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June 01-30, 2017
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Date:01ThursdayJune 2017Lecture
Through the looking glass: The red queens race and other tales of immunovirology
More information Time 11:15Title Virology ClubLocation Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Leslie LobelOrganizer Department of Molecular GeneticsContact -
Date:04SundayJune 201705MondayJune 2017Conference
From Molecular beams to photosynthesis-Conference in honor of Ron Naaman
More information Time 08:00 - 08:00Location David Lopatie Conference Centre
Kimmel AuditoriumChairperson David CahenHomepage Contact -
Date:04SundayJune 2017Lecture
Metabolome analysis:Finding a Needle in a Haystack
More information Time 09:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Sergey MalitskyOrganizer Department of Life Sciences Core Facilities
Seminar -
Date:04SundayJune 2017Lecture
Deciphering the wastewater resistome and its potential impact on downstream environments
More information Time 11:00Location Sussman Family Building for Environmental Sciences
M. Magaritz Seminar RoomLecturer Eddie Cytryn, PhD
Institute of Soil, Water and Environmental Sciences Volcani Center, Agricultural Research OrganizationOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Wastewater treatment plants consolidate high loads of fecal ...» Wastewater treatment plants consolidate high loads of fecal and environmental bacteria and residual concentrations of antibiotics and consequentially, effluents released from these facilities may contribute to antibiotic resistance in downstream ecosystems. This is especially relevant in arid and semi-arid environments, where treated wastewater (TWW) is used for irrigation. The goal of this study was to pinpoint key antibiotic resistance genes (ARGs) in wastewater effluents and to determine the impact of TWW irrigation on antibiotic resistance in terrestrial and food-associated microbiomes. The diversity and abundance of ARGs was evaluated in wastewater effluents, in TWW -irrigated soils and in crops irrigated with TWW using state of the art molecular, genomic and bioinformatic analyses. Three specific methods were applied: (A) a novel high-throughput amplicon sequencing methodology that specifically targeted ARGs associated with integron gene cassettes in effluents from 12 wastewater treatment facilities across Europe and in pristine vs. wastewater effluent-saturated soil; (B) quantitative PCR that assessed the abundance of selected ARGs along freshwater- and TWW-irrigated, water-soil-crop continuum; and (C) comparative in-silico-based analyses of human gut, wastewater and soil metagenomes to determine specific associations between wastewater and soil resistomes. Our results reveal that wastewater effluents contain a diverse array of ARGs, and that specific ARGs and class 1 integrons (mobile genetic elements that often harbor ARGs) are profuse and strongly associated with wastewater effluents. In contrast we found that other ARGs that are ubiquitous to soil regardless of TWW irrigation suggesting that these elements are common in environmental microbiomes. Collectively, the study indicates the distribution of ARGs in the environment is highly complex and is impacted by both natural and anthropogenic factors, and that while the impact of wastewater-derived ARGs in TWW-irrigated soils is limited, there is evidence that plasmid- and integron-associated ARGs are disseminated to soil microbiomes.
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Date:04SundayJune 2017Lecture
Aggregation of a bacterial extracellular matrix protein
More information Time 11:00 - 12:00Location Perlman Chemical Sciences Building
Room 404Lecturer Dr. Liraz Chai
Institute of Chemistry, HUJIOrganizer Department of Molecular Chemistry and Materials Science
Soft Matter and BiomaterialsDetails Show full text description of Biofilms are groups of microbial cells that are encased in a...» Biofilms are groups of microbial cells that are encased in an extracellular matrix (ECM) composed mainly of proteins and polysaccharides. Biofilms can be beneficial, for example when protecting the roots of plants, but they are often detrimental to the host: their formation on medical devices and implants such as catheters, artificial hips, or contact lenses may lead to both acute and chronic infections. The ECM functions as an inter-cellular glue and it is also known to protect the cells from external toxins. The major proteinaceous component of the ECM forms fibrillar appendages that are ‘functional amyloids’. In contrast to amyloid proteins that are related with disease, functional amyloids are not considered harmful but rather, they have a functional role as they provide mechanical stability to biofilms. The formation of amyloid fibers has been extensively studied in the context of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. However, very little is known about the mechanisms of functional - amyloid - fiber formation. We use the ECM of the soil bacterium B. subtilis as a model organism for biofilm formation. Specifically, we study the processes that lead to the aggregation of the ECM protein, TasA. Here we describe our aggregation experiments in solution and at the surface of membranes. Understanding the properties of the ECM and the mechanisms that underlie its assembly may lead the way for antibiofilm drugs that target the extracellular matrix.
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Date:04SundayJune 2017Lecture
To be announced
More information Time 13:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Inna Averbukh
Naama Barkai's and Benny Shilo's groups, Dept. of Molecular Genetics, WISOrganizer Department of Molecular Genetics -
Date:04SundayJune 2017Lecture
RECYCLE THE BRAIN: Glutamine repeats (polyQ) shape cell recycling in health and neurodegeneration
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
Seminar RoomLecturer Dr. Avraham Ashkenazi
Cambridge Institute for Medical Research, University of CambridgeOrganizer Department of Immunology and Regenerative Biology , Department of Biomolecular SciencesContact -
Date:04SundayJune 2017Lecture
When Lithium Travels in Solid State Disorder
More information Time 15:00 - 16:00Location Perlman Chemical Sciences Building
Room 404Lecturer Prof. Jennifer Rupp
Dept. Materials Science, MITOrganizer Department of Molecular Chemistry and Materials ScienceDetails Show full text description of Next generation of energy storage and sensors may largely ...»
Next generation of energy storage and sensors may largely benefit from fast Li+ ceramic electrolyte conductors to allow for safe and efficient batteries and real-time monitoring anthropogenic CO2. Recently, Li-solid state conductors based on Li-garnet structures received attention due to their fast transfer properties and safe operation over a wide temperature range. Through this presentation basic theory and history of Li-garnets will first be introduced and critically reflected towards new device opportunities. Central to our research is the fundamental investigation of the electro-chemo-mechanic characteristics and design of disordered to crystallizing Li-garnet strucure types and their description. Understanding the fundamental transport in solid state and asking the provokative question: how do Li-amorphous to crystalline structures conduct? As well, as how can we alter their charge-and mass transport properties for solid electrolytes and towards electrodes is discussed. Here, we firstly present new Li-garnet battery architectures for which we discuss lithium titanate and antimony electrodes in their making, electrochemistry and assembly to full battery architectures1-4. Secondly, new insights on degree of glassy to crystalline Li-garnet thin films are presented based on model experiments of the structure types. Here, the thermodynamic stability range of maximum Li-conduction, phase, nucleation and growth of nanostructure is discussed using high resolution TEM studies, near order Raman investigations on the Li-bands and electrochemical transport measurements. The insights provide novel aspects of material structure designs for both the Li-garnet structures (bulk to films) and their interfaces to electrodes, which we either functionalize to store energy for next generation solid state batteries or ... make new applications such as Li-operated CO2 sensor tracker chips.
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Date:04SundayJune 2017Lecture
A key role of c-Abl tyrosine kinase in metabolic physiology
More information Time 15:00 - 16:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Prof. Yosef Shaul
Department of Molecular GeneticsOrganizer Life Sciences
Metabollic Research ForumContact -
Date:05MondayJune 2017Lecture
AMO Special Seminar
More information Time 11:00Title Photon Processing in the Frequency DomainLocation Edna and K.B. Weissman Building of Physical Sciences
Drory AuditoriumLecturer Prof. Alexander Gaeta
Columbia UniversityOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about Nonlinear optical processes play a central role in many quan...» Nonlinear optical processes play a central role in many quantum information devices. I will describe our recent work in which we explore the use of quantum frequency conversion based on four-wave mixing to process photons with high quantum efficiency without adding noise. I will describe how we use this conversion process to create a single-photon Ramsey interferometer, temporally magnify photon wavepackets, and perform frequency multiplexing to create a quasi-deterministic photon source. -
Date:06TuesdayJune 2017Lecture
"Mechanisms of bone surface sensing by osteoclasts"
More information Time 09:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Michal Shemesh
WIS Departments of Structural Biology and Molecular Cell BiologyOrganizer Department of Chemical and Structural BiologyDetails Show full text description of Ph.D. student of Prof. Lia Addadi and Prof. Benny Geiger...» Ph.D. student of Prof. Lia Addadi and Prof. Benny Geiger -
Date:06TuesdayJune 2017Lecture
Regulating the 20S proteasome degradation pathway
More information Time 10:00 - 10:30Location Wolfson Building for Biological Research
AuditoriumLecturer Dr. Maya Olshina
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about The protein degradation machinery in cells plays a critical ...» The protein degradation machinery in cells plays a critical role in the maintenance of homeostasis, preventing the accumulation of damaged or misfolded proteins and controlling the levels of regulatory proteins. The predominant degradation pathway involves the ubiquitin-dependent 26S proteasome, however recent evidence has identified an alternate ubiquitin-independent pathway involving only the 20S core particle of the proteasome. The regulatory mechanisms controlling its function are poorly understood, and only a small number of regulators have been identified. Using a combination of bioinformatics, structural and in vivo analyses, as well as native mass spectrometry techniques, new 20S proteasome regulatory proteins were identified, hinting towards an as yet undescribed regulatory network of the 20S proteasome. -
Date:06TuesdayJune 2017Lecture
Andor Dragonfly - High speed confocal imaging Platform
More information Time 10:30 - 11:30Location Max and Lillian Candiotty Building
Seminar RoomLecturer Dr. Bruno Combettes
Business Development Manager ANDOR TechnologyOrganizer Department of Life Sciences Core Facilities
Seminar -
Date:06TuesdayJune 2017Lecture
Computational Design of Novel Enzymes Guided By Evolutionary Data
More information Time 10:30 - 10:00Location Wolfson Building for Biological Research
AuditoriumLecturer Gideon Lapidoth
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about The ability to computationally design efficient, specific ...» The ability to computationally design efficient,
specific enzymes is a rigorous test of our understanding of the principles of catalysis and molecular recognition.
