Tzahor Lab

Home

About us

Our lab forms a bridge between developmental biology and regenerative medicine aiming to develop novel approaches for mammalian heart regeneration

Selected Publications

Yahalom-Ronen, Y; Rajchman, D; Sarig, R; Geiger, B; Tzahor, E (2015). Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion..  eLife. 2015, 4 .
D'Uva, G; Aharonov, A; Lauriola, M; Kain, D; Yahalom-Ronen, Y; Carvalho, S; Weisinger, K; Bassat, E; Rajchman, D; Yifa, O; Lysenko, M; Konfino, T; Hegesh, J; Brenner, O; Neeman, M; Yarden, Y; Leor, J; Sarig, R; Harvey, RP; Tzahor, E (2015). ERBB2 triggers mammalian heart regeneration by promoting cardiorlyocyte dedifferentiation and proliferation.  NATURE CELL BIOLOGY. 2015, 17 :627-U207.

Research

Cardiomyocyte cell-cycle control and dedifferentiation

Ischemic heart disease is the most common cardiac ailment, and the leading cause of death in the Western world today. We combine novel approaches to study cardiomyocyte (CM) renewal by promoting CM cell division and dedifferentiation, as a potential therapeutic strategy to cure the injured heart. We focus on various signaling strategies (e.g., NRG/ERBB signaling pathway), combined with attention to the microenvironment. We focus on the biophysical properties (e.g., matrix rigidity) of the heart microenvironment as well on biochemical contents of the ECM and ECM- associated molecules. Finally, we employ a novel state-of-the-art high-throughput screening platform to identify molecules that promote CM proliferation and to study their effects on cardiac regeneration in mice. We have identified several novel compounds which significantly increase the proliferation of adult CMs. Understanding how mature CMs can disassemble their sarcomeric architecture and re-enter the cell cycle, combined with the development of novel procedures that can facilitate CM dedifferentiation and proliferation, are major challenges facing current biomedical research. Our research into myogenesis and cardiogenesis in chick embryos demonstrates that the FGF-ERK signaling pathway plays an inhibitory role in myogenic differentiation. We now seek to understand the molecular and cellular underpinnings of this phenomenon using adult muscle stem cells.

Cardiac and craniofacial development

We are interested in learning how the heart is formed during embryogenesis and, more specifically, the cellular origins of distinct heart progenitor populations. We use both chick and mouse embryonic models to address these questions. In the process, we have revealed novel developmental roles of vascular endothelial cells during heart and craniofacial development. Our search for the developmental mechanisms driving organogenesis led to identification of a gene regulatory network that orchestrates heart and craniofacial morphogenesis, findings that could pave the way toward a deeper understanding of certain birth defects (e.g., DiGeorge syndrome). We are also using a novel electroporation technique in chick embryos to follow the dynamics of cardiovascular lineage diversification.

Manipulating tumorigenic processes to stimulate heart regeneration

Perhaps one of the most surprising and interesting aspects of the adult heart is the fact that cardiac tumors rarely develop. This implies that some factor/s within the heart, which we are keen to identify, resists tumorigenesis. Inducing oncogenic transformation of cardiac cells may help to understand the heart resistance to cancer. Unleashing cell cycle control is a hallmark of cancer; on the other hand, these same mechanisms could be very useful in promoting heart regeneration. Hence, another angle of our research focus on the pros and cons of cell-cycle re-entry, finding just the right balance between these two processes (regeneration and tumorigenesis).

