Publications

Kahlon S., Shreibman D., Unger T., Ben-Yehuda D. & Elias S. (). The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.  Blood Cancer Journal. 8:(5)
Goldsmith M., Barad S., Knafo M., Savidor A., Ben-Dor S., Brandis A., Mehlman T., Peleg Y., Albeck S., Dym O., Ben-Zeev E., Barbole R. S., Aharoni A. & Reich Z. (). Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea.  The journal of Biological chemistry. 298:(5)
Mishra N. K., Peleg Y., Cirri E., Belogus T., Lifshitz Y., Voelker D. R., Apell H., Garty H. & Karlish S. J. (). FXYD proteins stabilize Na,K-ATpase: Amplification of specific phosphatidylserine-protein interactions.  Journal of Biological Chemistry. 286:(11)9699-9712.
Quinn S., Zhang N., Fenton T. A., Brusel M., Muruganandam P., Peleg Y., Giladi M., Haitin Y., Lerche H., Bassan H., Liu Y., Ben-Shalom R. & Rubinstein M. (). Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy.  Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870:(5)
Mishra N. K., Habeck M., Kirchner C., Haviv H., Peleg Y., Eisenstein M., Apell H. J. & Karlish S. J. D. (). Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase.  Journal of Biological Chemistry. 290:(48)28746-28759.
Goihberg E., Dym O., Tel-Or S., Levin I., Peretz M. & Burstein Y. (). A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase.  Proteins-Structure Function And Bioinformatics. 66:(1)196-204.
Peleg Y. & Unger T. (). Application of the Restriction-Free (RF) cloning for multicomponents assembly.  . 73-87.
Berry I. M., Dym O., Esnouf R. M., Harlos K., Meged R., Perrakis A., Sussman J., Walter T. S., Wilson J. & Messerschmidt A. (). SPINE high-throughput crystallization, crystal imaging and recognition techniques: Current state, performance analysis, new technologies and future aspects.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1137-1149.
Zimhony O., Schwarz A., Raitses-Gurevich M., Peleg Y., Dym O., Albeck S., Burstein Y. & Shakked Z. (). AcpM, the meromycolate extension Acyl carrier protein of mycobacterium tuberculosis, is activated by the 4-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.  Biochemistry. 54:(14)2360-2371.
Krieg E., Albeck S., Weissman H., Shimoni E. & Rybtchinski B. (). Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane.  PLoS ONE. 8:(5)
Rozenberg A., Kaczmarczyk I., Matzov D., Vierock J., Nagata T., Sugiura M., Katayama K., Kawasaki Y., Konno M., Nagasaka Y., Aoyama M., Das I., Pahima E., Church J., Adam S., Borin V. A., Chazan A., Augustin S., Wietek J., Dine J., Peleg Y., Kawanabe A., Fujiwara Y., Yizhar O., Sheves M., Schapiro I., Furutani Y., Kandori H., Inoue K., Hegemann P., Beja O. & Shalev-Benami M. (). Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels.  Nature Structural and Molecular Biology. 29:(6)592-603.
Albeck S. & Schreiber G. (). Biophysical characterization of the interaction of the β-lactamase TEM- 1 with its protein inhibitor BLIP.  Biochemistry. 38:(1)11-21.
Albeck S., Addadi L. & Weiner S. (). Regulation of calcite crystal morphology by intracrystalline acidic proteins and glycoproteins.  Connective Tissue Research. 35:(1-4)365-370.
Feigelson S. W., Dadosh T., Levi N., Sapoznikov A., Weinstein-Marom H., Blokon-Kogan D., Avraham Y., Unger T., Gross G., Dahan R. & Alon R. (). CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens.  Frontiers in Immunology. 16.
Levi Y., Albeck S., Brack A., Weiner S. & Addadi L. (). Control over aragonite crystal nucleation and growth: An in vitro study of biomineralization.  Chemistry-A European Journal. 4:(3)389-396.
Erez Z., Steinberger-Levy I., Shamir M., Doron S., Stokar Avihail A. A., Peleg Y., Melamed S., Leavitt A., Savidor A., Albeck S., Amitai G. & Sorek R. (). Communication between viruses guides lysis-lysogeny decisions.  Nature. 541:(7638)488-493.
Aizenberg J., Albeck S., Weiner S. & Addadi L. (). Crystal-protein interactions studied by overgrowth of calcite on biogenic skeletal elements.  Journal of Crystal Growth. 142:(1-2)156-164.
Busso D., Peleg Y., Heidebrecht T., Romier C., Jacobovitch Y., Dantes A., Salim L., Troesch E., Schuetz A., Heinemann U., Folkers G. E., Geerlof A., Wilmanns M., Polewacz A., Quedenau C., Buessow K., Adamson R., Blagova E., Walton J., Cartwright J. L., Bird L. E., Owens R. J., Berrow N. S., Wilson K. S., Sussman J., Perrakis A. & Celie P. H. N. (). Expression of protein complexes using multiple Escherichia coli protein co-expression systems: A benchmarking study.  Journal of Structural Biology. 175:(2)159-170.
