The Department of Immunology and Regenerative Biology (IRB) currently comprises 17 research groups and a total of over 200 people. We are located on the Weizmann campus in the Candiotty, Britannia, and Wolfson buildings. 

The IRB’s research activities include a broad spectrum of basic and clinically relevant topics, ranging from fundamental aspects of immunology and cancer to tissue regeneration. Research areas include lymphatic and vascular biology, hematopoiesis, stem cell biology, cell differentiation, metabolism, intercellular communication, extracellular matrix remodeling, and the genetic and epigenetic mechanisms contributing to these processes. With a unique focus on immune cell development and function, we study a wide range of physiological and pathophysiological settings, including the host-pathogen interface, embryonic development, adult stem cells, inflammation, tissue regeneration post-infection and injury, and vascular and lymph angiogenesis. State-of-the-art approaches developed by our members include intra-vital and whole organ 3D imaging, multiplexed ex vivo staining, conditional gene manipulation in animal models, organoid research, advanced genomics and proteomics, and human-derived samples and their bioinformatic analysis at the single cell level. By combining preclinical mouse models and patient samples, we also develop novel therapeutic strategies for tissue regeneration, cancer, immunotherapies and vaccinations.