Tzahor Lab

  • Sarig R., Rimmer R., Bassat E., Zhang L., Umansky K. B., Lendengolts D., Perlmoter G., Yaniv K. & Tzahor E. (2019). Transient p53-Mediated Regenerative Senescence in the Injured Heart.  Circulation. 2019 May , 139 (21):2491-2494.
  • Sah J. P., Nguyen Thi Thu Hao, Kim Y., Eigler T., Tzahor E., Kim S., Hwang Y. & Yoon J. K. (2019). MBP-FGF2-Immobilized Matrix Maintains Self-Renewal and Myogenic Differentiation Potential of Skeletal Muscle Stem Cells.  International Journal of Stem Cells. 2019 Jul , 12 (2):360-366.
  • Fukuda R., Aharonov A., Ong Y. T., Stone O. A., El-Brolosy M., Maischein H., Potente M., Tzahor E. & Stainier D. Y. R. (2019). Metabolic modulation regulates cardiac wall morphogenesis in zebrafish.  eLife. 2019 Dec , 8 .
  • Tzahor, E; Poss, K (2017). Cardiac regeneration strategies: Staying young at heart..  SCIENCE. 2017, 356 (6342):1035-1039.
  • Tzahor E. & Sarig R. (2017). The cancer paradigms of mammalian regeneration: can mammals regenerate as amphibians?.  Carcinogenesis. 2017 Apr , 38 (4):359-366.
  • Aghajanian H., Cho Y. K., Manderfield L. J., Herling M. R., Gupta M., Ho V. C., Li L., Degenhardt K., Aharonov A., Tzahor E. & Epstein J. A. (2016). Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor.  Nature Communications. 2016 Jun , 7 .
  • Leinonen J. V., Korkus-Emanuelov A., Wolf Y., Milgrom-Hoffman M., Lichtstein D., Hoss S., Lotan C., Tzahor E., Jung S. & Beeri R. (2016). Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45-stem cell-like phenotype.  International Journal of Cardiology. 2016 Apr , 209 :296-306.
  • Buzaglo-Azriel L., Kuperman Y., Tsoory M., Zaltsman Y., Shachnai L., Levin-Zaidman S., Bassat E., Michailovici I., Sarver A., Tzahor E., Haran M., Vernochet C. & Gross A. (2016). Loss Of Muscle Mtch2 Increases Whole-Body Energy Utilization And Protects From Diet-Induced Obesity.  Cell Reports. 2016 Feb , 14 (7):1602-1610.
  • D'Uva G. & Tzahor E. (2015). The key roles of ERBB2 in cardiac regeneration.  Cell Cycle. 2015 Aug , 14 (15):2383-2384.
  • Yahalom-Ronen Y., Rajchman D., Sarig R., Geiger B. & Tzahor E. (2015). Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion..  eLife. 2015, 4 .
  • Milgrom-Hoffman M., Michailovici I., Ferrara N., Zelzer E. & Tzahor E. (2014). Endothelial cells regulate neural crest and second heart field morphogenesis.  Biology Open. 2014 Aug , 3 (8):679-688.
  • Michailovici I., Harrington H. A., Azogui H. H., Yahalom-Ronen Y., Plotnikov A., Ching S., Stumpf M. P. H., Klein O. D., Seger R. & Tzahor E. (2014). Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.  Development. 2014 Jul , 141 (13):2611-2620.
  • Vandoorne K., Vandsburger M. H., Raz T., Shalev M., Weisinger K., Biton I., Brumfeld V., Raanan C., Nevo N., Eilam R., Hemmings B. A., Tzahor E., Harmelin A., Gepstein L. & Neeman M. (2013). Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction.  Circulation-Cardiovascular Imaging. 2013 Nov , 6 (6):992-1000.
  • Gruenbaum-Cohen Y., Harel I., Umansky K., Tzahor E., Snapper S. B., Shilo B. & Schejter E. D. (2012). The actin regulator N-WASp is required for muscle-cell fusion in mice.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul , 109 (28):11211-11216.
  • Harel I., Maezawa Y., Avraham R., Rinon A., Ma H., Cross J. W., Leviatan N., Hegesh J., Roy A., Jacob-Hirsch J., Rechavi G., Carvajal J., Tole S., Kioussi C., Quaggin S. & Tzahor E. (2012). Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov , 109 (46):18839-18844.