KolářOvá L., ZahradníK J., HuličIak M., Mikulecký P., Peleg Y., Shemesh M., Schreiber G. & Schneider B. (). De novo developed protein binders mimicking Interferon lambda signaling.  The FEBS journal. 289:(9)2672-2684.
Juven-Gershon T., Shifman O., Unger T., Elkeles A., Haupt Y. & Oren M. (). The Mdm2 oncoprotein interacts with the cell fate regulator numb.  Molecular and Cellular Biology. 18:(7)3974-3982.
Baron S., Peleg Y., Grunwald J., Morgenstern D., Elad N., Peretz M., Albeck S., Levin Y., Welch J. T., Deweerd K. A., Schwarz A., Burstein Y., Diskin R., Shakked Z. & Zimhony O. (). Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli.  PLoS ONE. (9)
Itkin M., Heinig U., Tzfadia O., Bhide A. J., Shinde B. A., Cardenas P. D., Bocobza S. E., Unger T., Malitsky S., Finkers R., Tikunov Y., Bovy A., Chikate Y. R., Singh P., Rogachev I., Beekwilder J., Giri A. P. & Aharoni A. (). Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes.  Science. 341:(6142)175-179.
Peleg Y., Vincentelli R., Collins B. M., Chen K., Livingstone E. K., Weeratunga S., Leneva N., Guo Q., Remans K., Perez K., Bjerga G. E., Larsen Ø., VaněK O., SkořEpa O., Jacquemin S., Poterszman A., Kjaer S., Christodoulou E., Albeck S., Dym O., Ainbinder E., Unger T., Schuetz A., Matthes S., Bader M., De Marco A., Storici P., Semrau M. S., Stolt-Bergner P., Aigner C., Suppmann S., Goldenzweig A. & Fleishman S. J. (). Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.  Journal of Molecular Biology. 433:(13)
Hatai J., Prasad P. K., Lahav-Mankovski N., Oppenheimer-Low N., Unger T., Sirkis Y. F., Dadosh T., Motiei L. & Margulies D. (). Assessing Changes in the Expression Levels of Cell Surface Proteins with a Turn-on Fluorescent Molecular Probe.  Chemical Communications. 57:(15)1875-1878.
Vazana Y., Barak Y., Unger T., Peleg Y., Shamshoum M., Ben-Yehezkel T., Mazor Y., Shapiro E., Lamed R. & Bayer E. (). A synthetic biology approach for evaluating the functional contribution of designer cellulosome components to deconstruction of cellulosic substrates.  Biotechnology for Biofuels. 6:(1)
Franz F., Tapia-Rojo R., Winograd-Katz S., Boujemaa-Paterski R., Li W., Unger T., Albeck S., Aponte-Santamaria C., Garcia-Manyes S., Medalia O., Geiger B. & GräTer F. (). Allosteric activation of vinculin by talin.  Nature Communications. 14:(1)
Zeev-Ben-Mordehai T., Mylonas E., Paz A., Peleg Y., Toker L., Silman I., Svergun D. I. & Sussman J. (). The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.  Biophysical Journal. 97:(8)2316-2326.
Berman P., De Haro L. A., Cavaco A. R., Panda S., Dong Y., Kuzmich N., Lichtenstein G., Peleg Y., Harat H., Jozwiak A., Cai J., Heinig U., Meir S., Rogachev I. & Aharoni A. (). The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction.  Molecular Plant. 17:(7)1129-1150.
Albeck S., Unger R. & Schreiber G. (). Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges.  Journal of Molecular Biology. 298:(3)503-520.
Albeck S., Weiner S. & Addadi L. (). Polysaccharides of intracrystalline glycoproteins modulate calcite crystal growth in vitro.  Chemistry-A European Journal. 2:(3)278-284.
Peleg Y. & Unger T. (). Resolving bottlenecks for recombinant protein expression in E. coli.  . 173-186.
Yagound B., Dogantzis K. A., Zayed A., Lim J., Broekhuyse P., Remnant E. J., Beekman M., Allsopp M. H., Aamidor S. E., Dim O., Buchmann G. & Oldroyd B. P. (). A Single Gene Causes Thelytokous Parthenogenesis, the Defining Feature of the Cape Honeybee Apis mellifera capensis.  Current Biology. 30:(12)2248-2259.
Meged R., Dym O. & Sussman J. L. (). High throughput pH optimization of protein crystallization.  Methods in molecular biology (Clifton, N.J.). 426:411-418.
Unger T., Mietz J. A., Scheffner M., Yee C. L. & Howley P. M. (). Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.  Molecular and Cellular Biology. 13:(9)5186-94.
Scheerer D., Adkar B. V., Bhattacharyya S., Levy D., Iljina M., Riven I., Dym O., Haran G. & Shakhnovich E. I. (). Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase.  Proceedings of the National Academy of Sciences - PNAS. 120:(18)
Nissinkorn Y., Lahav-Mankovski N., Rabinkov A., Albeck S., Motiei L. & Margulies D. (). Sensing Protein Surfaces with Targeted Fluorescent Receptors.  Chemistry - A European Journal. 21:(45)15981-15987.
Addadi L., Aizenberg J., Albeck S., Falini G. & Weiner S. (). Structural control over the formation of calcium carbonate mineral phases in biomineralization.  Supramolecular Stereochemistry. 473:127-139.
Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M. (). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.  Analytical Chemistry. 89:(8)4708-4715.
Sela-Passwell N. A., Kikkeri R., Dym O., Rozenberg H., Margalit R., Arad-Yellin R., Eisenstein M., Brenner O., Shoham T., Danon T., Shanzer A. & Sagi I. (). Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.  Nature Medicine. 18:(1)143-147.
Sen S., Bhowmik P., Tiwari S., Peleg Y. & Bandyopadhyay B. (). Versatility of reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) from diagnosis of early pathological infection to mutation detection in organisms.  Molecular Biology Reports. 51:(1)
Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y. (). Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms.  Biochemistry. 49:(9)1943-1953.
Saikia C., Dym O., Altman-Gueta H., Gordon D., Reuveny E. & Karbat I. (). A Molecular Lid Mechanism of K+ Channel Blocker Action Revealed by a Cone Peptide.  Journal of Molecular Biology. 433:(17)
Asher G., Dym O., Tsvetkov P., Adler J. & Shaul Y. (). The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.  Biochemistry. 45:(20)6372-6378.
Sonawane P. D., Jozwiak A., Barbole R., Panda S., Abebie B., Kazachkova Y., Gharat S. A., Ramot O., Unger T., Wizler G., Meir S., Rogachev I., Doron-Faigenboim A., Petreikov M., Schaffer A., Giri A. P., Scherf T. & Aharoni A. (). 2-Oxoglutarate-Dependent Dioxygenases Drive Expansion of Steroidal Alkaloid Structural Diversity in the Genus Solanum.  The New Phytologist. 234:(4)1394-1410.
Jiang W., Wang X. W., Unger T., Forgues M., Kim J. W., Hussain S. P., Bowman E., Spillare E. A., Lipsky M. M., Meck J. M., Cavalli L. R., Haddad B. R. & Harris C. C. (). Cooperation of tumor-derived HBx mutants and p53-249ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.  International Journal of Cancer. 127:(5)1011-1020.
Cohen J., Unger T., Rechavi G., Canaani E. & Givol D. (). Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas.  Nature. 306:(5945)797-799.
Lahav-Mankovski N., Prasad P. K., Oppenheimer-Low N., Raviv G., Dadosh T., Unger T., Salame T. M., Motiei L. & Margulies D. (). Decorating Bacteria with Self-Assembled Synthetic Receptors.  Nature Communications. 11:(1)
Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.  Molecular Cell. 72:(1)178-186.e5.
Shemi A., Ben-Dor S., Rotkopf R., Dym O. & Vardi A. (). Phylogeny and biogeography of the algal DMS-releasing enzyme in the global ocean.  ISME Communications. 3.
Erijman A., Shifman J. M. & Peleg Y. (). A single-tube assembly of DNA using the transfer-PCR (TPCR) platform.  . 89-101.
Ofir-Birin Y., Ben Ami Pilo H., Camacho A. C., Rudik A., Rivkin A., Revach O., Nir N., Tamin T. B., Karam P. A., Kiper E., Peleg Y., Nevo R., Solomon A., Havkin-Solomon T., Rojas A., Rotkopf R., Porat Z., Avni D., Schwartz E., Zillinger T., Hartmann G., Di Pizio A., Ben Quashie N., Dikstein R., Gerlic M., Torrecilhas A. C., Levy C., Hoen E. N. M. N., Bowie A. G. & Regev-Rudzki N. (). Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration.  Nature Communications. 12:(1)
Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (). Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.  Molecular Biology and Evolution. 37:(4)1133-1147.
Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 63:(2)337-346.
Unger T. & Peleg Y. (). Recombinant protein expression in the baculovirus-infected insect cell system.  . 187-199.
Mohan V., Gaffney J. P., Solomonov I., Levin M., Klepfish M., Akbareian S., GrüNwald B., Dym O., Eisenstein M., Yu K. H., Kelsen D. P., KrüGer A., Edwards D. R. & Sagi I. (). Conformation-specific inhibitory anti-mmp-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill.  Cancers. 13:(7)
Albeck S., Nordlund P. & Sussman J. L. (). New trends in protein expression.  Journal of Structural Biology. 172:(1)1-2.
Meltzer H., Marom E., Alyagor I., Mayseless O., Berkun V., Segal-Gilboa N., Unger T., Luginbuhl D. & Schuldiner O. (). Tissue-specific (ts) CRISPR as an efficient strategy for in vivo screening in Drosophila.  Nature Communications. 10:(1)
Rezenman S., Knafo M., Tsigalnitski I., Barad S., Jona G., Levi D., Dym O., Reich Z. & Kapon R. (). gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution.  PLoS ONE. 18:(6)e0286696.
Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K. E. & Karlish S. J. (). A C-terminal lobe of the β subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.  Biochemistry. 48:(36)8684-8691.
Addadi L., Aizenberg J., Albeck S., Berman A., Leiserowitz L. & Weiner S. (). Controlled occlusion of proteins: A tool for modulating the properties of skeletal elements.  Molecular Crystals and Liquid Crystals. 248:(1)185-198.
