek J., Dine J., Peleg Y., Kawanabe A., Fujiwara Y., Yizhar O., Sheves M., Schapiro I., Furutani Y., Kandori H., Inoue K., Hegemann P., Beja O. & Shalev-Benami M. (). Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels.  Nature Structural and Molecular Biology. 29:(6)592-603.
Manicka S., Peleg Y., Unger T., Albeck S., Dym O., Greenblatt H. A., Bourenkov G., Lamzin V., Krishnaswamy S. & Sussman J. (). Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12.  Proteins-Structure Function And Bioinformatics. 71:(4)2102-2108.
Berman P., De Haro L. A., Cavaco A. R., Panda S., Dong Y., Kuzmich N., Lichtenstein G., Peleg Y., Harat H., Jozwiak A., Cai J., Heinig U., Meir S., Rogachev I. & Aharoni A. (). The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction.  Molecular Plant. 17:(7)1129-1150.
Juven-Gershon T., Shifman O., Unger T., Elkeles A., Haupt Y. & Oren M. (). The Mdm2 oncoprotein interacts with the cell fate regulator numb.  Molecular and Cellular Biology. 18:(7)3974-3982.
Daniel E., Maksimainen M. M., Smith N., Ratas V., Biterova E., Murthy S. N., Tanvir Rahman M., Kiema T. R., Sridhar S., Cordara G., Dalwani S., Venkatesan R., Prilusky J., Dym O., Lehtio L., Kristian Koski M., Ashton A. W., Sussman J. L. & Wierenga R. K. (). IceBear: An intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.  Acta Crystallographica Section D: Structural Biology. 77:(2)151-163.
Aizenberg J., Albeck S., Weiner S. & Addadi L. (). Crystal-protein interactions studied by overgrowth of calcite on biogenic skeletal elements.  Journal of Crystal Growth. 142:(1-2)156-164.
Mishra N. K., Peleg Y., Cirri E., Belogus T., Lifshitz Y., Voelker D. R., Apell H., Garty H. & Karlish S. J. (). FXYD proteins stabilize Na,K-ATpase: Amplification of specific phosphatidylserine-protein interactions.  Journal of Biological Chemistry. 286:(11)9699-9712.
Vazana Y., Barak Y., Unger T., Peleg Y., Shamshoum M., Ben-Yehezkel T., Mazor Y., Shapiro E., Lamed R. & Bayer E. (). A synthetic biology approach for evaluating the functional contribution of designer cellulosome components to deconstruction of cellulosic substrates.  Biotechnology for Biofuels. 6:(1)
Bose T., Fridkin G., Davidovich C., Krupkin M., Dinger N., Falkovich A. H., Peleg Y., Agmon I., Bashan A. & Yonath A. (). Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds.  Nucleic Acids Research. 50:(4)1815-1828.
Alzari P. M., Berglund H., Berrow N. S., Blagova E., Busso D., Cambillau C., Campanacci V., Christodoulou E., Eiler S., Fogg M. J., Folkers G., Geerlof A., Hart D., Haouz A., Herman M. D., Macieira S., Nordlund P., Perrakis A., Quevillon-Cheruel S., Tarandeau F., Van Tilbeurgh H., Unger T., Luna-Vargas M., Velarde M., Willmanns M. & Owens R. J. (). Implementation of semi-automated cloning and prokaryotic expression screening: The impact of SPINE.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1103-1113.
Berry I. M., Dym O., Esnouf R. M., Harlos K., Meged R., Perrakis A., Sussman J., Walter T. S., Wilson J. & Messerschmidt A. (). SPINE high-throughput crystallization, crystal imaging and recognition techniques: Current state, performance analysis, new technologies and future aspects.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1137-1149.
Albeck S., Unger R. & Schreiber G. (). Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges.  Journal of Molecular Biology. 298:(3)503-520.
Goihberg E., Dym O., Tel-Or S., Levin I., Peretz M. & Burstein Y. (). A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase.  Proteins-Structure Function And Bioinformatics. 66:(1)196-204.
Franz F., Tapia-Rojo R., Winograd-Katz S., Boujemaa-Paterski R., Li W., Unger T., Albeck S., Aponte-Santamaria C., Garcia-Manyes S., Medalia O., Geiger B. & GräTer F. (). Allosteric activation of vinculin by talin.  Nature Communications. 14:(1)
Khersonsky O., RöThlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D. S. (). Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the ke07 series.  Journal of Molecular Biology. 396:(4)1025-1042.
Halfin O., Avram L., Albeck S., Unger T., Motiei L. & Margulies D. (). Unnatural enzyme activation by a metal-responsive regulatory protein.  Chemical Science.
Unger T., Mietz J. A., Scheffner M., Yee C. L. & Howley P. M. (). Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.  Molecular and Cellular Biology. 13:(9)5186-94.
ZahradníK J., Marciano S., Shemesh M., Zoler E., Harari D., Chiaravalli J., Meyer B., Rudich Y., Li C., Marton I., Dym O., Elad N., Lewis M., Andersen H., Gagne M., Seder R., Douek D. & Schreiber G. (). SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution.  Nature Microbiology. 6:(9)1188-1198.
Peleg Y. & Unger T. (). Application of the Restriction-Free (RF) cloning for multicomponents assembly.  . 73-87.
