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  • December 31, 2025

    Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice

    Lanton T., Eidelshtein D., Rachmilewitz J., Abramovitch R., Pappo O., Udi S., Baraghithy S., Tam J., Perles S., Williams E. , et al. , Elgavish S., Ruppo S., Benyamini H., Mor U., Elinav E., Schmidt-Arras D., Rehman A., Rosenstiel P., Giannou A., Huber S., Rose-John S., Galun E. & Axelrod J. H. Gastro Hep Advances | 2026
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  • November 03, 2025

    Women in STEM becoming independent: Put science and discovery ahead of your ego

    Devarajan P., Zappasodi R., Pishesha N., Weng J. H., Alexander K., Soto-Feliciano Y. & Kedmi R. The Journal of experimental medicine | 2025
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  • October 16, 2025

    High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer

    Koblan L. W., Yost K. E., Zheng P., Colgan W. N., Jones M. G., Yang D., Kumar A., Sandhu J., Schnell A., Sun D. , et al. , Ergen C., Saunders R. A., Zhuang X., Allen W. E., Yosef N. & Weissman J. S. Science | 2025
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  • October 13, 2025

    Deep generative modeling of sample-level heterogeneity in single-cell genomics

    Boyeau P., Hong J., Gayoso A., Kim M., McFaline-Figueroa J. L., Jordan M. I., Azizi E., Ergen C. & Yosef N. Nature Methods | 2025
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  • September 30, 2025

    ConvexML: Fast and Accurate Branch Length Estimation under Irreversible Mutation Models, Illustrated through Applications to CRISPR/Cas9-Based Lineage Tracing

    Prillo S., Ravoor A., Yosef N. & Song Y. S. Systematic Biology | 2025
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  • September 09, 2025

    Zelig Eshhar (1941-2025)

    Elinav E., Agemy L. & Friedmann-Morvinski D. Immunity | 2025
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  • September 08, 2025

    Scvi-hub: an actionable repository for model-driven single-cell analysis

    Ergen C., Pour Amiri V. V., Kim M., Kronfeld O., Streets A., Gayoso A. & Yosef N. Nature Methods | 2025
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  • September 04, 2025

    Viral effectors trigger innate immunity across the tree of life

    Barthes K., Rousset F. & Wein T. Philosophical Transactions of the Royal Society B: Biological Sciences | 2025
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  • August 31, 2025

    The immune receptor SLAMF5 regulates myeloid-cell mediated neuroinflammation in multiple sclerosis

    Bellassen L., David K., Lampert B., Sarusi-Portuguez A., Tsoory M., Lubliner J., Hornstein E., Osherov M., Milo R., Brenner O. , et al. , Becker-Herman S. & Shachar I. PLoS Biology | 2025
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  • August 28, 2025

    Septal LYVE1<sup>+</sup> macrophages control adipocyte stem cell adipogenic potential

    Yu X., Hu Y., Lim H. Y., Li Z., Jaitin D. A., Yang K., Kong W. T., Xu J., Bejarano D. A., Bied M. , et al. , Orliaguet L., Rengasamy G., Chow Z., Lee C. Z. W., Lum J., Tian J., Zhang X. M., Liu H., Tan S. W., Chen J., See P., Loh Y. H., Malleret B., Baig S., Yassin S. M., Toh S. A. E. S., Malissen B., Fu X., Kabashima K., Ng L. G., Blériot C., Liu Z., Sheng L., Zheng D. N., Qu J., Venteclef N., Su B., Amit I., Schlitzer A., Angeli V., Ginhoux F. & Chakarov S. Science | 2025
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  • August 21, 2025

    A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense

    Chang R. B., Toyoda H. C., Hobbs S. J., Hadary R., Richmond-Buccola D., Wein T., Osterman I., Burger N., Chouchani E. T., Sorek R. & Kranzusch P. J. Molecular Cell | 2025
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  • August 13, 2025

    Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

    Wells S. B., Rainbow D. B., Mark M., Szabo P. A., Ergen C., Caron D. P., Maceiras A. R., Rahmani E., Benuck E., Valiollah Pour Amiri V. , et al. , Chen D., Wagner A., Howlett S. K., Jarvis L. B., Ellis K. L., Kubota M., Matsumoto R., Mahbubani K., Saeb-Parsy K., Conde C. D., Richardson L., Xu C., Li S., Mamanova L., Bolt L., Wilk A., Teichmann S. A., Farber D. L., Sims P. A., Jones J. L. & Yosef N. Nature Immunology | 2025
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  • August 07, 2025

    Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs

    Yilmaz A., Gurhan G., Comar M. Y., Viukov S., Serfaty I., Gayretli M., Golenchenko S., Lokshtanov D., Ashouokhi S., Polanco A. , et al. , Berlad I., Ha T. W., Aguilera-Castrejon A., Tarazi S., Cohen M., Livnat N., Kumar K., Cholakkal H., Levy N., Yosef N., Khatib N., Kakun R. R., Kedmi M., Nachman I. B., Keren-Shaul H., Addadi Y., Orenbuch A. H., Korovin K., Molchadsky A., Hochedlinger K., Gafni O., Maza I., Novershtern N., Oldak B. & Hanna J. H. Cell Stem Cell | 2025
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  • July 14, 2025

    ZEB2 is a master switch controlling the tumor-associated macrophage program

    Sheban F., Phan T. S., Xie K., Ingelfinger F., Gur C., Shapir Itai Y., Blecher-Gonen R., Yu C., Avellino R., Chalan P. , et al. , Freitag K., Yofe I., Yutkin V., Boyeau P., Ergen C., Hong J., Mazuz K., Liu Y., Chen K., Dahan R., Kortylewski M., Yosef N., Weiner A. & Amit I. Cancer Cell | 2025
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  • July 08, 2025

    MEBOCOST maps metabolite-mediated intercellular communications using single-cell RNA-seq

    Zheng R., Zhang Y., Tsuji T., Gao X., Shamsi F., Wagner A., Yosef N., Cui K., Chen H., Kiebish M. A. , et al. , Aristizabal-Henao J. J., Narain N. R., Zhang L., Tseng Y. H. & Chen K. Nucleic Acids Research | 2025
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  • June 30, 2025

    Cdc48 plays a crucial role in redox homeostasis through dynamic reshaping of its interactome during early stationary phase

    Radzinski M., Oppenheim T., Yogev O., Levy A., Naomi M. B., Kacen A., Merbl Y., Ravid T. & Reichmann D. Redox Biology | 2025
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  • June 24, 2025

    The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

    Wang C., Wagner A., Fessler J., DeTomaso D., Zaghouani S., Zhou Y., Pierce K., Sobel R. A., Clish C., Yosef N. & Kuchroo V. K. Cell Reports | 2025
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  • June 04, 2025

    The gut microbiome connects nutrition and human health

    Sanz Y., Cryan J. F., Deschasaux-Tanguy M., Elinav E., Lambrecht R. & Veiga P. Nature Reviews Gastroenterology and Hepatology | 2025
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  • May 31, 2025

    Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance

    Tzemach R., Gur C., Phan T. S., David E., Zada M., Shmueli M. D., Mazuz K., Sheban F., Kurilovich A., Yehuda M. B. , et al. , Furer V., Polachek A., Gertel S., Snir N., Eviatar T., Nevo S., Merbl Y., Paran D., Wang S. Y., Elkayam O. & Amit I. Science immunology | 2025
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  • May 29, 2025

    The microbiome for clinicians

    Porcari S., Ng S. C., Zitvogel L., Sokol H., Weersma R. K., Elinav E., Gasbarrini A., Cammarota G., Tilg H. & Ianiro G. Cell | 2025
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  • May 27, 2025

    A coordinated cellular network regulates tolerance to food

    Rudnitsky A., Oh H., Margolin M., Dassa B., Shteinberg I., Stoler-Barak L., Shulman Z. & Kedmi R. Nature | 2025
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  • May 12, 2025

    Translation dysregulation in cancer as a source for targetable antigens

    Weller C., Bartok O., McGinnis C. S., Palashati H., Chang T. G., Malko D., Shmueli M. D., Nagao A., Hayoun D., Murayama A. , et al. , Sakaguchi Y., Poulis P., Khatib A., Erlanger Avigdor B., Gordon S., Cohen Shvefel S., Zemanek M. J., Nielsen M. M., Boura-Halfon S., Sagie S., Gumpert N., Yang W., Alexeev D., Kyriakidou P., Yao W., Zerbib M., Greenberg P., Benedek G., Litchfield K., Petrovich-Kopitman E., Nagler A., Oren R., Ben-Dor S., Levin Y., Pilpel Y., Rodnina M., Cox J., Merbl Y., Satpathy A. T., Carmi Y., Erhard F., Suzuki T., Buskirk A. R., Olweus J., Ruppin E., Schlosser A. & Samuels Y. Cancer Cell | 2025
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  • May 02, 2025

    T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses

    Sala E., Nelli M., Laura C., Di Lucia P., Beccaria C. G., Bono E. B., Mangione M., Marotta D., Sperto V., Grillo M. , et al. , Giustini L., Tosi F., Nie J., Kim D., Furiato G., Malpighi C., Consolo E., Becher B., David E., Cohen M., Giladi A., Amit I., Bosselut R., Guidotti L. G., Iannacone M. & Kuka M. EMBO Journal | 2025
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  • April 25, 2025

    Tree Reconstruction Guarantees from CRISPR-Cas9 Lineage Tracing Data Using Neighbor-Joining

    Prillo S., An K., Wu W., Kristanto I., Jones M. G., Song Y. S. & Yosef N. | 2025
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  • April 17, 2025

    Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution

    Wu Z., Wang Y., Chen W. w., Sun H., Chen X., Li X., Wang Z., Liang W., Wang S. Y., Luan X. , et al. , Li Y., Huang S., Liang Y., Zhang J., Chen Z. F., Wang G., Gao Y., Liu Y., Wang J., Liu Z., Shi P., Liu C., Lv L., Hou A., Wu C., Yao C., Hong Z., Dai J., Lu Z., Pan F., Chen X., Kettenmann H., Amit I., Speakman J. R., Chen Y., Ginhoux F., Cui R., Huang T. & Li H. Cell | 2025
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  • April 14, 2025

    Diet-microbiome interactions in cancer

    Abdeen S. K., Mastandrea I., Stinchcombe N., Puschhof J. & Elinav E. Cancer Cell | 2025
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  • March 31, 2025

    Clinical translation of microbiome research

    Gilbert J. A., Azad M. B., Bäckhed F., Blaser M. J., Byndloss M., Chiu C. Y., Chu H., Dugas L. R., Elinav E., Gibbons S. M. , et al. , Gilbert K. E., Henn M. R., Ishaq S. L., Ley R. E., Lynch S. V., Segal E., Spector T. D., Strandwitz P., Suez J., Tropini C., Whiteson K. & Knight R. Nature Medicine | 2025
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  • March 27, 2025

    Cell-autonomous innate immunity by proteasome-derived defence peptides

    Goldberg K., Lobov A., Antonello P., Shmueli M. D., Yakir I., Weizman T., Ulman A., Sheban D., Laser E., Kramer M. P. , et al. , Shteinvil R., Chen G., Ibraheem A., Sysoeva V., Fishbain-Yoskovitz V., Mohapatra G., Abramov A., Shimshi S., Ogneva K., Nandy M., Amidror S., Bootz-Maoz H., Kuo S. H., Dezorella N., Kacen A., Javitt A., Lau G. W., Yissachar N., Hayouka Z. & Merbl Y. Nature | 2025
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  • March 20, 2025

    CARD domains mediate anti-phage defence in bacterial gasdermin systems

    Wein T., Millman A., Lange K., Yirmiya E., Hadary R., Garb J., Melamed S., Amitai G., Dym O., Steinruecke F. , et al. , Hill A. B., Kranzusch P. J. & Sorek R. Nature | 2025
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  • March 06, 2025

    From big data and experimental models to clinical trials: Iterative strategies in microbiome research

    Turjeman S., Rozera T., Elinav E., Ianiro G. & Koren O. Cell | 2025
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  • March 01, 2025

    Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma

    Shvefel S. C., Pai J. A., Cao Y., Pal L. R., Bartok O., Levy R., Zemanek M. J., Weller C., Herzog E., Yao W. , et al. , Hiam-Galvez K. J., Cheng K., Yin Y., Du P. P., Raposo C. J., Gumpert N., Welti M., Martínez Gómez J. M., Sella F., Yakubovich E., Orr I., Ben-Dor S., Oren R., Fellus-Alyagor L., Golani O., Brenner O. J., Salame T. M., Zerbib M., Goliand I., Ranmar D., Savchenko I., Ketrarou N., Schäffer A. A., Dahan R., Levesque M. P., Ruppin E., Satpathy A. T. & Samuels Y. Cancer Discovery | 2025
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  • February 20, 2025

    Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease

    Valdés-Mas R., Leshem A., Zheng D., Cohen Y., Kern L., Zmora N., He Y., Katina C., Eliyahu-Miller S., Yosef-Hevroni T. , et al. , Richman L., Raykhel B., Allswang S., Better R., Shmueli M., Saftien A., Cullin N., Slamovitz F., Ciocan D., Ouyang K. S., Mor U., Dori-Bachash M., Molina S., Levin Y., Atarashi K., Jona G., Puschhof J., Harmelin A., Stettner N., Chen M., Suez J., Honda K., Lieb W., Bang C., Kori M., Maharshak N., Merbl Y., Shibolet O., Halpern Z., Shouval D. S., Shamir R., Franke A., Abdeen S. K., Shapiro H., Savidor A. & Elinav E. Cell | 2025
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  • February 10, 2025

    CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens

    Feigelson S. W., Dadosh T., Levi N., Sapoznikov A., Weinstein-Marom H., Blokon-Kogan D., Avraham Y., Unger T., Gross G., Dahan R. & Alon R. Frontiers in Immunology | 2025
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  • January 31, 2025

    Towards the Next Generation of Data-Driven Therapeutics Using Spatially Resolved Single-Cell Technologies and Generative AI

    Rodov A., Baniadam H., Zeiser R., Amit I., Yosef N., Wertheimer T. & Ingelfinger F. European Journal of Immunology | 2025
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  • January 31, 2025

    International consensus statement on microbiome testing in clinical practice

    Porcari S., Mullish B. H., Asnicar F., Ng S. C., Zhao L., Hansen R., O'Toole P. W., Raes J., Hold G., Putignani L. , et al. , Hvas C. L., Zeller G., Koren O., Tun H., Valles-Colomer M., Collado M. C., Fischer M., Allegretti J., Iqbal T., Chassaing B., Keller J., Baunwall S. M., Abreu M., Barbara G., Zhang F., Ponziani F. R., Costello S. P., Paramsothy S., Kao D., Kelly C., Kupcinskas J., Youngster I., Franceschi F., Khanna S., Vehreschild M., Link A., De Maio F., Pasolli E., Miguez A. B., Brigidi P., Posteraro B., Scaldaferri F., Stojanovic M. R., Megraud F., Malfertheiner P., Masucci L., Arumugam M., Kaakoush N., Segal E., Bajaj J., Leong R., Cryan J., Weersma R. K., Knight R., Guarner F., Shanahan F., Cani P. D., Elinav E., Sanguinetti M., de Vos W. M., El-Omar E., Dorè J., Marchesi J., Tilg H., Sokol H., Segata N., Cammarota G., Gasbarrini A. & Ianiro G. The Lancet Gastroenterology and Hepatology | 2025
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  • December 31, 2024

    Repertoires and Tumor-Reactivity Analysis of B Cell Immunoglobulins Derived from Cancer Patients

    Stoler-Barak L., Sarusi-Portuguez A. & Shulman Z. Methods in molecular biology (Clifton, N.J.) | 2025
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  • December 23, 2024

    Modeling cancermicrobiome interactions in vitro: A guide to co-culture platforms

    Moskal K., Khurana N., Siegert L., Lee Y. S., Clevers H., Elinav E. & Puschhof J. International Journal of Cancer | 2024
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  • December 20, 2024

    Protocol for assessing murine cell doublet engagement and subsequent effects using flow cytometry and imaging flow cytometry

    Shapir Itai Y., Porat Z. & Dahan R. STAR Protocols | 2024
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  • December 03, 2024

    Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner

    Jaber Y., Sarusi-Portuguez A., Netanely Y., Naamneh R., Yacoub S., Saar O., Drawshave N., Eli-Berchoer L., Shapiro H., Elinav E. , et al. , Wilensky A. & Hovav A. H. npj Biofilms and Microbiomes | 2024
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  • November 30, 2024

    Microbiome modulation of antigen presentation in tolerance and inflammation

    He Y., Mohapatra G., Asokan S., Nobs S. P. & Elinav E. Current Opinion in Immunology | 2024
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  • November 26, 2024

    CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer

    Rabani S., Gunes E. G., Gunes M., Pellegrino B., Lampert B., David K., Pillai R., Li A., Becker-Herman S., Rosen S. T. & Shachar I. Cell Reports | 2024
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  • November 20, 2024

    Consensus prediction of cell type labels in single-cell data with popV

    Ergen C., Xing G., Xu C., Kim M., Jayasuriya M., McGeever E., Oliveira Pisco A., Streets A. & Yosef N. Nature Genetics | 2024
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  • November 20, 2024

    The commitment of the human cell atlas to humanity

    Amit I., Ardlie K., Arzuaga F., Awandare G., Bader G., Bernier A., Carninci P., Donnelly S., Eils R., Forrest A. R. , et al. , Greely H. T., Guigo R., Hacohen N., Haniffa M., Kirby E. S., Knoppers B. M., Kriegstein A., Lein E. S., Linnarsson S., Majumder P. P., Merad M., Meyer K., Mhlanga M. M., Nolan G., Ntusi N. A., Peer D., Prabhakar S., Raven-Adams M., Regev A., Rozenblatt-Rosen O., Saha S., Saltzman A., Shalek A. K., Shin J. W., Stunnenberg H., Teichmann S. A., Tickle T., Villani A. C., Wells C., Wold B., Yang H. & Zhuang X. Nature Communications | 2024
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  • November 15, 2024

    VI-VS: calibrated identification of feature dependencies in single-cell multiomics

    Boyeau P., Bates S., Ergen C., Jordan M. I. & Yosef N. Genome Biology | 2024
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  • November 04, 2024

    SMARCA5-mediated chromatin remodeling is required for germinal center formation

    Stoler-Barak L., Schmiedel D., Sarusi-Portuguez A., Rogel A., Blecher-Gonen R., Haimon Z., Stopka T. & Shulman Z. Journal of Experimental Medicine | 2024
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  • November 01, 2024

    Fc-optimized checkpoint antibodies for cancer immunotherapy

    Dahan R. & Korman A. J. Trends in Molecular Medicine | 2024
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  • October 31, 2024

    CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells

    Pellegrino B., David K., Rabani S., Lampert B., Tran T., Doherty E., Piecychna M., Meza-Romero R., Leng L., Hershkovitz D. , et al. , Vandenbark A. A., Bucala R., Becker-Herman S. & Shachar I. PLoS Biology | 2024
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  • October 28, 2024

    Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy

    Prasad R., Rehman A., Rehman L., Darbaniyan F., Blumenberg V., Schubert M. L., Mor U., Zamir E., Schmidt S., Hayase T. , et al. , Chang C. C., McDaniel L., Flores I., Strati P., Nair R., Chihara D., Fayad L. E., Ahmed S., Iyer S. P., Wang M., Jain P., Nastoupil L. J., Westin J., Arora R., Turner J., Khawaja F., Wu R., Dennison J. B., Menges M., Hidalgo-Vargas M., Reid K., Davila M. L., Dreger P., Korell F., Schmitt A., Tanner M. R., Champlin R. E., Flowers C. R., Shpall E. J., Hanash S., Neelapu S. S., Schmitt M., Subklewe M., Francois-Fahrmann J., Stein-Thoeringer C. K., Elinav E., Jain M. D., Hayase E., Jenq R. R. & Saini N. Y. Blood | 2024
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  • October 17, 2024

    Engineered T cell therapy for central nervous system injury

    Gao W., Kim M. W., Dykstra T., Du S., Boskovic P., Lichti C. F., Ruiz-Cardozo M. A., Gu X., Weizman Shapira T., Rustenhoven J. , et al. , Molina C., Smirnov I., Merbl Y., Ray W. Z. & Kipnis J. Nature | 2024
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  • October 08, 2024

    Antigen-presenting cells as specialized drivers of intestinal T cell functions

    Kedmi R. & Littman D. R. Immunity | 2024
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  • September 25, 2024

    Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration

    Kern L., Mastandrea I., Melekhova A. & Elinav E. Cell Chemical Biology | 2024
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  • September 10, 2024

    Microbes and metabolites in immunity

    Elinav E., Devkota S., Meisel M., Zhu S., Chu H., Chen H., Puschhof J., McAllister F., Platt R. J. & Honda K. Immunity | 2024
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  • August 31, 2024

    Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

    Aviel G., Elkahal J., Umansky K. B., Bueno-Levy H., Petrover Z., Kotlovski Y., Lendengolts D., Kain D., Shalit T., Zhang L. , et al. , Miyara S., Kramer M. P., Merbl Y., Kozlovski S., Alon R., Aharoni R., Arnon R., Mishali D., Katz U., Nachman D., Asleh R., Amir O., Tzahor E. & Sarig R. Nature Cardiovascular Research | 2024
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  • August 15, 2024

    Diagnosis and Risk Factors of Prediabetes and Diabetes in People Living With Human Immunodeficiency Virus: Evaluation of Clinical and Microbiome Parameters: Evaluation of Clinical and Microbiome Parameters

    Bar Ziv O., Cahn A., Jansen T., Istomin V., Kedem E., Olshtain-Pops K., Israel S., Oster Y., Orenbuch-Harroch E., Korem M. , et al. , Strahilevitz J., Levy I., Valdés-Mas R., Ivanova V., Elinav E., Shahar E. & Elinav H. Journal of Infectious Diseases | 2024
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  • August 14, 2024

    Comprehensive network modeling approaches unravel dynamic enhancer-promoter interactions across neural differentiation

    DeGroat W., Inoue F., Ashuach T., Yosef N., Ahituv N. & Kreimer A. Genome Biology | 2024
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  • July 31, 2024

    p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

    Majewska J., Agrawal A., Mayo A., Roitman L., Chatterjee R., Sekeresova Kralova J., Landsberger T., Katzenelenbogen Y., Meir-Salame T., Hagai E. , et al. , Sopher I., Perez-Correa J. F., Wagner W., Maimon A., Amit I., Alon U. & Krizhanovsky V. Nature Cell Biology | 2024
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  • July 31, 2024

    Turbinate-homing IgA-secreting cells originate in the nasal lymphoid tissues

    Liu J., Stoler-Barak L., Hezroni-Bravyi H., Biram A., Lebon S., Davidzohn N., Kedmi M., Chemla M., Pilzer D., Cohen M. , et al. , Brenner O., Biton M. & Shulman Z. Nature | 2024
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  • July 05, 2024

    Defining myeloid-derived suppressor cells

    Akkari L., Amit I., Bronte V., Fridlender Z. G., Gabrilovich D. I., Ginhoux F., Hedrick C. C. & Ostrand-Rosenberg S. Nature Reviews Immunology | 2024
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  • July 04, 2024

    NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

    Simoneau C. R., Chen P. Y., Xing G. K., Hayashi J. M., Chen I. P., Khalid M. M., Meyers N. L., Taha T. Y., Leon K. E., Suryawanshi R. K. , et al. , McCavitt-Malvido M., Ashuach T., Fontaine K. A., Rodriguez L., Joehnk B., Walcott K., Vasudevan S., Fang X., Maishan M., Schultz S., Roose J. P., Matthay M. A., Sil A., Arjomandi M., Yosef N. & Ott M. Scientific Reports | 2024
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  • June 11, 2024

    The tumor-driven antibody-mediated immune response in cancer

    Paparoditis P. & Shulman Z. Current Opinion in Immunology | 2024
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  • June 11, 2024

    The CD8<sup>+</sup> T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

    Van Der Byl W., Nüssing S., Peters T. J., Ahn A., Li H., Ledergor G., David E., Koh A. S., Wagle M. V., Deguit C. D. T. , et al. , de Menezes M. N., Travers A., Sampurno S., Ramsbottom K. M., Li R., Kallies A., Beavis P. A., Jungmann R., Bastings M. M., Belz G. T., Goel S., Trapani J. A., Crabtree G. R., Chang H. Y., Amit I., Goodnow C. C., Luciani F. & Parish I. A. Immunity | 2024
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  • May 31, 2024

    Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span

    Gray I., Caron D. P., Wells S. B., Guyer R., Szabo P., Rainbow D., Ergen C., Rybkina K., Bradley M. C., Matsumoto R. , et al. , Pethe K., Kubota M., Teichmann S., Jones J., Yosef N., Atkinson M., Brusko M., Brusko T. M., Connors T. J., Sims P. A. & Farber D. L. Science immunology | 2024
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  • May 14, 2024

    The potential importance of the built-environment microbiome and its impact on human health

    Bosch T. C., Wigley M., Colomina B., Bohannan B., Meggers F., Amato K. R., Azad M. B., Blaser M. J., Brown K., Dominguez-Bello M. G. , et al. , Ehrlich S. D., Elinav E., Finlay B. B., Geddie K., Geva-Zatorsky N., Giles-Vernick T., Gros P., Guillemin K., Haraoui L. P., Johnson E., Keck F., Lorimer J., McFall-Ngai M. J., Nichter M., Pettersson S., Poinar H., Rees T., Tropini C., Undurraga E. A., Zhao L. & Melby M. K. Proceedings of the National Academy of Sciences | 2024
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  • May 04, 2024

    Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort

    Braun T., Feng R., Amir A., Levhar N., Shacham H., Mao R., Toren I., Abu-Saad K., Zhuo S., Efroni G. , et al. , Malik A., Picard O., Yavzori M., Agranovich B., Liu T. C., Stappenbeck T. S., Denson L., Kalter-Leibovici O., Gottlieb E., Borenstein E., Elinav E., Chen M., Ben-Horin S. & Haberman Y. Nature Communications | 2024
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  • April 30, 2024

    A microbial iron fist to fight tumors

    Nobs S. P. & Elinav E. Nature Immunology | 2024
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  • April 30, 2024

    Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

    Barboy O., Bercovich A., Li H., Lubling Y., Yalin A., Shapir Itai Y., Abadie K., Zada M., David E., Shlomi S. , et al. , Katzenelenbogen Y., Adhemar D., Gur C., Yofe I., Feferman T., Cohen M., Dahan R., Newell E., Lifshitz A., Tanay A. & Amit I. Nature Cancer | 2024
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  • April 30, 2024

    Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics

    Porcari S., Fusco W., Spivak I., Fiorani M., Gasbarrini A., Elinav E., Cammarota G. & Ianiro G. The Lancet Gastroenterology and Hepatology | 2024
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  • April 09, 2024

    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

    Gaur P., Rajendran Y., Srivastava B., Markandey M., Fishbain-Yoskovitz V., Mohapatra G., Suhail A., Chaudhary S., Tyagi S., Yadav S. C. , et al. , Pandey A. K., Merbl Y., Bajaj A., Ahuja V. & Srikanth C. eLife | 2024
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  • March 31, 2024

    Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism

    Landsberger T., Amit I. & Alon U. GeroScience | 2024
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  • March 29, 2024

    T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection

    Kagan Ben Tikva S., Gurwitz N., Sivan E., Hirsch D., Hezroni-Barvyi H., Biram A., Moss L., Wigoda N., Egozi A., Monziani A. , et al. , Golani O., Gross M., Tenenbaum A. & Shulman Z. Science immunology | 2024
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  • March 05, 2024

    Complement(ing) the microbiome in infants through breastmilk

    Nobs S. P. & Elinav E. Cell Research | 2024
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  • March 04, 2024

    FcγRIIB is an immune checkpoint limiting the activity of Treg-targeting antibodies in the tumor microenvironment

    Knorr D. A., Blanchard L., Leidner R. S., Jensen S. M., Meng R., Jones A., Ballesteros-Merino C., Bell R. B., Baez M., Marino A. , et al. , Sprott D., Bifulco C. B., Piening B., Dahan R., Osorio J. C., Fox B. A. & Ravetch J. V. Cancer Immunology Research | 2024
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  • February 28, 2024

    Optimizing sequence design strategies for perturbation MPRAs: a computational evaluation framework

    Liu J., Ashuach T., Inoue F., Ahituv N., Yosef N. & Kreimer A. Nucleic Acids Research | 2024
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  • February 22, 2024

    CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

    Jain S., Bakolitsa C., Brenner S. E., Radivojac P., Moult J., Repo S., Hoskins R. A., Andreoletti G., Barsky D., Chellapan A. , et al. , Chu H., Dabbiru N., Kollipara N. K., Ly M., Neumann A. J., Pal L. R., Odell E., Fishilevich S., Lancet D. & Yosef N. Genome Biology | 2024
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  • February 08, 2024

    Bacterial Skin Dysbiosis in Darier Disease

    Reiter O., Leshem A., Alexander-Shani R., Brandwein M., Cohen Y., Yeshurun A., Ziv M., Elinav E., Hodak E. & Dodiuk-Gad R. P. Dermatology | 2024
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  • January 18, 2024

    Bispecific dendritic-T cell engager potentiates anti-tumor immunity

    Shapir Itai Y., Barboy O., Salomon R., Bercovich A., Xie K., Winter E., Shami T., Porat Z., Erez N., Tanay A. , et al. , Amit I. & Dahan R. Cell | 2024
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  • January 18, 2024

    Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz

    Uehata T., Yamada S., Ori D., Vandenbon A., Giladi A., Jelinski A., Murakawa Y., Watanabe H., Takeuchi K., Toratani K. , et al. , Mino T., Kiryu H., Standley D. M., Tsujimura T., Ikawa T., Kondoh G., Landthaler M., Kawamoto H., Rodewald H. R., Amit I., Yamamoto R., Miyazaki M. & Takeuchi O. Blood | 2024
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  • January 04, 2024

    Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma

    Kirschenbaum D., Xie K., Ingelfinger F., Katzenelenbogen Y., Abadie K., Look T., Sheban F., Phan T. S., Li B., Zwicky P. , et al. , Yofe I., David E., Mazuz K., Hou J., Chen Y., Shaim H., Shanley M., Becker S., Qian J., Colonna M., Ginhoux F., Rezvani K., Theis F. J., Yosef N., Weiss T., Weiner A. & Amit I. Cell | 2024
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  • December 31, 2023

    Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells

    Gayoso A., Weiler P., Lotfollahi M., Klein D., Hong J., Streets A., Theis F. J. & Yosef N. Nature Methods | 2024
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  • December 21, 2023

    Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes

    Nobs S. P., Kolodziejczyk A. A., Adler L., Horesh N., Botscharnikow C., Herzog E., Mohapatra G., Hejndorf S., Hodgetts R. J., Spivak I. , et al. , Schorr L., Fluhr L., Kviatcovsky D., Zacharia A., Njuki S., Barasch D., Stettner N., Dori-Bachash M., Harmelin A., Brandis A., Mehlman T., Erez A., He Y., Ferrini S., Puschhof J., Shapiro H., Kopf M., Moussaieff A., Abdeen S. K. & Elinav E. Nature | 2023
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  • December 19, 2023

    Hepatitis C virus infects and perturbs liver stem cells

    Meyers N. L., Ashuach T., Lyons D. E., Khalid M. M., Simoneau C. R., Erickson A. L., Bouhaddou M., Nguyen T. T., Renuka Kumar G., Taha T. Y. , et al. , Natarajan V., Baron J. L., Neff N., Zanini F., Mahmoudi T., Quake S. R., Krogan N. J., Cooper S., McDevitt T. C., Yosef N. & Ott M. mBio | 2023
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  • December 18, 2023

    Utilization of the microbiome in personalized medicine

    Ratiner K., Ciocan D., Abdeen S. K. & Elinav E. Nature Reviews Microbiology | 2023
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  • December 13, 2023

    What makes people with diabetes more susceptible to serious lung infections?

    Nobs S. P. & Elinav E. Nature | 2023
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  • December 04, 2023

    Neural plate progenitors give rise to both anterior and posterior pituitary cells

    Chen Q., Leshkowitz D., Li H., van Impel A., Schulte-Merker S., Amit I., Rizzoti K. & Levkowitz G. Developmental Cell | 2023
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  • December 01, 2023

    Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary

    Yofe I., Shami T., Cohen N., Landsberger T., Sheban F., Stoler-Barak L., Yalin A., Phan T. S., Li B., Monteran L. , et al. , Scharff Y., Giladi A., Elbaz M., David E., Gurevich-Shapiro A., Gur C., Shulman Z., Erez N. & Amit I. Cancer Discovery | 2023
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  • November 30, 2023

    Role of natural transformation in the evolution of small cryptic plasmids in Synechocystis sp. PCC 6803

    Nies F., Wein T., Hanke D. M., Springstein B. L., Alcorta J., Taubenheim C. & Dagan T. Environmental Microbiology Reports | 2023
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  • November 21, 2023

    Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

    Tsitsou-Kampeli A., Suzzi S., Kenigsbuch M., Satomi A., Strobelt R., Singer O., Feldmesser E., Purnapatre M., Colaiuta S. P., David E. , et al. , Cahalon L., Hahn O., Wyss-Coray T., Shaul Y., Amit I. & Schwartz M. Cell Reports Medicine | 2023
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  • October 31, 2023

    The cellular states and fates of shed intestinal cells

    Bahar Halpern K., Korem Kohanim Y., Biram A., Harnik Y., Egozi A., Yakubovsky O., Shulman Z. & Itzkovitz S. Nature metabolism | 2023
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  • October 20, 2023

    Phage therapy in noncommunicable diseases

    Kviatcovsky D., Valdés-Mas R., Federici S. & Elinav E. Science (New York, N.Y.) | 2023
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  • October 19, 2023

    Clustering predicted structures at the scale of the known protein universe

    Barrio-Hernandez I., Yeo J., Jänes J., Mirdita M., Gilchrist C. L., Wein T., Varadi M., Velankar S., Beltrao P. & Steinegger M. Nature | 2023
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  • October 09, 2023

    Intracellular bacteria in cancerprospects and debates

    Schorr L., Mathies M., Elinav E. & Puschhof J. npj Biofilms and Microbiomes | 2023
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  • September 30, 2023

    β2-adrenergic signaling promotes higher-affinity B cells and antibodies

    Ben-Shalom N., Sandbank E., Abramovitz L., Hezroni H., Levine T., Trachtenberg E., Fogel N., Mor M., Yefet R., Stoler-Barak L. , et al. , Hagin D., Nakai A., Noda M., Suzuki K., Shulman Z., Ben-Eliyahu S. & Freund N. T. Brain, Behavior, and Immunity | 2023
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  • September 28, 2023

    An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

    Wang Z., Wu Z., Wang H., Feng R., Wang G., Li M., Wang S. Y., Chen X., Su Y., Wang J. , et al. , Zhang W., Bao Y., Lan Z., Song Z., Wang Y., Luo X., Zhao L., Hou A., Tian S., Gao H., Miao W., Liu Y., Wang H., Yin C., Ji Z. L., Feng M., Liu H., Diao L., Amit I., Chen Y., Zeng Y., Ginhoux F., Wu X., Zhu Y. & Li H. Cell | 2023
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  • September 12, 2023

    Langerhans cells shape postnatal oral homeostasis in a mechanical-force-dependent but microbiota and IL17-independent manner

    Jaber Y., Netanely Y., Naamneh R., Saar O., Zubeidat K., Saba Y., Georgiev O., Kles P., Barel O., Horev Y. , et al. , Yosef O., Eli-Berchoer L., Nadler C., Betser-Cohen G., Shapiro H., Elinav E., Wilensky A. & Hovav A. H. Nature Communications | 2023
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  • August 31, 2023

    Single-cell multiomic analysis of thymocyte development reveals drivers of CD4<sup>+</sup> T cell and CD8<sup>+</sup> T cell lineage commitment

    Steier Z., Aylard D. A., McIntyre L. L., Baldwin I., Kim E. J. Y., Lutes L. K., Ergen C., Huang T. S., Robey E. A., Yosef N. & Streets A. Nature Immunology | 2023
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  • August 31, 2023

    The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

    Dougherty M. W., Valdés-Mas R., Wernke K. M., Gharaibeh R. Z., Yang Y., Brant J. O., Riva A., Muehlbauer M., Elinav E., Puschhof J. , et al. , Herzon S. B. & Jobin C. Neoplasia (United States) | 2023
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  • August 31, 2023

    Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency

    Rein A., Geron I., Kugler E., Fishman H., Gottlieb E., Abramovich I., Giladi A., Amit I., Mulet-Lazaro R., Delwel R. , et al. , Gröschel S., Levin-Zaidman S., Dezorella N., Holdengreber V., Rao T. N., Yacobovich J., Steinberg-Shemer O., Huang Q., Tan Y., Chen S., Izraeli S. & Birger Y. Haematologica | 2023
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  • August 31, 2023

    Short-term dietary changes can result in mucosal and systemic immune depression

    Siracusa F., Schaltenberg N., Kumar Y., Lesker T. R., Steglich B., Liwinski T., Cortesi F., Frommann L., Diercks B. P., Bönisch F. , et al. , Fischer A. W., Scognamiglio P., Pauly M. J., Casar C., Cohen Y., Pelczar P., Agalioti T., Delfs F., Worthmann A., Wahib R., Jagemann B., Mittrücker H. W., Kretz O., Guse A. H., Izbicki J. R., Lassen K. G., Strowig T., Schweizer M., Villablanca E. J., Elinav E., Huber S., Heeren J. & Gagliani N. Nature Immunology | 2023
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  • August 21, 2023

    The Role of Artificial Intelligence in Deciphering Diet-Disease Relationships: Case Studies

    Cohen Y., Valdés-Mas R. & Elinav E. Annual Review of Nutrition | 2023
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  • July 31, 2023

    Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

    Kotsiliti E., Leone V., Schuehle S., Govaere O., Li H., Wolf M. J., Horvatic H., Bierwirth S., Hundertmark J., Inverso D. , et al. , Zizmare L., Sarusi-Portuguez A., Gupta R., O'Connor T., Giannou A. D., Shiri A. M., Schlesinger Y., Beccaria M. G., Rennert C., Pfister D., Öllinger R., Gadjalova I., Ramadori P., Rahbari M., Rahbari N., Healy M. E., Fernández-Vaquero M., Yahoo N., Janzen J., Singh I., Fan C., Liu X., Rau M., Feuchtenberger M., Schwaneck E., Wallace S. J., Cockell S., Wilson-Kanamori J., Ramachandran P., Kho C., Kendall T. J., Leblond A. L., Keppler S. J., Bielecki P., Steiger K., Hofmann M., Rippe K., Zitzelsberger H., Weber A., Malek N., Luedde T., Vucur M., Augustin H. G., Flavell R., Parnas O., Rad R., Pabst O., Henderson N. C., Huber S., Macpherson A., Knolle P., Claassen M., Geier A., Trautwein C., Unger K., Elinav E., Waisman A., Abdullah Z., Haller D., Tacke F., Anstee Q. M. & Heikenwalder M. Journal of Hepatology | 2023
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  • July 31, 2023

    MultiVI: deep generative model for the integration of multimodal data

    Ashuach T., Gabitto M. I., Koodli R. V., Saldi G. A., Jordan M. I. & Yosef N. Nature Methods | 2023
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  • July 24, 2023

    Corrigendum: CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma (vol 6, e141683, 2021)

    Lewinsky H., Gunes E. G., David K., Radomir L., Kramer M. P., Pellegrino B., Perpinial M., Chen J., He T. F., Mansour A. G. , et al. , Teng K. Y., Bhattacharya S., Caserta E., Troadec E., Lee P., Feng M., Keats J., Krishnan A., Rosenzweig M., Yu J., Caligiuri M. A., Cohen Y., Shevetz O., Becker-Herman S., Pichiorri F., Rosen S. & Shachar I. JCI insight | 2023
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  • July 11, 2023

    Single-cell biology: what does the future hold?

    Polychronidou M., Hou J., Babu M. M., Liberali P., Amit I., Deplancke B., Lahav G., Itzkovitz S., Mann M., Saez-Rodriguez J. , et al. , Theis F. & Eils R. Molecular Systems Biology | 2023
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  • July 06, 2023

    TET2 and TET3 loss disrupts small intestine differentiation and homeostasis

    Ansari I., Solé-Boldo L., Ridnik M., Gutekunst J., Gilliam O., Korshko M., Liwinski T., Jickeli B., Weinberg-Corem N., Shoshkes-Carmel M. , et al. , Pikarsky E., Elinav E., Lyko F. & Bergman Y. Nature Communications | 2023
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  • July 03, 2023

    Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics

    Bootz-Maoz H., Simon A., Del Mare-Roumani S., Bennet Y., Toister E., Romano H., Zheng D., Amidror S., Elinav E. & Yissachar N. npj Biofilms and Microbiomes | 2023
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  • July 01, 2023

    Fungi and cancer

    Saftien A., Puschhof J. & Elinav E. Gut | 2023
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  • July 01, 2023

    Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

    Goldman O., Adler L. N., Hajaj E., Croese T., Darzi N., Galai S., Tishler H., Ariav Y., Lavie D., Fellus-Alyagor L. , et al. , Oren R., Kuznetsov Y., David E., Jaschek R., Stossel C., Singer O., Malitsky S., Barak R., Seger R., Erez N., Amit I., Tanay A., Saada A., Golan T., Rubinek T., Sang Lee J., Ben-Shachar S., Wolf I. & Erez A. Cancer Discovery | 2023
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  • June 30, 2023

    Engineering bacteria to modulate host metabolism

    Ciocan D. & Elinav E. Acta Physiologica | 2023
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  • June 15, 2023

    Editorial: Microglia in neuroinflammation

    Ayata P., Amit I. & Cuda C. M. Frontiers in Immunology | 2023
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  • May 31, 2023

    Microbiome-phage interactions in inflammatory bowel disease

    Federici S., Kviatcovsky D., Valdés-Mas R. & Elinav E. Clinical Microbiology and Infection | 2023
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  • May 31, 2023

    Dietary fibers & immunitymore than meets the eye

    Cohen Y. & Elinav E. Cell Research | 2023
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  • May 31, 2023

    Impact of caloric restriction on the gut microbiota

    Kern L., Kviatcovsky D., He Y. & Elinav E. Current Opinion in Microbiology | 2023
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  • May 24, 2023

    Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma

    Look T., Puca E., Bühler M., Kirschenbaum D., De Luca R., Stucchi R., Ravazza D., Di Nitto C., Roth P., Katzenelenbogen Y. , et al. , Weiner A., Rindlisbacher L., Becher B., Amit I., Weller M., Neri D., Hemmerle T. & Weiss T. Science Translational Medicine | 2023
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  • May 23, 2023

    An empirical Bayes method for differential expression analysis of single cells with deep generative models

    Boyeau P., Regier J., Gayoso A., Jordan M. I., Lopez R. & Yosef N. Proceedings of the National Academy of Sciences of the United States of America | 2023
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  • May 15, 2023

    Nonnutritive sweeteners and glucose intolerance: Where do we go from here?

    Nobs S. P. & Elinav E. The Journal of Clinical Investigation | 2023
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  • May 01, 2023

    TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer

    Zorea J., Motro Y., Mazor R. D., Carmi Y. K., Shulman Z., Mahajna J., Moran-Gilad J. & Elkabets M. Journal of Experimental and Clinical Cancer Research | 2023
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  • April 30, 2023

    Bystander activation of tissue-resident memory CD4 T cells: Getting by with a little help from unfamiliar T-cell friends

    Cornelis R. & Shulman Z. European Journal of Immunology | 2023
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  • April 30, 2023

    The scverse project provides a computational ecosystem for single-cell omics data analysis

    Virshup I., Bredikhin D., Heumos L., Palla G., Sturm G., Gayoso A., Kats I., Koutrouli M., Berger B., Pe'er D. , et al. , Regev A., Teichmann S. A., Finotello F., Wolf F. A., Yosef N., Stegle O. & Theis F. J. Nature biotechnology | 2023
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  • April 30, 2023

    EMSY stabilization in KEAP1-mutant lung cancer disrupts genome stability and type I interferon signaling

    Sheban D. & Merbl Y. Cell Death and Differentiation | 2023
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  • April 30, 2023

    Immunometabolism at the crossroads of obesity and cancera Keystone Symposia report

    Cable J., Rathmell J. C., Pearce E. L., Ho P. C., Haigis M. C., Mamedov M. R., Wu M. J., Kaech S. M., Lynch L., Febbraio M. A. , et al. , Bapat S. P., Hong H. S., Zou W., Belkaid Y., Sullivan Z. A., Keller A., Wculek S. K., Green D. R., Postic C., Amit I., Benitah S. A., Jones R. G., Reina-Campos M., Torres S. V., Beyaz S., Brennan D., O'Neill L. A., Perry R. J. & Brenner D. Annals of the New York Academy of Sciences | 2023
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  • April 30, 2023

    The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC

    Javitt A., Shmueli M. D., Kramer M. P., Kolodziejczyk A. A., Cohen I. J., Radomir L., Sheban D., Kamer I., Litchfield K., Bab-Dinitz E. , et al. , Zadok O., Neiens V., Ulman A., Wolf-Levy H., Eisenberg-Lerner A., Kacen A., Alon M., Rêgo A. T., Stacher-Priehse E., Lindner M., Koch I., Bar J., Swanton C., Samuels Y., Levin Y., da Fonseca P. C., Elinav E., Friedman N., Meiners S. & Merbl Y. Nature Cancer | 2023
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  • April 30, 2023

    The transcriptional and regulatory identity of erythropoietin producing cells

    Kragesteen B. K., Giladi A., David E., Halevi S., Geirsdóttir L., Lempke O. M., Li B., Bapst A. M., Xie K., Katzenelenbogen Y. , et al. , Dahl S. L., Sheban F., Gurevich-Shapiro A., Zada M., Phan T. S., Avellino R., Wang S., Barboy O., Shlomi-Loubaton S., Winning S., Markwerth P. P., Dekalo S., Keren-Shaul H., Kedmi M., Sikora M., Fandrey J., Korneliussen T. S., Prchal J. T., Rosenzweig B., Yutkin V., Racimo F., Willerslev E., Gur C., Wenger R. H. & Amit I. Nature Medicine | 2023
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  • April 10, 2023

    A single-cell census of mouse limb development identifies complex spatiotemporal dynamics of skeleton formation

    Markman S., Zada M., David E., Giladi A., Amit I. & Zelzer E. Developmental Cell | 2023
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  • March 31, 2023

    A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

    Stein-Thoeringer C. K., Saini N. Y., Zamir E., Blumenberg V., Schubert M. L., Mor U., Fante M. A., Schmidt S., Hayase E., Hayase T. , et al. , Rohrbach R., Chang C. C., McDaniel L., Flores I., Gaiser R., Edinger M., Wolff D., Heidenreich M., Strati P., Nair R., Chihara D., Fayad L. E., Ahmed S., Iyer S. P., Steiner R. E., Jain P., Nastoupil L. J., Westin J., Arora R., Wang M. L., Turner J., Menges M., Hidalgo-Vargas M., Reid K., Dreger P., Schmitt A., Müller-Tidow C., Locke F. L., Davila M. L., Champlin R. E., Flowers C. R., Shpall E. J., Poeck H., Neelapu S. S., Schmitt M., Subklewe M., Jain M. D., Jenq R. R. & Elinav E. Nature Medicine | 2023
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  • March 31, 2023

    Large-Scale Immunopeptidome Analysis Reveals Recurrent Posttranslational Splicing of Cancer- and Immune-Associated Genes

    Levy R., Alter Regev T., Paes W., Gumpert N., Cohen Shvefel S., Bartok O., Dayan-Rubinov M., Alon M., Shmueli M., Levin Y. , et al. , Merbl Y., Ternette N. & Samuels Y. Molecular and Cellular Proteomics | 2023
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  • March 31, 2023

    Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation

    Zheng D., Mohapatra G., Kern L., He Y., Shmueli M. D., Valdés-Mas R., Kolodziejczyk A. A., Próchnicki T., Vasconcelos M. B., Schorr L. , et al. , Hertel F., Lee Y. S., Rufino M. C., Ceddaha E., Shimshy S., Hodgetts R. J., Dori-Bachash M., Kleimeyer C., Goldenberg K., Heinemann M., Stettner N., Harmelin A., Shapiro H., Puschhof J., Chen M., Flavell R. A., Latz E., Merbl Y., Abdeen S. K. & Elinav E. Nature Immunology | 2023
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  • March 21, 2023

    Theoretical guarantees for phylogeny inference from single-cell lineage tracing

    Wang R., Zhang R., Khodaverdian A. & Yosef N. Proceedings of the National Academy of Sciences of the United States of America | 2023
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  • March 16, 2023

    B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

    Stoler-Barak L., Harris E., Peres A., Hezroni H., Kuka M., Di Lucia P., Grenov A., Gurwicz N., Kupervaser M., Yip B. H. , et al. , Iannacone M., Yaari G., Crispino J. D. & Shulman Z. Nature Communications | 2023
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  • February 28, 2023

    Diversifying nutritional sciencesdietary practices and gut bacteria in individuals of Latino and Hispanic ancestry

    Leshem A. & Elinav E. American Journal of Clinical Nutrition | 2023
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  • February 28, 2023

    Author Correction: A shared disease-associated oligodendrocyte signature among multiple CNS pathologies (Nature Neuroscience, (2022), 25, 7, (876-886), 10.1038/s41593-022-01104-7)

    Kenigsbuch M., Bost P., Halevi S., Chang Y., Chen S., Ma Q., Hajbi R., Schwikowski B., Bodenmiller B., Fu H. , et al. , Schwartz M. & Amit I. Nature Neuroscience | 2023
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  • February 28, 2023

    Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy

    Saban N. C., Yalin A., Landsberger T., Salomon R., Alva A., Feferman T., Amit I. & Dahan R. Science immunology | 2023
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  • February 28, 2023

    Human microbiome research: Growing pains and future promises

    Puschhof J. & Elinav E. PLoS Biology | 2023
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  • February 15, 2023

    Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry

    Reddi R. N., Rogel A., Gabizon R., Rawale D. G., Harish B., Marom S., Tivon B., Arbel Y. S., Gurwicz N., Oren R. , et al. , David K., Liu J., Duberstein S., Itkin M., Malitsky S., Barr H., Katz B., Herishanu Y., Shachar I., Shulman Z. & London N. Journal of the American Chemical Society | 2023
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  • February 08, 2023

    A microbial workout

    Kviatcovsky D. & Elinav E. Cell Host and Microbe | 2023
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  • February 07, 2023

    Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs

    Côrte-Real B. F., Hamad I., Arroyo Hornero R., Geisberger S., Roels J., Van Zeebroeck L., Dyczko A., van Gisbergen M. W., Kurniawan H., Wagner A. , et al. , Yosef N., Weiss S. N., Schmetterer K. G., Schröder A., Krampert L., Haase S., Bartolomaeus H., Hellings N., Saeys Y., Dubois L. J., Brenner D., Kempa S., Hafler D. A., Stegbauer J., Linker R. A., Jantsch J., Müller D. N. & Kleinewietfeld M. Cell Metabolism | 2023
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  • January 31, 2023

    Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis

    Räuber S., Schroeter C. B., Strippel C., Nelke C., Ruland T., Dik A., Golombeck K. S., Regner-Nelke L., Paunovic M., Esser D. , et al. , Münch C., Rosenow F., van Duijn M., Henes A., Ruck T., Amit I., Leypoldt F., Titulaer M. J., Wiendl H., Meuth S. G., Meyer zu Hörste G. & Melzer N. Journal of Autoimmunity | 2023
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  • January 31, 2023

    CAR-T Cell Therapy and the Gut Microbiota

    Asokan S., Cullin N., Stein-Thoeringer C. K. & Elinav E. Cancers | 2023
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  • January 31, 2023

    Capturing the diversity of protein modifications on presented tumor antigens

    Javitt A. & Merbl Y. Nature biotechnology | 2023
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  • January 31, 2023

    Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

    Kacen A., Javitt A., Kramer M. P., Morgenstern D., Tsaban T., Shmueli M. D., Teo G. C., Leprevost F. d. V., Barnea E., Yu F. , et al. , Admon A., Eisenbach L., Samuels Y., Schueler-Furman O., Levin Y., Nesvizhskii A. & Merbl Y. Nature Biotechnology | 2023
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  • January 31, 2023

    Microbiota-dependent and -independent postnatal development of salivary immunity

    Zubeidat K., Jaber Y., Saba Y., Barel O., Naamneh R., Netanely Y., Horev Y., Eli-berchoer L., Shhadeh A., Yosef O. , et al. , Arbib E., Betser-Cohen G., Nadler C., Shapiro H., Elinav E., Aframian D. J., Wilensky A. & Hovav A. Cell Reports | 2023
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  • January 27, 2023

    Tingible body macrophages arise from lymph noderesident precursors and uptake B cells by dendrites

    Gurwicz N., Stoler-Barak L., Schwan N., Bandyopadhyay A., Meyer-Hermann M. & Shulman Z. Journal of Experimental Medicine | 2023
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  • January 10, 2023

    Neighbor-specific gene expression revealed from physically interacting cells during mouse embryonic development

    Kim J., Rothová M. M., Madan E., Rhee S., Weng G., Palma A. M., Liao L., David E., Amit I., Hajkarim M. C. , et al. , Vudatha V., Gutiérrez-García A., Moreno E., Winn R., Trevino J., Fisher P. B., Brickman J. M., Gogna R. & Won K. J. Proceedings of the National Academy of Sciences - PNAS | 2023
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  • December 31, 2022

    In Synergy: Optimizing CAR T Development and Personalizing Patient Care Using Single-Cell Technologies

    Barboy O., Katzenelenbogen Y., Shalita R. & Amit I. Cancer Discovery | 2023
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  • December 31, 2022

    Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration

    Benyair R., Panapakkam Giridharan S. S., Rivero-Ríos P., Hasegawa J., Bristow E., Eskelinen E. L., Shmueli M. D., Fishbain-Yoskovitz V., Merbl Y., Sharkey L. M. , et al. , Paulson H. L., Hanson P. I., Patnaik S., Al-Ramahi I., Botas J., Marugan J. & Weisman L. S. Autophagy Reports | 2023
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  • December 31, 2022

    Small Intestinal Microbiota Oscillations, Host Effects and RegulationA Zoom into Three Key Effector Molecules

    Ratiner K., Fachler-Sharp T. & Elinav E. Biology | 2023
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  • December 21, 2022

    Distinct gene programs underpinning disease tolerance and resistance in influenza virus infection

    Cohn O., Yankovitz G., Peshes-Yaloz N., Steuerman Y., Frishberg A., Brandes R., Mandelboim M., Hamilton J. R., Hagai T., Amit I. , et al. , Netea M. G., Hacohen N., Iraqi F. A., Bacharach E. & Gat-Viks I. Cell Systems | 2022
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  • November 30, 2022

    Effects of personalized diets by prediction of glycemic responses on glycemic control and metabolic health in newly diagnosed T2DM: a randomized dietary intervention pilot trial

    Rein M., Ben-Yacov O., Godneva A., Shilo S., Zmora N., Kolobkov D., Cohen-Dolev N., Wolf B., Kosower N., Lotan-Pompan M. , et al. , Weinberger A., Halpern Z., Zelber-Sagi S., Elinav E. & Segal E. BMC Medicine | 2022
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  • November 30, 2022

    Time-resolved single-cell RNA-seq using metabolic RNA labelling

    Erhard F., Saliba A., Lusser A., Toussaint C., Hennig T., Prusty B. K., Kirschenbaum D., Abadie K., Miska E. A., Friedel C. C. , et al. , Amit I., Micura R. & Doelken L. Nature Reviews Methods Primers | 2022
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  • November 17, 2022

    A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage

    Afriat A., Zuzarte-Luis V., Halpern K. B., Buchauer L., Marques S., Chora A. F., Lahree A., Amit I., Mota M. M. & Itzkovitz S. Nature | 2022
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  • November 08, 2022

    Upper airway and brain protection by plasma cells: A local affair

    Cornelis R. & Shulman Z. Immunity | 2022
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  • November 02, 2022

    Microglia states and nomenclature: A field at its crossroads

    Paolicelli R. C., Sierra A., Stevens B., Tremblay M., Aguzzi A., Ajami B., Amit I., Audinat E., Bechmann I., Bennett M. , et al. , Bennett F., Bessis A., Biber K., Bilbo S., Blurton-Jones M., Boddeke E., Brites D., Brône B., Brown G. C., Butovsky O., Carson M. J., Castellano B., Colonna M., Cowley S. A., Cunningham C., Davalos D., De Jager P. L., de Strooper B., Denes A., Eggen B. J., Eyo U., Galea E., Garel S., Ginhoux F., Glass C. K., Gokce O., Gomez-Nicola D., González B., Gordon S., Graeber M. B., Greenhalgh A. D., Gressens P., Greter M., Gutmann D. H., Haass C., Heneka M. T., Heppner F. L., Hong S., Hume D. A., Jung S., Kettenmann H., Kipnis J., Koyama R., Lemke G., Lynch M., Majewska A., Malcangio M., Malm T., Mancuso R., Masuda T., Matteoli M., McColl B. W., Miron V. E., Molofsky A. V., Monje M., Mracsko E., Nadjar A., Neher J. J., Neniskyte U., Neumann H., Noda M., Peng B., Peri F., Perry V. H., Popovich P. G., Pridans C., Priller J., Prinz M., Ragozzino D., Ransohoff R. M., Salter M. W., Schaefer A., Schafer D. P., Schwartz M., Simons M., Smith C. J., Streit W. J., Tay T. L., Tsai L., Verkhratsky A., von Bernhardi R., Wake H., Wittamer V., Wolf S. A., Wu L. & Wyss-Coray T. Neuron | 2022
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  • November 02, 2022

    The industrial genomic revolution: A new era in neuroimmunology

    Shalita R. & Amit I. Neuron | 2022
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  • November 01, 2022

    CD74 as a regulator of transcription in normal B cells

    David K., Friedlander G., Pellegrino B., Radomir L., Lewinsky H., Leng L., Bucala R., Becker-Herman S. & Shachar I. Cell Reports | 2022
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  • October 31, 2022

    Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling

    Yofe I., Landsberger T., Yalin A., Solomon I., Costoya C., Demane D. F., Shah M., David E., Borenstein C., Barboy O. , et al. , Matos I., Peggs K. S., Quezada S. A. & Amit I. Nature Cancer | 2022
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  • October 31, 2022

    CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia

    Thavayogarajah T., Sinitski D., El Bounkari O., Torres-Garcia L., Lewinsky H., Harjung A., Chen H., Panse J., Vankann L., Shachar I. , et al. , Bernhagen J. & Koschmieder S. Experimental Hematology | 2022
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  • October 27, 2022

    A RORγt<sup>+</sup> cell instructs gut microbiota-specific T<sub>reg</sub> cell differentiation

    Kedmi R., Najar T. A., Mesa K. R., Grayson A., Kroehling L., Hao Y., Hao S., Pokrovskii M., Xu M., Talbot J. , et al. , Germino J., Wang J., Lareau C. A., Satpathy A. T., Anderson M. S., Laufer T. M., Aifantis I., Bartleson J. M., Allen P. M., Paidassi H., Gardner J. M., Stoeckius M. & Littman D. R. Nature | 2022
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  • October 21, 2022

    Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern

    Cohen-Dvashi H., Weinstein J., Katz M., Ashkenazy-Eilon M., Mor Y., Shimon A., Achdout H., Tamir H., Israely T., Strobelt R. , et al. , Shemesh M., Stoler-Barak L., Shulman Z., Paran N., Fleishman S. J. & Diskin R. iScience | 2022
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  • October 15, 2022

    Trimming Trem2 and possible impacts on the metabolic syndrome

    Shapiro H., Leshem A. & Elinav E. The Journal of physiology | 2022
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  • October 06, 2022

    Local and systemic effects of microbiome-derived metabolites

    Spivak I., Fluhr L. & Elinav E. EMBO Reports | 2022
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  • October 06, 2022

    Deep generative modeling for quantifying sample-level heterogeneity in single-cell omics

    Boyeau P., Hong J., Gayoso A., Jordan M., Azizi E. & Yosef N. BioRxiv | 2022
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  • October 01, 2022

    Spatiotemporal Omics-Refining the landscape of precision medicine

    Zhang J., Yin J., Heng Y., Xie K., Chen A., Amit I., Bian X. & Xu X. Life Medicine | 2022
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  • October 01, 2022

    Human microglia development in the embryonic brain

    Li B., Li Y., Li Z., Jiao J. & Amit I. Life Medicine | 2022
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  • September 30, 2022

    Bacterial origins of human cell-autonomous innate immune mechanisms

    Wein T. & Sorek R. Nature reviews. Immunology | 2022
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  • September 13, 2022

    Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling

    Pawlak M., DeTomaso D., Schnell A., Meyer Zu Horste G., Lee Y., Nyman J., Dionne D., Regan B. M. L., Singh V., Delorey T. , et al. , Schramm M. A., Wang C., Wallrapp A., Burkett P. R., Riesenfeld S. J., Anderson A. C., Regev A., Xavier R. J., Yosef N. & Kuchroo V. K. Immunity | 2022
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  • September 01, 2022

    Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

    Suez J., Cohen Y., Valdés-Mas R., Mor U., Dori-Bachash M., Federici S., Zmora N., Leshem A., Heinemann M., Linevsky R. , et al. , Zur M., Ben-Zeev Brik R., Bukimer A., Eliyahu-Miller S., Metz A., Fischbein R., Sharov O., Malitsky S., Itkin M., Stettner N., Harmelin A., Shapiro H., Stein-Thoeringer C. K., Segal E. & Elinav E. Cell | 2022
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  • August 31, 2022

    DestVI identifies continuums of cell types in spatial transcriptomics data

    Lopez R., Li B., Keren-Shaul H., Boyeau P., Kedmi M., Pilzer D., Jelinski A., Yofe I., David E., Wagner A. , et al. , Ergen C., Addadi Y., Golani O., Ronchese F., Jordan M. I., Amit I. & Yosef N. Nature biotechnology | 2022
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  • August 31, 2022

    Smoking-induced microbial dysbiosis in health and disease

    Shapiro H., Goldenberg K., Ratiner K. & Elinav E. Clinical science (1979) | 2022
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  • August 09, 2022

    Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration

    Silvin' A., Uderhardt S., Piot C., Da Mesquita S., Yang K., Geirsdottir L., Mulder K., David E., Liu Z., Bridlance C. , et al. , Thion M. S., Zhang X., Ting Kong W., Deloger M., Fontes V., Weiner A., Ee R., Dress R., Wen Hang J., Balachander A., Chakarov S., Malleret B., Dunsmore G., Cexus O., Chen J., Garel S., Dutertre C. A., Amit I., Kipnis J. & Ginhoux F. Immunity | 2022
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  • August 08, 2022

    Ets21C sustains a pro-regenerative transcriptional program in blastema cells of Drosophila imaginal discs

    Worley M. I., Everetts N. J., Yasutomi R., Chang R. J., Saretha S., Yosef N. & Hariharan I. K. Current Biology | 2022
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  • August 04, 2022

    Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

    Federici S., Kredo-Russo S., Valdes Mas R., Kviatcovsky D., Weinstock E., Matiuhin Y., Silberberg Y., Atarashi K., Furuichi M., Oka A. , et al. , Liu B., Fibelman M., Weiner I., Khabra E., Cullin N., Ben-Yishai N., Inbar D., Ben David H., Nicenboim J., Kowalsman N., Lieb W., Kario E., Cohen T., Friedman Geffen Y., Zelcbuch L., Cohen A., Rappo U., Gahali-Sass I., Golembo M., Lev Goldman V., Dori-Bachash M., Shapiro H., Moresi C., Cuevas Sierra A., Mohapatra G., Kern L., Zheng D., Nobs S. P., Suez J., Harmelin A., Stettner N., Zak N., Puttagunta S., Bassan M., Honda K., Sokol H., Bang C., Franke A., Schramm C., Maharshak N., Balfour Sartor R., Sorek R. & Elinav E. Cell | 2022
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  • August 02, 2022

    NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

    Simoneau C. R., Chen P., Xing G. K., Khalid M. M., Meyers N. L., Hayashi J. M., Taha T. Y., Leon K. E., Ashuach T., Fontaine K. A. , et al. , Rodriguez L., Joehnk B., Walcott K., Vasudevan S., Fang X., Maishan M., Schultz S., Roose J., Matthay M. A., Sil A., Arjomandi M., Yosef N. & Ott M. BioRxiv | 2022
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  • July 28, 2022

    Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation

    Baßler K., Fujii W., Kapellos T. S., Dudkin E., Reusch N., Horne A., Reiz B., Luecken M. D., Osei-Sarpong C., Warnat-Herresthal S. , et al. , Bonaguro L., Schulte-Schrepping J., Wagner A., Günther P., Pizarro C., Schreiber T., Knoll R., Holsten L., Kröger C., Becker M., De Domenico E., Händler K., Wohnhaas C. T., Baumgartner F., Köhler M., Theis H., Kraut M., Wadsworth M. H., Hughes T. K., Ferreira H. J., Hinkley E., Kaltheuner I. H., Geyer M., Thiele C., Shalek A. K., Feißt A., Thomas D., Dickten H., Beyer M., Yosef N., Baum P., Aschenbrenner A. C., Ulas T., Hasenauer J., Theis F. J., Skowasch D. & Schultze J. L. Frontiers in Immunology | 2022
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  • July 13, 2022

    Next Generation CD40 Agonistic Antibodies for Cancer Immunotherapy

    Salomon R. & Dahan R. Frontiers in Immunology | 2022
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  • July 10, 2022

    Directed Shortest Walk on Temporal Graphs

    Khodaverdian A. & Yosef N. BioRxiv | 2022
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  • July 01, 2022

    Erratum: Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients (Clin Infect Dis DOI: 10.1093/cid/ciab902)

    De Castilhos J., Zamir E., Hippchen T., Rohrbach R., Schmidt S., Hengler S., Schumacher H., Neubauer M., Kunz S., Müller-Esch T. , et al. , Hiergeist A., Gessner A., Khalid D., Gaiser R., Cullin N., Papagiannarou S. M., Beuthien-Baumann B., Krämer A., Bartenschlager R., Jäger D., Müller M., Herth F., Duerschmied D., Schneider J., Schmid R. M., Eberhardt J. F., Khodamoradi Y., Vehreschild M. J., Teufel A., Ebert M. P., Hau P., Salzberger B., Schnitzler P., Poeck H., Elinav E., Merle U. & Stein-Thoeringer C. K. Clinical Infectious Diseases | 2022
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  • July 01, 2022

    Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients

    de Castilhos J., Zamir E., Hippchen T., Rohrbach R., Schmidt S., Hengler S., Schumacher H., Neubauer M., Kunz S., Mueller-Esch T. , et al. , Hiergeist A., Gessner A., Khalid D., Gaiser R., Cullin N., Papagiannarou S. M., Beuthien-Baumann B., Kraemer A., Bartenschlager R., Jaeger D., Mueller M., Herth F., Duerschmied D., Schneider J., Schmid R. M., Eberhardt J. F., Khodamoradi Y., Vehreschild M. J. G. T., Teufel A., Ebert M. P., Hau P., Salzberger B., Schnitzler P., Poeck H., Elinav E., Merle U. & Stein-Thoeringer C. K. Clinical Infectious Diseases | 2022
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  • June 30, 2022

    Extrathymic expression of Aire controls the induction of effective T<sub>H</sub>17 cell-mediated immune response to Candida albicans

    Dobeš J., Ben-Nun O., Binyamin A., Stoler-Barak L., Oftedal B. E., Goldfarb Y., Kadouri N., Gruper Y., Givony T., Zalayat I. , et al. , Kováčová K., Böhmová H., Valter E., Shulman Z., Filipp D., Husebye E. S. & Abramson J. Nature Immunology | 2022
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  • June 30, 2022

    Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis

    Zhang G., Wang Q., Tao W., Jiang W., Elinav E., Wang Y. & Zhu S. Nature Biomedical Engineering | 2022
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  • June 30, 2022

    Dimensionality reduction of longitudinalomics data using modern tensor factorizations

    Mor U., Cohen Y., Valdés-Mas R., Kviatcovsky D., Elinav E. & Avron H. PLoS Computational Biology | 2022
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  • June 30, 2022

    A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

    Kenigsbuch M., Bost P., Halevi S., Chang Y., Chen S., Ma Q., Hajbi R., Schwikowski B., Bodenmiller B., Fu H. , et al. , Schwartz M. & Amit I. Nature Neuroscience | 2022
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  • June 30, 2022

    Identifying cell stateassociated alternative splicing events and their coregulation

    Buen Abad Najar C. F., Burra P., Yosef N. & Lareau L. F. Genome Research | 2022
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  • June 08, 2022

    Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes

    Artzy-Schnirman A., Abu-Shah E., Chandrawati R., Altman E., Yusuf N., Wang S., Ramos J., Hansel C. S., Haus-Cohen M., Dahan R. , et al. , Arif S., Dustin M. L., Peakman M., Reiter Y. & Stevens M. M. Nano Letters | 2022
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  • June 02, 2022

    The spatiotemporal program of zonal liver regeneration following acute injury

    Ben-Moshe S., Veg T., Manco R., Dan S., Papinutti D., Lifshitz A., Kolodziejczyk A. A., Bahar Halpern K., Elinav E. & Itzkovitz S. Cell Stem Cell | 2022
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  • May 31, 2022

    Histone degradation by the proteasome regulates chromatin and cellular plasticity

    Shmueli M. D., Sheban D., Eisenberg-Lerner A. & Merbl Y. FEBS Journal | 2022
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  • May 31, 2022

    Identification of the central intermediate in the extra-embryonic to embryonic endoderm transition through single-cell transcriptomics

    Rothová M. M., Nielsen A. V., Proks M., Wong Y. F., Riveiro A. R., Linneberg-Agerholm M., David E., Amit I., Trusina A. & Brickman J. M. Nature Cell Biology | 2022
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  • May 31, 2022

    Cell types of origin of the cell-free transcriptome

    Vorperian S. K., Moufarrej M. N., Wyss-Coray T., Wu S. M., Wu A., Sonnenburg J. L., Relman D. A., Reiter J., Red-Horse K., Rando T. A. , et al. , Nguyen P., Kuo C. S., Kim S. K., Idoyaga J., Huang K. C., Huang F. W., Giudice L. C., Clarke M. F., Beachy P. A. & Yosef N. Nature biotechnology | 2022
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  • May 31, 2022

    Physically interacting beta-delta pairs in the regenerating pancreas revealed by single-cell sequencing

    Yanowski E., Yacovzada N. S., David E., Giladi A., Jaitin D., Farack L., Egozi A., Ben-Zvi D., Itzkovitz S., Amit I. & Hornstein E. Molecular metabolism (Germany) | 2022
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  • May 31, 2022

    Risk factors for non-alcoholic fatty liver disease delineate the battlegrounds in optimizing disease prevention

    Spivak I. & Elinav E. Hepatobiliary surgery and nutrition | 2022
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  • May 31, 2022

    Time-limited diets and the gut microbiota in cardiometabolic disease

    Ratiner K., Shapiro H., Goldenberg K. & Elinav E. Journal of Diabetes | 2022
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  • May 26, 2022

    Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution

    Yang D., Jones M. G., Naranjo S., Rideout W. M., Min K. H. (., Ho R., Wu W., Replogle J. M., Page J. L., Quinn J. J. , et al. , Horns F., Qiu X., Chen M. Z., Freed-Pastor W. A., McGinnis C. S., Patterson D. M., Gartner Z. J., Chow E. D., Bivona T. G., Chan M. M., Yosef N., Jacks T. & Weissman J. S. Cell | 2022
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  • May 19, 2022

    Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

    Hobbs S. J., Wein T., Lu A., Morehouse B. R., Schnabel J., Leavitt A., Yirmiya E., Sorek R. & Kranzusch P. J. Nature | 2022
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  • May 13, 2022

    The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

    Consortium T. S. & Yosef N. Science | 2022
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  • May 13, 2022

    Cross-tissue immune cell analysis reveals tissue-specific features in humans

    Domínguez Conde C., Xu C., Jarvis L. B., Rainbow D. B., Wells S. B., Gomes T., Howlett S. K., Suchanek O., Polanski K., King H. W. , et al. , Mamanova L., Huang N., Szabo P. A., Richardson L., Bolt L., Fasouli E. S., Mahbubani K. T., Prete M., Tuck L., Richoz N., Tuong Z. K., Campos L., Mousa H. S., Needham E. J., Pritchard S., Li T., Elmentaite R., Park J., Rahmani E., Chen D., Menon D. K., Bayraktar O. A., James L. K., Meyer K. B., Yosef N., Clatworthy M. R., Sims P. A., Farber D. L., Saeb-Parsy K., Jones J. L. & Teichmann S. A. Science | 2022
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  • May 12, 2022

    Identifying Systematic Variation at the Single-Cell Level by Leveraging Low-Resolution Population-Level Data

    Rahmani E., Jordan M. I. & Yosef N. | 2022
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  • May 03, 2022

    YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation

    Grenov A., Hezroni H., Lasman L., Hanna J. H. & Shulman Z. Cell Reports | 2022
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  • April 25, 2022

    Interactive, integrated analysis of single-cell transcriptomic and phylogenetic data with PhyloVision

    Jones M. G., Rosen Y. & Yosef N. Cell Reports Methods | 2022
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  • April 14, 2022

    LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma

    Gur C., Wang S., Sheban F., Zada M., Li B., Kharouf F., Peleg H., Aamar S., Yalin A., Kirschenbaum D. , et al. , Braun-Moscovici Y., Jaitin D. A., Meir-Salame T., Hagai E., Kragesteen B. K., Avni B., Grisariu S., Bornstein C., Shlomi-Loubaton S., David E., Shreberk-Hassidim R., Molho-Pessach V., Amar D., Tzur T., Kuint R., Gross M., Barboy O., Moshe A., Fellus-Alyagor L., Hirsch D., Addadi Y., Erenfeld S., Biton M., Tzemach T., Elazary A., Naparstek Y., Tzemach R., Weiner A., Giladi A., Balbir-Gurman A. & Amit I. Cell | 2022
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  • April 06, 2022

    Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism

    Strobelt R., Adler J., Paran N., Yahalom-Ronen Y., Melamed S., Politi B., Shulman Z., Schmiedel D. & Shaul Y. Scientific Reports | 2022
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  • April 06, 2022

    Brain metastases: Not all tumors are created equal

    Kirschenbaum D. & Amit I. Neuron | 2022
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  • March 31, 2022

    Protozoa populations are ecosystem engineers that shape prokaryotic community structure and function of the rumen microbial ecosystem

    Solomon R., Wein T., Levy B., Eshed S., Dror R., Reiss V., Zehavi T., Furman O., Mizrahi I. & Jami E. ISME Journal | 2022
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  • March 31, 2022

    MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

    Alborzinia H., Flórez A. F., Kreth S., Brückner L. M., Yildiz U., Gartlgruber M., Odoni D. I., Poschet G., Garbowicz K., Shao C. , et al. , Klein C., Meier J., Zeisberger P., Nadler-Holly M., Ziehm M., Paul F., Burhenne J., Bell E., Shaikhkarami M., Würth R., Stainczyk S. A., Wecht E. M., Kreth J., Büttner M., Ishaque N., Schlesner M., Nicke B., Stresemann C., Llamazares-Prada M., Reiling J. H., Fischer M., Amit I., Selbach M., Herrmann C., Wölfl S., Henrich K., Höfer T., Trumpp A. & Westermann F. Nature Cancer | 2022
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  • March 31, 2022

    Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

    Mazor R. D., Nathan N., Gilboa A., Stoler-Barak L., Moss L., Solomonov I., Hanuna A., Divinsky Y., Shmueli M. D., Hezroni H. , et al. , Zaretsky I., Mor M., Golani O., Sabah G., Jakobson-Setton A., Yanichkin N., Feinmesser M., Tsoref D., Salman L., Yeoshoua E., Peretz E., Erlich I., Mendelson Cohen N., Gershoni J. M., Freund N., Merbl Y., Yaari G., Eitan R., Sagi I. & Shulman Z. Cell | 2022
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  • March 28, 2022

    PeakVI: A deep generative model for single-cell chromatin accessibility analysis

    Ashuach T., Reidenbach D. A., Gayoso A. & Yosef N. Cell Reports Methods | 2022
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  • March 21, 2022

    Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation

    Kreimer A., Ashuach T., Inoue F., Khodaverdian A., Deng C., Yosef N. & Ahituv N. Nature Communications | 2022
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  • March 08, 2022

