Stress Circuitry and Regulation

Ezra-Nevo G, Volk N, Ramot A, Kühne C, Tsoory M, Deussing JM, Chen A.
Inferior olive CRF plays a role in motor performance under challenging conditions. Transl. Psychiatry. 8:107.

Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM.
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 21(6):803-807.

Balsevich G, Häusl AS, Meyer CW, Karamihalev S, Feng X, Pöhlmann ML, Dournes C, Uribe-Marino A, Santarelli S, Labermaier C, Hafner K, Mao T, Breitsamer M, Theodoropoulou M, Namendorf C, Uhr M, Paez-Pereda M, Winter G, Hausch F, Chen A, Tschöp MH, Rein T, Gassen NC, Schmidt MV.
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. Nat Commun. 8(1):1725.

Dedic N, Chen A, Deussing JM.
The CRF family of neuropeptides and their receptors - mediators of the central stress response. Curr Mol Pharmacol. 11(1):4-31.

Ramot A, Jiang Z, Tian JB, Nahum T, Kuperman Y, Justice NJ, Chen A.
Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nat Neurosci. 20:385-388.

Henckens MJAG, Deussing JM, Chen A.
Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat Rev Neurosci. 17:636-651.

Henckens MJAG, Printz Y, Shamgar U, Lebow M, Drori Y, Kuehne C, Kolarz A, Deussing JM, Justice NJ, Yizhar O, Chen A.
The posterior bed nucleus of the stria terminalis critically contributes to stress recovery. Mol. Psychiatry 22:1691–1700.

Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Eliott E, Tabouy L, Ezra G, Adler ES, Ben-Efraim Y, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing JM, Schneidman E, Yizhar O, Chen A.
Ucn3–CRFR2 in the medial amygdala regulates complex social dynamics. Nat Neurosci. 19:1489-1496.

Kuperman Y, Weiss M, Dine J, Staikin K, Golani O, Ramot A, Nahum T, Kühne C, Shemesh Y, Wurst W, Harmelin A, Deussing JM, Eder M and Chen A.
CRFR1 in AgRP neurons modulates sympathetic nervous system activity to adapt to cold stress and fasting. Cell Metab. 23:1185-1199.

Lebow M and Chen A.
Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders. Mol. Psychiatry 21:450-463.