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Gene X stress Interaction: Epigenetic Mechanisms

Engel M and Chen A.
The emerging role of mRNA methylation in normal and pathological behavior. Genes Brain Behav. 2017;e12428.

Schroeder M, Jakovcevski M, Polacheck T, Lebow M, Drori Y, Engel M, Ben-Dor S, Chen A.
A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype. Cell Metab. 25:1269-1281.

Volk N, Pape JC, Engel M, Zannas AS, Cattane N, Cattaneo A, Binder EB, Chen A.
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. Cell Rep. 17:1882-1891.

Elliott E, Manashirov S, Zwang R, Gil S, Tsoory M, Shemesh Y, Chen A.
Dnmt3a in the medial prefrontal cortex regulates anxiety-like behavior in adult mice. J Neurosci. 36:730-740.

Issler O and Chen A.
Determining the role of microRNAs in psychiatric disorders. Nat Rev Neurosci. 16:201-212. [20]

Volk N, Paul ED, Haramati S, Eitan C, Fields BK, Zwang R, Gil S, Lowry CA, Chen A.
MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1. J Neurosci. 34:15070-15082. [10]

Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A.
MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron 83:344-360. [75]

Haramati H, Navon I, Issler O, Ezra-Nevo G, Gil1 S, Zwang R Hornstein E, Chen A.
microRNA as repressors of stress induced anxiety: the case of amygdalar miR-34. J Neurosci. 31:14191-14203. [95]

Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A.
Resilience to social stress coincides with functional DNA methylation of the CRF gene in adult mice. Nat Neurosci. 13:1351-1353. [201]

Haramati S, Chapnik E, Sztainberg H, Eilam-Altstadter R, Zwang R, Gershoni N, McGlinn E, Heiser PW, Wills AM, Wirguin I, Rubin L, Misawa H, Tabin CJ, Brown R, Chen A, Hornstein E.
miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci USA 107:13111-13116. [151]

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