We elucidate the structures, activities, and dynamical properties of living matter, from single macromolecules to living systems. Our research uses state-of-the-art techniques in electron microscopy, diffraction, nuclear magnetic resonance, molecular dynamics, mass spectrometry, and single-molecule spectroscopy. Our department is highly interdisciplinary, at the interface of Biology, Chemistry, and Physics. See the Research page for more details.
Tal Feldman, Tal Ilani, and Iris Grossman - paper in Oncotarget
Congratulations to Tal Feldman, Tal Ilani, and former student Iris Grossman from the Fass Group, on their paper in Oncotarget showing that antibodies inhibiting the enzyme QSOX1 slow tumor growth and metastasis in vivo.
Prof. Joel Sussman - New Honor Announcement
Prof. Joel Sussman awarded Honorary Doctorate from Charles University
Meta Heidenreich wins Clifford Felder Prize 2019
Congratulations to Meta Heidenreich, who received the Clifford Felder Prize for outstanding accomplishments during the Ph.D.
Congratulations to Gabe Javitt from Deborah Fass group for solving the structure of the colon mucin multimerization domain
Javitt et al., Intestinal Gel-Forming Mucins Polymerize by Disulfide-Mediated Dimerization of D3 Domains, Journal of Molecular Biology, in press.
Lavi Bigman - JBC paper
Congratulations to Lavi Bigman from Koby Levy's group for his paper (JBC, in press) on resolving a controversy regarding GroEL’s mechanism of action
Aliza Katz receives a poster award in the Israel Crystallography Association meeting in the Technion
Aliza Katz from Ron Diskin's group received a poster award in the Israel Crystallography Association Meeting that took place at the Technion in June 2019
Neta Varsano receives the Dimitris N. Chorafas Prize of Excellence
Neta Varsano from Lia Addadi's group received the Dimitris N. Chorafas Prize of excellence in recognition of her PhD accomplishments at the 2019 Annual Graduation Ceremony
Prof. Ada Yonath - Nobel Prize in Chemistry 2009
For studies of the structure and function of the ribosome
Beyond the Basics
"People called me a dreamer," says Prof. Ada Yonath of the Structural Biology Department, recalling her decision to undertake research on ribosomes – the cell's protein factories. Solving the ribosome's structure would give scientists unprecedented insight into how the genetic code is translated into proteins; by the late 1970s, however, top scientific teams around the world had already tried and failed to get these complex structures of protein and R.N.A to take on a crystalline form that could be studied. Dreamer or not, it was hard work that brought results: Yonath and colleagues made a staggering 25,000 attempts before they succeeded in creating the first ribosome crystals, in 1980.
And their work was just beginning. Over the next 20 years, Yonath and her colleagues would continue to improve their technique. In 2000, teams at Weizmann and the Max Planck Institute in Hamburg, Germany – both headed by Yonath – solved, for the first time, the complete spatial structure of both subunits of a bacterial ribosome. Science magazine counted this achievement among the ten most important scientific developments of that year. The next year, Yonath's teams revealed exactly how certain antibiotics are able to eliminate pathogenic bacteria by binding to their ribosomes, preventing them from producing crucial proteins.
Yonath's studies, which have stimulated intensive research worldwide, have now gone beyond the basic structure. She has revealed in detail how the genetic information is decoded, how the ribosome's inherent flexibility contributes to antibiotic selectivity and the secrets of cross-resistance to various antibiotic families. Her findings are crucial for developing advanced antibiotics.
Prof. Yonath is the Martin S. and Helen Kimmel Professor of Structural Biology. Prof. Ada Yonath's research is supported by the Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly.