October 01-31, 2016
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Date:09SundayOctober 2016Lecture
Neurodevelopmental disorders from basic science to novel therapeutic approaches
More information Time 10:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Yehezkel (Hezi) Sztainberg
Dept of Molecular and Human Genetics, Baylor College of Medicine and The Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston TXOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Neurodevelopmental disorders encompass a wide range of child...» Neurodevelopmental disorders encompass a wide range of childhood-onset medical conditions caused by different genetic mutations and interaction with environmental factors, affect ~2% of the population, and are a leading cause of intellectual disability and autism spectrum disorder. Evidence is accumulating that either loss or gain in dosage of proteins involved in cognitive and behavioural processes can be deleterious to the nervous system by causing a failure in the ability to maintain neuronal homeostasis. My studies are focused on the MECP2 duplication syndrome, one of the most common genomic rearrangements in males, characterized by autism, intellectual disability, motor dysfunction, anxiety, epilepsy, recurrent respiratory tract infections and early death. To determine whether the phenotypes of MECP2 duplication are reversible upon normalization of MeCP2 levels, I first generated and characterized a new mouse model that over-expresses a conditional allele of Mecp2 that could be deleted in the adult animal (Nature 2015). Upon normalization of MeCP2 in adult symptomatic mice, several phenotypes were rescued at the behavioral, physiological, and molecular levels. Next, I reduced MeCP2 using an antisense oligonucleotide (ASO) strategy, which has greater translational potential. I found that ASO treatment induced a broad phenotypic rescue in adult symptomatic MECP2 duplication mice, abolished abnormal EEG discharges and behavioral seizures, and corrected abnormal gene expression in the hippocampus. I am currently characterizing a novel “humanized” mouse model of MECP2 duplication syndrome that will precisely mimic the human condition by having two copies of human MECP2 and no copies of the mouse gene. These mice will serve as the ideal model for preclinical tests as they represent the closest construct validity model for the human condition. In addition, I am generating and characterizing neurons and cortical spheroids induced from patients’ derived pluripotent stem cells (iPSCs).
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Date:09SundayOctober 2016Lecture
Guest Seminar
More information Time 10:00 - 11:00Title Gene Therapy Approach for Cardiac Regeneration Using Modified mRNALocation Wolfson Building for Biological Research
AuditoriumLecturer Dr. Lior ZangiOrganizer Department of Systems Immunology
System BiologyContact -
Date:18TuesdayOctober 2016Lecture
RNA function in germ and stem cell biology
More information Time 10:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Prof. Dónal O'Carroll
Prof of Stem Cell Biology; Associate Director of MRC Centre for Regenerative Medicine The University of Edinburgh | MRCOrganizer Department of Molecular GeneticsContact Abstract Show full text abstract about The integrity of the genome transmitted to the next generati...» The integrity of the genome transmitted to the next generation intrinsically relies on cells of the germ line. Processes that ensure germ cell development, genomic stability, and reproductive lifespan are essential for the long-term success of a species. Dónal O'Carroll is interested in characterizing spermatogonial stem cell (SSC) populations that support fertility as well the regenerative capacity of the testis throughout adult life. In addition, O'Carroll lab tackles fundamental questions regarding the mammalian male germ line and heredity from an RNA perspective. Specifically, their research explores the contribution of non-coding RNA (miRNA, piRNA and lncRNA) and RNA modification pathways within germ cell development as well as testicular homeostasis/regeneration. The research objectives focus on the contribution of these emerging pathways on the underlying circuitry of self-renewal that underpins the SSC, as well as the coordination of the various cellular/differentiation processes of spermatogenesis. -