Busso D., Peleg Y., Heidebrecht T., Romier C., Jacobovitch Y., Dantes A., Salim L., Troesch E., Schuetz A., Heinemann U., Folkers G. E., Geerlof A., Wilmanns M., Polewacz A., Quedenau C., Buessow K., Adamson R., Blagova E., Walton J., Cartwright J. L., Bird L. E., Owens R. J., Berrow N. S., Wilson K. S., Sussman J., Perrakis A. & Celie P. H. N. (). Expression of protein complexes using multiple Escherichia coli protein co-expression systems: A benchmarking study.  Journal of Structural Biology. 175:(2)159-170.
Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M. (). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.  Analytical Chemistry. 89:(8)4708-4715.
Erez Z., Steinberger-Levy I., Shamir M., Doron S., Stokar Avihail A. A., Peleg Y., Melamed S., Leavitt A., Savidor A., Albeck S., Amitai G. & Sorek R. (). Communication between viruses guides lysis-lysogeny decisions.  Nature. 541:(7638)488-493.
Scheerer D., Adkar B. V., Bhattacharyya S., Levy D., Iljina M., Riven I., Dym O., Haran G. & Shakhnovich E. I. (). Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase.  Proceedings of the National Academy of Sciences - PNAS. 120:(18)
Cohen J., Unger T., Rechavi G., Canaani E. & Givol D. (). Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas.  Nature. 306:(5945)797-799.
Seal M., Jash C., Jacob R., Feintuch A., Harel Y., Albeck S., Unger T. & Goldfarb D. (). Evolution of CPEB4 Dynamics across its Liquid-Liquid Phase Separation Transition.  Journal Of Physical Chemistry B. 125:(47)12947-12957.
Asher G., Dym O., Tsvetkov P., Adler J. & Shaul Y. (). The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.  Biochemistry. 45:(20)6372-6378.
Hatai J., Prasad P. K., Lahav-Mankovski N., Oppenheimer-Low N., Unger T., Sirkis Y. F., Dadosh T., Motiei L. & Margulies D. (). Assessing changes in the expression levels of cell surface proteins with a turn-on fluorescent molecular probe.  Chemical Communications. 57:(15)1875-1878.
Sen S., Bhowmik P., Tiwari S., Peleg Y. & Bandyopadhyay B. (). Versatility of reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) from diagnosis of early pathological infection to mutation detection in organisms.  Molecular Biology Reports. 51:(1)
Zeev-Ben-Mordehai T., Mylonas E., Paz A., Peleg Y., Toker L., Silman I., Svergun D. I. & Sussman J. (). The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.  Biophysical Journal. 97:(8)2316-2326.
Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.  Molecular Cell. 72:(1)178-186.e5.
Sonawane P. D., Jozwiak A., Barbole R., Panda S., Abebie B., Kazachkova Y., Gharat S. A., Ramot O., Unger T., Wizler G., Meir S., Rogachev I., Doron-Faigenboim A., Petreikov M., Schaffer A., Giri A. P., Scherf T. & Aharoni A. (). 2-Oxoglutarate-Dependent Dioxygenases Drive Expansion of Steroidal Alkaloid Structural Diversity in the Genus Solanum.  The New Phytologist. 234:(4)1394-1410.
Romier C., Ben Jelloul M., Albeck S., Buchwald G., Busso D., Celie P. H., Christodoulou E., De Marco V., Van Gerwen S., Knipscheer P., Lebbink J. H., Notenboom V., Poterszman A., Rochel N., Cohen S. X., Unger T., Sussman J. L., Moras D., Sixma T. K. & Perrakis A. (). Co-expression of protein complexes in prokaryotic and eukaryotic hosts: Experimental procedures, database tracking and case studies.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1232-1242.
Quinn S., Zhang N., Fenton T. A., Brusel M., Muruganandam P., Peleg Y., Giladi M., Haitin Y., Lerche H., Bassan H., Liu Y., Ben-Shalom R. & Rubinstein M. (). Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy.  Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870:(5)
Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (). Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.  Molecular Biology and Evolution. 37:(4)1133-1147.
Albeck S., Weiner S. & Addadi L. (). Polysaccharides of intracrystalline glycoproteins modulate calcite crystal growth in vitro.  Chemistry-A European Journal. 2:(3)278-284.
Shemi A., Ben-Dor S., Rotkopf R., Dym O. & Vardi A. (). Phylogeny and biogeography of the algal DMS-releasing enzyme in the global ocean.  ISME Communications. 3.
Bharat T. A. M., Zbaida D., Eisenstein M., Frankenstein Z., Mehlman T., Weiner L., Sorzano C. O. S., Barak Y., Albeck S., Briggs J. A. G., Wolf S. G. & Elbaum M. (). Variable internal flexibility characterizes the helical capsid formed by agrobacterium VirE2 protein on single-stranded DNA.  Structure. 21:(7)1158-1167.
Yifrach E., Holbrook\U2010smith D., BüRgi J., Othman A., Eisenstein M., Roermund C. W., Visser W., Tirosh A., Rudowitz M., Bibi C., Galor S., Weill U., Fadel A., Peleg Y., Erdmann R., Waterham H. R., Wanders R. J. A., Wilmanns M., Zamboni N., Schuldiner M. & Zalckvar E. (). Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions.  Molecular Systems Biology. 18:(9)