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April 27, 2015
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Date:26SundayApril 201529WednesdayApril 2015Conference
Cortical Development in Health and Disease
More information Time 08:00 - 18:00Location David Lopatie Conference Centre
Kimmel AuditoriumChairperson Orly ReinerHomepage Contact -
Date:26SundayApril 2015Lecture
Biological Molecules Search for Chemistry
More information Time 12:00 - 13:00Location Dolfi and Lola Ebner AuditoriumLecturer Prof. Koby Levy
Department of Structural BiologyOrganizer Communications and Spokesperson DepartmentContact -
Date:26SundayApril 2015Lecture
The missing Lincs: Elucidating the roles of Cytomegalovirus Long Intergenic Non-Coding RNAs in viral lytic infection
More information Time 13:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Sharon Karniely
Noam Stern-Ginossar's group, Dept. of Molecular Genetics, WISOrganizer Life SciencesContact -
Date:27MondayApril 2015Colloquia
Pearlman Lecture - "Exploring Complex Chemical Systems"
More information Time 11:00 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Leroy (Lee) Cronin
School of Chemistry, University of GlasgowOrganizer Faculty of ChemistryContact Details Show full text description of How do high nuclearity inorganic and supramolecular assembli...» How do high nuclearity inorganic and supramolecular assemblies form? Can understanding the minimal information content of the structures help us understand their assembly? Is there a general route to explore the mechanism and how can one given compound dominate from a combinatorial explosion of possibilities? In our current work we are using new approaches to probability theory and template design to explore the possibility of using high probability templates to assemble low probability structures with 1000s of atoms in a single molecule. Take the example of a recent molecule discovered in our laboratory: A palladium oxometalate {Pd84}-ring cluster 3.3 nm in diameter; [Pd84O42(OAc)28(PO4)42]70- ({Pd84} ≡ {Pd12}7) which is formed in water just by mixing two reagents at room temperature and can be observed in solution within a few days mixing and crystallised with a week, see Figure 1. The key question is how could a ring as large as the {Pd84} spontaneously form and crystallize within the period of days. Indeed the state space for the molecule, just considering the unique arrangements of distinct 84 Pd atoms, ignoring symmetry, gives an upper limit on the combinatorial space of 84! = 3.3 × 10126. It is therefore perhaps safe to assume that the structure therefore did not ‘spontaneously’ form by random chance, but a series of templating events, combined with the correct kinetics, allowed this cluster to be selected from the vast envelope of possible structures available in solution. In this lecture I will propose a new theory that may explain the mechanism of self-assembly of gigantic systems, as well as an approach to understand and use the information content of complex molecular structures. -
Date:27MondayApril 2015Lecture
Chirality and Polarity: Two Mechanisms for Microstructure Formation in Soft Materials
More information Time 14:15Location Edna and K.B. Weissman Building of Physical Sciences
Room ALecturer Jonathan Selinger
Kent State UniversityOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about From liquid crystals to biological membranes, many soft mate...» From liquid crystals to biological membranes, many soft materials exhibit order in the molecular orientation. This order may be uniform across the material, or it may have some systematic modulation. In this talk, we survey mechanisms for the formation of modulated structures. Many of these structures arise from chirality (left-right asymmetry), which induces a favored twist. On macroscopic scale, this favored twist leads to cholesteric liquid crystals (with helical modulation), blue phases (with cubic lattices of double twist), and twisted membranes. We point out that related structures can arise from polarity (vector asymmetry), which induces a favored splay or bend. We compare and contrast polar structures with chiral structures, and show how each can be observed in experiments.