Date:20ThursdayOctober 2016Cultural Events
Karius & Bactus - Children's theater
More information Time 17:30 - 19:00Location Michael and Anna Wix AuditoriumContact -
Date:25TuesdayOctober 2016Lecture
The hidden layer of regulatory RNA in human development and cognition
More information Time 10:00 - 11:00Location Camelia Botnar Building
Botnar AuditoriumLecturer Prof. John Mattick
Executive Director of the Garvan Institute of Medical Research in SydneyOrganizer Department of Immunology and Regenerative BiologyContact -
Date:25TuesdayOctober 2016Lecture
SEMINAR CANCELLED: Coordination of auxin triggered leaf initiation by tomato LEAFLESS
More information Time 11:15Location Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Dr. Yossi Capua
Lab of Prof. Yuval Eshed, Dept. of Plant and Environmental SciencesOrganizer Department of Plant and Environmental SciencesContact Details Show full text description of THIS SEMINAR IS POSTPONED TO 2017...» THIS SEMINAR IS POSTPONED TO 2017 -
Date:26WednesdayOctober 2016Cultural Events
Moscow Circus - show for the whole family
More information Time 18:00 - 19:30Location Michael and Anna Wix AuditoriumContact -
Date:27ThursdayOctober 2016Conference
TRANSLATIONAL PLANT BIOLOGY
More information Time 08:00 - 08:00Location David Lopatie Conference Centre
AuditoriumChairperson Marvin EdelmanHomepage Contact -
Date:28FridayOctober 2016Cultural Events
Nathan's Friends - Music from all over the world
More information Time 20:00Location Michael and Anna Wix AuditoriumContact -
Date:30SundayOctober 2016Lecture
Multiexciton generation at the nanometer scale
More information Time 11:00Title Joint Chemical Physics and Materials and Interfaces SeminarLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Eran Rabani
Department of Chemistry University of California, BerkeleyOrganizer Department of Chemical and Biological PhysicsContact -
Date:30SundayOctober 2016Lecture
Mass Spectrometry of Atmospheric Aerosol: 1 nanometer to 1 micron
More information Time 11:00Location Sussman Family Building for Environmental Sciences
M. Magaritz Seminar RoomLecturer Douglas R. Worsnop
Aerodyne Research Harvard UniversityOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Despite much effort in the past decades, uncertainties in bo...» Despite much effort in the past decades, uncertainties in both climate impacts and health effects of atmospheric aerosols remain large. During the last ten years, aerosol mass spectrometry (AMS) has shown that sub-micron aerosol chemical composition is roughly 50:50 inorganic and organic worldwide, with secondary highly oxidized organics dominating the latter. Parallel application of ToFMS has provided the first observation of molecular cluster ions involved in atmospheric nucleation. Chemical ionization mass spectrometry (CIMS) has extended detection to neutral molecules and clusters, detecting highly oxidized multifunctional (HOM) organics in the gas phase. Ambient sampling and photochemical chamber experiments have resolved the interaction of H2SO4 and HOM in nanoparticle nucleation and growth. These results will be discussed in the context of their impact on atmospheric aerosols, clouds and climate. -
Date:31MondayOctober 201601TuesdayNovember 2016Conference
Student-Organized Conference on The Molecular Basis of Disease
More information Time 08:00 - 08:00Chairperson Maya OlshinaHomepage Contact -
Date:31MondayOctober 2016Colloquia
"Chirality and spin- from spintronics to water splitting"
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Ron Naaman
Department of Chemical Physics, WISOrganizer Faculty of ChemistryContact -
Date:31MondayOctober 2016Lecture
Promoting Repair in the Nervous System by Controlling Phagocytic Activity in Microglia and Macrophages
More information Time 11:00Location Wolfson Building for Biological Research
AuditoriumLecturer Prof. Shlomo RotshenkerOrganizer Department of Systems ImmunologyContact -
Date:31MondayOctober 2016Lecture
HARNESSING THE INNATE IMMUNE SYSTEM FOR IMMUNOTHERAPY
More information Time 14:00Location Raoul and Graziella de Picciotto Building for Scientific and Technical Support
LobbyLecturer Dr. NIr Ben Chetrit
Weil Cornell Medicine and New York Genome CenterOrganizer Department of Immunology and Regenerative BiologyContact