    Single-cell immunology: Past, present, and future

    Ginhoux F., Yalin A., Dutertre C. A. & Amit I. Immunity | 2022
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  • March 08, 2022

    Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

    Biram A., Liu J., Hezroni-Bravyi H., Davidzohn N., Schmiedel D., Khatib-Massalha E., Haddad M., Grenov C. A., Lebon S., Salame T. M. , et al. , Dezorella N., Hoffman D., Abou Karam P., Biton M., Lapidot T., Bemark M., Avraham R., Jung S. & Shulman Z. Immunity | 2022
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  • March 01, 2022

    Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways

    Benyair R., Eisenberg-Lerner A. & Merbl Y. Cells | 2022
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  • February 28, 2022

    Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting

    Salomon R., Rotem H., Katzenelenbogen Y., Weiner A., Cohen Saban N., Feferman T., Amit I. & Dahan R. Nature Cancer | 2022
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  • February 28, 2022

    Systems-based approaches to study immunometabolism

    Purohit V., Wagner A., Yosef N. & Kuchroo V. K. Cellular & molecular immunology | 2022
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  • February 28, 2022

    The interaction of CD4<sup>+</sup> helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

    Cohen M., Giladi A., Barboy O., Hamon P., Li B., Zada M., Gurevich-Shapiro A., Beccaria C. G., David E., Maier B. B. , et al. , Buckup M., Kamer I., Deczkowska A., Le Berichel J., Bar J., Iannacone M., Tanay A., Merad M. & Amit I. Nature Cancer | 2022
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  • February 28, 2022

    Utilization of Host and Microbiome Features in Determination of Biological Aging

    Ratiner K., Abdeen S. K., Goldenberg K. & Elinav E. Microorganisms (Basel) | 2022
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  • February 25, 2022

    Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism

    He C., Maniyar R. R., Avraham Y., Zappasodi R., Rusinova R., Newman W., Heath H., Wolchok J. D., Dahan R., Merghoub T. & Meyerson J. Science advances | 2022
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  • February 18, 2022

    Batf-mediated epigenetic control of effector CD8<sup>+</sup> T cell differentiation

    Tsao H., Kaminski J., Kurachi M., Barnitz R. A., DiIorio M. A., LaFleur M. W., Ise W., Kurosaki T., Wherry E. J., Haining W. N. & Yosef N. Science immunology | 2022
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  • February 07, 2022

    A Python library for probabilistic analysis of single-cell omics data

    Gayoso A., Lopez R., Xing G., Boyeau P., Valiollah Pour Amiri V., Hong J., Wu K., Jayasuriya M., Mehlman E., Langevin M. , et al. , Liu Y., Samaran J., Misrachi G., Nazaret A., Clivio O., Xu C., Ashuach T., Gabitto M., Lotfollahi M., Svensson V., da Veiga Beltrame E., Kleshchevnikov V., Talavera-López C., Pachter L., Theis F. J., Streets A., Jordan M. I., Regier J. & Yosef N. Nature biotechnology | 2022
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    Innate immune responses
    Adaptive Immunity
    Immune Disorders
    January 31, 2022

    Affinity-based clonal selection in Peyer's patches

    Jingjing L. & Ziv S. Current Opinion in Immunology | 2022
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  • January 31, 2022

    Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis

    Musiu C., Caligola S., Fiore A., Lamolinara A., Frusteri C., Del Pizzo F. D., De Sanctis F., Cane S., Adamo A., Hofer F. , et al. , Barouni R. M., Grilli A., Zilio S., Serafini P., Tacconelli E., Donadello K., Gottin L., Polati E., Girelli D., Polidoro I., Iezzi P. A., Angelucci D., Capece A., Chen Y., Shi Z., Murray P. J., Chilosi M., Amit I., Bicciato S., Iezzi M., Bronte V. & Ugel S. Cell Death and Differentiation | 2022
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  • January 31, 2022

    Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages

    Gupta A., Shamsi F., Altemose N., Dorlhiac G. F., Cypess A. M., White A. P., Yosef N., Patti M. E., Tseng Y. & Streets A. Genome Research | 2022
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  • January 18, 2022

    CXCR3 regulates stem and proliferative CD8+ T cells during chronic infection by promoting interactions with DCs in splenic bridging channels

    Bangs D. J., Tsitsiklis A., Steier Z., Chan S. W., Kaminski J., Streets A., Yosef N. & Robey E. A. Cell Reports | 2022
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  • January 18, 2022

    Early antitumor activity of oral Langerhans cells is compromised by a carcinogen

    Saba Y., Aizenbud I., Matanes D., Koren N., Barel O., Zubeidat K., Capucha T., David E., Eli-Berchoer L., Stoitzner P. , et al. , Wilensky A., Amit I., Czerninski R., Yona S. & Hovav A. Proceedings of the National Academy of Sciences of the United States of America | 2022
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  • January 15, 2022

    Mucosal Vaccination with Cyclic Dinucleotide Adjuvants Induces Effective T Cell Homing and IL-17-Dependent Protection against Mycobacterium tuberculosis Infection

    Jong R. M., Van Dis E., Berry S. B., Nguyenla X., Baltodano A., Pastenkos G., Xu C., Fox D., Yosef N., McWhirter S. M. & Stanley S. A. Journal of Immunology | 2022
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  • January 14, 2022

    Bacterial gasdermins reveal an ancient mechanism of cell death

    Johnson A. G., Wein T., Mayer M. L., Duncan-Lowey B., Yirmiya E., Oppenheimer-Shaanan Y., Amitai G., Sorek R. & Kranzusch P. J. Science | 2022
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  • January 06, 2022

    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

    Sheban D., Shani T., Maor R., Aguilera-Castrejon A., Mor N., Oldak B., Shmueli M. D., Eisenberg-Lerner A., Bayerl J., Hebert J. , et al. , Viukov S., Chen G., Kacen A., Krupalnik V., Chugaeva V., Tarazi S., Rodríguez-delaRosa A., Zerbib M., Ulman A., Masarwi S., Kupervaser M., Levin Y., Shema E., David Y., Novershtern N., Hanna J. H. & Merbl Y. Molecular Cell | 2022
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  • January 01, 2022

    Gastrointestinal microbiome: Evaluation of testing technologies

    Spivak I. & Elinav E. | 2022
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  • December 31, 2021

    Publisher Correction: XCR1 <sup>+</sup> type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis (Nature Medicine, (2021), 27, 6, (1043-1054), 10.1038/s41591-021-01344-3)

    Deczkowska A., David E., Ramadori P., Pfister D., Safran M., Li B., Giladi A., Jaitin D. A., Barboy O., Cohen M. , et al. , Yofe I., Gur C., Shlomi-Loubaton S., Henri S., Suhail Y., Qiu M., Kam S., Hermon H., Lahat E., Ben Yakov G., Cohen-Ezra O., Davidov Y., Likhter M., Goitein D., Roth S., Weber A., Malissen B., Weiner A., Ben-Ari Z., Heikenwälder M., Elinav E. & Amit I. Nature Medicine | 2022
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  • December 31, 2021

    Complete Visualization of T Follicular Helper Cells in Germinal Centers by Light Sheet Fluorescence Microscopy

    Stoler-Barak L. & Shulman Z. | 2022
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  • December 31, 2021

    Mapping single-cell data to reference atlases by transfer learning

    Lotfollahi M., Naghipourfar M., Luecken M. D., Khajavi M., Büttner M., Wagenstetter M., Avsec Ž., Gayoso A., Yosef N., Interlandi M. , et al. , Rybakov S., Misharin A. V. & Theis F. J. Nature biotechnology | 2022
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  • December 31, 2021

    Alzheimers disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis

    Dvir-Szternfeld R., Castellani G., Arad M., Cahalon L., Colaiuta S. P., Keren-Shaul H., Croese T., Burgaletto C., Baruch K., Ulland T. , et al. , Colonna M., Weiner A., Amit I. & Schwartz M. Nature Aging | 2022
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  • December 23, 2021

    Gut microbiota modulates weight gain in mice after discontinued smoke exposure

    Fluhr L., Mor U., Kolodziejczyk A. A., Dori-Bachash M., Leshem A., Itav S., Cohen Y., Suez J., Zmora N., Moresi C. , et al. , Ayalon N., Valdés-Mas R., Molina S., Hornstein S., Karbi H., Kviatcovsky D., Livne A., Bukimer A., Eliyahu-Miller S., Metz A., Brandis A., Mehlman T., Kuperman Y., Tsoory M., Stettner N., Harmelin A., Shapiro H. & Elinav E. Nature | 2021
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  • December 14, 2021

    Anti-SARS-CoV-2 antibodies elicited by COVID-19 mRNA vaccine exhibit a unique glycosylation pattern

    Farkash I., Feferman T., Cohen-Saban N., Avraham Y., Morgenstern D., Mayuni G., Barth N., Lustig Y., Miller L., Shouval D. S. , et al. , Biber A., Kirgner I., Levin Y. & Dahan R. Cell Reports | 2021
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  • December 08, 2021

    Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry

    Reddi R. N., Rogel A., Resnick E., Gabizon R., Prasad P. K., Gurwicz N., Barr H., Shulman Z. & London N. Journal of the American Chemical Society | 2021
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  • December 02, 2021

    Self-guarding of MORC3 enables virulence factor-triggered immunity

    Gaidt M. M., Morrow A., Fairgrieve M., Karr J., Yosef N. & Vance R. E. Nature | 2021
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  • December 01, 2021

    Clump sequencing exposes the spatial expression programs of intestinal secretory cells

    Manco R., Averbukh I., Porat Z., Bahar Halpern K., Amit I. & Itzkovitz S. Nature Communications | 2021
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  • November 08, 2021

    Epitome: Predicting epigenetic events in novel cell types with multi-cell deep ensemble learning

    Morrow A. K., Hughes J. W., Singh J., Joseph A. D. & Yosef N. Nucleic Acids Research | 2021
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  • November 04, 2021

    Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

    Beyaz S., Chung C., Mou H., Bauer-Rowe K. E., Xifaras M. E., Ergin I., Dohnalova L., Biton M., Shekhar K., Eskiocak O. , et al. , Papciak K., Ozler K., Almeqdadi M., Yueh B., Fein M., Annamalai D., Valle-Encinas E., Erdemir A., Dogum K., Shah V., Alici-Garipcan A., Meyer H. V., Özata D. M., Elinav E., Kucukural A., Kumar P., McAleer J. P., Fox J. G., Thaiss C. A., Regev A., Roper J., Orkin S. H. & Yilmaz Ö. H. Cell Stem Cell | 2021
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  • October 31, 2021

    Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

    van der Leun A. M., Hoekstra M. E., Reinalda L., Scheele C. L. G. J., Toebes M., van de Graaff M. J., Chen L. Y. Y., Li H., Bercovich A., Lubling Y. , et al. , David E., Thommen D. S., Tanay A., van Rheenen J., Amit I., van Kasteren S. I. & Schumacher T. N. Nature Chemical Biology | 2021
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  • October 31, 2021

    Reporting guidelines for human microbiome research: the STORMS checklist

    Elinav E. & Segal E. Nature Medicine | 2021
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  • October 31, 2021

    Dichotomous metabolic networks govern human ILC2 proliferation and function

    Surace L., Doisne J., Croft C. A., Thaller A., Escoll P., Marie S., Petrosemoli N., Guillemot V., Dardalhon V., Topazio D. , et al. , Cama A., Buchrieser C., Taylor N., Amit I., Musumeci O. & Di Santo J. P. Nature Immunology | 2021
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  • October 31, 2021

    Postbiotics when simplification fails to clarify

    Aguilar-Toalá J. E., Arioli S., Behare P., Belzer C., Berni Canani R., Chatel J., DAuria E., de Freitas M. Q., Elinav E., Esmerino E. A. , et al. , García H. S., da Cruz A. G., González-Córdova A. F., Guglielmetti S., de Toledo Guimarães J., Hernández-Mendoza A., Langella P., Liceaga A. M., Magnani M., Mohamad Lal M. T., Martin R., Mora D., Moradi M., Morelli L., Mosca F., Nazzaro F., Pimentel T. C., Ran C., Ranadheera C. S., Rescigno M., Salas A., SantAna A. S., Sivieri K., Sokol H., Taverniti V., Vallejo-Cordoba B., Zelenka J. & Zhou Z. Nature reviews. Gastroenterology & hepatology | 2021
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  • October 28, 2021

    Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development

    Alameda D., Goicoechea I., Vicari M., Arriazu E., Nevone A., Rodríguez S., Lasa M., Puig N., Cedena M., Alignani D. , et al. , Garate S., Lara-Astiaso D., Vilas-Zornoza A., Sarvide S., Ocio E. M., Lecumberri R., Garcia de Coca A., Labrador J., Gonzalez M., Palomera L., Gironella M., Cabañas V., Casanova M., Oriol A., Krsnik I., Pérez-Montaña A., de la Rubia J., de la Puerta J., de Arriba F., Fazio V. M., Martinez-Lopez J., Lahuerta J., Mateos M., Odero M. D., Prosper F., Weiner A., Amit I., Nuvolone M., San-Miguel J. F. F. & Paiva B. Blood | 2021
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  • October 15, 2021

    Altered Protein Abundance and Localization Inferred from Sites of Alternative Modification by Ubiquitin and SUMO: Revealing new insights into protein function from Sites of Alternative Modifications (SAM)

    Ulman A., Levin T., Dassa B., Javitt A., Kacen A., Shmueli M. D., Eisenberg-Lerner A., Sheban D., Fishllevich S., Levy E. D. & Merbl Y. Journal of Molecular Biology | 2021
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  • October 11, 2021

    Microbiome and cancer

    Cullin N., Azevedo Antunes C., Straussman R., Stein-Thoeringer C. K. & Elinav E. Cancer Cell | 2021
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  • September 30, 2021

    Commensal inter-bacterial interactions shaping the microbiota

    Kern L., Abdeen S. K., Kolodziejczyk A. A. & Elinav E. Current Opinion in Microbiology | 2021
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  • September 01, 2021

    Brg1 Supports B Cell Proliferation and Germinal Center Formation Through Enhancer Activation

    Schmiedel D., Hezroni H., Hamburg A. & Shulman Z. Frontiers in Immunology | 2021
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  • August 31, 2021

    Personalized Postprandial Glucose ResponseTargeting Diet Versus Mediterranean Diet for Glycemic Control in Prediabetes

    Ben-Yacov O., Godneva A., Rein M., Shilo S., Kolobkov D., Koren N., Cohen Dolev N., Travinsky Shmul T., Wolf B. C., Kosower N. , et al. , Sagiv K., Lotan-Pompan M., Zmora N., Weinberger A., Elinav E. & Segal E. Diabetes Care | 2021
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  • August 31, 2021

    Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

    Dubiella C., Pinch B. J., Koikawa K., Zaidman D., Poon E., Manz T. D., Nabet B., He S., Resnick E., Rogel A. , et al. , Langer E. M., Daniel C. J., Seo H., Chen Y., Adelmant G., Sharifzadeh S., Ficarro S. B., Martins da Costa B., Jamin Y., Zimmerman M. W., Lian X., Kibe S., Kozono S., Doctor Z. M., Browne C. M., Yang A., Stoler-Barak L., Shah R. B., Vangos N. E., Geffken E. A., Oren R., Koide E., Sidi S., Shulman Z., Wang C., Marto J. A., Dhe-Paganon S., Look T., Zhou X. Z., Lu K. P., Sears R. C., Chesler L., Gray N. S. & London N. Nature Chemical Biology | 2021
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  • August 24, 2021

    Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

    Sano T., Kageyama T., Fang V., Kedmi R., Martinez C. S., Talbot J., Chen A., Cabrera I., Gorshko O., Kurakake R. , et al. , Yang Y., Ng C., Schwab S. R. & Littman D. R. Cell Reports | 2021
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  • August 23, 2021

    Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers

    Klompus S., Leviatan S., Vogl T., Mazor R., Kalka I., Stoler-Barak L., Nathan N., Peres A., Moss L., Godneva A. , et al. , Kagan Ben Tikva S., Shinar E., Dvashi H. C., Gabizon R., London N., Diskin R., Yaari G., Weinberger A., Shulman Z. & Segal E. Science immunology | 2021
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  • August 18, 2021

    Benchmarked approaches for reconstruction of in vitro cell lineages and in silico models of C. elegans and M. musculus developmental trees

    Gong W., Granados A. A., Hu J., Jones M. G., Raz O., Salvador-Martínez I., Zhang H., Chow K. K., Kwak I., Retkute R. , et al. , Prusokas A., Prusokas A., Khodaverdian A., Zhang R., Rao S., Wang R., Rennert P., Saipradeep V. G., Sivadasan N., Rao A., Joseph T., Srinivasan R., Peng J., Han L., Shang X., Garry D. J., Yu T., Chung V., Mason M., Liu Z., Guan Y., Yosef N., Shendure J., Telford M. J., Shapiro E., Elowitz M. B. & Meyer P. Cell Systems | 2021
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  • August 17, 2021

    The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers

    Grenov A. C., Moss L., Edelheit S., Cordiner R., Schmiedel D., Biram A., Hanna J. H., Jensen T. H., Schwartz S. & Shulman Z. Journal of Experimental Medicine | 2021
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  • August 05, 2021

    Polyamine metabolism is a central determinant of helper T cell lineage fidelity

    Puleston D. J., Baixauli F., Sanin D. E., Edwards-Hicks J., Villa M., Kabat A. M., Kamiński M. M., Stanckzak M., Weiss H. J., Grzes K. M. , et al. , Piletic K., Field C. S., Corrado M., Haessler F., Wang C., Musa Y., Schimmelpfennig L., Flachsmann L., Mittler G., Yosef N., Kuchroo V. K., Buescher J. M., Balabanov S., Pearce E. J., Green D. R. & Pearce E. L. Cell | 2021
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  • August 05, 2021

    Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

    Wagner A., Wang C., Fessler J., DeTomaso D., Avila-Pacheco J., Kaminski J., Zaghouani S., Christian E., Thakore P., Schellhaass B. , et al. , Akama-Garren E., Pierce K., Singh V., Ron-Harel N., Douglas V. P., Bod L., Schnell A., Puleston D., Sobel R. A., Haigis M., Pearce E. L., Soleimani M., Clish C., Regev A., Kuchroo V. K. & Yosef N. Cell | 2021
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  • July 31, 2021

    Gut microbiome and its potential link to personalized nutrition

    Kviatcovsky D., Zheng D. & Elinav E. Current Opinion in Physiology | 2021
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  • July 31, 2021

    Probiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner

    Montassier E., Valdés-Mas R., Batard E., Zmora N., Dori-Bachash M., Suez J. & Elinav E. Nature Microbiology | 2021
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  • July 22, 2021

    The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination

    Wimmers F., Donato M., Kuo A., Ashuach T., Gupta S., Li C., Dvorak M., Foecke M. H., Chang S. E., Hagan T. , et al. , De Jong S. E., Maecker H. T., van der Most R., Cheung P., Cortese M., Bosinger S. E., Davis M., Rouphael N., Subramaniam S., Yosef N., Utz P. J., Khatri P. & Pulendran B. Cell | 2021
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  • July 12, 2021

    Essential gene acquisition destabilizes plasmid inheritance

    Wein T., Wang Y., Barz M., Stücker, F. T., Hammerschmt K. & Dagan T. PLoS Genetics | 2021
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  • July 01, 2021

    Designer fibre meals sway human gut microbes

    Leshem A. & Elinav E. Nature | 2021
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  • June 30, 2021

    Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine

    Beharier O., Plitman Mayo R., Raz T., Nahum Sacks K., Schreiber L., Suissa-Cohen Y., Chen R., Gomez-Tolub R., Hadar E., Gabbay-Benziv R. , et al. , Jaffe Moshkovich Y., Biron-Shental T., Shechter-Maor G., Farladansky-Gershnabel S., Yitzhak Sela H., Benyamini-Raischer H., Sela N. D., Goldman-Wohl D., Shulman Z., Many A., Barr H., Yagel S., Neeman M. & Kovo M. Journal of Clinical Investigation | 2021
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  • June 30, 2021

    Unified platform for genetic and serological detection of COVID-19 with single-molecule technology

    Furth N., Shilo S., Cohen N., Erez N., Fedyuk V., Schrager A. M., Weinberger A., Dror A. A., Zigron A., Shehadeh M. , et al. , Sela E., Srouji S., Amit S., Levy I., Segal E., Dahan R., Jones D., Douek D. C. & Shema E. PLoS ONE | 2021
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  • June 30, 2021

    Gatekeepers of the gut: The roles of proteasomes at the gastrointestinal barrier

    Mohapatra G., Eisenberg-Lerner A. & Merbl Y. Biomolecules | 2021
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  • June 21, 2021

    Basic biology of rhythms and the microbiome

    Heinemann M., Ratiner K. & Elinav E. | 2021
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  • June 11, 2021

    Machine learning in clinical decision making

    Adlung L., Cohen Y., Mor U. & Elinav E. Med | 2021
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  • June 08, 2021

    Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

    McFarland A. P., Yalin A., Wang S., Cortez V. S., Landsberger T., Sudan R., Peng V., Miller H. L., Ricci B., David E. , et al. , Faccio R., Amit I. & Colonna M. Immunity (Cambridge, Mass.) | 2021
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  • May 31, 2021

    Heads or tails: histone tail clipping regulates macrophage activity

    Kragesteen B. K. & Amit I. Nature Immunology | 2021
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  • May 31, 2021

    Getting toGether in Germinal centers

    Stoler-Barak L. & Shulman Z. Science immunology | 2021
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  • May 31, 2021

    XCR1<sup>+</sup> type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

    Deczkowska A., David E., Ramadori P., Pfister D., Safran M., Li B., Giladi A., Jaitin D. A., Barboy O., Cohen M. , et al. , Yofe I., Gur C., Shlomi-Loubaton S., Henri S., Suhail Y., Qiu M., Kam S., Hermon H., Lahat E., Ben Yakov G., Cohen-Ezra O., Davidov Y., Likhter M., Goitein D., Roth S., Weber A., Malissen B., Weiner A., Ben-Ari Z., Heikenwälder M., Elinav E. & Amit I. Nature Medicine | 2021
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  • May 30, 2021

    Reconstructing unobserved cellular states from paired single-cell lineage tracing and transcriptomics data

    Ouardini K., Lopez R., Jones M. G., Prillo S., Zhang R., Jordan M. I. & Yosef N. bioArxiv | 2021
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  • May 25, 2021

    A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion

    Gonçalves C. A., Larsen M., Jung S., Stratmann J., Nakamura A., Leuschner M., Hersemann L., Keshara R., Perlman S., Lundvall L. , et al. , Thuesen L. L., Hare K. J., Amit I., Jørgensen A., Kim Y. H., del Sol A. & Grapin-Botton A. Nature Communications | 2021
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  • May 24, 2021

    CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data

    Amit I., Iancu O., Levy-Jurgenson A., Kurgan G., McNeill M. S., Rettig G. R., Allen D., Breier D., Ben Haim N., Wang Y. , et al. , Anavy L., Hendel A. & Yakhini Z. Nature Communications | 2021
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  • May 19, 2021

    Hotspot identifies informative gene modules across modalities of single-cell genomics

    DeTomaso D. & Yosef N. Cell Systems | 2021
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  • May 12, 2021

    T cell self-reactivity during thymic development dictates the timing of positive selection

    Lutes L. K., Steier Z., McIntyre L. L., Pandey S., Kaminski J., Hoover A. R., Ariotti S., Streets A., Yosef N. & Robey E. A. eLife | 2021
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  • May 01, 2021

    Toward a better understanding of intermittent fasting effects: Ramadan fasting as a model

    Abdeen S. K. & Elinav E. The American journal of clinical nutrition | 2021
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  • April 15, 2021

    NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Pfister D., Núñez N. G., Pinyol R., Govaere O., Pinter M., Szydlowska M., Gupta R., Qiu M., Deczkowska A., Weiner A. , et al. , Müller F., Sinha A., Friebel E., Engleitner T., Lenggenhager D., Moncsek A., Heide D., Stirm K., Kosla J., Kotsiliti E., Leone V., Dudek M., Yousuf S., Inverso D., Singh I., Teijeiro A., Castet F., Montironi C., Haber P. K., Tiniakos D., Bedossa P., Cockell S., Younes R., Vacca M., Marra F., Schattenberg J. M., Allison M., Bugianesi E., Ratziu V., Pressiani T., DAlessio A., Personeni N., Rimassa L., Daly A. K., Scheiner B., Pomej K., Kirstein M. M., Vogel A., Peck-Radosavljevic M., Hucke F., Finkelmeier F., Waidmann O., Trojan J., Schulze K., Wege H., Koch S., Weinmann A., Bueter M., Rössler F., Siebenhüner A., De Dosso S., Mallm J. P., Umansky V., Jugold M., Luedde T., Schietinger A., Schirmacher P., Emu B., Augustin H. G., Billeter A., Müller-Stich B., Kikuchi H., Duda D. G., Kütting F., Waldschmidt D. T., Ebert M. P., Rahbari N., Mei H. E., Schulz A. R., Ringelhan M., Malek N., Spahn S., Bitzer M., Ruiz de Galarreta M., Lujambio A., Dufour J. F., Marron T. U., Kaseb A., Kudo M., Huang Y. H., Djouder N., Wolter K., Zender L., Marche P. N., Decaens T., Pinato D. J., Rad R., Mertens J. C., Weber A., Unger K., Meissner F., Roth S., Jilkova Z. M., Claassen M., Anstee Q. M., Amit I., Knolle P., Becher B., Llovet J. M. & Heikenwalder M. Nature (London) | 2021
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  • April 07, 2021

    Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry

    Reddi R. N., Resnick E., Rogel A., Rao B. V., Gabizon R., Goldenberg K., Gurwicz N., Zaidman D., Plotnikov A., Barr H. , et al. , Shulman Z. & London N. Journal of the American Chemical Society | 2021
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  • March 31, 2021

    The path of the T-bet-ian CD8<sup>+</sup> T cells

    Stoler-Barak L. & Shulman Z. Nature Immunology | 2021
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  • March 31, 2021

    Breakthroughs and Bottlenecks in Microbiome Research

    Liwinski T., Leshem A. & Elinav E. Trends in Molecular Medicine | 2021
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  • March 16, 2021

    Correction for Finlay et al., The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome

    Finlay B. B., Amato K. R., Azad M., Blaser M. J., Bosch T. C., Chu H., Dominguez-Bello M. G., Ehrlich S. D., Elinav E., Geva-Zatorsky N. , et al. , Gros P., Guillemin K., Keck F., Korem T., McFall-Ngai M. J., Melby M. K., Nichter M., Pettersson S., Poinar H., Rees T., Tropini C., Zhao L. & Giles-Vernick T. Proceedings of the National Academy of Sciences of the United States of America | 2021
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  • March 05, 2021

    Deciphering the state of immune silence in fatal COVID-19 patients

    Bost P., De Sanctis F., Canè S., Ugel S., Donadello K., Castellucci M., Eyal D., Fiore A., Anselmi C., Barouni R. M. , et al. , Trovato R., Caligola S., Lamolinara A., Iezzi M., Facciotti F., Mazzariol A., Gibellini D., De Nardo P., Tacconelli E., Gottin L., Polati E., Schwikowski B., Amit I. & Bronte V. Nature Communications | 2021
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  • March 04, 2021

    CD74 is a regulator of hematopoietic stem cell maintenance

    Becker-Herman S., Rozenberg M., Hillel-Karniel C., Gil-Yarom N., Kramer M., Barak A., Sever L., David K., Radomir L., Lewinsky H. , et al. , Levi M., Friedlander G., Bucala R., Peled A. & Shachar I. PLoS Biology | 2021
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  • February 28, 2021

    Joint probabilistic modeling of single-cell multi-omic data with totalVI

    Gayoso A., Steier Z., Lopez R., Regier J., Nazor K. L., Streets A. & Yosef N. Nature Methods | 2021
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  • February 28, 2021

    Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

    Everetts N. J., Worley M. I., Yasutomi R., Yosef N. & Hariharan I. K. eLife | 2021
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  • February 28, 2021

    Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

    Zada M., Wang S., Bornstein C., David E., Moshe A., Li B., Shlomi-loubaton S., Gatt M. E., Gur C., Lavi N. , et al. , Ganzel C., Luttwak E., Chubar E., Rouvio O., Vaxman I., Pasvolsky O., Ballan M., Tadmor T., Nemets A., Jarchowcky-dolberg O., Shvetz O., Laiba M., Shpilberg O., Dally N., Avivi I., Weiner A. & Amit I. Nature Medicine | 2021
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  • February 28, 2021

    The NLRP6 inflammasome

    Zheng D., Kern L. & Elinav E. Immunology | 2021
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  • February 26, 2021

    Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

    Quinn J. J., Jones M. G., Okimoto R. A., Nanjo S., Chan M. M., Yosef N., Bivona T. G. & Weissman J. S. Science | 2021
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  • February 23, 2021

    Remembering past infections: training exercise for gut microbes

    Nobs S. P. & Elinav E. Cell Research | 2021
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  • February 22, 2021

    CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma

    Lewinsky H., Gunes E. G., David K., Radomir L., Kramer M. P., Pellegrino B., Perpinial M., Chen J., He T. F., Mansour A. G. , et al. , Teng K. Y., Bhattacharya S., Caserta E., Troadec E., Lee P., Feng M., Keats J., Krishnan A., Rosenzweig M., Yu J., Caligiuri M. A., Cohen Y., Shevetz O., Becker-Herman S., Pichiorri F., Rosen S. & Shachar I. JCI insight | 2021
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  • February 10, 2021

    Maturation of the neonatal oral mucosa involves unique epithelium-microbiota interactions

    Koren N., Zubeidat K., Saba Y., Horev Y., Barel O., Wilharm A., Heyman O., Wald S., Eli-berchoer L., Shapiro H. , et al. , Nadler C., Elinav E., Wilensky A., Prinz I., Bercovier H. & Avi-Hai H. Cell Host and Microbe | 2021
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  • February 09, 2021

    The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome

    Finlay B. B., Amato K. R., Azad M., Blaser M. J., Bosch T. C., Chu H., Dominguez-Bello M. G., Ehrlich S. D., Elinav E., Geva-Zatorsky N. , et al. , Gros P., Guillemin K., Keck F., Korem T., McFall-Ngai M. J., Melby M. K., Nichter M., Pettersson S., Poinar H., Rees T., Tropini C., Zhao L. & Giles-Vernick T. Proceedings of the National Academy of Sciences of the United States of America | 2021
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  • February 01, 2021

    JEM career launchpad

    Bigas A., Zanoni I., Hepworth M. R., Eisenbarth S. C., Masters S. L., Kipnis J., Vinuesa C. G., Good-Jacobson K. L., Tangye S. G., Yamazaki S. , et al. , Hivroz C., Wojno E. T., Shulman Z. & Colonna M. Journal of Experimental Medicine | 2021
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  • January 31, 2021

    Harnessing smartphones to personalize nutrition in a time of global pandemic

    Zmora N. & Elinav E. Nutrients | 2021
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  • January 27, 2021

    Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis

    Watson A., Li H., Ma B., Weiss R., Bendayan D., Abramovitz L., Ben-Shalom N., Mor M., Pinko E., Bar Oz M. , et al. , Wang Z., Du F., Lu Y., Rybniker J., Dahan R., Huang H., Barkan D., Xiang Y., Javid B. & Freund N. T. Nature Communications | 2021
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  • January 20, 2021

    The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)

    Boddy S. L., Giovannelli I., Sassani M., Cooper-Knock J., Snyder M. P., Segal E., Elinav E., Barker L. A., Shaw P. J. & McDermott C. J. BMC Medicine | 2021
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  • January 19, 2021

    Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis

    Pompura S. L., Wagner A., Kitz A., Yosef N., LaPerche J., Dominguez-Villar M. & Hafler D. A. Journal of Clinical Investigation | 2021
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  • January 15, 2021

    Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

    Kult S., Olender T., Osterwalder M., Markman S., Leshkowitz D., Krief S., Blecher-Gonen R., Ben-Moshe S., Farack L., Keren-Shaul H. , et al. , Salame T. M., Capellini T. D., Itzkovitz S., Amit I., Visel A. & Zelzer E. eLife | 2021
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  • January 12, 2021

    Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

    Heming M., Li X., Räuber S., Mausberg A. K., Börsch A. L., Hartlehnert M., Singhal A., Lu I. N., Fleischer M., Szepanowski F. , et al. , Witzke O., Brenner T., Dittmer U., Yosef N., Kleinschnitz C., Wiendl H., Stettner M. & Meyer zu Hörste G. Immunity | 2021
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  • January 04, 2021

    NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis

    Sever D., Hershko-Moshe A., Srivastava R., Eldor R., Hibsher D., Keren-Shaul H., Amit I., Bertuzzi F., Krogvold L., Dahl-Jørgensen K. , et al. , Ben-Dov I. Z., Landsman L. & Melloul D. Cell Death Discovery | 2021
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  • December 31, 2020

    CD4<sup>+</sup> and CD8<sup>+</sup> cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG<sub>4</sub>-related disease

    Perugino C. A., Kaneko N., Maehara T., Mattoo H., Kers J., Allard-Chamard H., Mahajan V. S., Liu H., Della-Torre E., Murphy S. J. , et al. , Ghebremichael M., Wallace Z. S., Bolster M. B., Harvey L. M., Mylvaganam G., Tuncay Y., Liang L., Montesi S. B., Zhang X., Tinju A., Mochizuki K., Munemura R., Sakamoto M., Moriyama M., Nakamura S., Yosef N., Stone J. H. & Pillai S. Journal of Allergy and Clinical Immunology | 2021
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  • December 31, 2020

    Probabilistic harmonization and annotation of single-cell transcriptomics data with deep generative models

    Xu C., Lopez R., Mehlman E., Regier J., Jordan M. & Yosef N. Molecular Systems Biology | 2021
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  • December 31, 2020

    Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

    Cohen M., Giladi A., Raposo C., Zada M., Li B., Ruckh J., Deczkowska A., Mohar B., Shechter R., Lichtenstein R. G. , et al. , Amit I. & Schwartz M. Life Science Alliance | 2021
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  • December 06, 2020

    Decision-making with auto-encoding variational Bayes

    Lopez R., Boyeau P., Yosef N., Jordan M. I. & Regier J. | 2020
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  • December 03, 2020

    Our Microbiome: On the Challenges, Promises, and Hype

    Federici S., Suez J. & Elinav E. | 2020
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  • December 03, 2020

    Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

    Marmor-Kollet H., Siany A., Kedersha N., Knafo N., Rivkin N., Danino Y. M., Moens T. G., Olender T., Sheban D., Cohen N. , et al. , Dadosh T., Addadi Y., Ravid R., Eitan C., Toth Cohen B., Hofmann S., Riggs C. L., Advani V. M., Higginbottom A., Cooper-Knock J., Hanna J. H., Merbl Y., Van Den Bosch L., Anderson P., Ivanov P., Geiger T. & Hornstein E. Molecular Cell | 2020
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  • December 01, 2020

    Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

    Schafflick D., Xu C. A., Hartlehnert M., Cole M., Schulte-Mecklenbeck A., Lautwein T., Wolbert J., Heming M., Meuth S. G., Kuhlmann T. , et al. , Gross C. C., Wiendl H., Yosef N. & Meyer zu Horste G. Nature Communications | 2020
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  • November 30, 2020

    A single cell atlas of the human liver tumor microenvironment

    Massalha H., Bahar Halpern K., Abu-Gazala S., Jana T., Massasa E. E., Moor A. E., Buchauer L., Rozenberg M., Pikarsky E., Amit I. , et al. , Zamir G. & Itzkovitz S. Molecular Systems Biology | 2020
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  • November 23, 2020

    Testing IgG antibodies against the RBD of SARS-CoV-2 is sufficient and necessary for COVID-19 diagnosis

    Indenbaum V., Koren R., Katz-Likvornik S., Yitzchaki M., Halpern O., Regev-Yochay G., Cohen C., Biber A., Feferman T., Saban N. C. , et al. , Dahan R., Levin T., Gozlan Y., Weil M., Mor O., Mandelboim M., Sofer D., Mendelson E. & Lustig Y. PLoS ONE | 2020
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  • November 18, 2020

    CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

    Rosenblum D., Gutkin A., Kedmi R., Ramishetti S., Veiga N., Jacobi A. M., Schubert M. S., Friedmann-Morvinski D., Cohen Z. R., Behlke M. A. , et al. , Lieberman J. & Peer D. Science advances | 2020
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  • November 15, 2020

    A hidden sedimentary phosphate pool inside benthic foraminifera from the Peruvian upwelling region might nucleate phosphogenesis

    Glock N., Romero D., Roy A. S., Woehle C., Dale A. W., Schönfeld J., Wein T., Weissenbach J. & Dagan T. Geochimica et Cosmochimica Acta | 2020
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  • November 12, 2020

    Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome (vol 182, pg 1460, 2020): Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome (Cell (2020) 182(6) (14601473.e17), (S0092867420309983), (10.1016/j.cell.2020.08.007))

    Mars R. A., Yang Y., Ward T., Houtti M., Priya S., Lekatz H. R., Tang X., Sun Z., Kalari K. R., Korem T. , et al. , Bhattarai Y., Zheng T., Bar N., Frost G., Johnson A. J., van Treuren W., Han S., Ordog T., Grover M., Sonnenburg J., D'Amato M., Camilleri M., Elinav E., Segal E., Blekhman R., Farrugia G., Swann J. R., Knights D. & Kashyap P. C. Cell | 2020
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  • October 31, 2020

    High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

    Grosheva I., Zheng D., Levy M., Polansky O., Lichtenstein A., Golani O., Dori-Bachash M., Moresi C., Shapiro H., Del Mare-Roumani S. , et al. , Valdes-Mas R., He Y., Karbi H., Chen M., Harmelin A., Straussman R., Yissachar N., Elinav E. & Geiger B. Gastroenterology | 2020
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  • October 27, 2020

    The gut microbiome and individual-specific responses to diet

    Leshem A., Segal E. & Elinav E. mSystems | 2020
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  • October 26, 2020

    Acute liver failure is regulated by MYC- and microbiome-dependent programs

    Kolodziejczyk A. A., Federici S., Zmora N., Mohapatra G., Dori-Bachash M., Hornstein S., Leshem A., Reuveni D., Zigmond E., Tobar A. , et al. , Salame T. M., Harmelin A., Shlomai A., Shapiro H., Amit I. & Elinav E. Nature Medicine | 2020
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  • October 10, 2020

    Rationale and design of a randomised controlled trial testing the effect of personalised diet in individuals with pre-diabetes or type 2 diabetes mellitus treated with metformin

    Htet T. D., Godneva A., Liu Z., Chalmers E., Kolobkov D., Snaith J. R., Richens R., Toth K., Danta M., Hng T. M. , et al. , Elinav E., Segal E., Greenfield J. R. & Samocha-Bonet D. BMJ Open | 2020
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  • October 05, 2020

    Antibiotics Interfere with the Evolution of Plasmid Stability

    Wein T., Wang Y., Hülter N. F., Hammerschmidt K. & Dagan T. Current Biology | 2020
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  • October 05, 2020

    Plasmid evolution

    Wein T. & Dagan T. Current Biology | 2020
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  • September 23, 2020

    Nutrition Regulates Innate Immunity in Health and Disease

    Nobs S. P., Zmora N. & Elinav E. Annual Review of Nutrition | 2020
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  • September 17, 2020

    Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

    Silvin A., Chapuis N., Dunsmore G., Goubet A., Dubuisson A., Derosa L., Almire C., Henon C., Kosmider O., Droin N. , et al. , Rameau P., Catelain C., Alfaro A., Dussiau C., Friedrich C., Sourdeau E., Marin N., Szwebel T., Cantin D., Mouthon L., Borderie D., Deloger M., Bredel D., Mouraud S., Drubay D., Andrieu M., Lhonneur A., Saada V., Stoclin A., Willekens C., Pommeret F., Griscelli F., Ng L. G., Zhang Z., Bost P., Amit I., Barlesi F., Marabelle A., Pene F., Gachot B., Andre F., Zitvogel L., Ginhoux F., Fontenay M. & Solary E. Cell | 2020
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  • September 17, 2020

    Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis

    Tuganbaev T., Mor U., Bashiardes S., Liwinski T., Nobs S. P., Leshem A., Dori-Bachash M., Thaiss C. A., Pinker E. Y., Ratiner K. , et al. , Adlung L., Federici S., Kleimeyer C., Moresi C., Yamada T., Cohen Y., Zhang X., Massalha H., Massasa E., Koni P. A., Kuperman Y., Harmelin A., Gao N., Itzkovitz S., Honda K., Shapiro H. & Elinav E. Cell | 2020
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  • September 17, 2020

    Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome

    Mars R. A. T., Ward T., Houtti M., Priya S., Lekatz H. R., Tang X., Sun Z., Kalari K. R., Bhattarai Y., Zheng T. , et al. , Bar N., Frost G., Johnson A. J., van Treuren W., Han S., Ordog T., Grover M., Sonnenburg J., D'Amato M., Camilleri M., Elinav E., Segal E., Blekhman R., Farrugia G., Swann J. R., Knights D. & Kashyap P. C. Cell | 2020
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  • September 08, 2020

    Phages and their potential to modulate the microbiome and immunity

    Federici S., Nobs S. P. & Elinav E. Cellular and Molecular Immunology | 2020
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  • September 07, 2020

    LifeTime and improving European healthcare through cell-based interceptive medicine

    Rajewsky N., Almouzni G., Amit I., Tanay A. & Reiner O. Nature | 2020
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  • September 04, 2020

    Intracellular Competitions Reveal Determinants of Plasmid Evolutionary Success

    Hülter N. F., Wein T., Effe J., Garoña A. & Dagan T. Frontiers in Microbiology | 2020
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  • September 01, 2020

    Enhancing scientific discoveries in molecular biology with deep generative models

    Lopez R., Gayoso A. & Yosef N. Molecular Systems Biology | 2020
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  • August 31, 2020

    Niche rather than origin dysregulates mucosal Langerhans cells development in aged mice

    Horev Y., Salameh R., Nassar M., Capucha T., Saba Y., Barel O., Zubeidat K., Matanes D., Leibovich A., Heyman O. , et al. , Eli-Berchoer L., Hanhan S., Betser-Cohen G., Shapiro H., Elinav E., Bercovier H., Wilensky A. & Hovav A. Mucosal Immunology | 2020
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  • August 20, 2020

    Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

    Katzenelenbogen Y., Sheban F., Yalin A., Yofe I., Svetlichnyy D., Jaitin D. A., Bornstein C., Moshe A., Keren-Shaul H., Cohen M. , et al. , Wang S., Li B., David E., Salame T., Weiner A. & Amit I. Cell | 2020
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  • August 01, 2020

    lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements

    Gordon M. G., Inoue F., Martin B., Schubach M., Agarwal V., Whalen S., Feng S., Zhao J., Ashuach T., Ziffra R. , et al. , Kreimer A., Georgakopoulos-Soares I., Yosef N., Ye C. J., Pollard K. S., Shendure J., Kircher M. & Ahituv N. Nature protocols | 2020
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  • July 20, 2020

    Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

    Chen Y., Yin J., Li W., Li H., Chen D., Zhang C., Lv J., Wang Y., Li X., Li J. , et al. , Zhang P., Li Y., He Q., Yang X., Lei Y., Tang L., Zhou G., Mao Y., Wei C., Xiong K., Zhang H., Zhu S., Hou Y., Sun Y., Dean M., Amit I., Wu K., Kuang D., Li G., Liu N. & Ma J. Cell Research | 2020
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  • July 15, 2020

    Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

    Khatib-Massalha E., Bhattacharya S., Massalha H., Biram A., Golan K., Kollet O., Kumari A., Avemaria F., Petrovich-Kopitman E., Gur-Cohen S. , et al. , Itkin T., Brandenburger I., Spiegel A., Shulman Z., Gerhart-Hines Z., Itzkovitz S., Gunzer M., Offermanns S., Alon R., Ariel A. & Lapidot T. Nature Communications | 2020
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  • July 13, 2020

    The microbiome and cytosolic innate immune receptors

    Liwinski T., Zheng D. & Elinav E. Immunological Reviews | 2020
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  • July 08, 2020

    Efficient targeted degradation via reversible and irreversible covalent PROTACs

    Gabizon R., Shraga A., Gehrtz P., Livnah E., Shorer Y., Gurwicz N., Avram L., Unger T., Aharoni H., Albeck S. , et al. , Brandis A., Shulman Z., Katz B., Herishanu Y. & London N. Journal of the American Chemical Society | 2020
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  • June 30, 2020

    T cell help to B cells: Cognate and atypical interactions in peripheral and intestinal lymphoid tissues

    Biram A. & Shulman Z. Immunological Reviews | 2020
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  • June 30, 2020

    Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4(+) and PDPN+ CAFs to clinical outcome

    Friedman G., Levi-Galibov O., David E., Bornstein C., Giladi A., Dadiani M., Mayo A., Halperin C., Pevsner-Fischer M., Lavon H. , et al. , Mayer S., Nevo R., Stein Y., Balint-Lahat N., Barshack I., Ali H. R., Caldas C., Nili-Gal-Yam E., Alon U., Amit I. & Scherz-Shouval R. Nature Cancer | 2020
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  • June 25, 2020

    Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

    Bost P., Giladi A., Liu Y., Bendjelal Y., Xu G., David E., Blecher-Gonen R., Cohen M., Medaglia C., Li H. , et al. , Deczkowska A., Zhang S., Schwikowski B., Zhang Z. & Amit I. Cell | 2020
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  • June 11, 2020

    The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

    Deczkowska A., Weiner A. & Amit I. Cell | 2020
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  • June 09, 2020

    Inflammasome activation and regulation: toward a better understanding of complex mechanisms

    Zheng D., Liwinski T. & Elinav E. Cell Discovery | 2020
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  • June 05, 2020

    Amyotrophic lateral sclerosis and intestinal microbiota-toward establishing cause and effect

    Gotkine M., Kviatcovsky D. & Elinav E. Gut Microbes | 2020
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  • June 01, 2020

    Plasmidevolution ermöglicht das überdauern von Antibiotikaresistenzgenen

    Wein T. BioSpektrum | 2020
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  • June 01, 2020

    Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

    Liao M., Liu Y., Yuan J., Wen Y., Xu G., Zhao J., Cheng L., Li J., Wang X., Wang F. , et al. , Liu L., Amit I., Zhang S. & Zhang Z. Nature Medicine | 2020
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  • June 01, 2020

    Interpretable factor models of single-cell RNA-seq via variational autoencoders

    Svensson V., Gayoso A., Yosef N. & Pachter L. Bioinformatics | 2020
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  • May 31, 2020

    Coverage-dependent bias creates the appearance of binary splicing in single cells

    Najar C. F. B. A., Yosef N. & Lareau L. F. eLife | 2020
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  • May 31, 2020

    Interaction between microbiota and immunity in health and disease

    Zheng D., Liwinski T. & Elinav E. Cell Research | 2020
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  • May 31, 2020

    Circadian Influences of Diet on the Microbiome and Immunity

    Zheng D., Ratiner K. & Elinav E. Trends in Immunology | 2020
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  • May 21, 2020

    Immune-Microbiota Interplay and Colonization Resistance in Infection

    Leshem A., Liwinski T. & Elinav E. Molecular Cell | 2020
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  • May 11, 2020

    Moving from probiotics to precision probiotics

    Veiga P., Suez J., Derrien M. & Elinav E. Nature Microbiology | 2020
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  • May 07, 2020

    Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels

    Slobodin B., Bahat A., Sehrawat U., Becker-Herman S., Zuckerman B., Weiss A. N., Han R., Elkon R., Agami R., Ulitsky I. , et al. , Shachar I. & Dikstein R. Molecular Cell | 2020
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  • May 07, 2020

    C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

    de Laval B., Maurizio J., Kandalla P. K., Brisou G., Simonnet L., Huber C., Gimenez G., Matcovitch-Natan O., Reinhardt S., David E. , et al. , Mildner A., Leutz A., Nadel B., Bordi C., Amit I., Sarrazin S. & Sieweke M. H. Cell Stem Cell | 2020
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  • May 05, 2020

    Evaluation of B Cell Proliferation in vivo by EdU Incorporation Assay

    Biram A. & Shulman Z. Bio-Protocol | 2020
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  • May 01, 2020

    Dissecting cellular crosstalk by sequencing physically interacting cells

    Giladi A., Cohen M., Medaglia C., Baran Y., Li B., Zada M., Bost P., Blecher-Gonen R., Salame T., Mayer J. U. , et al. , David E., Ronchese F., Tanay A. & Amit I. Nature Biotechnology | 2020
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  • April 30, 2020

    The RNA modification N6-methyladenosine as a novel regulator of the immune system

    Shulman Z. & Stern-Ginossar N. Nature Immunology | 2020
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  • April 30, 2020

    Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

    Giladi A., Wagner L. K., Li H., Doerr D., Medaglia C., Paul F., Shemer A., Jung S., Yona S., Mack M. , et al. , Leutz A., Amit I. & Mildner A. Nature Immunology | 2020
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  • April 22, 2020

    Lgr5+telocytes are a signaling source at the intestinal villus tip

    Bahar Halpern K., Massalha H., Zwick R. K., Moor A. E., Castillo-Azofeifa D., Rozenberg M., Farack L., Egozi A., Miller D. R., Averbukh I. , et al. , Harnik Y., Weinberg-Corem N., de Sauvage F. J., Amit I., Klein O. D., Shoshkes-Carmel M. & Itzkovitz S. Nature Communications | 2020
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  • April 20, 2020

    Microbiome genomics for cancer prediction

    Adlung L., Elinav E., Greten T. F. & Korangy F. Nature Cancer | 2020
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  • April 14, 2020

    Inference of single-cell phylogenies from lineage tracing data using Cassiopeia

    Jones M. G., Khodaverdian A., Quinn J. J., Chan M. M., Hussmann J. A., Wang R., Xu C., Weissman J. S. & Yosef N. GENOME BIOLOGY | 2020
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  • March 20, 2020

    Characterization of Immunological Niches within Peyers Patches by ex vivo Photoactivation and Flow Cytometry Analysis

    Biram A. & Shulman Z. Bio-Protocol | 2020
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  • March 02, 2020

    Syk degradation restrains plasma cell formation and promotes zonal transitions in germinal centers

    Davidzohn N., Biram A., Stoler-Barak L., Grenov A., Dassa B. & Shulman Z. Journal of Experimental Medicine | 2020
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  • February 29, 2020

    Bystander IFN-gamma activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

    Thibaut R., Bost P., Milo I., Cazaux M., Lemaitre F., Garcia Z., Amit I., Breart B., Cornuot C., Schwikowski B. & Bousso P. Nature Cancer | 2020
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  • February 27, 2020

    Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner

    Barak A. F., Lewinsky H., Perpinial M., Huber V., Radomir L., Kramer M. P., Sever L., Wolf Y., Shapiro M., Herishanu Y. , et al. , Jung S., Becker-Herman S. & Shachar I. Oncogene | 2020
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  • February 17, 2020

    Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4(+) T cells

    De Giovanni M., Cutillo V., Giladi A., Sala E., Maganuco C. G., Medaglia C., Di Lucia P., Bono E., Cristofani C., Consolo E. , et al. , Giustini L., Fiore A., Eickhoff S., Kastenmueller W., Amit I., Kuka M. & Iannacone M. Nature Immunology | 2020
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  • February 11, 2020

    B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

    Biram A., Winter E., Denton A. E., Zaretsky I., Dassa B., Bemark M., Linterman M. A., Yaari G. & Shulman Z. Cell Reports | 2020
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  • February 03, 2020

    Single-cell genomic approaches for developing the next generation of immunotherapies

    Yofe I., Dahan R. & Amit I. Nature Medicine | 2020
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  • February 03, 2020

    The microbiota programs DNA methylation to control intestinal homeostasis and inflammation

    Ansari I., Raddatz G., Gutekunst J., Ridnik M., Cohen D., Abu-Remaileh M., Tuganbaev T., Shapiro H., Pikarsky E., Elinav E. , et al. , Lyko F. & Bergman Y. Nature Microbiology | 2020
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  • January 21, 2020

    Golgi organization is regulated by proteasomal degradation

    Eisenberg-Lerner A., Benyair R., Hizkiahou N., Nudel N., Maor R., Kramer M. P., Shmueli M. D., Zigdon I., Lev M. C., Ulman A. , et al. , Sagiv J. Y., Dayan M., Dassa B., Rosenwald M., Shachar I., Li J., Wang Y., Dezorella N., Khan S., Shimoni E., Porat Z., Avinoam O. & Merbl Y. Nature Communications | 2020
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  • January 17, 2020

    Are noncommunicable diseases communicable?