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Date:28TuesdayApril 2015Lecture
TBA
More information Time 10:30Location Neve ShalomLecturer BARTUMEU FIOL
UNIVERSITY OF BARCELONAOrganizer Department of Particle Physics and Astrophysics
High Energy Theory Joint SeminarContact Details Show full text description of 10:20 Gathering and coffee...» 10:20 Gathering and coffee -
Date:28TuesdayApril 2015Lecture
Challenges in carotenoid biosynthesis research: From metabolism to genetic regulation
More information Time 11:15Location Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Prof. Joseph Hirschberg
Department of Genetics, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, JerusalemOrganizer Department of Plant and Environmental SciencesContact -
Date:28TuesdayApril 2015Lecture
NELSON BRAGA
More information Time 12:00Location Neve ShalomLecturer NELSON BRAGA
FEDERAL UNIVERSITY OF RIO DE JANERIO, BRAZILOrganizer Department of Particle Physics and Astrophysics
High Energy Theory Joint SeminarContact Abstract Show full text abstract about It is by now well known that the AdS/CFT duality provides an...» It is by now well known that the AdS/CFT duality provides an interesting way of calculating anomalous dimensions at high spin, for a gauge theory at strong coupling. A high spin operator, made of adjoint fields, is represented by (or dual to) a rotating open string in anti-de Sitter space. The anomalous dimension shows up, in the string side of the correspondence, simply as the difference between string energy and spin. On the other hand it is also know that it is possible to introduce matter degrees of freedom - fields in the fundamental representation of the gauge group - in the AdS/CFT duality by introducing probe (flavour) branes. This approach leads to a nice description of meson states. So, a natural question to be asked is : can one calculate the anomalous dimension for operators in the fundamental representation, like a quark anti-quark, using AdS/CFT? This question will be the main issue of this seminar. We will see that the presence of an energy scale makes it a non trivial task the identification of a quantity representing, in the string side, the dimension of the gauge theory operator. Serching for the solution to this problem, we found a new entry in the dictionary of AdS/CFT: the anomalous dimension at high spin is proportional to the string proper length. Also, we found strong indications that, in the case of a non conformal duality, the operator properties are obtained from measurements made by a local observer (not sensible to energy scales) in the anti-de Sitter space, while the description of the states comes from a coordinate time observer. (reference: JHEP 1408, 104 (2014) at ArXiv:1405.7388) -
Date:28TuesdayApril 2015Lecture
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
More information Time 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Amit Zeisel
Division of Molecular Neurobiology, Dept of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, SwedenOrganizer Department of Brain SciencesContact Abstract Show full text abstract about The mammalian cerebral cortex supports cognitive functions s...» The mammalian cerebral cortex supports cognitive functions such as sensorimotor integration, memory, and social behaviors. Normal brain function relies on a diverse set of differentiated cell types, including neurons, glia, and vasculature. Here, we have used large-scale single-cell RNA sequencing (RNA-seq) to classify cells in the mouse somatosensory cortex and hippocampal CA1 region. We found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex. We identified numerous marker genes, which allowed alignment with known cell types, morphology, and location. -
Date:28TuesdayApril 2015Lecture
New Insights into the Transport Mechanism of the Neurotransmitter:Sodium Symporter Family
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Dr. Lina Malinauskaite
University of OxfordOrganizer Department of Chemical and Structural BiologyContact -
Date:28TuesdayApril 2015Cultural Events
Music at noon - Beatles tribute concert
More information Time 16:30 - 17:30Location Michael and Anna Wix AuditoriumContact Details Show full text description of Magical mystery band ...» Magical mystery band -
Date:29WednesdayApril 2015Lecture
Cell competition and Tumorigenesis
More information Time 10:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Gines Morata
Centro de Biología Molecular, CSIC-UAM, Universidad Autónoma de Madrid, SpainOrganizer Life SciencesContact -
Date:29WednesdayApril 2015Lecture
Turbulent Magnetic Field Amplification in Young Galaxies
More information Time 10:15 - 11:15Location Dannie N. Heineman Laboratory
Benoziyo Center for Astrophysics Seminar RoomLecturer Jennifer SchoberOrganizer Nella and Leon Benoziyo Center for AstrophysicsContact Abstract Show full text abstract about Magnetic fields play an important role in present-day galaxi...» Magnetic fields play an important role in present-day galaxies, for instance by influencing the star formation process. In models of young galaxies magnetic fields are usually not considered as they were assumed not to be dynamical important at high redshifts. In the presence of turbulence, however, the small-scale or turbulent dynamo can amplify weak magnetic seed fields by randomly stretching, twisting, and folding the field lines. The details of this process depend on the nature of turbulence, i.e. on the hydrodynamic and magnetic Reynolds numbers, and on the compressibility of the gas. In my talk I will introduce the basics of the turbulent dynamo and sketch our recent progress in describing it analytically and numerically. With a model of a typical young galaxy, where turbulence is driven by accretion and by supernova explosions, we determine the growth rate of the small-scale dynamo. We follow the exponential growth of the magnetic field on the viscous scale and also the subsequent transport of the magnetic energy to larger scales in the non-linear dynamo phase. Depending on the parameters of our model we find that equipartition of magnetic and kinetic energy, which corresponds to a field strength of roughly 10^(-5) G, is reached within 4 to 270 Myr. Thus, we expect that the turbulent dynamo can generate strong unordered fields already in very young galaxies which should be considered in future models of galaxy evolution. -
Date:29WednesdayApril 2015Colloquia
Special Chemistry Colloquium - "Bond, Chemical Bond"
More information Time 11:00 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Wilson Ho
Department of Physics and Astronomy, University of California/USAOrganizer Faculty of ChemistryContact -
Date:29WednesdayApril 2015Lecture
Deviation from identity of macroscopic properties of enantiomers –via water chiral preference. (Is water chiral?)
More information Time 14:00Location Perlman Chemical Sciences Building
Room 404Lecturer Dr. Yosef Scolnik
IYAR (Israel Institute for Advanced Research). Weizmann InstituteOrganizer Department of Molecular Chemistry and Materials ScienceContact Details Show full text description of Abstract Mirror-image asymmetric molecules, i.e. enantiomer...» Abstract
Mirror-image asymmetric molecules, i.e. enantiomers, are classically considered as chemically identical. Parity violation by the nuclear weak force induces a tiny energy difference between chiral isomers. Upon combination with a massive amplification process, expansion of this difference to a detectable macroscopic level may be achieved. In our studies we have prove this in several systems: Stearoylserine "quasi peptide" formation
Solubility and cluster formation of Alanine
Peptide Transitions to alpha –helix, shortly described hereafter and others
We compared structural and dynamic features of synthetic D- and L-polyglutamic acid and polylysine molecules each of 24 identical residues. The helix and random coil configurations and their transition were determined in this study by circular dichroism (CD) and isothermal titration calorimetry (ITC) in water and deuterium oxide. Distinct differences in structure and transition energies between the enantiomer polypeptides were detected by both CD and ITC when dissolved in water. Intriguingly, these differences were by and large abolished in deuterium oxide. Our findings suggest that deviation from physical invariance between the D- and L-polyamino acids is induced in part by different hydration in water which is eliminated in deuterium oxide. We suggest that ortho-H2O, which constitutes 75% of bulk H2O, has a preferential affinity to L-enantiomers.In other words, these studies, prove that indeed water has chiral preferences, Accordingly, Heavy Water has no chiral preference. Differential hydration of enantiomers may have played a role in the selection of L-amino acids by early forms of life.
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Date:29WednesdayApril 2015Lecture
Investigations of Implosions on the National Ignition Facility and discussion on the fusion yield from NIF
More information Time 15:15Location Edna and K.B. Weissman Building of Physical Sciences
Drory AuditoriumLecturer H. A. Scott, B. A. Hammel
Lawrence Livermore National Laboratory, Livermore, CA USAOrganizer Department of Particle Physics and Astrophysics
Plasma SeminarContact Details Show full text description of 15:00 – Light refreshments ...» 15:00 – Light refreshmentsAbstract Show full text abstract about Hydrodynamic instabilities are a primary impediment to the s...» Hydrodynamic instabilities are a primary impediment to the success of inertial confinement fusion (ICF), as they can severely degrade capsule performance [1]. Even with perfectly smooth capsules, the fill tube and capsule support provide perturbations that seed instabilities. Consequently,
understanding the evolution of perturbations and their effects on capsule performance is critical to the success of an ICF program. We discuss here the use of spectroscopic methods to diagnose the growth of hydrodynamic instabilities in imploding capsules. To understand capsule evolution and guide experimental design and interpretation, we use high-resolution HYDRA [2] simulations, postprocessed with Cretin [3], to simulate the spectra produced by capsules with specified initial perturbations. The
spectral simulations cover a wide range of conditions, from the multi-keV hot spot to the cold dense pusher.
For capsules with mid-Z dopants, the resulting X-ray spectrum can be analyzed to obtain information about the plasma conditions. An analysis of the dopant K-shell line emission has been used to estimate the mass of ablator material mixed into the hot spot [4]. Other spectral features can be used to provide information about the shell and further constrain the mixed mass. Other recent work has focused on using spectroscopy to quantitatively characterize the growth of perturbations. Capsules containing a small amount of argon in the gas produce sufficient emission before peak compression to provide radiographic information. The analysis of simulated spectra from capsules with machined perturbations demonstrates the possibility of extracting quantitative measures of perturbation growth.
References
[1] B.A. Hammel, et al, High Energy Density Physics, 6 (2010) 171.
[2] M. Marinak, et al, Phys. Plasmas 8 (2001) 2275.
[3] H.A. Scott, J Quant Spectrosc Radiat Transfer 71 (2001) 681.
[4] S.P. Regan et al. Phys. Rev, Lett. 111, 045001 (2013).
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Date:30ThursdayApril 2015Lecture
Nanobots: vesicle-templates assembly and applications of functional nanocapsules
More information Time 11:00 - 12:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof Eugene PinkhassikOrganizer Department of Molecular Chemistry and Materials Science
Special SeminarContact -
Date:30ThursdayApril 2015Lecture
'Cellular Origin and Functional Specialization of Tissue-resident Macrophages
More information Time 11:00 - 12:00Location Wolfson Building for Biological Research
AuditoriumLecturer Dr. Martin GuilliamsOrganizer Department of Systems ImmunologyContact -
Date:30ThursdayApril 2015Colloquia
Spotting the elusive Majorana under the microscope
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical Sciences
AuditoriumLecturer Ali Yazdani
PrincetonOrganizer Faculty of PhysicsContact Details Show full text description of 11:00 – coffee, tea, and more...» 11:00 – coffee, tea, and moreAbstract Show full text abstract about Topological superconductors are a distinct form of matter th...» Topological superconductors are a distinct form of matter that is predicted to host boundary Majorana fermions. These quasi-particles are the emergent condensed matter analogs of the putative elementary spin-1/2 particles originally proposed by Ettore Majorana with the intriguing property of being their own anti-particles. The search for Majorana quasi-particles in condensed matter systems is motivated in part by their potential use as topological qubits to perform fault-tolerant computation aided by their non-Abelian characteristics. Recently, we have proposed a new platform for the realization of Majorana fermions in condensed matter, based on chains of magnetic atoms on the surface of a superconductor. This platform lends itself to measurements with the scanning tunneling microscope (STM) that can be used to directly visualize the Majorana edge modes with both high energy and spatial resolution. Using rather unique STM instrumentation, we have succeeded in creating this platform and have observed the predicted signatures of localized Majorana edge modes. I will describe our Majorana platform, the experiments to date, and the outlook for further experiments on Majorana fermions in condensed matter systems. -
Date:30ThursdayApril 2015Lecture
Demystifying publication process at Nature Neuroscience
More information Time 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Min Cho, PhD, Senior Editor
Nature Neuroscience, Nature Publishing GroupOrganizer Department of Brain SciencesContact Details Show full text description of Speaker Biography: Min Cho, Ph.D. is a senior editor of Nat...» Speaker Biography:
Min Cho, Ph.D. is a senior editor of Nature Neuroscience where he manages the selection of original research manuscripts for publication. He received his doctorate degree in molecular biology and neuroscience from Princeton University where he investigated the molecular mechanisms underlying mammalian learning and memory processes. Using genetic engineering techniques in mice, he continued this work at Boston University before joining Nature Neuroscience in late 2007. Prior to his formal training, he coordinated a clinical and academic research program at the Cardiovascular Research Institute at the University of California, San Francisco on projects concerning genetic and molecular basis of cardiovascular diseases and lipid/cholesterol disorders. Prior to his non-neuroscience stint at UCSF, he received an undergraduate training in neuroscience from New York University, Center for Neural Science and received Bachelor of Science degree in 1997.
Abstract Show full text abstract about Scientific publishing is a natural part of the research ende...» Scientific publishing is a natural part of the research endeavor as it marks the end of one project and the start of another. Even so, the actual publication process spanning from manuscript submission, initial editorial evaluation, peer-review and the journal’s decision to publish a given manuscript may appear mysterious from the author’s perspective. In high profile, high impact journals where the published manuscripts are given exposure to the widest audience possible, the manuscript selection process can be especially arduous and competitive at times. This presentation will discuss the general issues and framework of publishing in high profile scientific journals, and will explain the editorial process and manuscript selection in Nature Neuroscience. Also included in the discussion are suggestions for efficient writing of scientific manuscripts and rebuttal letters, potential utility of presubmission inquiry, and transference of manuscripts and reviews from one journal to another in Nature Publishing Group’s portfolio and beyond.