Publications

  • Buzaglo-Azriel, L; Kuperman, Y; Tsoory, M; Zaltsman, Y; Shachnai, L; Zaidman, SL; Bassat, E; Michailovici, I; Sarver, A; Tzahor, E; Haran, M; Vernochet, C; Gross, A (2016). Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.  CELL REPORTS. 2016, 14 :1602-1610.
  • Aghajanian, H; Cho, YK; Manderfield, LJ; Herling, MR; Gupta, M; Ho, VC; Li, L; Degenhardt, K; Aharonov, A; Tzahor, E; Epstein, JA (2016). Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor.  NATURE COMMUNICATIONS. 2016, 7 .
  • Leinonen, JV; Korkus-Emanuelov, A; Wolf, Y; Milgrom-Hoffman, M; Lichtstein, D; Hoss, S; Lotan, C; Tzahor, E; Jung, S; Beeri, R (2016). Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45-stem cell-like phenotype.  INTERNATIONAL JOURNAL OF CARDIOLOGY. 2016, 209 :296-306.
  • Tzahor, E (2015). Cardiac and craniofacial development and regeneration.  FASEB JOURNAL. 2015, 29 .
  • Michailovici, I; Eigler, T; Tzahor, E (2015). Craniofacial Muscle Development.  CRANIOFACIAL DEVELOPMENT. 2015, 115 :3-30.
  • D'Uva, G; Aharonov, A; Lauriola, M; Kain, D; Yahalom-Ronen, Y; Carvalho, S; Weisinger, K; Bassat, E; Rajchman, D; Yifa, O; Lysenko, M; Konfino, T; Hegesh, J; Brenner, O; Neeman, M; Yarden, Y; Leor, J; Sarig, R; Harvey, RP; Tzahor, E (2015). ERBB2 triggers mammalian heart regeneration by promoting cardiorlyocyte dedifferentiation and proliferation.  NATURE CELL BIOLOGY. 2015, 17 :627-U207.
  • Diogo, R; Kelly, RG; Christiaen, L; Levine, M; Ziermann, JM; Molnar, JL; Noden, DM; Tzahor, E (2015). A new heart for a new head in vertebrate cardiopharyngeal evolution.  NATURE. 2015, 520 :466-473.
  • D'Uva, G; Tzahor, E (2015). The key roles of ERBB2 in cardiac regeneration.  CELL CYCLE. 2015, 14 :2383-2384.
  • Yahalom-Ronen, Y; Rajchman, D; Sarig, R; Geiger, B; Tzahor, E (2015). Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion..  eLife. 2015, 4 .
  • Milgrom-Hoffman, M; Michailovici, I; Ferrara, N; Zelzer, E; Tzahor, E (2014). Endothelial cells regulate neural crest and second heart field morphogenesis.  BIOLOGY OPEN. 2014, 3 :679-688.
  • Michailovici, I; Harrington, HA; Azogui, HH; Yahalom-Ronen, Y; Plotnikov, A; Ching, S; Stumpf, MPH; Klein, OD; Seger, R; Tzahor, E (2014). Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.  Development. 2014, 141 :2611-2620.
  • Vandoorne, K; Vandsburger, MH; Raz, T; Shalev, M; Weisinger, K; Biton, I; Brumfeld, V; Raanan, C; Nevo, N; Eilam, R; Hemmings, BA; Tzahor, E; Harmelin, A; Gepstein, L; Neeman, M (2013). Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction.  Circulation-Cardiovascular Imaging. 2013, 6 :992-1000.
  • Leinonen, J; Korkus-Emanuelov, A; Milgrom-Hoffman, M; Hoss, S; Lotan, C; Tzahor, E; Beeri, R (2013). Cardiac progenitor cells from the left atrial appendage may originate from a resident non-hematopoietic myeloid progenitor population.  European Heart Journal. 2013, 34 :280.
  • Harel, I; Maezawa, Y; Avraham, R; Rinon, A; Ma, HY; Cross, JW; Leviatan, N; Hegesh, J; Roy, A; Jacob-Hirsch, J; Rechavi, G; Carvajal, J; Tole, S; Kioussi, C; Quaggin, S; Tzahor, E (2012). Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 2012, 109 :18839-18844.
  • Gruenbaum-Cohen, Y; Harel, I; Umansky, KB; Tzahor, E; Snapper, SB; Shilo, BZ; Schejter, ED (2012). The actin regulator N-WASp is required for muscle-cell fusion in mice.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 2012, 109 :11211-11216.
  • Rinon, A; Molchadsky, A; Nathan, E; Yovel, G; Rotter, V; Sarig, R; Tzahor, E (2011). p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.  Development. 2011, 138 :1827-1838.
  • Tzahor, E; Evans, SM (2011). Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis.  Cardiovascular Research. 2011, 91 :196-202.
  • Sarig, R; Tzahor, E (2011). p53 and epithelial-mesenchymal transition A linking thread between embryogenesis and cancer.  Cell Cycle. 2011, 10 :3036-3037.
  • Milgrom-Hoffman, M; Harrelson, Z; Ferrara, N; Zelzer, E; Evans, SM; Tzahor, E (2011). The heart endocardium is derived from vascular endothelial progenitors.  Development. 2011, 138 :4777-4787.
  • Tirosh-Finkel, L; Zeisel, A; Brodt-Ivenshitz, M; Shamai, A; Yao, Z; Seger, R; Domany, E; Tzahor, E (2010). BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.  Development. 2010, 137 :2989-3000.