    Finlay B. B., Blaser M. J., Bosch T. C. G., Dominguez -Bello M. C. & Elinav E. Science | 2020
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  • January 02, 2020

    Probiotics in the next-generation sequencing era

    Suez J., Zmora N. & Elinav E. Gut Microbes | 2020
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  • December 31, 2019

    The intestinal microbiota fuelling metabolic inflammation

    Tilg H., Zmora N., Adolph T. E. & Elinav E. Nature Reviews Immunology | 2020
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  • December 30, 2019

    Harnessing the microbiota for therapeutic purposes

    Liwinski T. & Elinav E. American Journal of Transplantation | 2019
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  • December 20, 2019

    Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

    Reznik N., Kozer N., Eisenberg-Lerner A., Barr H., Merbl Y. & London N. ACS Chemical Biology | 2019
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  • December 18, 2019

    Mango: Exploratory Data Analysis for Large-Scale Sequencing Datasets

    Morrow A. K., He G. Z., Nothaft F. A., Tu E. T., Paschall J., Yosef N. & Joseph A. D. Cell Systems | 2019
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  • December 12, 2019

    Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

    Geirsdottir L., David E., Keren-Shaul H., Weiner A., Bohlen S. C., Neuber J., Balic A., Giladi A., Sheban F., Dutertre C. , et al. , Pfeifle C., Peri F., Raffo-Romero A., Vizioli J., Matiasek K., Scheiwe C., Meckel S., Maetz-Rensing K., van der Meer F., Thormodsson F. R., Stadelmann C., Zilkha N., Kimchi T., Ginhoux F., Ulitsky I., Erny D., Amit I. & Prinz M. Cell | 2019
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  • December 01, 2019

    Simulating multiple faceted variability in single cell RNA sequencing

    Zhang X., Xu C. & Yosef N. Nature Communications | 2019
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  • December 01, 2019

    Personalized Nutrition: Are We There Yet?

    Bashiardes S., Abdeen S. K. & Elinav E. Journal of Pediatric Gastroenterology and Nutrition | 2019
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  • December 01, 2019

    Functional interpretation of single cell similarity maps

    DeTomaso D., Jones M. G., Subramaniam M., Ashuach T., Ye C. J. & Yosef N. Nature Communications | 2019
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  • December 01, 2019

    Stable contacts of naive CD4 T cells with migratory dendritic cells are ICAM-1-dependent but dispensable for proliferation in vivo

    Kozlovski S., Atrakchi O., Feigelson S. W., Shulman Z. & Alon R. Cell Adhesion & Migration | 2019
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  • November 30, 2019

    Diet-microbiota interactions and personalized nutrition

    Kolodziejczyk A. A., Zheng D. & Elinav E. Nature Reviews Microbiology | 2019
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  • November 30, 2019

    Quantification of plasmid-mediated antibiotic resistance in an experimental evolution approach

    Wein T., Stücker F. T., Hülter N. F. & Dagan T. Journal of Visualized Experiments | 2019
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  • November 10, 2019

    Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target

    Veiga N., Goldsmith M., Diesendruck Y., Ramishetti S., Rosenblum D., Elinav E., Behlke M. A., Benhar I. & Peer D. Journal of Controlled Release | 2019
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  • November 07, 2019

    Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction

    Inoue F., Kreimer A., Ashuach T., Ahituv N. & Yosef N. Cell Stem Cell | 2019
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  • November 01, 2019

    The Effect of Population Bottleneck Size and Selective Regime on Genetic Diversity and Evolvability in Bacteria

    Wein T. & Dagan T. Genome Biology and Evolution | 2019
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  • October 31, 2019

    B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging

    Stoler-Barak L., Biram A., Davidzohn N., Addadi Y., Golani O. & Shulman Z. Journal of Experimental Medicine | 2019
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  • October 23, 2019

    Embrace the fat when getting old

    Adlung L., Amit I. & Elinav E. AGING-US | 2019
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  • October 14, 2019

    Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease

    Carson D., Barry R., Hopkins E. G. D., Roumeliotis T., Garcia-Weber D., Mullineaux-Sanders C., Elinav E., Arrieumerlou C., Choudhary J. S. & Frankel G. Cellular Microbiology | 2019
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  • October 07, 2019

    A Joint Model of RNA Expression and Surface Protein Abundance in Single Cells

    Gayoso A., Lopez R., Steier Z., Regier J., Streets A. & Yosef N. bioArxiv | 2019
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  • October 07, 2019

    Detecting Zero-Inflated Genes in Single-Cell Transcriptomics Data

    Clivio O., Lopez R., Regier J., Gayoso A., Jordan M. I. & Yosef N. bioArxiv | 2019
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  • October 04, 2019

    Deep Generative Models for Detecting Differential Expression in Single Cells

    Boyeau P., Lopez R., Regier J., Gayoso A., Jordan M. I. & Yosef N. bioArxiv | 2019
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  • October 03, 2019

    Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice

    Hu B., Friedman G., Elinav E. & Flavell R. A. OncoImmunology | 2019
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  • October 01, 2019

    Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms

    Kaushansky N., Bakos E., Becker-Herman S., Shachar I. & Ben-Nun A. Journal of Immunology | 2019
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  • October 01, 2019

    ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

    Srivastava S., Nataraj N. B., Sekar A., Ghosh S., Bornstein C., Drago-Garcia D., Roth L., Romaniello D., Marrocco I., David E. , et al. , Gilad Y., Lauriola M., Rotkopf R., Kimchi A., Haga Y., Tsutsumi Y., Mirabeau O., Surdez D., Zinovyev A., Delattre O., Kovar H., Amit I. & Yarden Y. Cell Reports | 2019
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  • September 30, 2019

    Currency, Exchange, and Inheritance in the Evolution of Symbiosis

    Wein T., Romero Picazo D., Blow F., Woehle C., Jami E., Reusch T. B., Martin W. F. & Dagan T. Trends in Microbiology | 2019
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  • September 30, 2019

    Vaginal microbiome transplantation in women with intractable bacterial vaginosis

    Lev-Sagie A., Goldman-Wohl D., Cohen Y., Dori-Bachash M., Leshem A., Mor U., Strahilevitz J., Moses A. E., Shapiro H., Yagel S. & Elinav E. Nature Medicine | 2019
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  • September 30, 2019

    When Cultures Meet: The Landscape of "Social" Interactions between the Host and Its Indigenous Microbes

    Geva-Zatorsky N., Elinav E. & Pettersson S. BioEssays | 2019
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  • September 02, 2019

    MPRAnalyze: Statistical framework for massively parallel reporter assays

    Ashuach T., Fischer D. S., Kreimer A., Ahituv N., Theis F. J. & Yosef N. GENOME BIOLOGY | 2019
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  • September 01, 2019

    Meta-analysis of massively parallel reporter assays enables prediction of regulatory function across cell types

    Kreimer A., Yan Z., Ahituv N. & Yosef N. Human Mutation | 2019
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  • August 22, 2019

    Potential roles of gut microbiome and metabolites in modulating ALS in mice

    Blacher E., Bashiardes S., Shapiro H., Rothschild D., Mor U., Dori-Bachash M., Kleimeyer C., Moresi C., Harnik Y., Zur M. , et al. , Zabari M., Brik R. B., Kviatcovsky D., Zmora N., Cohen Y., Bar N., Levi I., Amar N., Mehlman T., Brandis A., Biton I., Kuperman Y., Tsoory M., Alfahel L., Harmelin A., Schwartz M., Israelson A., Arike L., Johansson M. E. V., Hansson G. C., Gotkine M., Segal E. & Elinav E. Nature | 2019
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  • August 13, 2019

    SLAMF9 regulates pDC homeostasis and function in health and disease

    Sever L., Radomir L., Strim K., Weiner A., Shchottlender N., Lewinsky H., Barak A. F., Friedlander G., Ben-Dor S., Becker-Herman S. & Shachar I. Proceedings of the National Academy of Sciences of the United States of America | 2019
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  • August 02, 2019

    Walk on the wildling side

    Nobs S. P. & Elinav E. Science | 2019
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  • July 31, 2019

    Reconstructing B-cell receptor sequences from short-read single-cell RNA sequencing with BRAPeS

    Afik S., Raulet G. & Yosef N. Life Science Alliance | 2019
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  • July 25, 2019

    Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

    Jaitin D. A., Adlung L., Thaiss C. A., Weiner A., Li B., Descamps H., Lundgren P., Bleriot C., Liu Z., Deczkowska A. , et al. , Keren-Shaul H., David E., Zmora N., Eldar S. M., Lubezky N., Shibolet O., Hill D. A., Lazar M. A., Colonna M., Ginhoux F., Shapiro H., Elinav E. & Amit I. Cell | 2019
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  • July 19, 2019

    Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

    Rojo R., Raper A., Ozdemir D. D., Lefevre L., Grabert K., Wollscheid-Lengeling E., Bradford B., Caruso M., Gazova I., Sanchez A. , et al. , Lisowski Z. M., Alves J., Molina-Gonzalez I., Davtyan H., Lodge R. J., Glover J. D., Wallace R., Munro D. A. D., David E., Amit I., Miron V. E., Priller J., Jenkins S. J., Hardingham G. E., Blurton-Jones M., Mabbott N. A., Summers K. M., Hohenstein P., Hume D. A. & Pridans C. Nature Communications | 2019
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  • July 04, 2019

    A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

    Khoo W. H., Ledergor G., Weiner A., Roden D. L., Terry R. L., McDonald M. M., Chai R. C., De Veirman K., Owen K. L., Opperman K. S. , et al. , Vandyke K., Clark J. R., Seckinger A., Kovacic N., Nguyen A., Mohanty S. T., Pettitt J. A., Xiao Y., Corr A. P., Seeliger C., Novotny M., Lasken R. S., Nguyen T., Oyajobi B. O., Aftab D., Swarbrick A., Parker B., Hewett D. R., Hose D., Vanderkerken K., Zannettino A. C. W., Amit I., Phan T. G. & Croucher P. Blood | 2019
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  • June 30, 2019

    SLAMF receptors on normal and malignant B cells

    Shachar I., Barak A., Lewinsky H., Sever L. & Radomir L. Clinical Immunology | 2019
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  • June 30, 2019

    The cancer microbiome

    Elinav E., Garrett W. S., Trinchieri G. & Wargo J. Nature Reviews Cancer | 2019
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  • June 30, 2019

    Plasmacytoid dendritic cells develop from Ly6D(+) lymphoid progenitors distinct from the myeloid lineage

    Dress R. J., Dutertre C., Giladi A., Schlitzer A., Low I., Shadan N. B., Tay A., Lum J., Kairi M. F. B. M., Hwang Y. Y. , et al. , Becht E., Cheng Y., Chevrier M., Larbi A., Newell E. W., Amit I., Chen J. & Ginhoux F. Nature Immunology | 2019
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  • June 14, 2019

    IL-23-producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response

    Bernshtein B., Curato C., Ioannou M., Thaiss C. A., Gross-Vered M., Kolesnikov M., Wang Q., David E., Chappell-Maor L., Harmelin A. , et al. , Elinav E., Thakker P., Papayannopoulos V. & Jung S. Science immunology | 2019
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  • June 14, 2019

    Fecal Microbial Transplantation and Its Potential Application in Cardiometabolic Syndrome

    Leshem A., Horesh N. & Elinav E. Frontiers in Immunology | 2019
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  • June 13, 2019

    Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance

    Wein T., Hülter N. F., Mizrahi I. & Dagan T. Nature Communications | 2019
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  • June 12, 2019

    The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

    Virtue A. T., McCright S. J., Wright J. M., Jimenez M. T., Mowel W. K., Kotzin J. J., Joannas L., Basavappa M. G., Spencer S. P., Clark M. L. , et al. , Eisennagel S. H., Williams A., Levy M., Manne S., Henrickson S. E., Wherry E. J., Thaiss C. A., Elinav E. & Henao-Mejia J. Science Translational Medicine | 2019
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  • June 06, 2019

    Molecular recording of mammalian embryogenesis

    Chan M. M., Smith Z. D., Grosswendt S., Kretzmer H., Norman T. M., Adamson B., Jost M., Quinn J. J., Yang D., Jones M. G. , et al. , Khodaverdian A., Yosef N., Meissner A. & Weissman J. S. Nature | 2019
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  • June 03, 2019

    Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome

    Komban R. J., Stromberg A., Biram A., Cervin J., Lebrero-Fernandez C., Mabbott N., Yrlid U., Shulman Z., Bemark M. & Lycke N. Nature Communications | 2019
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  • June 01, 2019

    MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing

    Keren-Shaul H., Kenigsberg E., Jaitin D. A., David E., Paul F., Tanay A. & Amit I. Nature Protocols | 2019
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  • May 29, 2019

    Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress

    Kertser A., Baruch K., Deczkowska A., Weiner A., Croese T., Kenigsbuch M., Cooper I., Tsoory M., Ben-Hamo S., Amit I. & Schwartz M. Science Advances | 2019
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  • May 06, 2019

    A joint model of unpaired data from scRNA-seq and spatial transcriptomics for imputing missing gene expression measurements

    Lopez R., Nazaret A., Langevin M., Samaran J., Regier J., Jordan M. I. & Yosef N. arxiv.org | 2019
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  • April 30, 2019

    The pros, cons, and many unknowns of probiotics

    Suez J., Zmora N., Segal E. & Elinav E. Nature Medicine | 2019
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  • April 25, 2019

    DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node

    Curato C., Bernshtein B., Zupancic E., Dufner A., Jaitin D., Giladi A., David E., Chappell-Maor L., Leshkowitz D., Knobeloch K. , et al. , Amit I., Florindo H. F. & Jung S. Frontiers in Immunology | 2019
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  • April 24, 2019

    Performance Assessment and Selection of Normalization Procedures for Single-Cell RNA-Seq

    Cole M. B., Risso D., Wagner A., DeTomaso D., Ngai J., Purdom E., Dudoit S. & Yosef N. Cell Systems | 2019
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  • April 01, 2019

    Microbiome diurnal rhythmicity and its impact on host physiology and disease risk

    Nobs S. P., Tuganbaev T. & Elinav E. EMBO Reports | 2019
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  • April 01, 2019

    Cell composition analysis of bulk genomics using single-cell data

    Frishberg A., Peshes-Yaloz N., Cohn O., Rosentul D., Steuerman Y., Valadarsky L., Yankovitz G., Mandelboim M., Iraqi F. A., Amit I. , et al. , Mayo L., Bacharach E. & Gat-Viks I. Nature Methods | 2019
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  • March 31, 2019

    BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer's patches

    Biram A., Stromberg A., Winter E., Stoler-Barak L., Salomon R., Addadi Y., Dahan R., Yaari G., Bemark M. & Shulman Z. Nature Immunology | 2019
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  • March 15, 2019

    T cell interactions with B cells during germinal center formation, a three-step model

    Biram A., Davidzohn N. & Shulman Z. Immunological Reviews | 2019
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  • March 08, 2019

    Connectivity problems on heterogeneous graphs

    Wu J., Khodaverdian A., Weitz B. & Yosef N. Algorithms for Molecular Biology | 2019
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  • March 01, 2019

    Segregational Drift and the Interplay between Plasmid Copy Number and Evolvability

    Ilhan J., Kupczok A., Woehle C., Wein T., Hülter N. F., Rosenstiel P., Landan G., Mizrahi I. & Dagan T. Molecular Biology and Evolution | 2019
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  • February 28, 2019

    Evolthon: A community endeavor to evolve lab evolution

    Kaminski Strauss S., Schirman D., Jona G., Brooks A. N., Kunjapur A. M., Ba A. N. N., Flint A., Solt A., Mershin A., Dixit A. , et al. , Yona A. H., Csorgo B., Busby B. P., Hennig B. P., Pal C., Schraivogel D., Schultz D., Wernick D. G., Agashe D., Levi D., Zabezhinsky D., Russ D., Sass E., Tamar E., Herz E., Levy E. D., Church G. M., Yelin I., Nachman I., Gerst J. E., Georgeson J. M., Adamala K. P., Steinmetz L. M., Ruebsam M., Ralser M., Klutstein M., Desai M. M., Walunjkar N., Yin N., Hefetz N. A., Jakimo N., Snitser O., Adini O., Kumar P., Smith R. S. H., Zeidan R., Hazan R., Rak R., Kishony R., Johnson S., Nouriel S., Vonesch S. C., Foster S., Dagan T., Wein T., Karydis T., Wannier T. M., Stiles T., Olin-Sandoval V., Mueller W. F., Bar-On Y. M., Dahan O. & Pilpel Y. PLoS Biology | 2019
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  • February 27, 2019

    Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity

    Blecher-Gonen R., Bost P., Hilligan K. L., David E., Salame T. M., Roussel E., Connor L. M., Mayer J. U., Halpern K. B., Toth B. , et al. , Itzkovitz S., Schwikowski B., Ronchese F. & Amit I. Cell Systems | 2019
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  • February 19, 2019

    Metabolic preference of nitrate over oxygen as an electron acceptor in foraminifera from the Peruvian oxygen minimum zone

    Glock N., Roy A. S., Romero D., Wein T., Weissenbach J., Revsbech N. P., Høgslund S., Clemens D., Sommer S. & Dagan T. Proceedings of the National Academy of Sciences | 2019
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  • February 18, 2019

    Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression

    Javitt A., Barnea E., Kramer M. P., Wolf-Levy H., Levin Y., Admon A. & Merbl Y. Frontiers in Immunology | 2019
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  • February 12, 2019

    Mutual interplay between IL-17producing γδT cells and microbiota orchestrates oral mucosal homeostasis

    Wilharm A., Tabib Y., Nassar M., Reinhardt A., Mizraji G., Sandrock I., Heyman O., Barros-Martins J., Aizenbud Y., Khalaileh A. , et al. , Eli-Berchoer L., Elinav E., Wilensky A., Foerster R., Bercovier H., Prinz I. & Hovav A. Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences | 2019
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  • February 07, 2019

    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

    Zviran A., Mor N., Rais Y., Gingold H., Peles S., Chomsky E., Viukov S., Buenrostro J. D., Scognamiglio R., Weinberger L. , et al. , Manor Y. S., Krupalnik V., Zerbib M., Hezroni H., Jaitin D. A., Larastiaso D., Gilad S., Benjamin S., Gafni O., Mousa A., Ayyash M., Sheban D., Bayerl J., Aguilera-Castrejon A., Massarwa R., Maza I., Hanna S., Stelzer Y., Ulitsky I., Greenleaf W. J., Tanay A., Trumpp A., Amit I., Pilpel Y., Novershtern N. & Hanna J. H. Cell Stem Cell | 2019
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  • February 07, 2019

    Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

    Li H., van der Leun A. M., Yofe I., Lubling Y., Gelbard-Solodkin D., van Akkooi A. C. J., van den Braber M., Rozeman E. A., Haanen J. B. A. G., Blank C. U. , et al. , Horlings H. M., David E., Baran Y., Bercovich A., Lifshitz A., Schumacher T. N., Tanay A. & Amit I. Cell | 2019
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  • January 31, 2019

    The role of the microbiome in NAFLD and NASH

    Kolodziejczyk A. A., Zheng D., Shibolet O. & Elinav E. EMBO Molecular Medicine | 2019
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  • January 30, 2019

    Transforming medicine with the microbiome

    Zmora N., Soffer E. & Elinav E. Science Translational Medicine | 2019
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  • January 28, 2019

    PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

    Rosenzweig N., Dvir-Szternfeld R., Tsitsou-Kampeli A., Keren-Shaul H., Ben-Yehuda H., Weill-Raynal P., Cahalon L., Kertser A., Baruch K., Amit I. , et al. , Weiner A. & Schwartz M. Nature Communications | 2019
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  • January 17, 2019

    Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

    Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T. , et al. , Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N. Cell Chemical Biology | 2019
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  • January 05, 2019

    Epigenetics and the microbiome

    Pevsner-Fischer M., Zmora N., Braverman S. & Elinav E. | 2019
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  • December 31, 2018

    Global views of proteasome-mediated degradation by mass spectrometry

    Javitt A. & Merbl Y. Expert Review of Proteomics | 2019
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  • December 31, 2018

    You are what you eat: diet, health and the gut microbiota

    Zmora N., Suez J. & Elinav E. Nature Reviews Gastroenterology and Hepatology | 2019
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  • December 21, 2018

    Impaired immune surveillance accelerates accumulation of senescent cells and aging

    Ovadya Y., Landsberger T., Leins H., Vadai E., Gal H., Biran A., Yosef R., Sagiv A., Agrawal A., Shapira A. , et al. , Windheim J., Tsoory M., Schirmbeck R., Amit I., Geiger H. & Krizhanovsky V. Nature Communications | 2018
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  • December 03, 2018

    CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia

    Lewinsky H., Barak A. F., Huber V., Kramer M. P., Radomir L., Sever L., Orr I., Mirkin V., Dezorella N., Shapiro M. , et al. , Cohen Y., Shvidel L., Seiffert M., Herishanu Y., Becker-Herman S. & Shachar I. Journal of Clinical Investigation | 2018
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  • December 01, 2018

    Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

    Veiga N., Goldsmith M., Granot Y., Rosenblum D., Dammes N., Kedmi R., Ramishetti S. & Peer D. Nature Communications | 2018
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  • December 01, 2018

    Deep generative modeling for single-cell transcriptomics

    Lopez R., Regier J., Cole M. B., Jordan M. I. & Yosef N. Nature Methods | 2018
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  • November 30, 2018

    Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

    Ledergor G., Weiner A., Zada M., Wang S., Cohen Y. C., Gatt M. E., Snir N., Magen H., Koren-Michowitz M., Herzog-Tzarfati K. , et al. , Keren-Shaul H., Bornstein C., Rotkopf R., Yofe I., David E., Yellapantula V., Kay S., Salai M., Ben Yehuda D., Nagler A., Shvidel L., Orr-Urtreger A., Halpern K. B., Itzkovitz S., Landgren O., San-Miguel J., Paiva B., Keats J. J., Papaemmanuil E., Avivi I., Barbash G. I., Tanay A. & Amit I. Nature Medicine | 2018
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  • November 01, 2018

    Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

    Cohen M., Giladi A., Gorki A., Galbard Solodkin D., Zada M., Hladik A., Miklosi A., Salame T., Halpern K. B., David E. , et al. , Itzkovitz S., Harkany T., Knapp S. & Amit I. Cell | 2018
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  • November 01, 2018

    Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

    Halpern K. B., Shenhav R., Massalha H., Toth B., Egozi A., Massasa E. E., Medgalia C., David E., Giladi A., Moor A. E. , et al. , Porat Z., Amit I. & Itzkovitz S. Nature Biotechnology | 2018
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  • October 31, 2018

    Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides

    Wolf-Levy H., Javitt A., Eisenberg-Lerner A., Kacenl A., Ulman A., Sheban D., Dassa B., Fishbain-Yoskovitz V., Carmona-Rivera C., Kramer M. P. , et al. , Nudel N., Regev I., Zahavi L., Elinger D., Kaplan M. J., Morgenstern D., Levin Y. & Merbl Y. Nature Biotechnology | 2018
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  • October 31, 2018

    Translating microbiome futures

    Taroncher-Oldenburg G., Jones S., Blaser M., Bonneau R., Christey P., Clemente J. C., Elinav E., Ghedin E., Huttenhower C., Kelly D. , et al. , Kyle D., Littman D., Maiti A., Maue A., Olle B., Segal L., Vlieg J. E. T. v. H. & Wang J. Nature Biotechnology | 2018
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  • October 23, 2018

    Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity

    Knorr D. A., Dahan R. & Ravetch J. Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences | 2018
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  • October 08, 2018

    Combining Developmental and Perturbation-Seq Uncovers Transcriptional Modules Orchestrating Neuronal Remodeling

    Alyagor I., Berkun V., Keren-Shaul H., Marmor-Kollet N., David E., Mayseless O., Issman-Zecharya N., Amit I. & Schuldiner O. Developmental Cell | 2018
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  • September 30, 2018

    From the Human Cell Atlas to dynamic immune maps in human disease

    Adlung L. & Amit I. Nature Reviews Immunology | 2018
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  • September 30, 2018

