Research

Silencing of virulence genes of Entamoeba histolytica

One of Mirelman’s main scientific interests, which was supported during the 1980’s by the Rockefeller and McArthur Foundations Program on “ Neglected Parasitic Diseases “, was to investigate the virulence mechanisms of the human intestinal parasitic pathogen –Entamoeba histolytica which causes life threatening dysentery.

Therapy of Aspergillosis by conjugates of AB-Alliinase that produce Allicin

In the late 1980s, Mirelman participated in a Conference in Shanghai on Dysenteric Diseases and became intrigued by the long established Chinese Medical practice to use alcoholic extracts of freshly crushed Garlic cloves, to treat patients with intestinal pathogens.

Removal of Excess Brain Glutamate following Ischemic Stroke

Continuation of Research of the late Prof. Vivan Teichberg

In 2011, Prof. Vivian Teichberg , a close friend and colleague at the Institute, passed away. Mirelman had recently retired and had helped Teichberg’s lab during Teichberg’s long illness. Weizmann President asked Mirelman to help and continue the very promising scientific project of his deceased friend. The important objective of Teichberg was the development of a novel drug to significantly reduce the neurological damage following an ischemic cerebral stroke.