Tzahor Lab

  • Tzahor, E; Poss, K (2017). Cardiac regeneration strategies: Staying young at heart..  SCIENCE. 2017, 356 (6342):1035-1039.
  • Bassat, E; Mutlak, YE; Genzelinakh, A; Shadrin, IY; Baruch, KU; Yifa, O; Kain, D; Rajchman, D; Leach, J; Bassat, RD; Udi, Y; Sarig, R; Sagi, I; Martin, JF; Bursac, N; Cohen, S; Tzahor, E; (2017). The extracellular matrix protein agrin promotes heart regeneration in mice.  NATURE . 2017, 547 :179–184 .
  • Leinonen, JV; Korkus-Emanuelov, A; Wolf, Y; Milgrom-Hoffman, M; Lichtstein, D; Hoss, S; Lotan, C; Tzahor, E; Jung, S; Beeri, R (2016). Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45-stem cell-like phenotype.  INTERNATIONAL JOURNAL OF CARDIOLOGY. 2016, 209 :296-306.
  • Buzaglo-Azriel, L; Kuperman, Y; Tsoory, M; Zaltsman, Y; Shachnai, L; Zaidman, SL; Bassat, E; Michailovici, I; Sarver, A; Tzahor, E; Haran, M; Vernochet, C; Gross, A (2016). Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.  CELL REPORTS. 2016, 14 :1602-1610.
  • Aghajanian, H; Cho, YK; Manderfield, LJ; Herling, MR; Gupta, M; Ho, VC; Li, L; Degenhardt, K; Aharonov, A; Tzahor, E; Epstein, JA (2016). Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor.  NATURE COMMUNICATIONS. 2016, 7 .
  • Yahalom-Ronen, Y; Rajchman, D; Sarig, R; Geiger, B; Tzahor, E (2015). Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion..  eLife. 2015, 4 .
  • Tzahor, E (2015). Cardiac and craniofacial development and regeneration.  FASEB JOURNAL. 2015, 29 .
  • Michailovici, I; Eigler, T; Tzahor, E (2015). Craniofacial Muscle Development.  CRANIOFACIAL DEVELOPMENT. 2015, 115 :3-30.
  • D'Uva, G; Aharonov, A; Lauriola, M; Kain, D; Yahalom-Ronen, Y; Carvalho, S; Weisinger, K; Bassat, E; Rajchman, D; Yifa, O; Lysenko, M; Konfino, T; Hegesh, J; Brenner, O; Neeman, M; Yarden, Y; Leor, J; Sarig, R; Harvey, RP; Tzahor, E (2015). ERBB2 triggers mammalian heart regeneration by promoting cardiorlyocyte dedifferentiation and proliferation.  NATURE CELL BIOLOGY. 2015, 17 :627-U207.
  • Diogo, R; Kelly, RG; Christiaen, L; Levine, M; Ziermann, JM; Molnar, JL; Noden, DM; Tzahor, E (2015). A new heart for a new head in vertebrate cardiopharyngeal evolution.  NATURE. 2015, 520 :466-473.
  • D'Uva, G; Tzahor, E (2015). The key roles of ERBB2 in cardiac regeneration.  CELL CYCLE. 2015, 14 :2383-2384.
  • Michailovici, I; Harrington, HA; Azogui, HH; Yahalom-Ronen, Y; Plotnikov, A; Ching, S; Stumpf, MPH; Klein, OD; Seger, R; Tzahor, E (2014). Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.  Development. 2014, 141 :2611-2620.
  • Milgrom-Hoffman, M; Michailovici, I; Ferrara, N; Zelzer, E; Tzahor, E (2014). Endothelial cells regulate neural crest and second heart field morphogenesis.  BIOLOGY OPEN. 2014, 3 :679-688.
  • Leinonen, J; Korkus-Emanuelov, A; Milgrom-Hoffman, M; Hoss, S; Lotan, C; Tzahor, E; Beeri, R (2013). Cardiac progenitor cells from the left atrial appendage may originate from a resident non-hematopoietic myeloid progenitor population.  European Heart Journal. 2013, 34 :280.
  • Vandoorne, K; Vandsburger, MH; Raz, T; Shalev, M; Weisinger, K; Biton, I; Brumfeld, V; Raanan, C; Nevo, N; Eilam, R; Hemmings, BA; Tzahor, E; Harmelin, A; Gepstein, L; Neeman, M (2013). Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction.  Circulation-Cardiovascular Imaging. 2013, 6 :992-1000.
  • Harel, I; Maezawa, Y; Avraham, R; Rinon, A; Ma, HY; Cross, JW; Leviatan, N; Hegesh, J; Roy, A; Jacob-Hirsch, J; Rechavi, G; Carvajal, J; Tole, S; Kioussi, C; Quaggin, S; Tzahor, E (2012). Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 2012, 109 :18839-18844.
  • Gruenbaum-Cohen, Y; Harel, I; Umansky, KB; Tzahor, E; Snapper, SB; Shilo, BZ; Schejter, ED (2012). The actin regulator N-WASp is required for muscle-cell fusion in mice.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 2012, 109 :11211-11216.
  • Milgrom-Hoffman, M; Harrelson, Z; Ferrara, N; Zelzer, E; Evans, SM; Tzahor, E (2011). The heart endocardium is derived from vascular endothelial progenitors.  Development. 2011, 138 :4777-4787.
  • Rinon, A; Molchadsky, A; Nathan, E; Yovel, G; Rotter, V; Sarig, R; Tzahor, E (2011). p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.  Development. 2011, 138 :1827-1838.
  • Tzahor, E; Evans, SM (2011). Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis.  Cardiovascular Research. 2011, 91 :196-202.