  • Milgrom-Hoffman M., Harrelson Z., Ferrara N., Zelzer E., Evans S. M. & Tzahor E. (2011). The heart endocardium is derived from vascular endothelial progenitors.  Development. 2011 Nov , 138 (21):4777-4787.
  • Sarig R. & Tzahor E. (2011). p53 and epithelial-mesenchymal transition A linking thread between embryogenesis and cancer.  Cell Cycle. 2011 Sept , 10 (18):3036-3037.
  • Tzahor E. & Evans S. M. (2011). Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis.  Cardiovascular Research. 2011 Jul , 91 (2):196-202.
  • Tirosh-Finkel L., Zeisel A., Brodt-Ivenshitz M., Shamai A., Yao Z., Seger R., Domany E. & Tzahor E. (2010). BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.  Development. 2010 Sept , 137 (18):2989-3000.
  • Ben-Shoshan J., Maysel-Auslender S., Luboshits G., Barshack I., Polak-Charcon S., Tzahor E., Keren G. & George J. (2009). Hypoxia-Inducible Factor-1 alpha and-2 alpha Additively Promote Endothelial Vasculogenic Properties.  Journal of Vascular Research. 2009, 46 (4):299-310.
  • Nathan E. & Tzahor E. (2009). sFRPs: a declaration of (Wnt) independence.  Nature Cell Biology. 2009 Jan , 11 (1):13-14.
  • Tzahor E. (2009). Heart and craniofacial muscle development: A new developmental theme of distinct myogenic fields.  Developmental Biology. 2009 Mar , 327 (2):273-279.
  • Harel I., Nathan E., Tirosh-Finkel L., Zigdon H., Guimaraes-Camboa N., Evans S. M. & Tzahor E. (2009). Distinct Origins and Genetic Programs of Head Muscle Satellite Cells.  Developmental Cell. 2009 Jun , 16 (6):822-832.
  • Kang J., Nathan E., Xu S., Tzahor E. & Black B. L. (2009). Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm.  Developmental Biology. 2009 Oct , 334 (2):513-522.
  • Rinon A., Nathan E. & Tzahor E. (2009). p53 involvement in early cranial neural crest development in the chick.  Developmental Biology. 2009 Jul , 331 (2):430-430.
  • Ben-Shoshan J., Schwartz S., Luboshits G., Maysel-Auslender S., Barzelay A., Polak-Charcon S., Tzahor E., Barshack I., Barak A., Levkovitch-Verbin H., Keren G. & George J. (2008). Constitutive Expression of HIF-1 alpha and HIF-2 alpha in Bone Marrow Stromal Cells Differentially Promotes Their Proangiogenic Properties.  Stem Cells. 2008, 26 (10):2634-2643.
  • Molchadsky A., Shats I., Goldfinger N., Pevsner-Fischer M., Olson M., Rinon A., Tzahor E., Lozano G., Zipori D., Sarig R. & Rotter V. (2008). p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner.  PLoS One. 2008 Nov , 3 (11):1-15.
  • Nathan E., Monovich A., Tirosh-Finkel L., Harrelson Z., Rousso T., Rinon A., Harel I., Evans S. M. & Tzahor E. (2008). The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development.  Development. 2008 Feb , 135 (4):647-657.
  • Wasserstrom A., Frumkin D., Adar R., Itzkovitz S., Stern T., Kaplan S., Shefer G., Shur I., Zangi L., Reizel Y., Harmelin A., Dor Y., Dekel N., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008). Estimating cell depth from somatic mutations.  PLoS Computational Biology. 2008 May , 4 (5).
  • Klaus A., Saga Y., Taketo M. M., Tzahor E. & Birchmeier W. (2007). Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2007 Nov , 104 (47):18531-18536.
  • Tzahor E. (2007). Wnt/beta-catenin signaling and cardiogenesis: Timing does matter.  Developmental Cell. 2007 Jul , 13 (1):10-13.
  • Tirosh-Finkel L., Elhanany H., Rinon A. & Tzahor E. (2006). Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract.  Development. 2006 May , 133 (10):1943-1953.