Successful designs have to date shown several limitations:
they only targeted simple reactions, involving two to three catalytic residues with low efficiencies and selectivities, and impaired stability. We developed a new algorithm using Rosetta to combine compatible backbone fragments from natural enzymes of the
same enzyme superfamily to generate novel conformations. The designs’ sequences are then optimized, guided by sequence conservation data to improve stability and expressibility. We used the algorithm to design novel TIM barrel fold enzymes belonging to the
GH10 family capable of hydrolyzing xylan, an abundant plant polysaccharide, with Kcat/Km values similar to those of natural xylanases. The designed enzyme conformations differ from one another and from any other known natural xylanase conformations and have
different substrate specificities.
The algorithm is completely automated and can be
applied to other enzymes of modular fold to efficiently and broadly explore the potential selectivities of the superfamily. -
Date:06TuesdayJune 2017Lecture
Processing of Chemical Signals by Enzymatic and Organic Reactions
More information Time 11:00 - 12:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Dr. Sergey Semenov
Dept. of Chemistry and Chemical Biology Harvard UniversityOrganizer Department of Molecular Chemistry and Materials Science -
Date:06TuesdayJune 2017Colloquia
Life Sciences Colloquium
More information Time 11:00 - 12:00Title A chemo-evolutionary basis for polypharmacologyLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Brian K. Shoichet
UCSFOrganizer Life SciencesHomepage Contact -
Date:06TuesdayJune 2017Lecture
Utilizing nework analysis to identify functions: from deep time evolution of oxidoreductases to virulence mechanisms of plant pathogens
More information Time 11:15Location Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Dr. Arik Harel
Department of Vegetable and Crop Science, Institute of Plant Sciences, Agricultural Research Organization (ARO), Volcani Center, Rishon LeZion.Organizer Department of Plant and Environmental SciencesDetails Show full text description of http://www.agri.gov.il/people/1127.aspx...» http://www.agri.gov.il/people/1127.aspx -
Date:06TuesdayJune 2017Lecture
MCB - Students seminar
More information Time 12:15Title TBALocation Wolfson Building for Biological Research
AuditoriumOrganizer Department of Molecular Cell Biology -
Date:06TuesdayJune 2017Lecture
Presynaptic dysfunction in Fragile X syndrome
More information Time 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Vitaly Klyachko
Dept of Biomedical Engineering, Dept of Cell Biology and Physiology Washington University School of MedicineOrganizer Department of Brain SciencesDetails Show full text description of Host: Dr. Ofer Yizhar ofer.yizhar@weizmann.ac.il tel: 6957 ...» Host: Dr. Ofer Yizhar ofer.yizhar@weizmann.ac.il tel: 6957
For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
Abstract Show full text abstract about I will discuss our efforts towards understanding synaptic an...» I will discuss our efforts towards understanding synaptic and circuit dysfunction in Fragile X syndrome, the most common heritable cause of intellectual disability and the leading genetic cause of autism. I will describe our studies identifying major presynaptic defects in excitability and neurotransmitter release in Fragile X and the role of ion channel dysregulation in these deficits. Finally, I will present evidence for a direct link between presynaptic dysregulation and specific Fragile X phenotypes in a patient. -
Date:06TuesdayJune 2017Lecture
"New Structure-activity Paradigms for Amyloids from Pathogenic Microbes"
More information Time 13:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Prof.Meytal Landau
TechnionOrganizer Department of Chemical and Structural BiologyContact