  • Sarig, R; Tzahor, E (2011). p53 and epithelial-mesenchymal transition A linking thread between embryogenesis and cancer.  Cell Cycle. 2011, 10 :3036-3037.
  • Theis, S; Patel, K; Valasek, P; Otto, A; Pu, Q; Harel, I; Tzahor, E; Tajbakhsh, S; Christ, B; Huang, RJ (2010). The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature.  Development. 2010, 137 :2961-2971.
  • Tirosh-Finkel, L; Zeisel, A; Brodt-Ivenshitz, M; Shamai, A; Yao, Z; Seger, R; Domany, E; Tzahor, E (2010). BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.  Development. 2010, 137 :2989-3000.
  • Harel, I; Nathan, E; Tirosh-Finkel, L; Zigdon, H; Guimaraes-Camboa, N; Evans, SM; Tzahor, E (2009). Distinct Origins and Genetic Programs of Head Muscle Satellite Cells.  Developmental Cell. 2009, 16 :822-832.
  • Ben-Shoshan, J; Maysel-Auslender, S; Luboshits, G; Barshack, I; Polak-Charcon, S; Tzahor, E; Keren, G; George, J (2009). Hypoxia-Inducible Factor-1 alpha and-2 alpha Additively Promote Endothelial Vasculogenic Properties.  Journal Of Vascular Research. 2009, 46 :299-310.
  • Kang, J; Nathan, E; Xu, SM; Tzahor, E; Black, BL (2009). Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm.  Developmental Biology. 2009, 334 :513-522.
  • Nathan, E; Tzahor, E (2009). sFRPs: a declaration of (Wnt) independence.  Nature Cell Biology. 2009, 11 :13-14.
  • Rinon, A; Nathan, E; Tzahor, E (2009). p53 involvement in early cranial neural crest development in the chick.  Developmental Biology. 2009, 331 :430.
  • Tzahor, E (2009). Heart and craniofacial muscle development: A new developmental theme of distinct myogenic fields.  Developmental Biology. 2009, 327 :273-279.
  • Wasserstrom, A; Frumkin, D; Adar, R; Itzkovitz, S; Stern, T; Kaplan, S; Shefer, G; Shur, I; Zangi, L; Reizel, Y; Harmelin, A; Dor, Y; Dekel, N; Reisner, Y; Benayahu, D; Tzahor, E; Segal, E; Shapiro, E (2008). Estimating cell depth from somatic mutations.  Plos Computational Biology. 2008, 4 .
  • Ben-Shoshan, J; Schwartz, S; Luboshits, G; Maysel-Auslender, S; Barzelay, A; Polak-Charcon, S; Barshack, I; Tzahor, E; Barak, A; Levkovitch-Verbin, H; Keren, G; George, J (2008). Constitutive expression of HIF-1 alpha and HIF-2 alpha in bone marrow stromal cells differentially promote their pro-angiogenic properties.  Human Gene Therapy. 2008, 19 :1180.
  • Ben-Shoshan, J; Maysel-Auslender, S; Luboshits, G; Barshack, I; Polak-Charcon, S; Tzahor, E; Keren, G; George, J (2008). Hypoxia inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha additively promote endothelial vasculogenic properties.  Human Gene Therapy. 2008, 19 :1111.
  • Ben-Shoshan, J; Schwartz, S; Luboshits, G; Maysel-Auslender, S; Barzelay, A; Polak-Charcon, S; Tzahor, E; Barshack, I; Barak, A; Levkovitch-Verbin, H; Keren, G; George, J (2008). Constitutive Expression of HIF-1 alpha and HIF-2 alpha in Bone Marrow Stromal Cells Differentially Promotes Their Proangiogenic Properties.  Stem Cells. 2008, 26 :2634-2643.
  • Klaus, A; Tzahor, E; Birchmeier, W (2008). Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.  European Journal Of Cell Biology. 2008, 87 :435.
  • Nathan, E; Monovich, A; Tirosh-Finkel, L; Harrelson, Z; Rousso, T; Rinon, A; Harel, I; Evans, SM; Tzahor, E (2008). The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development.  Development. 2008, 135 :647-657.
  • Wasserstrom, A; Adar, R; Shefer, G; Frumkin, D; Itzkovitz, S; Stern, T; Shur, I; Zangi, L; Kaplan, S; Harmelin, A; Reisner, Y; Benayahu, D; Tzahor, E; Segal, E; Shapiro, E (2008). Reconstruction of Cell Lineage Trees in Mice.  Plos One. 2008, 3 .
  • Molchadsky, A; Shats, I; Goldfinger, N; Pevsner-Fischer, M; Olson, M; Rinon, A; Tzahor, E; Lozano, G; Zipori, D; Sarig, R; Rotter, V (2008). p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner.  Plos One. 2008, 3 .
  • Rinon, A; Lazar, S; Marshall, H; Buchmann-Moller, S; Neufeld, A; Elhanany-Tamir, H; Taketo, MM; Sommer, L; Krumlauf, R; Tzahor, E (2007). Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.  Development. 2007, 134 :3065-3075.
  • Tzahor, E (2007). The contribution of second heart field cells to the jaw muscle reveals the multipotential nature of the cardio-craniofacial mesoderm.  Circulation Research. 2007, 101 :E69.
  • Tzahor, E (2007). Wnt/beta-catenin signaling and cardiogenesis: Timing does matter.  Developmental Cell. 2007, 13 :10-13.
  • Tirosh-Finkel, L; Elhanany, H; Rinon, A; Tzahor, E (2006). Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract.  Development. 2006, 133 :1943-1953.