  • Theis, S; Patel, K; Valasek, P; Otto, A; Pu, Q; Harel, I; Tzahor, E; Tajbakhsh, S; Christ, B; Huang, RJ (2010). The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature.  Development. 2010, 137 :2961-2971.
  • Ben-Shoshan, J; Maysel-Auslender, S; Luboshits, G; Barshack, I; Polak-Charcon, S; Tzahor, E; Keren, G; George, J (2009). Hypoxia-Inducible Factor-1 alpha and-2 alpha Additively Promote Endothelial Vasculogenic Properties.  Journal Of Vascular Research. 2009, 46 :299-310.
  • Kang, J; Nathan, E; Xu, SM; Tzahor, E; Black, BL (2009). Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm.  Developmental Biology. 2009, 334 :513-522.
  • Nathan, E; Tzahor, E (2009). sFRPs: a declaration of (Wnt) independence.  Nature Cell Biology. 2009, 11 :13-14.
  • Rinon, A; Nathan, E; Tzahor, E (2009). p53 involvement in early cranial neural crest development in the chick.  Developmental Biology. 2009, 331 :430.
  • Tzahor, E (2009). Heart and craniofacial muscle development: A new developmental theme of distinct myogenic fields.  Developmental Biology. 2009, 327 :273-279.
  • Harel, I; Nathan, E; Tirosh-Finkel, L; Zigdon, H; Guimaraes-Camboa, N; Evans, SM; Tzahor, E (2009). Distinct Origins and Genetic Programs of Head Muscle Satellite Cells.  Developmental Cell. 2009, 16 :822-832.
  • Ben-Shoshan, J; Maysel-Auslender, S; Luboshits, G; Barshack, I; Polak-Charcon, S; Tzahor, E; Keren, G; George, J (2008). Hypoxia inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha additively promote endothelial vasculogenic properties.  Human Gene Therapy. 2008, 19 :1111.
  • Ben-Shoshan, J; Schwartz, S; Luboshits, G; Maysel-Auslender, S; Barzelay, A; Polak-Charcon, S; Tzahor, E; Barshack, I; Barak, A; Levkovitch-Verbin, H; Keren, G; George, J (2008). Constitutive Expression of HIF-1 alpha and HIF-2 alpha in Bone Marrow Stromal Cells Differentially Promotes Their Proangiogenic Properties.  Stem Cells. 2008, 26 :2634-2643.
  • Klaus, A; Tzahor, E; Birchmeier, W (2008). Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.  European Journal Of Cell Biology. 2008, 87 :435.
  • Nathan, E; Monovich, A; Tirosh-Finkel, L; Harrelson, Z; Rousso, T; Rinon, A; Harel, I; Evans, SM; Tzahor, E (2008). The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development.  Development. 2008, 135 :647-657.
  • Wasserstrom, A; Adar, R; Shefer, G; Frumkin, D; Itzkovitz, S; Stern, T; Shur, I; Zangi, L; Kaplan, S; Harmelin, A; Reisner, Y; Benayahu, D; Tzahor, E; Segal, E; Shapiro, E (2008). Reconstruction of Cell Lineage Trees in Mice.  Plos One. 2008, 3 .
  • Molchadsky, A; Shats, I; Goldfinger, N; Pevsner-Fischer, M; Olson, M; Rinon, A; Tzahor, E; Lozano, G; Zipori, D; Sarig, R; Rotter, V (2008). p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner.  Plos One. 2008, 3 .
  • Wasserstrom, A; Frumkin, D; Adar, R; Itzkovitz, S; Stern, T; Kaplan, S; Shefer, G; Shur, I; Zangi, L; Reizel, Y; Harmelin, A; Dor, Y; Dekel, N; Reisner, Y; Benayahu, D; Tzahor, E; Segal, E; Shapiro, E (2008). Estimating cell depth from somatic mutations.  Plos Computational Biology. 2008, 4 .
  • Ben-Shoshan, J; Schwartz, S; Luboshits, G; Maysel-Auslender, S; Barzelay, A; Polak-Charcon, S; Barshack, I; Tzahor, E; Barak, A; Levkovitch-Verbin, H; Keren, G; George, J (2008). Constitutive expression of HIF-1 alpha and HIF-2 alpha in bone marrow stromal cells differentially promote their pro-angiogenic properties.  Human Gene Therapy. 2008, 19 :1180.
  • Tzahor, E (2007). The contribution of second heart field cells to the jaw muscle reveals the multipotential nature of the cardio-craniofacial mesoderm.  Circulation Research. 2007, 101 :E69.
  • Tzahor, E (2007). Wnt/beta-catenin signaling and cardiogenesis: Timing does matter.  Developmental Cell. 2007, 13 :10-13.
  • Rinon, A; Lazar, S; Marshall, H; Buchmann-Moller, S; Neufeld, A; Elhanany-Tamir, H; Taketo, MM; Sommer, L; Krumlauf, R; Tzahor, E (2007). Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.  Development. 2007, 134 :3065-3075.
  • Tirosh-Finkel, L; Elhanany, H; Rinon, A; Tzahor, E (2006). Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract.  Development. 2006, 133 :1943-1953.

