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November 2021

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Lecture
Brain-wide networks underlying behavior - Insights from functional ultrasound imaging
11/02/2021
08:19

Brain-wide networks underlying behavior - Insights from functional ultrasound imaging

Dr. Emilie Macé | Max Planck Institute of Neurobiology, Martinsried, Germany

Tue, Nov 02, 12:30 |

Functional ultrasound imaging (fUS) is an emerging neuroimaging tool capable of measuring brain-wide vascular signals linked to neuronal activity with a high spatial-temporal resolution (100 µm, 10 Hz) in real-time. This technology is portable, affordable and adaptable to many species, and has already found applications in areas ranging from basic research to the clinic. Focusing on fundamental neuroscience, I will outline some of the recent technical advancements of fUS, such as the capacity to image the entire rodent brain while manipulating specific neuronal circuits with optogenetics. I will exemplify how promising this imaging technique is for shedding new light on the brain-wide circuits underlying behavior, as fUS is one of the few methods that enables imaging of activity deep in the brain of behaving mice. Zoom link: https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09 Meeting ID: 954 0689 3197 Password: 750421
 
 
 
 
 
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Lecture
Firing Rate Homeostasis in Neural Circuits: From basic principles to malfunctions
11/09/2021
08:19

Firing Rate Homeostasis in Neural Circuits: From basic principles to malfunctions

Prof. Inna Slutsky | Head, Dept of Physiology and Pharmacology Sackler Faculty of Medicine, Tel Aviv University

Tue, Nov 09, 12:30 | Gerhard M.J. Schmidt Lecture Hall

Maintaining average activity level within a set-point range constitutes a fundamental property of central neural circuits. Accumulated evidence suggests that firing rate distributions and their means represent physiological variables regulated by homeostatic systems. Utilizing basic concepts of control theory, we developed a theoretical and experimental framework for identifying the core members of homeostatic machinery. I will describe an integrative approach to study the relationships between ongoing spiking activity of individual neurons and neuronal populations in local microcircuits, synaptic transmission and plasticity, sleep and memory functions. I will show our new data on a state-dependent regulation of firing rate set-points, their dysregulation at the presymptomatic stage of Alzheimer’s disease, and the role of mitochondria in these processes.
 
 
 
 
 
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Lecture
To be announced
11/23/2021
08:19

To be announced

Prof. Michal Irani | Dept of Computer Science and Applied Mathematics, WIS

Tue, Nov 23, 12:30 | Gerhard M.J. Schmidt Lecture Hall

 
 
 
 
 
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Lecture
To be announced
11/30/2021
08:19

To be announced

Catherine Dulac | Harvard

Tue, Nov 30, 14:00 |