  • Theis S., Patel K., Valasek P., Otto A., Pu Q., Harel I., Tzahor E., Tajbakhsh S., Christ B. & Huang R. (). The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature.  Development. , 137 (17):2961-2971.
  • Han Y., Chen A., Umansky K., Oonk K. A., Choi W., Dickson A. L., Ou J., Cigliola V., Yifa O., Cao J., Tornini V. A., Cox B. D., Tzahor E. & Poss K. D. (). Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.  Developmental Cell. , 48 (6):853-863.e5.
  • del Monte-Nieto G., Ramialison M., Adam A. A. S., Wu B., Aharonov A., D'Uva G., Bourke L. M., Pitulescu M. E., Chen H., Luis de la Pompa J., Shou W., Adams R. H., Harten S. K., Tzahor E., Zhou B. & Harvey R. P. (). Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.  Nature. , 557 (7705):439-+.
  • D'Uva G., Aharonov A., Lauriola M., Kain D., Yahalom-Ronen Y., Carvalho S., Weisinger K., Bassat E., Rajchman D., Yifa O., Lysenko M., Konfino T., Hegesh J., Brenner O., Neeman M., Yarden Y., Leor J., Sarig R., Harvey R. P. & Tzahor E. (). ERBB2 triggers mammalian heart regeneration by promoting cardiorlyocyte dedifferentiation and proliferation.  Nature Cell Biology. , 17 (5):627-U207.
  • Tzahor E. & Poss K. D. (). Cardiac regeneration strategies: Staying young at heart.  Science. , 356 (6342):1035-1039.
  • Diogo R., Kelly R. G., Christiaen L., Levine M., Ziermann J. M., Molnar J. L., Noden D. M. & Tzahor E. (). A new heart for a new head in vertebrate cardiopharyngeal evolution.  Nature. , 520 (7548):466-473.
  • Wasserstrom A., Adar R., Shefer G., Frumkin D., Itzkovitz S., Stern T., Shur I., Zangi L., Kaplan S., Harmelin A., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (). Reconstruction of Cell Lineage Trees in Mice.  PLoS One. , 3 (4).
  • Yifa O., Weisinger K., Bassat E., Li H., Kain D., Barr H., Kozer N., Genzelinakh A., Rajchman D., Eigler T., Umansky K. B., Lendengolts D., Brener O., Bursac N. & Tzahor E. (). The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.  JCI insight. , 4 (22).
  • Bassat E., Mutlak Y. E., Genzelinakh A., Shadrin I. Y., Umansky K., Yifa O., Kain D., Rajchman D., Leach J., Bassat D. R., Udi Y., Sarig R., Sagi I., Martin J. F., Bursac N., Cohen S. & Tzahor E. (). The extracellular matrix protein agrin promotes heart regeneration in mice.  Nature. , 547 (7662):179-+.
  • Zamir L., Singh R., Nathan E., Patrick R., Yifa O., Yahalom-Ronen Y., Arraf A. A., Schultheiss T. M., Suo S., Han J., Peng G., Jing N., Wang Y., Palpant N., Tam P. P., Harvey R. P. & Tzahor E. (). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.  eLife. , .
  • Rinon A., Molchadsky A., Nathan E., Yovel G., Rotter V., Sarig R. & Tzahor E. (). p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.  Development. , 138 (9):1827-1838.
  • Michailovici I., Eigler T. & Tzahor E. (). Craniofacial Muscle Development.  . , :3-30.
  • Rinon A., Lazar S., Marshall H., Buechmann-Moller S., Neufeld A., Elhanany-Tamir H., Taketo M. M., Sommer L., Krumlauf R. & Tzahor E. (). Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.  Development. , 134 (17):3065-3075.
  • Honkoop H., de Bakker D. E. M., Aharonov A., Kruse F., Shakked A., Nguyen P. D., de Heus C., Garric L., Muraro M. J., Shoffner A., Tessadori F., Peterson J. C., Noort W., Bertozzi A., Weidinger G., Posthuma G., Grun D., van der Laarse W. J., Klumperman J., Jaspers R. T., Poss K. D., van Oudenaarden A., Tzahor E. & Bakkers J. (). Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.  eLife. , 8 .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .
  • (). .  . , .