Tal L., Friedlander G., Gilboa N. S., Unger T., Gilad S. & Eshed Y. (). Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein.  Plant Cell. 29:(4)681-696.
RöThlisberger D., Khersonsky O., Wollacott A. M., Jiang L., Dechancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. S. & Baker D. (). Kemp elimination catalysts by computational enzyme design.  Nature. 453:(7192)190-195.
Chaturvedi A. K., Dym O., Levin Y. & Fluhr R. (). PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE1A redox states alleviate photoinhibition during changes in light intensity.  Plant Physiology. 194:(2)1059-1074.
Dym O., Mevarech M. & Sussman J. L. (). Structural features that stabilize halophilic malate dehydrogenase from an archaebacterium.  Science. 267:(5202)1344-1346.
ZahradníK J., Marciano S., Shemesh M., Zoler E., Harari D., Chiaravalli J., Meyer B., Rudich Y., Li C., Marton I., Dym O., Elad N., Lewis M., Andersen H., Gagne M., Seder R., Douek D. & Schreiber G. (). SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution.  Nature Microbiology. 6:(9)1188-1198.
Shpilka T., Welter E., Borovsky N., Amar N., Shimron F., Peleg Y. & Elazar Z. (). Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast.  Proceedings of the National Academy of Sciences of the United States of America. 112:(5)1434-1439.
Saikia C., Altman-Gueta H., Dym O., Karbat I. & Reuveny E. (). Conkunitzin-C2 from Conus consors induces an incomplete block of the Shaker K+ channel using a unique mode of action.  Biophysical Journal. 121:(3(1))500a-500a.
Katzir N., Rechavi G., Cohen J., Unger T., Simoni F., Segal S., Cohen D. & Givol D. (). 'Retroposon' insertion into the cellular oncogene c-myc in canine transmissible venereal tumor.  Proceedings of the National Academy of Sciences of the United States of America. 82:(4)1054-1058.
Seal M., Jash C., Jacob R., Feintuch A., Harel Y., Albeck S., Unger T. & Goldfarb D. (). Evolution of CPEB4 Dynamics across its Liquid-Liquid Phase Separation Transition.  Journal Of Physical Chemistry B. 125:(47)12947-12957.
Pode Z., Peri-Naor R., Georgeson J. M., Ilani T., Kiss V., Unger T., Markus B., Barr H. M., Motiei L. & Margulies D. (). Protein Recognition by a Pattern-Generating Fluorescent Molecular Probe.  Nature Nanotechnology. 12:(12)1161-1168.
Cardenas P. D., Sonawane P. D., Heinig U., Jozwiak A., Panda S., Abebie B., Kazachkova Y., Pliner M., Unger T., Wolf D., Ofner I., Vilaprinyo E., Meir S., Davydov O., Gal-On A., Burdman S., Giri A., Zamir D., Scherf T., Szymanski J., Rogachev I. & Aharoni A. (). Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases.  Nature Communications. 10.
Khmelnitsky L., Milo A., Dym O. & Fass D. (). Diversity of CysD domains in gel-forming mucins.  FEBS Journal.
Wong E., Maretzky T., Peleg Y., Blobel C. P. & Sagi I. (). The functional maturation of a disintegrin and metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site.  The journal of Biological chemistry. 290:(19)12135-12146.
Singh A., Erijman A., Noronha A., Kumar H., Peleg Y., Yarden Y. & Shifman J. M. (). Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anti-cancer activities in lung adenocarcinoma.  Journal of Biological Chemistry. 297:(6)
Zeev-Ben-Mordehai T., Paz A., Peleg Y., Toker L., Wolf S. G., Rydberg E. H., Sussman J. & Silman I. (). Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization.  Protein Expression and Purification. 63:(2)147-157.
Khersonsky O., Kiss G., RöThlisberger D., Dym O., Albeck S., Houk K. N., Baker D. & Tawfik D. S. (). Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.  Proceedings of the National Academy of Sciences of the United States of America. 109:(26)10358-10363.
Albeck S., Alzari P., Andreini C., Banci L., Berry I. M., Bertini I., Cambillau C., Canard B., Carter L., Cohen S. X., Diprose J. M., Dym O., Esnouf R. M., Felder C., Ferron F., Guillemot F., Hamer R., Ben Jelloul J. M., Laskowski R. A., Laurent T., Longhi S., Lopez R., Luchinat C., Malet H., Mochel T., Morris R. J., Moulinier L., Oinn T., Pajon A., Peleg Y., Perrakis A., Poch O., Prilusky J., Rachedi A., Ripp R., Rosato A., Silman I., Stuart D. I., Sussman J., Thierry J. -., Thompson J. D., Thornton J. M., Unger T., Vaughan B., Vranken W., Watson J. D., Whamond G. & Henrick K. (). SPINE bioinformatics and data-management aspects of high-throughput structural biology.  Acta Crystallographica Section D-Structural Biology. 62:(10)1184-1195.
Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Nissan G. B., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (). Erratum: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces (PLoS Computational Biology(2019)15: 8(e1007207)Doi: 10.1371/journal.pcbi.1007207).  PLoS Computational Biology. 16:(10)
Lal M., Kesselman E., Wachtel E., Kleinerman O., Peleg Y., Albeck S., Majhi K., Sheves M. & Patchornik G. (). His-tag based supramolecular biopolymerization.  Scientific Reports. 14.
Graslund S., Peleg Y., Albeck S., Unger T., Dym O., Prilusky J. & Sussman J. L. (). Protein production and purification.  Nature Methods. 5:(2)135-146.
Khersonsky O., Goldsmith M., Zaretsky I., Hamer-Rogotner S., Dym O., Unger T., Yona M., Fridmann-Sirkis Y. & Fleishman S. J. (). Stable Mammalian Serum Albumins Designed for Bacterial Expression.  Journal of Molecular Biology. 435:(17)
Khersonsky O., RöThlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D. S. (). Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the ke07 series.  Journal of Molecular Biology. 396:(4)1025-1042.
Allouche-Arnon H., Khersonsky O., Tirukoti N. D., Peleg Y., Dym O., Albeck S., Brandis A., Mehlman T., Avram L., Harris T., Yadav N. N., Fleishman S. J. & Bar-Shir A. (). Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.  Nature biotechnology. 40:(7)1143-1149.
Sonawane P. D., Pollier J., Panda S., Szymanski J., Massalha H., Yona M., Unger T., Malitsky S., Arendt P., Pauwels L., Almekias-Siegl E., Rogachev I., Meir S., Cardenas P. D., Masri A., Petrikov M., Schaller H., Schaffer A. A., Kamble A., Giri A. P., Goossens A. & Aharoni A. (). Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.  Nature Plants. 3.
Arfi Y., Shamshoum M., Rogachev I., Peleg Y. & Bayer E. (). Integration of bacterial lytic polysaccharide monooxygenases into designer cellulosomes promotes enhanced cellulose degradation.  Proceedings of the National Academy of Sciences of the United States of America. 111:(25)9109-9114.
Yeshaya N., Gupta P. K., Dym O., Morgenstern D., Major D. T. & Fass D. (). VWD domain stabilization by autocatalytic Asp-Pro cleavage.  Protein Science. 33:(3)
Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (). The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.  Biochemistry. 49:(29)6184-6192.
Gurfinkel N., Unger T., Givol D. & Mushinski J. F. (). Expression of the bcl2 gene in mouse B lymphocytic cell lines is differentiation stage specific.  European Journal of Immunology. 17:(4)567-570.
Xu Y., Li M., Greenblatt H., Chen W., Paz A., Dym O., Peleg Y., Chen T., Shen X., He J., Jiang H., Silman I. & Sussman J. (). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.  Acta Crystallographica Section D: Biological Crystallography. 68:(1)13-25.
Goldsmith M., Barad S., Peleg Y., Albeck S., Dym O., Brandis A., Mehlman T. & Reich Z. (). The identification and characterization of an oxalyl-CoA synthetase from grass pea ( Lathyrus sativus L.).  RSC Chemical Biology. 3:(3)320-333.
Siton O., Ideses Y., Albeck S., Unger T., Bershadsky A. D., Gov N. S. & Bernheim-Groswasser A. (). Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches.  Current Biology. 21:(24)2092-2097.
Chill J., Nivasch R., Levy R., Albeck S., Schreiber G. & Anglister J. (). The human interferon receptor: NMR-based modeling, mapping of the IFN-α2 binding site, and observed ligand-induced tightening.  Biochemistry. 41:(11)3575-3585.
Halfin O., Avram L., Albeck S., Unger T., Motiei L. & Margulies D. (). Unnatural Enzyme Activation by a Metal-Responsive Regulatory Protein.  Chemical Science. 15:(35)14209-14217.
Gabizon R., Shraga A., Gehrtz P., Livnah E., Shorer Y., Gurwicz N., Avram L., Unger T., Aharoni H., Albeck S., Brandis A., Shulman Z., Katz B., Herishanu Y. & London N. (). Efficient targeted degradation via reversible and irreversible covalent PROTACs.  Journal of the American Chemical Society. 142:(27)11734-11742.
Dym O., Aggarwal N., Ashani Y., Leader H., Albeck S., Unger T., Hamer-Rogotner S., Silman I., Tawfik D. S. & Sussman J. L. (). The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.  Acta Crystallographica Section D: Structural Biology. 79:(Pt 11)992-1009.
Aricescu A. R., Assenberg R., Bill R. M., Busso D., Chang V. T., Davis S. J., Dubrovsky A., Gustafsson L., Hedfalk K., Heinemann U., Jones I. M., Ksiazek D., Lang C., Maskos K., Messerschmidt A., Macieira S., Peleg Y., Perrakis A., Poterszman A., Schneider G., Sixma T. K., Sussman J., Sutton G., Tarboureich N., Zeev-Ben-Mordehai T. & Jones E. Y. (). Eukaryotic expression: Developments for structural proteomics.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1114-1124.
Goldsmith M., Avram L., Brandis A., Mehlman T., Ben-Dor S., Peleg Y., Ben-Zeev E., Barbole R. S. & Reich Z. (). LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea.  Nature Communications. 15.
