Stress Circuitry and Regulation

Chen NA, Jupp B, Sztainberg Y, Lebow M, Brown RM, Kim JH, Chen A, Lawrence AJ.
Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice. J Neurosci. 34:11560-11570. [5]

Greenman Y, Kuperman Y, Drori Y, Asa SL, Navon I, Forkosh O, Gil S, Stern N, Chen A.
Postnatal Ablation of POMC Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior. Mol Endocrinol. 27:1091-1102. [19]

Lucas M, Chen A, Richter-Levin G.
Hypothalamic corticotropin-releasing factor is centrally involved in learning under moderate stress. Neuropsychopharmacology 38:1825-1832.

Neufeld-Cohen A, Kelly PA, Paul ED, Carter RN, Skinner E, Olverman HJ, Vaughan JM, Issler O, Kuperman Y, Lowry CA, Vale WW, Seckl JR, Chen A, Jamieson PM.
Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge. Biol Psychiatry 72:437-447. [17]

Bale TL, Chen A.
Minireview: CRF and Wylie Vale: A Story of 41 Amino Acids and a Texan with Grit. Endocrinology 153:2556-2561. [11]

Lebow M, Neufeld-Cohen A, Kuperman Y, Gil S and Chen A.
Susceptibility to PTSD is mediated by CRF receptor type 2 levels in the bed nucleus of the stria terminalis. J Neurosci. 32:6906-6916. [33]

Regev R, Tsoory M, Gil S, Chen A.
Site-specific genetic manipulation of amygdala CRF reveals its imperative role in mediating behavioral response to challenge. Biol Psychiatry 71:317-326. [41]

Amir-Zilberstein L, Blechman J, Sztainberg Y, Norton WHJ, Reuveny A, Borodovsky N, Tahor M, Bonkowsky JL, Chen A, Levkowitz G.
Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress. Neuron 73:279-291. [28]

Sztainberg Y, Kuperman Y, Justice N, Chen A.
An anxiolytic role for CRF receptor type 1 in the globus pallidus. J Neurosci. 31:17416-17424. [21]

Regev L, Neufeld A, Tsoory M, Kuperman Y, Getselter D, Chen A.
Prolonged and site-specific over-expression of corticotropin releasing factor reveals differential role for extended amygdala nuclei in emotional regulation. Mol. Psychiatry 6:714-728.