The Elson Group
We are interested how cell signaling affects function in the bone system, focusing primarily on osteoclasts, the cells that degrade bone. This issue is highly relevant to undersdtanding the basic biology of bone, in normal health and development as well as in major diseases, such as osteoporosis, osteopetrosis, and cancer-related bone loss. Our studies include protein tyrosine kinases and phosphatases as well as other molecules, and combine studies at the molecular, cellular, and whole-animal levels. We use cutting edge methdologies such as production of genetically-modified mice by CRISPR, and transcriptomic and proteomic profiling of relevant cells. Our goal is to understand the basic biology of these systems and to contribute towards developing treatments for diseases that affect them.