Members

Members

Eldad Tzahor

Prof. Eldad Tzahor

Associate Professor,יועץ לנשיא,Center Head,Department Head,ראש מחלקה,ראש מרכז
Candiotty, room: 208/6
Phone08-9343715
Rachel Sarig

Dr. Rachel Sarig

Associate Staff Scientist
Candiotty, room: 207
Phone08-9342913
Kfir-Baruch Umansky

Dr. Kfir-Baruch Umansky

Intern
Wolfson, room: 207
Tamar Eigler

Dr. Tamar Eigler

Postdoctoral fellow
Candiotty, room: 207
Phone08-9342762
Alla Aharonov

Alla Aharonov

PhD student
Candiotty, room: 206
Phone08-9342762
Divya Nair

Dr. Divya Nair

PhD student
Wolfson
Elad Bassat

Elad Bassat

PhD student
Candiotty, room: 206
Phone08-9342762
Oren Yifa

Oren Yifa

PhD student
Candiotty, room: 206
Phone08-9342762
Alexander Genzelinakh

Alexander Genzelinakh

MSc student
Candiotty, room: 206
Phone08-9342762
David Kain

Dr. David Kain

Consultant
Candiotty
Shanny Goldsmith

Shanny Goldsmith

עובד מעבדה שעתי
Candiotty
Racheli Levine

Racheli Levine

עובד מעבדה שעתי
Wolfson
Avraham Shakked

Avraham Shakked

PhD student
Wolfson
Ameed Abualteen

Ameed Abualteen

MSc student
Wolfson, room: 005
Phone08-9346358

Postdoc
Karen Weisinger - kweisinger2@gmail.com
Gabriele D'uva - duva.gabriele@gmail.com
Miriam Ivenshitz - miriam.ivenshitz@gmail.com
Vardina Bensoussan Trigano - vardina.trigano@gmail.com

PhD
Michal Milgrom-Hoffman - michalmilgrom@yahoo.com
Libbat Tirosh - libbatt@gmail.com
Itamar Harel - itamarharel1980@gmail.com
Inbal Michailovici - inbalit11@gmail.com
Arial Rinon - ariel.rinon@gmail.com
Elisha Natan - elishanatan@gmail.com
Adam Wasserstrom - adam.wasserstrom@gmail.com

MSc
Ayelet Levit - ayeletshamai@gmail.com
Elik Chapnik - elikcha@gmail.com
Hadar Hay - hadar.hay2@gmail.com
Roni Winkler - roni.winkler@weizmann.ac.il
Adi Neufeld - adi.neufeld@yahoo.com
Amir Monovich
Hadas Elhanany-Tamir
Shlomi Lazar

Galleries

  • Scientific gallery
  • Monday - FunDay 2017
  • Gabi and Inbal's Goodbye party, 2015
  • Michal's Goodbye party, 2014
  • Hanukka 2014
  • Itamar's Goodbye party, 2013
  • Lab trip to Jaffa, 2012
  • Amir's Goodbye Party, 2008
  • Ayelet's Goodbye Party, 2007
  • Retreat to Mitzpe Ramon, 2005

Contact

 

Prof. Eldad Tzahor

Weizmann Institute of Science
Department of Molecular Cell Biology
Wolfson Building
Rehovot, 76100, Israel

Office: +972-8-934-3715
Mobile: +972-50-510-9606
Email: eldad.tzahor@weizmann.ac.il

 

Find us on campus, Building 33.