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If you require further information, please contact Chaya Moykopf (4048)

Dr Silberstein did his MD studies in Russia. He later trained in London as an Internist and Hematologist and completed a PhD in molecular hematopoiesis with Dr. Tony Green at the University of Cambridge prior to joining the laboratory of Dr David Scadden at Massachusetts General Hospital. In collaboration with the laboratory of Dr Charles Lin, he developed a novel experimental platform - proximity-based single cell analysis - which enables molecular characterization of normal hematopoietic microenvironments in-vivo at the single cell level based on micro- anatomical relationship between transplanted hematopoietic stem and progenitor cells (HSPC) and putative bone marrow stromal niche cells, and demonstrated the power of this approach by identifying several novel niche-derived regulators of stem cell quiescence. In the future, he would like to apply this approach to studies of the microenvironment in hematological malignancies in order to gain further insights into non cell-autonomous mechanisms of chemoresistance, as well as to extend his current work by investigating the relationship between stem cell quiescence and self-renewal in the context of acquired bone marrow failure syndromes and myelodysplasia.