Research

  • Biomineralization
  • Antibody-membrane interactions
  • Cell adhesion (osteoclasts)
  • NMR and site-directed mutagenesis studies of HIV-1 gp120
  • Chemokines interactions with the CCR5 chemokine receptor
  • Structure based design of synthetic HIV-1 vaccine
  • Structural biology viral glycoproteins
  • Therapeutic antibodies and immunogen design for HIV
  • Large protein complex formations
  • Structures and dynamics of enzymes that catalyze disulfide bond formation for protein folding and assembly
  • Physiological functions and therapeutic applications relating to a secreted disulfide bond catalyst
  • Oxidative protein folding during assembly of large double-stranded DNA viruses
  • Molecular Systems Biology
  • Single molecule dynamics in stochastic gene expression

 

  • Molecular chaperones
  • Protein folding
  • Allosteric systems
  • The cellular architecture: how proteins localize and interact inside of a cell.
  • Structural properties of proteins and of protein interactions
  • Evolution of proteins, protein interactions and protein-complexes
  • Biophysics and evolution of post-translational modifications
  • Protein folding mechanism
  • Protein-DNA interactions and implications on DNA search
Prof. Abraham (Avi) Minsky
  • Structural and biochemical aspects of stress response and resistance
  • DNA repair in the cellular context
  • Giant viruses: infection cycles, viral factories, membrane assembly and DNA packaging.
  • Structure-function investigation of cytosolic and organellar aminoacyl-tRNA synthetases
  • Quality control in eukaryotic cells.
  • Structural studies of the tumor suppressor protein p53 and its complexes with DNA: exploring the structural code of sequence readout
  • Structural studies of oncogenic and functional mutants of p53 and their complexes with DNA: the structural basis of p53 loss of function and rescue
  • Structure-function studies on the mechanisms of p53 stabilization and proteosomal degradation
  • Proteopedia
  • X-ray crystallography
  • Proteins of the Nervous System
  • Intrinsically Flexible Proteins
  • Biomimeralization
  • Archaeological science
  • Ribosomes structure and function
  • Antibiotics and resistance to them
  • Origins of life