Reichmann D., Rahat O., Albeck S., Meged R., Dym O. & Schreiber G. (). The modular architecture of protein-protein binding interfaces.  Proceedings of the National Academy of Sciences of the United States of America. 102:(1)57-62.
Falini G., Albeck S., Weiner S. & Addadi L. (). Control of aragonite or calcite polymorphism by mollusk shell macromolecules.  Science. 271:(5245)67-69.
Albeck S., Burstein Y., Dym O., Jacobovitch Y., Levi N., Meged R., Michael Y., Peleg Y., Prilusky J., Schreiber G., Silman I., Unger T. & Sussman J. (). Three-dimensional structure determination of proteins related to human health in their functional context at the Israel Structural Proteomics Center (ISPC).  Acta Crystallographica Section D: Biological Crystallography. 61:(10)1364-1372.
Yifrach E., Holbrooksmith D., BüRgi J., Othman A., Eisenstein M., Roermund C. W., Visser W., Tirosh A., Rudowitz M., Bibi C., Galor S., Weill U., Fadel A., Peleg Y., Erdmann R., Waterham H. R., Wanders R. J. A., Wilmanns M., Zamboni N., Schuldiner M. & Zalckvar E. (). Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions.  Molecular Systems Biology. 18:(9)
Peri L., Matzov D., Huxley D. R., Rainish A., Fierro F., Sapir L., Pfeiffer T., Waterloo L., HüBner H., Peleg Y., Gmeiner P., Mccormick P. J., Weikert D., Niv M. Y. & Shalev-Benami M. (). A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR.  Nature Communications. 15.
Davidi D., Shamshoum M., Guo Z., Baron Y. M., Prywes N., Oz A., Jablonska J., Flamholz A., Wernick D. G., Antonovsky N., Pins B., Shachar L., Hochhauser D., Peleg Y., Albeck S., Sharon I., Muellercajar O. & Milo R. (). Highly active rubiscos discovered by systematic interrogation of natural sequence diversity.  The EMBO Journal. 39:(18)
Peleg Y., Prabahar V., Bednarczyk D. & Unger T. (). Harnessing the Profinity eXact™ System for Expression and Purification of Heterologous Proteins in E. coli.  . 33-43.
Bharat T. A. M., Zbaida D., Eisenstein M., Frankenstein Z., Mehlman T., Weiner L., Sorzano C. O. S., Barak Y., Albeck S., Briggs J. A. G., Wolf S. G. & Elbaum M. (). Variable internal flexibility characterizes the helical capsid formed by agrobacterium VirE2 protein on single-stranded DNA.  Structure. 21:(7)1158-1167.
Israeli H., Degtjarik O., Fierro F., Chunilal V., Gill A. K., Roth N. J., Botta J., Prabahar V., Peleg Y., Chan L. F., Ben-Zvi D., Mccormick P. J., Niv M. Y. & Shalev-Benami M. (). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.  Science. 372:(6544)808-814.
Sonawane P. D., Heinig U., Panda S., Gilboa N. S., Yona M., Kumar S. P., Alkan N., Unger T., Bocobza S., Pliner M., Malitsky S., Tkachev M., Meir S., Rogachev I. & Aharoni A. (). Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum.  Proceedings of the National Academy of Sciences of the United States of America. 115:(23)E5419-E5428.
Bednarczyk D., Dym O., Prabahar V., Peleg Y., Pike D. H. & Noy D. (). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.  Angewandte Chemie-International Edition. 55:(24)6901-6905.
Frenkiel-Krispin D., Wolf S. G., Albeck S., Unger T., Peleg Y., Jacobovitch J., Michael Y., Daube S., Sharon M., Robinson C. V., Svergun D. I., Fass D., Tzfira T. & Elbaum M. (). Plant transformation by Agrobacterium tumefaciens: Modulation of single-stranded DNA-VirE2 complex assembly by VirE.  Journal of Biological Chemistry. 282:(6)3458-3464.
Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (). Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.  Structure. 23:(1)104-115.
Giannoulis A., Feintuch A., Unger T., Amir S. & Goldfarb D. (). Monitoring the Conformation of the Sba1/Hsp90 Complex in the Presence of Nucleotides with Mn(II)-Based Double ElectronElectron Resonance.  Journal of Physical Chemistry Letters. 12:(51)12235-12241.
Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D. (). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.  Cell. 164:(3)476-486.
Bandyopadhyay B. & Peleg Y. (). Application of Restriction Free (RF) Cloning in Circular Permutation.  . 149-163.
Manicka S., Peleg Y., Unger T., Albeck S., Dym O., Greenblatt H. A., Bourenkov G., Lamzin V., Krishnaswamy S. & Sussman J. (). Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12.  Proteins-Structure Function And Bioinformatics. 71:(4)2102-2108.
Cohen S., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A. & Dym O. (). Cyt1Aa toxin: Crystal structure reveals implications for its membrane-perforating function.  Journal of Molecular Biology. 413:(4)804-814.
Wein T., Millman A., Lange K., Yirmiya E., Hadary R., Garb J., Melamed S., Amitai G., Dym O., Steinruecke F., Hill A. B., Kranzusch P. J. & Sorek R. (). CARD domains mediate anti-phage defence in bacterial gasdermin systems.  Nature.
Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (). Highly active enzymes by automated combinatorial backbone assembly and sequence design.  Nature Communications. 9.
Unger T., Jacobovitch Y., Dantes A., Bernheim R. & Peleg Y. (). Applications of the Restriction Free (RF) cloning procedure for molecular manipulations and protein expression.  Journal of Structural Biology. 172:(1)34-44.
SchüTz A., Bernhard F., Berrow N., Buyel J. F., Ferreira-Da-Silva F., Haustraete J., Van Den Heuvel J., Hoffmann J. E., De Marco A., Peleg Y., Suppmann S., Unger T., Vanhoucke M., Witt S. & Remans K. (). A concise guide to choosing suitable gene expression systems for recombinant protein production.  STAR Protocols. 4:(4)
Yosef E., Katz A., Peleg Y., Mehlman T. & Karlish S. J. (). Do Src kinase and caveolin interact directly with Na,K-ATPase?.  Journal of Biological Chemistry. 291:(22)11736-11750.
Heyne M., Shirian J., Cohen I., Peleg Y., Radisky E. S., Papo N. & Shifman J. M. (). Climbing up and down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein-Protein Complexes.  Journal of the American Chemical Society. 143:(41)17261-17275.
Sberro H., Leavitt A., Kiro R., Koh E., Peleg Y., Qimron U. & Sorek R. (). Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning.  Molecular Cell. 50:(1)136-148.
Shaaltiel Y., Bartfeld D., Hashmueli S., Baum G., Brill-Almon E., Galili G., Dym O., Boldin-Adamsky S. A., Silman I., Sussman J. L., Futerman A. H. & Aviezer D. (). Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.  Plant Biotechnology Journal. 5:(5)579-590.
Alzari P. M., Berglund H., Berrow N. S., Blagova E., Busso D., Cambillau C., Campanacci V., Christodoulou E., Eiler S., Fogg M. J., Folkers G., Geerlof A., Hart D., Haouz A., Herman M. D., Macieira S., Nordlund P., Perrakis A., Quevillon-Cheruel S., Tarandeau F., Van Tilbeurgh H., Unger T., Luna-Vargas M., Velarde M., Willmanns M. & Owens R. J. (). Implementation of semi-automated cloning and prokaryotic expression screening: The impact of SPINE.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1103-1113.
Osher E., Anis Y., Singer-Shapiro R., Urshanski N., Unger T., Albeck S., Bogin O., Weisinger G., Kohen F., Valevski A., Fattal-Valevski A., Sagi L., Weitman M., Shenberger Y., Sagiv N., Navon R., Wilchek M. & Stern N. (). Treating late-onset Tay Sachs disease: Brain delivery with a dual trojan horse protein.  Molecular Therapy Methods and Clinical Development. 32:(3)
Fogg M. J., Alzari P., Bahar M., Bertini I., Betton J. M., Burmeister W. P., Cambillau C., Canard B., Carrondo M. A., Coll M., Daenke S., Dym O., Egloff M. P., Enguita F. J., Geerlof A., Haouz A., Jones T. A., Ma Q., Manicka S. N., Migliardi M., Nordlund P., Owens R. J., Peleg Y., Schneider G., Schnell R., Stuart D. I., Tarbouriech N., Unge T., Wilkinson A. J., Wilmanns M., Wilson K. S., Zimhony O. & Grimes J. M. (). Erratum: Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens (Acta Crystallographica Section D: Biological Crystallography (2006) D62 (1196-1207)).  Acta Crystallographica Section D: Biological Crystallography. 62:(12)1571.
Erijman A., Dantes A., Bernheim R., Shifman J. M. & Peleg Y. (). Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering.  Journal of Structural Biology. 175:(2)171-177.
Pokorna S., Khersonsky O., Lipsh-Sokolik R., Goldenzweig A., Nielsen R., Ashani Y., Peleg Y., Unger T., Albeck S., Dym O., Tirosh A., Tarayra R., Hocquemiller M., Laufer R., Ben-Dor S., Silman I., Sussman J. L., Fleishman S. J. & Futerman A. H. (). Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.  FEBS Journal. 290:(13)3383-3399.
Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J. (). Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators.  Journal of Medicinal Chemistry. 54:(10)3575-3580.
Tarayrah-Ibraheim L., Maurice E. C., Hadary G., Ben-Hur S., Kolpakova A., Braun T., Peleg Y., Yacobi-Sharon K. & Arama E. (). DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.  Nature Communications. 12:(1)
Wong E., Cohen T., Romi E., Levin M., Peleg Y., Arad U., Yaron A., Milla M. E. & Sagi I. (). Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo.  Scientific Reports. 6.
Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J. (). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 114:(41)10900-10905.
Mock B., Givol D., Dhoostelaere L., Huppi K., Seldin M., Gurfinkel N., Unger T., Potter M. & Mushinski J. (). Mapping of the bcl-2 oncogene on mouse chromosome 1.  Cytogenetics and Cell Genetics. 47:(1-2)11-15.
Reichmann D., Cohen M., Abramovich R., Dym O., Lim D., Strynadka N. C. J. & Schreiber G. (). Binding Hot Spots in the TEM1-BLIP Interface in Light of its Modular Architecture.  Journal of Molecular Biology. 365:(3)663-679.
Gould N. L., Scherer G. R., Carvalho S., Shurrush K., Kayyal H., Edry E., Elkobi A., David O., Foqara M., Thakar D., Pavesi T., Sharma V., Walker M., Maitland M., Dym O., Albeck S., Peleg Y., Germain N., Babaev I., Sharir H., Lalzar M., Shklyar B., Hazut N., Khamaisy M., LéVesque M., Lajoie G., Avoli M., Amitai G., Lefker B., Subramanyam C., Shilton B., Barr H. & Rosenblum K. (). Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimers disease phenotype in mice.  Journal of Clinical Investigation. 133:(19)
Yadid I., Kirshenbaum N., Sharon M., Dym O. & Tawfik D. (). Metamorphic proteins mediate evolutionary transitions of structure.  Proceedings of the National Academy of Sciences of the United States of America. 107:(16)7287-7292.
Yifrach E., Rudowitz M., Cruz-Zaragoza L. D., Tirosh A., Gazi Z., Peleg Y., Kunze M., Eisenstein M., Schliebs W., Schuldiner M., Erdmann R. & Zalckvar E. (). Determining the targeting specificity of the selective peroxisomal targeting factor Pex9.  Biological Chemistry. 404:(2-3)121-133.
Albeck S., Aizenberg J., Addadi L. & Weiner S. (). Interactions of Various Skeletal Intracrystalline Components with Calcite Crystals.  Journal of the American Chemical Society. 115:(25)11691-11697.
Cohen S., Dym O., Albeck S., Ben-Dov E., Cahan R., Firer M. & Zaritsky A. (). High-Resolution Crystal Structure of Activated Cyt2Ba Monomer from Bacillus thuringiensis subsp. israelensis.  Journal of Molecular Biology. 380:(5)820-827.
Bose T., Fridkin G., Davidovich C., Krupkin M., Dinger N., Falkovich A. H., Peleg Y., Agmon I., Bashan A. & Yonath A. (). Origin of life: Protoribosome forms peptide bonds and links RNA and protein dominated worlds.  Nucleic Acids Research. 50:(4)1815-1828.
Ganor Y., Besser M., Ben-Zakay N., Unger T. & Levite M. (). Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.  Journal of Immunology. 170:(8)4362-4372.
Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N. (). Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.  Cell Chemical Biology. 26:(1)98 - 108.
Oranges M., Giannoulis A., Vanyushkina A., Sirkis Y. F., Dalaloyan A., Unger T., Su X. C., Sharon M. & Goldfarb D. (). C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains.  Biophysical Journal.
Berrow N. S., Buessow K., Coutard B., Diprose J., Ekberg M., Folkers G. E., Levy N., Lieu V., Owens R. J., Peleg Y., Pinaglia C., Quevillon-Cheruel S., Salim L., Scheich C., Vincentelli R. & Busso D. (). Recombinant protein expression and solubility screening in Escherichia coli: A comparative study.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1218-1226.
Adams E. M., Pezzotti S., Ahlers J., RüTtermann M., Levin M., Goldenzweig A., Peleg Y., Fleishman S. J., Sagi I. & Havenith M. (). Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction.  JACS Au. 1:(7)1076-1085.
Selzer T., Albeck S. & Schreiber G. (). Rational design of faster associating and tighter binding protein complexes.  Nature Structural Biology. 7:(7)537-541.
Daniel E., Maksimainen M. M., Smith N., Ratas V., Biterova E., Murthy S. N., Tanvir Rahman M., Kiema T. R., Sridhar S., Cordara G., Dalwani S., Venkatesan R., Prilusky J., Dym O., Lehtio L., Kristian Koski M., Ashton A. W., Sussman J. L. & Wierenga R. K. (). IceBear: An intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.  Acta Crystallographica Section D: Structural Biology. 77:(2)151-163.
Romier C., Ben Jelloul M., Albeck S., Buchwald G., Busso D., Celie P. H., Christodoulou E., De Marco V., Van Gerwen S., Knipscheer P., Lebbink J. H., Notenboom V., Poterszman A., Rochel N., Cohen S. X., Unger T., Sussman J. L., Moras D., Sixma T. K. & Perrakis A. (). Co-expression of protein complexes in prokaryotic and eukaryotic hosts: Experimental procedures, database tracking and case studies.  Acta Crystallographica Section D: Biological Crystallography. 62:(10)1232-1242.
Vitu E., Kim S., Sevier C. S., Lutzky O., Heldman N., Bentzur M., Unger T., Yona M., Kaiser C. A. & Fass D. (). Oxidative activity of yeast Ero1p on protein disulfide isomerase and related oxidoreductases of the endoplasmic reticulum.  Journal of Biological Chemistry. 285:(24)18155-18165.
Herynek Š., Svoboda J., HuličIak M., Peleg Y., ŠKultéTyová Ľ., Mikulecký P. & Schneider B. (). Increasing recombinant protein production in E. coli via FACS-based selection of N-terminal coding DNA libraries.  FEBS Journal.