    The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses

    Berger C. N., Crepin V. F., Roumeliotis T. I., Wright J. C., Serafini N., Pevsner-Fischer M., Yu L., Elinav E., Di Santo J. P., Choudhary J. S. & Frankel G. PLoS Pathogens | 2018
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  • September 16, 2018

    A Deep Generative Model for Semi-Supervised Classification with Noisy Labels

    Langevin M., Mehlman E., Regier J., Lopez R., Jordan M. I. & Yosef N. arxiv.org | 2018
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  • September 06, 2018

    Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

    Mor N., Rais Y., Sheban D., Peles S., Aguilera-Castrejon A., Zviran A., Elinger D., Viukov S., Geula S., Krupalnik V. , et al. , Zerbib M., Chomsky E., Lasman L., Shani T., Bayerl J., Gafni O., Hanna S., Buenrostro J. D., Hagai T., Masika H., Vainorius G., Bergman Y., Greenleaf W. J., Esteban M. A., Elling U., Levin Y., Massarwa R., Merbl Y., Novershtern N. & Hanna J. H. Cell Stem Cell | 2018
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  • September 06, 2018

    Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

    Suez J., Zmora N., Zilberman-Schapira G., Mor U., Dori-Bachash M., Bashiardes S., Zur M., Regev-Lehavi D., Brik R. B., Federici S. , et al. , Horn M., Cohen Y., Moor A. E., Zeevi D., Korem T., Kotler E., Harmelin A., Itzkovitz S., Maharshak N., Shibolet O., Pevsner-Fischer M., Shapiro H., Sharon I., Halpern Z., Segal E. & Elinav E. Cell | 2018
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  • September 06, 2018

    Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

    Zmora N., Zilberman-Schapira G., Suez J., Mor U., Dori-Bachash M., Bashiardes S., Kotler E., Zur M., Regev-Lehavi D., Brik R. B. , et al. , Federici S., Cohen Y., Linevsky R., Rothschild D., Moor A. E., Ben-Moshe S., Harmelin A., Itzkovitz S., Maharshak N., Shibolet O., Shapiro H., Pevsner-Fischer M., Sharon I., Halpern Z., Segal E. & Elinav E. Cell | 2018
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  • August 20, 2018

    A Novel Eukaryotic Denitrification Pathway in Foraminifera

    Woehle C., Roy A. S., Glock N., Wein T., Weissenbach J., Rosenstiel P., Hiebenthal C., Michels J., Schönfeld J. & Dagan T. Current Biology | 2018
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  • July 26, 2018

    Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

    Bornstein C., Nevo S., Giladi A., Kadouri N., Pouzolles M., Gerbe F., David E., Machado A., Chuprin A., Toth B. , et al. , Goldberg O., Itzkovitz S., Taylor N., Jay P., Zimmermann V. S., Abramson J. & Amit I. Nature | 2018
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  • July 17, 2018

    Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

    Lauridsen F. K. B., Jensen T. L., Rapin N., Aslan D., Wilhelmson A. S., Pundhir S., Rehn M., Paul F., Giladi A., Hasemann M. S. , et al. , Serup P., Amit I. & Porse B. T. Cell Reports | 2018
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  • June 30, 2018

    Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis

    Johnston D. G. W., Williams M. A., Thaiss C. A., Cabrera-Rubio R., Raverdeau M., McEntee C., Cotter P. D., Elinav E., O'Neill L. A. J. & Corr S. C. Journal of Crohn's and Colitis | 2018
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  • June 30, 2018

    The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation

    Milo I., Blecher-Gonen R., Barnett-Itzhaki Z., Bar-Ziv R., Tal O., Gurevich I., Feferman T., Drexler I., Amit I., Bousso P. & Shakhar G. European Journal of Immunology | 2018
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  • June 30, 2018

    Early metazoan cell type diversity and the evolution of multicellular gene regulation

    Sebe-Pedros A., Chomsky E., Pang K., Lara-Astiaso D., Gaiti F., Mukamel Z., Amit I., Hejnol A., Degnan B. M. & Tanay A. Nature ecology & evolution | 2018
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  • June 30, 2018

    Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

    Giladi A., Paul F., Herzog Y., Lubling Y., Weiner A., Yofe I., Jaitin D., Cabezas-Wallscheid N., Dress R., Ginhoux F. , et al. , Trumpp A., Tanay A. & Amit I. Nature Cell Biology | 2018
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  • June 30, 2018

    A phase I-II clinical trial of the anti-CD74 monoclonal antibody milatuzumab in frail patients with refractory chronic lymphocytic leukaemia: A patient based approach

    Haran M., Mirkin V., Braester A., Harpaz N., Shevetz O., Shtreiter M., Greenberg S., Mordich O., Amram O., Binsky-Ehrenreich I. , et al. , Marom A., Shachar I., Herishanu Y., Ruchlemer R., Berrebi A., Valinsky L., Shtalrid M. & Shvidel L. British Journal of Haematology | 2018
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  • June 27, 2018

    Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing

    Steuerman Y., Cohen M., Peshes-Yaloz N., Valadarsky L., Cohn O., David E., Frishberg A., Mayo L., Bacharach E., Amit I. & Gat-Viks I. Cell Systems | 2018
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  • May 31, 2018

    Towards utilization of the human genome and microbiome for personalized nutrition

    Bashiardes S., Godneva A., Elinav E. & Segal E. Current Opinion in Biotechnology | 2018
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  • May 31, 2018

    LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF

    Klasen C., Ziehm T., Huber M., Asare Y., Kapurniotu A., Shachar I., Bernhagen J. & El Bounkari O. Cellular Signalling | 2018
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  • May 17, 2018

    Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

    Deczkowska A., Keren-Shaul H., Weiner A., Colonna M., Schwartz M. & Amit I. Cell | 2018
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  • May 15, 2018

    Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

    Gamliel M., Goldman-Wohl D., Isaacson B., Gur C., Stein N., Yamin R., Berger M., Grunewald M., Keshet E., Rais Y. , et al. , Bornstein C., David E., Jelinski A., Eisenberg I., Greenfield C., Ben-David A., Imbar T., Gilad R., Haimov-Kochman R., Mankuta D., Elami-Suzin M., Amit I., Hanna J. H., Yagel S. & Mandelboim O. Immunity | 2018
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  • May 07, 2018

    Microglial immune checkpoint mechanisms

    Deczkowska A., Amit I. & Schwartz M. Nature Neuroscience | 2018
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  • April 17, 2018

    NLRP6 and Dysbiosis: Avoiding the Luring Attraction of Over-Simplification

    Elinav E., Henao-Mejia J., Strowig T. & Flavell R. Immunity | 2018
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  • March 23, 2018

    Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

    Thaiss C. A., Levy M., Grosheva I., Zheng D., Soffer E., Blacher E., Braverman S., Tengeler A. C., Barak O., Elazar M. , et al. , Ben-Zeev R., Lehavi-Regev D., Katz M. N., Pevsner-Fischer M., Gertler A., Halpern Z., Harmelin A., Aamar S., Serradas P., Grosfeld A., Shapiro H., Geiger B. & Elinav E. Science | 2018
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  • March 14, 2018

    Carrying capacity and colonization dynamics of Curvibacter in the hydra host habitat

    Wein T., Dagan T., Fraune S., Bosch T. C., Reusch T. B. & Hülter N. F. Frontiers in Microbiology | 2018
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  • March 08, 2018

    Environment dominates over host genetics in shaping human gut microbiota

    Rothschild D., Weissbrod O., Barkan E., Kurilshikov A., Korem T., Zeevi D., Costea P. I., Godneva A., Kalka I. N., Bar N. , et al. , Shilo S., Lador D., Vila A. V., Zmora N., Pevsner-Fischer M., Israeli D., Kosower N., Malka G., Wolf B. C., Avnit-Sagi T., Lotan-Pompan M., Weinberger A., Halpern Z., Carmi S., Fu J., Wijmenga C., Zhernakova A., Elinav E. & Segal E. Nature | 2018
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  • March 01, 2018

    A modular platform for targeted RNAi therapeutics

    Kedmi R., Veiga N., Ramishetti S., Goldsmith M., Rosenblum D., Dammes N., Hazan-Halevy I., Nahary L., Leviatan-Ben-Arye S., Harlev M. , et al. , Behlke M., Benhar I., Lieberman J. & Peer D. Nature Nanotechnology | 2018
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  • February 28, 2018

    The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota

    Alteber Z., Sharbi-Yunger A., Pevsner-Fischer M., Blat D., Roitman L., Tzehoval E., Elinav E. & Eisenbach L. Immunology and Cell Biology | 2018
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  • February 07, 2018

    Salient experiences are represented by unique transcriptional signatures in the mouse brain

    Mukherjee D., Ignatowska-Jankowska B. M., Itskovits E., Gonzales B. J., Turm H., Izakson L., Haritan D., Bleistein N., Cohen C., Amit I. , et al. , Shay T., Grueter B., Zaslaver A. & Citri A. eLife | 2018
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  • January 31, 2018

    Sequential BMP7/TGF-beta 1 signaling and microbiota instruct mucosal Langerhans cell differentiation

    Capucha T., Koren N., Nassar M., Heyman O., Nir T., Levy M., Zilberman-Schapira G., Zelentova K., Eli-Berchoer L., Zenke M. , et al. , Hieronymus T., Wilensky A., Bercovier H., Elinav E., Clausen B. E. & Hovav A. Journal of Experimental Medicine | 2018
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  • January 31, 2018

    Bile acids in glucose metabolism in health and disease

    Shapiro H., Kolodziejczyk A. A., Halstuch D. & Elinav E. Journal of Experimental Medicine | 2018
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  • January 31, 2018

    Probiotics administration following sleeve gastrectomy surgery: a randomized double-blind trial

    Sherf-Dagan S., Zelber-Sagi S., Zilberman-Schapira G., Webb M., Buch A., Keidar A., Raziel A., Sakran N., Goitein D., Goldenberg N. , et al. , Mahdi J. A., Pevsner-Fischer M., Zmora N., Dori-Bachash M., Segal E., Elinav E. & Shibolet O. International Journal of Obesity | 2018
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  • January 31, 2018

    Sieving through gut models of colonization resistance

    Mullineaux-Sanders C., Suez J., Elinav E. & Frankel G. Nature Microbiology | 2018
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  • January 29, 2018

    A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers

    Martin-Gayo E., Cole M. B., Kolb K. E., Ouyang Z., Cronin J., Kazer S. W., Ordovas-Montanes J., Lichterfeld M., Walker B. D., Yosef N. , et al. , Shalek A. K. & Yu X. G. GENOME BIOLOGY | 2018
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  • January 25, 2018

    Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

    Thion M. S., Low D., Silvin A., Chen J., Grisel P., Schulte-Schrepping J., Blecher R., Ulas T., Squarzoni P., Hoeffel G. , et al. , Coulpier F., Siopi E., David F. S., Scholz C., Shihui F., Lum J., Amoyo A. A., Larbi A., Poidinger M., Buttgereit A., Lledo P., Greter M., Chan J. K. Y., Amit I., Beyer M., Schultze J. L., Schlitzer A., Pettersson S., Ginhoux F. & Garel S. Cell | 2018
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  • January 25, 2018

    A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

    Bahr C., von Paleske L., Slu V. V. U., Emeseiro S. R., Takayama N., Ng S. W., Murison A., Langenfeld K., Petretich M., Scognamiglio R. , et al. , Zeisberger P., Benk A. S., Amit I., Zandstra P. W., Lupien M., Dick J. E., Trumpp A. & Spitz F. Nature | 2018
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  • January 23, 2018

    ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs

    Feigelson S. W., Solomon A., Biram A., Hatzav M., Lichtenstein M., Regev O., Kozlovski S., Varol D., Curato C., Leshkowitz D. , et al. , Jung S., Shulman Z. & Alon R. Cell Reports | 2018
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  • January 11, 2018

    Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

    Giladi A. & Amit I. Cell | 2018
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  • December 31, 2017

    Information constraints on auto-encoding variational Bayes

    Lopez R., Regier J., Jordan M. I. & Yosef N. Advances in Neural Information Processing Systems | 2018
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  • December 31, 2017

    Impulse model-based differential expression analysis of time course sequencing data

    Fischer D. S., Theis F. J. & Yosef N. Nucleic Acids Research | 2018
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  • December 22, 2017

    Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

    Medaglia C., Giladi A., Stoler-Barak L., De Giovanni M., Salame T. M., Biram A., David E., Li H., Iannacone M., Shulman Z. & Amit I. Science | 2017
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  • December 19, 2017

    Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa

    Mullineaux-Sanders C., Collins J. W., Ruano-Gallego D., Levy M., Pevsner-Fischer M., Glegola-Madejska I. T., Sågfors A. M., Wong J. L., Elinav E., Crepin V. F. & Frankel G. Cell Reports | 2017
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  • December 14, 2017

    Our Gut Microbiome: The Evolving Inner Self

    Kundu P., Blacher E., Elinav E. & Pettersson S. Cell | 2017
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  • December 07, 2017

    Injury Activates Transient Olfactory Stem Cell States with Diverse Lineage Capacities

    Gadye L., Das D., Sanchez M. A., Street K., Baudhuin A., Wagner A., Cole M. B., Choi Y. G., Yosef N., Purdom E. , et al. , Dudoit S., Risso D., Ngai J. & Fletcher R. B. Cell Stem Cell | 2017
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  • December 05, 2017

    Science Forum: The Human Cell Atlas

    Regev A., Teichmann S. A., Lander E. S., Amt I., Benoist C., Birney E., Bodenmiller B., Campbell P., Carninci P., Clatworthy M. , et al. , Clevers H., Deplancke B., Dunham I., Eberwine J., Elis R., Enard W., Farmer A., Fugger L., Gottgens B., Hacohen N., Haniffa M., Hemberg M., Kim S., Klenerman P., Kriegstein A., Lein E. D., Linnarsson S., Lundberg E., Lundeberg J., Majumder P., Marioni J. C., Merad M., Mhlanga M., Nawijin M., Netea M., Nolan G., Pe'er D., Phillipakis A., Ponting C. P., Quake S., Reik W., Rozenblatt-Rosen O., Sanes J., Satija R., Schumacher T. N., Shalek A., Shapiro E., Sharma P., Shin J. W., Stegle O. & eLife | 2017
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  • December 01, 2017

    Use antibiotics in cell culture with caution: Genome-wide identification of antibiotic-induced changes in gene expression and regulation

    Ryu A. H., Eckalbar W. L., Kreimer A., Yosef N. & Ahituv N. Scientific Reports | 2017
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  • December 01, 2017

    Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

    Deczkowska A., Matcovitch-Natan O., Tsitsou-Kampeli A., Ben-Hamo S., Dvir-Szternfeld R., Spinrad A., Singer O., David E., Winter D. R., Smith L. K. , et al. , Kertser A., Baruch K., Rosenzweig N., Terem A., Prinz M., Villeda S., Citri A., Amit I. & Schwartz M. Nature Communications | 2017
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  • November 30, 2017

    Microbiome at the Frontier of Personalized Medicine

    Kashyap P. C., Chia N., Nelson H., Segal E. & Elinav E. Mayo Clinic Proceedings | 2017
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  • November 07, 2017

    Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo

    Berger C. N., Crepin V. F., Roumeliotis T. I., Wright J. C., Carson D., Pevsner-Fischer M., Furniss R. C. D., Dougan G., Dori-Bachash M., Yu L. , et al. , Clements A., Collins J. W., Elinav E., Larrouy-Maumus G. J., Choudhary J. S. & Frankel G. Cell Metabolism | 2017
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  • November 07, 2017

    NFIL-trating the Host Circadian RhythmMicrobes Fine-Tune the Epithelial Clock

    Thaiss C. A., Nobs S. P. & Elinav E. Cell Metabolism | 2017
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  • November 01, 2017

    ICAMs support B cell interactions with T follicular helper cells and promote clonal selection

    Zaretsky I., Atrakchi O., Mazor R. D., Stoler-Barak L., Biram A., Feigelson S. W., Gitlin A. D., Engelhardt B. & Shulman Z. Journal of Experimental Medicine | 2017
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  • October 31, 2017

    An essential MIF-CD74 signaling axis in kidney tubular regeneration, with prospects for precision medicine and pharmacological augmentation

    Shachar I. American Journal Of Physiology-Renal Physiology | 2017
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  • October 27, 2017

    Personalized microbiome-based approaches to metabolic syndrome management and prevention

    Shapiro H., Suez J. & Elinav E. Journal of Diabetes | 2017
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  • October 20, 2017

    Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

    Atarashi K., Suda W., Luo C., Kawaguchi T., Motoo I., Narushima S., Kiguchi Y., Yasuma K., Watanabe E., Tanoue T. , et al. , Thaiss C. A., Sato M., Toyooka K., Said H. S., Yamagami H., Rice S. A., Gevers D., Johnson R. C., Segre J. A., Chen K., Kolls J. K., Elinav E., Morita H., Xavier R. J., Hattori M. & Honda K. Science | 2017
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  • October 15, 2017

    T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP

    Radomir L., Cohen S., Kramer M. P., Bakos E., Lewinsky H., Barak A., Porat Z., Bucala R., Stepensky P., Becker-Herman S. & Shachar I. Journal of Immunology | 2017
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  • October 01, 2017

    The remedy within: will the microbiome fulfill its therapeutic promise?

    Thaiss C. A. & Elinav E. Journal of Molecular Medicine | 2017
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  • September 19, 2017

    Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

    Afik S., Yates K. B., Bi K., Darko S., Godec J., Gerdemann U., Swadling L., Douek D. C., Klenerman P., Barnes E. J. , et al. , Sharpe A. H., Haining W. N. & Yosef N. Nucleic Acids Research | 2017
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  • September 07, 2017

    A deep generative model for gene expression profiles from single-cell RNA sequencing

    Lopez R., Regier J., Cole M., Jordan M. & Yosef N. arxiv.org | 2017
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  • September 05, 2017

    Women in Metabolism: The Next Generation

    Merbl Y. Cell Metabolism | 2017
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  • August 31, 2017

    Predicting gene expression in massively parallel reporter assays: A comparative study

    Kreimer A., Zeng H., Edwards M. D., Guo Y., Tian K., Shin S., Welch R., Wainberg M., Mohan R., Sinnott-Armstrong N. A. , et al. , Li Y., Eraslan G., Amin T. B., Tewhey R., Sabeti P. C., Goke J., Mueller N. S., Kellis M., Kundaje A., Beer M. A., Keles S., Gifford D. K. & Yosef N. Human Mutation | 2017
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  • August 15, 2017

    Post-translational modification profiling-functional proteomics for the analysis of immune regulation

    Eisenberg-Lerner A., Regev I. & Merbl Y. | 2017
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  • August 09, 2017

    Circadian Coordination of Antimicrobial Responses

    Tognini P., Thaiss C. A., Elinav E. & Sassone-Corsi P. Cell Host and Microbe | 2017
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  • July 31, 2017

    An evolutionary perspective on plasmid lifestyle modes

    Hülter N., Ilhan J., Wein T., Kadibalban A. S., Hammerschmidt K. & Dagan T. Current Opinion in Microbiology | 2017
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  • July 31, 2017

    The microbiome in anti-cancer therapy

    Bashiardes S., Tuganbaev T., Federici S. & Elinav E. Seminars in Immunology | 2017
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  • July 03, 2017

    Immunology, one cell at a time

    Giladi A. & Amit I. Nature | 2017
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  • July 01, 2017

    Inflammasomes and intestinal inflammation

    Zmora N., Levy M., Pevsner-Fischer M. & Elinav E. Mucosal Immunology | 2017
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  • June 30, 2017

    MicroRNA-142 controls thymocyte proliferation

    Mildner A., Chapnik E., Varol D., Aychek T., Lampl N., Rivkin N., Bringmann A., Paul F., Boura-Halfon S., Hayoun Y. S. , et al. , Barnett Itzhaki I. Z., Amit I., Hornstein E. & Jung S. European Journal of Immunology | 2017
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  • June 29, 2017

    The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia

    Wakim J., Arman E., Becker Herman S., Kramer M. P., Bakos E., Shachar I. & Elson A. Oncogene | 2017
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  • June 27, 2017

    An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling

    Mertins P., Przybylski D., Yosef N., Qiao J., Clauser K., Raychowdhury R., Eisenhaure T. M., Maritzen T., Haucke V., Satoh T. , et al. , Akira S., Carr S. A., Regev A., Hacohen N. & Chevrier N. Cell Reports | 2017
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  • June 20, 2017

    Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

    Varol D., Mildner A., Blank T., Shemer A., Barashi N., Yona S., David E., Boura-Halfon S., Segal-Hayoun Y., Chappell-Maor L. , et al. , Keren-Shaul H., Leshkowitz D., Hornstein E., Fuhrmann M., Amit I., Maggio N., Prinz M. & Jung S. Immunity | 2017
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  • June 15, 2017

    CCR2 regulates the immune response by modulating the interconversion and function of effector and regulatory T cells

    Bakos E., Thaiss C. A., Kramer M. P., Cohen S., Radomir L., Orr I., Kaushansky N., Ben-Nun A., Becker Herman S. & Shachar I. Journal of Immunology | 2017
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  • June 15, 2017

    A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

    Keren-Shaul H., Spinrad A., Weiner A., Matcovitch-Natan O., Dvir-Szternfeld R., Ulland T. K., David E., Baruch K., Lara-Astaiso D., Toth B. , et al. , Itzkovitz S., Colonna M., Schwartz M. & Amit I. Cell | 2017
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  • June 13, 2017

    MIF- and CD74-Dependent Mechanisms

    Becker-Herman S., Gil N., Radomir L. & Shachar I. | 2017
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  • June 06, 2017

    Bread Affects Clinical Parameters and Induces Gut Microbiome-Associated Personal Glycemic Responses

    Korem T., Zeevi D., Zmora N., Weissbrod O., Bar N., Lotan-Pompan M., Avnit Sagi S. T., Kosower N., Malka G., Rein M. , et al. , Suez J., Goldberg B. Z., Weinberger A., Levy A., Elinav E. & Segal E. Cell Metabolism | 2017
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  • June 01, 2017

    Deconstructing Olfactory Stem Cell Trajectories at Single-Cell Resolution

    Fletcher R. B., Das D., Gadye L., Street K. N., Baudhuin A., Wagner A., Cole M. B., Flores Q., Choi Y. G., Yosef N. , et al. , Purdom E., Dudoit S., Risso D. & Ngai J. Cell Stem Cell | 2017
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  • May 31, 2017

    Post-dieting weight gain: The role of persistent microbiome changes

    Thaiss C. A., Shapiro H. & Elinav E. Future Microbiology | 2017
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  • May 31, 2017

    Convolutional Kitchen Sinks for Transcription Factor Binding Site Prediction

    Morrow A., Shankar V., Petersohn D., Joseph A., Recht B. & Yosef N. arxiv.org | 2017
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  • May 25, 2017

    The path towards microbiome-based metabolite treatment

    Suez J. & Elinav E. Nature Microbiology | 2017
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  • May 16, 2017

    Genomic Characterization of Murine Monocytes Reveals C/EBP beta Transcription Factor Dependence of Ly6C(-) Cells

    Mildner A., Schoenheit J., Giladi A., David E., Lara Astiaso A. D., Lorenzo Vivas V. E., Paul F., Chappell-Maor L., Priller J., Leutz A. , et al. , Amit I. & Jung S. Immunity | 2017
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  • May 04, 2017

    Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

    Lavin Y., Kobayashi S., Leader A., Amir E. D., Elefant N., Bigenwald C., Remark R., Sweeney R., Becker C. D., Levine J. H. , et al. , Meinhof K., Chow A., Kim-Shulze S., Wolf A., Medaglia C., Li H., Rytlewski J. A., Emerson R. O., Solovyov A., Greenbaum B. D., Sanders C., Vignali M., Beasley M. B., Flores R., Gnjatic S., Pe'er D., Rahman A., Amit I. & Merad M. Cell | 2017
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  • April 26, 2017

    Signaling by antibodies: Recent progress

    Bournazos S., Wang T. T., Dahan R., Maamary J. & Ravetch J. V. ANNUAL REVIEW OF IMMUNOLOGY | 2017
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  • April 25, 2017

    Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

    Fiziev P., Akdemir K. C., Miller J. P., Keung E. Z., Samant N. S., Sharma S., Natale C. A., Terranova C. J., Maitituoheti M., Amin S. B. , et al. , Martinez-Ledesma E., Dhamdhere M., Axelrad J. B., Shah A., Cheng C. S., Mahadeshwar H., Seth S., Barton M. C., Protopopov A., Tsai K. Y., Davies M. A., Garcia B. A., Amit I., Chin L., Ernst J. & Rai K. Cell Reports | 2017
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  • April 18, 2017

    Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

    Arce Vargas F., Furness A. J., Solomon I., Joshi K., Mekkaoui L., Lesko M. H., Miranda Rota E., Dahan R., Georgiou A., Sledzinska A. , et al. , Ben Aissa A., Franz D., Werner Sunderland M., Wong Y. N. S., Henry J. Y., O'Brien T., Nicol D., Challacombe B., Beers S. A. & Spain L. Immunity | 2017
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  • April 01, 2017

    Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

    Wolf Y., Shemer A., Polonsky M., Gross-Vered M., Mildner A., Yona S., David E., Kim K., Goldmann T., Amit I. , et al. , Heikenwalder M., Nedospasov S., Prinz M., Friedman N. & Jung S. Journal of Experimental Medicine | 2017
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  • April 01, 2017

    Dysbiosis and the immune system

    Levy M., Kolodziejczyk A. A., Thaiss C. A. & Elinav E. Nature Reviews Immunology | 2017
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  • March 31, 2017

    NLRP6: A Multifaceted Innate Immune Sensor

    Levy M., Shapiro H., Thaiss C. A. & Elinav E. Trends in Immunology | 2017
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  • March 23, 2017

    A new way to build cell lineages

    Zhang X. & Yosef N. eLife | 2017
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  • March 22, 2017

    Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation

    Karwacz K., Miraldi E. R., Pokrovskii M., Madi A., Yosef N., Wortman I., Chen X., Watters A., Carriero N., Awasthi A. , et al. , Regev A., Bonneau R., Littman D. & Kuchroo V. K. Nature Immunology | 2017
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  • March 09, 2017

    Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation

    Lim A. I., Li Y., Lopez-Lastra S., Stadhouders R., Paul F., Casrouge A., Serafini N., Puel A., Bustamante J., Surace L. , et al. , Masse-Ranson G., David E., Strick-Marchand H., Le Bourhis B. L., Cocchi R., Topazio D., Graziano P., Muscarella L. A., Rogge L., Norel X., Sallenave J., Allez M., Graf T., Hendriks R. W., Casanova J., Amit I., Yssel H. & Di Santo S. J. P. Cell | 2017
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  • March 07, 2017

    The Role of the Immune System in Metabolic Health and Disease

    Zmora N., Bashiardes S., Levy M. & Elinav E. Cell Metabolism | 2017
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  • March 01, 2017

    Single-cell transcriptome conservation in cryopreserved cells and tissues

    Guillaumet-Adkins A., Rodriguez-Esteban G., Mereu E., Mendez-Lago M., Jaitin D. A., Villanueva A., Vidal A., Martinez-Marti A., Felip E., Vivancos A. , et al. , Keren-Shaul H., Heath S., Gut M., Amit I., Gut I. & Heyn H. GENOME BIOLOGY | 2017
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  • February 16, 2017

    Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

    Halpern K. B., Shenhav R., Matcovitch-Natan O., Toth B., Lemze D., Golan M., Massasa E. E., Baydatch S., Landen S., Moor A. E. , et al. , Brandis A., Giladi A., Stokar-Avihail A., David E., Amit I. & Itzkovitz S. Nature | 2017
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  • February 02, 2017

    CD84 mediates CLL-microenvironment interactions

    Marom A., Barak A. F., Kramer M. P., Lewinsky H., Binsky-Ehrenreich I., Cohen S., Tsitsou-Kampeli A., Kalchenko V. (., Kuznetsov Y., Mirkin V. , et al. , Dezorella N., Shapiro M., Schwartzberg P. L., Cohen Y., Shvidel L., Haran M., Becker Herman S., Herishanu Y. & Shachar I. Oncogene | 2017
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  • February 01, 2017

    Microbiome, metabolites and host immunity

    Levy M., Blacher E. & Elinav E. Current Opinion in Microbiology | 2017
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  • February 01, 2017

    Transcriptional programs that control expression of the autoimmune regulator gene Aire

    Herzig Y., Nevo S., Bornstein C., Brezis M. R., Ben-Hur S., Shkedy A., Eisenberg-Bord M., Levi B., Delacher M., Goldfarb Y. , et al. , David E., Weinberger L., Viukov S., Ben-Dor S., Giraud M., Hanna J. H., Breiling A., Lyko F., Amit I., Feuerer M. & Abramson J. Nature Immunology | 2017
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  • January 17, 2017

    CD74 is a novel transcription regulator

    Gil-Yarom N., Radomir L., Sever L., Kramer M. P., Lewinsky H., Bornstein C., Blecher-Gonen R., Barnett Itzhaki Z., Mirkin V., Friedlander G. , et al. , Shvidel L., Herishanu Y., Lolis E. J., Becker Herman S., Amit I. & Shachar I. Proceedings of the National Academy of Sciences of the United States of America | 2017
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  • January 17, 2017

    GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa

    Nassar M., Tabib Y., Capucha T., Mizraji G., Nir T., Pevsner-Fischer M., Zilberman-Schapira G., Heyman O., Nussbaum G., Bercovier H. , et al. , Wilensky A., Elinav E., Burstyn-Cohen T. & Hovav A. H. Proceedings of the National Academy of Sciences of the United States of America | 2017
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  • January 15, 2017

    Microbiome-modulated metabolites at the interface of host immunity

    Blacher E., Levy M., Tatirovsky E. & Elinav E. Journal of Immunology | 2017
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  • December 31, 2016

    ImpulseDE: Detection of differentially expressed genes in time series data using impulse models

    Sander J., Schultze J. L. & Yosef N. Bioinformatics | 2017
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  • December 31, 2016

    The gut microbiome and hypertension

    Pevsner-Fischer M., Blacher E., Tatirovsky E., Ben-Dov I. & Elinav E. Current Opinion in Nephrology and Hypertension | 2017
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  • December 22, 2016

    Persistent microbiome alterations modulate the rate of post-dieting weight regain

    Thaiss C. A., Itav S., Rothschild D., Meijer M. T., Levy M., Moresi C., Dohnalová L., Braverman S., Rozin S., Malitsky S. , et al. , Dori-Bachash M., Kuperman Y., Biton I., Gertler A., Harmelin A., Shapiro H., Halpern Z., Aharoni A., Segal E. & Elinav E. Nature | 2016
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  • December 15, 2016

    Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

    Jaitin D. A., Weiner A., Yofe I., Lara Astiaso D., Keren-Shaul H., David E., Salame T. M., Tanay A., van Oudenaarden A. & Amit I. Cell | 2016
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  • December 02, 2016

    The epigenetic landscape of T cell exhaustion

    Sen D. R., Kaminski J., Barnitz R. A., Kurachi M., Gerdemann U., Yates K. B., Tsao H., Godec J., LaFleur M. W., Brown F. D. , et al. , Tonnerre P., Chung R. T., Tully D. C., Allen T. M., Frahm N., Lauer G. M., Wherry E. J., Yosef N. & Haining W. N. Science | 2016
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  • December 01, 2016

    Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

    Thaiss C., Levy M., Korem T., Dohnalova L., Shapiro H., Jaitin D., David E., Winter D., Gury-BenAri M., Tatirovsky E. , et al. , Tuganbaev T., Federici S., Zmora N., Zeevi D., Dori-Bachash M., Pevsner-Fischer M., Kartvelishvily E., Brandis A., Harmelin A., Shibolet O., Halpern Z., Honda K., Amit I., Segal E. & Elinav E. Cell | 2016
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  • November 17, 2016

    The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Stunnenberg H. G., Abrignani S., Adams D., de Almeida M., Altucci L., Amin V., Amit I., Antonarakis S. E., Aparicio S., Arima T. , et al. , Arrigoni L., Arts R., Asnafi V., Badosa M. E., Bae J. B., Bassler K., Beck S., Berkman B., Bernstein B. E., Bilenky M., Bird A., Bock C., Boehm B., Bourque G., Breeze C. E., Brors B., Bujold D., Burren O., Bussemakers M. J., Butterworth A., Campo E., Carrillo-de-Santa-Pau E., Chadwick L., Chan K. M., Chen W., Cheung T. H., Chiapperino L., Choi N. H., Chung H. R., Clarke L., Connors J. M., Cronet P., Danesh J., Dermitzakis M., Drewes G., Durek P., Dyke S., Dylag T., Eaves C. J., Ebert P., Eils R., Eils J., Ennis C. A., Enver T., Feingold E. A., Felder B., Ferguson-Smith A., Fitzgibbon J., Flicek P., Foo R. S., Fraser P., Frontini M., Furlong E., Gakkhar S., Gasparoni N., Gasparoni G., Geschwind D. H., Glažar P., Graf T., Grosveld F., Guan X. Y., Guigo R., Gut I. G., Hamann A., Han B. G., Harris R. A., Heath S., Helin K., Hengstler J. G., Heravi-Moussavi A., Herrup K., Hill S., Hilton J. A., Hitz B. C., Horsthemke B., Hu M., Hwang J. Y., Ip N. Y., Ito T., Javierre B. M., Jenko S., Jenuwein T., Joly Y., Jones S. J., Kanai Y., Kang H. G., Karsan A., Kiemer A. K., Kim S. C., Kim B. J., Kim H. H., Kimura H., Kinkley S., Klironomos F., Koh I. U., Kostadima M., Kressler C., Kreuzhuber R., Kundaje A., Küppers R., Larabell C., Lasko P., Lathrop M., Lee D. H., Lee S., Lehrach H., Leitão E., Lengauer T., Lernmark Å., Leslie R. D., Leung G. K., Leung D., Loeffler M., Ma Y., Mai A., Manke T., Marcotte E. R., Marra M. A., Martens J. H., Martin-Subero J. I., Maschke K., Merten C., Milosavljevic A., Minucci S., Mitsuyama T., Moore R. A., Müller F., Mungall A. J., Netea M. G., Nordström K., Norstedt I., Okae H., Onuchic V., Ouellette F., Ouwehand W., Pagani M., Pancaldi V., Pap T., Pastinen T., Patel R., Paul D. S., Pazin M. J., Pelicci P. G., Phillips A. G., Polansky J., Porse B., Pospisilik J. A., Prabhakar S., Procaccini D. C., Radbruch A., Rajewsky N., Rakyan V., Reik W., Ren B., Richardson D., Richter A., Rico D., Roberts D. J., Rosenstiel P., Rothstein M., Salhab A., Sasaki H., Satterlee J. S., Sauer S., Schacht C., Schmidt F., Schmitz G., Schreiber S., Schröder C., Schübeler D., Schultze J. L., Schulyer R. P., Schulz M., Seifert M., Shirahige K., Siebert R., Sierocinski T., Siminoff L., Sinha A., Soranzo N., Spicuglia S., Spivakov M., Steidl C., Strattan J. S., Stratton M., Südbeck P., Sun H., Suzuki N., Suzuki Y., Tanay A., Torrents D., Tyson F. L., Ulas T., Ullrich S., Ushijima T., Valencia A., Vellenga E., Vingron M., Wallace C., Wallner S., Walter J., Wang H., Weber S., Weiler N., Weller A., Weng A., Wilder S., Wiseman S. M., Wu A. R., Wu Z., Xiong J., Yamashita Y., Yang X., Yap D. Y., Yip K. Y., Yip S., Yoo J. I., Zerbino D., Zipprich G. & Hirst M. Cell | 2016
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  • November 11, 2016

    The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

    Hu B., Jin C., Li H. B., Tong J., Ouyang X., Cetinbas N. M., Zhu S., Strowig T., Lam F. C., Zhao C. , et al. , Henao-Mejia J., Yilmaz O., Fitzgerald K. A., Eisenbarth S. C., Elinav E. & Flavell R. A. Science | 2016
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  • November 08, 2016

    Revealing the vectors of cellular identity with single-cell genomics

    Wagner A., Regev A. & Yosef N. Nature biotechnology | 2016
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  • October 12, 2016

    Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality

    Talmi-Frank D., Altboum Z., Solomonov I., Udi Y., Jaitin D. A., Klepfish M., David E., Zhuravlev A., Keren-Shaul H., Winter D. R. , et al. , Gat-Viks I., Mandelboim M., Ziv T., Amit I. & Sagi I. Cell Host & Microbe | 2016
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  • October 07, 2016

    Writ large: Genomic dissection of the effect of cellular environment on immune response

    Yosef N. & Regev A. Science | 2016
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  • September 27, 2016

    Distinct biological events generated by ECM proteolysis by two homologous collagenases

    Solomonov I., Zehorai E., Talmi-Frank D., Wolf S. G., Shainskaya A., Zhuravlev A., Kartvelishvily E., Visse R., Levin Y., Kampf N. , et al. , Jaitin D. A., David E., Amit I., Nagase H. & Sagi I. Proceedings of the National Academy of Sciences of the United States of America | 2016
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  • September 12, 2016

    Co-targeting of Adenosine Signaling Pathways for Immunotherapy: Potentiation by Fc Receptor Engagement

    Dahan R. & Ravetch J. V. Cancer Cell | 2016
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  • September 01, 2016

    Non-alcoholic fatty liver and the gut microbiota

    Bashiardes S., Shapiro H., Rozin S., Shibolet O. & Elinav E. Molecular Metabolism | 2016
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  • September 01, 2016

    Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution

    Weiner A., Lara Astiaso A. D., Krupalnik V., Gafni O., David E., Winter D. R., Hanna J. H. & Amit I. Nature biotechnology | 2016
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  • August 25, 2016

    The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

    Gury-BenAri M., Thaiss C. A., Serafini N., Winter D. R., Giladi A., Lara Astiaso A. D., Levy M., Salame T. M., Weiner A., David E. , et al. , Shapiro H., Dori-Bachash M., Pevsner-Fischer M., Lorenzo Vivas V. E., Keren-Shaul H., Paul F., Harmelin A., Eberl G., Itzkovitz S., Tanay A., Di Santo S. J. P., Elinav E. & Amit I. Cell | 2016
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  • August 23, 2016

    FastProject: A tool for low-dimensional analysis of single-cell RNA-Seq data

    DeTomaso D. & Yosef N. BMC Bioinformatics | 2016
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  • August 19, 2016

    Microglia development follows a stepwise program to regulate brain homeostasis

    Matcovitch-Natan O., Winter D. R., Giladi A., Vargas Aguilar A. S., Spinrad A., Sarrazin S., Ben-Yehuda H., David E., Zelada Gonzalez G. F., Perrin P. , et al. , Keren-Shaul H., Gury M., Lara-Astaiso D., Thaiss C. A., Cohen M., Bahar Halpern H. K., Baruch K., Deczkowska A., Lorenzo Vivas V. E., Itzkovitz S., Elinav E., Sieweke M. H., Schwartz M. & Amit I. Science | 2016
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  • August 19, 2016

    Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity

    Kohnz R. A., Roberts L. S., DeTomaso D., Bideyan L., Yan P., Bandyopadhyay S., Goga A., Yosef N. & Nomura D. K. ACS Chemical Biology | 2016
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  • August 16, 2016

    Regioselectivity of third-row maingroup dicarbides, C<sub>2</sub>X (X = K-Br) for CO interaction: Fukui function and topological analyses

    Parida S. K., Sahu S., Sharma S., Mao R., Pevsner-Fischer M., Ben-horin S., Elinav E., Zeng Z., Chen B., He Y. , et al. , Xiang A. P. & Chen M. Chemical Physics Letters | 2016
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  • August 01, 2016

    Post-translational modification profiling A novel tool for mapping the protein modification landscape in cancer

    Eisenberg-Lerner A., Ciechanover A. & Merbl Y. Experimental Biology and Medicine | 2016
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  • July 15, 2016

    Metabolites: Messengers between the microbiota and the immune system

    Levy M., Thaiss C. A. & Elinav E. GENES & DEVELOPMENT | 2016
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  • July 06, 2016

    The microbiome and innate immunity

    Thaiss C. A., Zmora N., Levy M. & Elinav E. Nature | 2016
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  • June 29, 2016

    Zooming in on selectins in cancer

    Kedmi R. & Peer D. Science Translational Medicine | 2016
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  • June 13, 2016

    Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement

    Dahan R., Barnhart B. C., Li F., Yamniuk A. P., Korman A. J. & Ravetch J. V. Cancer Cell | 2016
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  • June 03, 2016

    The gut microbiome in human immunodeficiency virus infection

    Zilberman G., Zmora N., Itav S., Bashiardes S., Elinav H. & Elinav E. BMC Medicine | 2016
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  • May 31, 2016

    M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration

    Barzilai S., Blecher-Gonen R., Barnett Itzhaki Z., Zauberman A., Lebel-Haziv Y., Amit I. & Alon R. Journal of Leukocyte Biology | 2016
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  • May 31, 2016

    Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

    Georgoudaki A. M., Prokopec K. E., Boura V. F., Hellqvist E., Sohn S., Östling J., Dahan R., Harris R. A., Rantalainen M., Klevebring D. , et al. , Sund M., Brage S. E., Fuxe J., Rolny C., Li F., Ravetch J. V. & Karlsson M. C. Cell Reports | 2016
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  • April 20, 2016

    Use of metatranscriptomics in microbiome research

    Bashiardes S., Zilberman-Schapira G. & Elinav E. Bioinformatics and Biology Insights | 2016
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  • April 19, 2016

    Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory

    Gitlin A. D., von Boehmer L., Gazumyan A., Shulman Z., Oliveira T. Y. & Nussenzweig M. C. Immunity | 2016
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  • April 10, 2016

    Role of the microbiome in non-gastrointestinal cancers

    Pevsner-Fischer M., Tuganbaev T., Meijer M., Zhang S., Zeng Z., Chen M. & Elinav E. World Journal of Clinical Oncology | 2016
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  • March 31, 2016

    Role of the microbiome in the normal and aberrant glycemic response

    Suez J., Shapiro H. & Elinav E. Clinical Nutrition Experimental | 2016
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  • March 08, 2016

    It's in the milk: Feeding the microbiome to promote infant growth

    Bashiardes S., Thaiss C. A. & Elinav E. Cell Metabolism | 2016
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  • March 01, 2016

    Voices of biotech

    Amit I., Baker D., Barker R., Berger B., Bertozzi C., Bhatia S., Biffi A., Demichelis F., Doudna J., Dowdy S. F. , et al. , Endy D., Helmstaedter M., Junca H., June C., Kamb S., Khvorova A., Kim D., Kim J., Krishnan Y., Lakadamyali M., Lappalainen T., Lewin S., Liao J., Loman N., Lundberg E., Lynd L., Martin C., Mellman I., Miyawaki A., Mummery C., Nelson K., Paz J., Peralta-Yahya P., Picotti P., Polyak K., Prather K., Qin J., Quake S., Regev A., Rogers J. A., Shetty R., Sommer M., Stevens M., Stolovitzky G., Takahashi M., Tang F., Teichmann S., Torres-Padilla M., Tripathi L., Vemula P., Verdine G., Vollmer F., Wang J., Ying J. Y., Zhang F. & Zhang T. Nature biotechnology | 2016
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  • February 19, 2016

    The Microbiota and Its Modulation in Immune-Mediated Disorders

    Pevsner-Fischer M., Rot C., Tuganbaev T. & Elinav E. | 2016
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  • February 01, 2016

    PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

    Baruch K., Deczkowska A., Rosenzweig N., Tsitsou-Kampeli A., Sharif A. M., Matcovitch-Natan O., Kertser A., David E., Amit I. & Schwartz M. Nature Medicine | 2016
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  • February 01, 2016

    Integration of Innate Immune Signaling

    Thaiss C. A., Levy M., Itav S. & Elinav E. Trends in Immunology | 2016
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  • February 01, 2016

    Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

    Decque A., Joffre O., Magalhaes J. G., Cossec J. C., Blecher-Gonen R., Lapaquette P., Silvin A., Manel N., Joubert P. E., Seeler J. S. , et al. , Albert M. L., Amit I., Amigorena S. & Dejean A. Nature Immunology | 2016
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  • January 13, 2016

    Taking it Personally: Personalized Utilization of the Human Microbiome in Health and Disease

    Zmora N., Zeevi D., Korem T., Segal E. & Elinav E. Cell Host & Microbe | 2016
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  • January 11, 2016

    CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease

    Zelman-Toister E., Bakos E., Cohen S., Zigmond E., Shezen E., Grabovsky V., Sagiv A., Hart G., Kaushansky N., Ben-Nun A. , et al. , Maharshak N., Sonnenberg A., Alon R., Becker Herman H. S. & Shachar I. Inflammatory Bowel Diseases | 2016
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  • January 01, 2016

    The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

    Amit I., Winter D. R. & Jung S. Nature Immunology | 2016
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  • December 31, 2015

    Novel CXCL13 transgenic mouse: Inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis

    Weiss J. M., Robinet M., Aricha R., Cufi P., Villeret B., Lantner F., Shachar I., Fuchs S., Souroujon M. C., Berrih-Aknin S. & Panse R. L. Oncotarget | 2016
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  • December 29, 2015

    Nuclear Retention of mRNA in Mammalian Tissues

    Halpern K. B., Caspi I., Lemze D., Levy M., Landen S., Elinav E., Ulitsky I. & Itzkovitz S. Cell Reports | 2015
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  • December 17, 2015

    Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

    Paul F., Arkin Y., Giladi A., Jaitin D. A., Kenigsberg E., Keren-Shaul H., Winter D., Lara-Astiaso D., Gury M., Weiner A. , et al. , David E., Cohen N., Lauridsen F. K. B., Haas S., Schlitzer A., Mildner A., Ginhoux F., Jung S., Trumpp A., Porse B. T., Tanay A. & Amit I. Cell | 2015
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  • December 06, 2015

    Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

    Nowarski R., Jackson R., Gagliani N., de Zoete M. R., Palm N. W., Bailis W., Low J. S., Harman C. C. D., Graham M., Elinav E. & Flavell R. A. Cell | 2015
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  • December 03, 2015

    Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

    Levy M., Thaiss C. A., Zeevi D., Dohnalova L., Zilberman-Schapira G., Mahdi J. A., David E., Savidor A., Korem T., Herzig Y. , et al. , Pevsner-Fischer M., Shapiro H., Christ A., Harmelin A., Halpern Z., Latz E., Flavell R. A., Amit I., Segal E. & Elinav E. Cell | 2015
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  • December 03, 2015

    CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

    Wang C., Yosef N., Gaublomme J., Wu C., Lee Y., Clish C. B., Kaminski J., Xiao S., Horste G. M. Z., Pawlak M. , et al. , Kishi Y., Joller N., Karwacz K., Zhu C., Ordovas-Montanes M., Madi A., Wortman I., Miyazaki T., Sobel R. A., Park H., Regev A. & Kuchroo V. K. Cell | 2015
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  • December 03, 2015

    Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

    Gaublomme J. T., Yosef N., Lee Y., Gertner R. S., Yang L. V., Wu C., Pandolfi P. P., Mak T., Satija R., Shalek A. K. , et al. , Kuchroo V. K., Park H. & Regev A. Cell | 2015
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  • November 20, 2015

    Metagenomic cross-talk: The regulatory interplay between immunogenomics and the microbiome

    Levy M., Thaiss C. A. & Elinav E. Genome Medicine | 2015
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  • November 19, 2015

    Personalized Nutrition by Prediction of Glycemic Responses

    Zeevi D., Korem T., Zmora N., Israeli D., Rothschild D., Weinberger A., Ben-Yacov O., Lador D., Avnit Sagi S. T., Lotan-Pompan M. , et al. , Suez J., Mahdi J. A., Matot E., Malka G., Kosower N., Rein M., Zilberman-Schapira G., Dohnalova L., Pevsner-Fischer M., Bikovsky R., Halpern Z., Elinav E. & Segal E. Cell | 2015
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  • November 16, 2015

    Oct1 and OCA-B are selectively required for CD4 memory T cell function

    Shakya A., Goren A., Shalek A., German C. N., Snook J., Kuchroo V. K., Yosef N., Chan R. C., Regev A., Williams M. A. & Tantin D. Journal of Experimental Medicine | 2015
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  • October 12, 2015

    Erratum to FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis [Cancer Cell 28, 285-295; September 14, 2015]

    Dahan R., Sega E., Engelhardt J., Selby M., Korman A. J. & Ravetch J. V. Cancer Cell | 2015
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  • September 25, 2015

    Making the case for chromatin profiling: A new tool to investigate the immune-regulatory landscape

    Winter D. R., Jung S. & Amit I. Nature Reviews Immunology | 2015
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  • September 14, 2015

    FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

    Dahan R., Sega E., Engelhardt J., Selby M., Korman A. J. & Ravetch J. V. Cancer Cell | 2015
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  • September 08, 2015

    From mass cytometry to cancer prognosis

    Winter D. R., Ledergor G. & Amit I. Nature Biotechnology | 2015
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  • September 04, 2015

    Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples

    Korem T., Zeevi D., Suez J., Weinberger A., Avnit Sagi S. T., Pompan-Lotan M., Matot E., Jona G., Harmelin A., Cohen N. , et al. , Sirota-Madi A., Thaiss C. A., Pevsner-Fischer M., Sorek R., Xavier R. J., Elinav E. & Segal E. Science (New York, N.Y.) | 2015
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  • August 18, 2015

    Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes

    Capucha T., Mizraji G., Segev H., Blecher-Gonen R., Winter D., Khalaileh A., Tabib Y., Attal T., Nassar M., Zelentsova K. , et al. , Kisos H., Zenke M., Sere K., Hieronymus T., Burstyn-Cohen T., Amit I., Wilensky A. & Hovav A. Immunity | 2015
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  • August 07, 2015

    T cell help controls the speed of the cell cycle in germinal center B cells

    Gitlin A. D., Mayer C. T., Oliveira T. Y., Shulman Z., Jones M. J. K., Koren A. & Nussenzweig M. C. Science | 2015
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  • July 28, 2015

    Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

    Ramishetti S., Kedmi R., Goldsmith M., Leonard F., Sprague A. G., Godin B., Gozin M., Cullis P. R., Dykxhoorn D. M. & Peer D. ACS Nano | 2015
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  • July 20, 2015

    DCs are ready to commit

    Winter D. & Amit I. Nature Immunology | 2015
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  • April 30, 2015

    Derivation of novel human ground state naive pluripotent stem cells (vol 504, pg 282, 2013): Derivation of novel human ground state naive pluripotent stem cells

    Gafni O., Weinberger L., Mansour A. A., Manor Y. S., Chomsky E., Ben-Yosef D., Kalma Y., Viukov S., Maza I., Zviran A. , et al. , Rais Y., Shipony Z., Mukamel Z., Krupalnik V., Zerbib M., Geula S., Caspi I., Schneir D., Shwartz T., Gilad S., Amann-Zalcenstein D., Benjamin S., Amit I., Tanay A., Massarwa R., Novershtern N. & Hanna J. H. Nature | 2015
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  • April 30, 2015

    Deterministic direct reprogramming of somatic cells to pluripotency (vol 502, pg 65, 2013): Deterministic direct reprogramming of somatic cells to pluripotency (Nature (2013) 502 (65-70) DOI: 10.1038/nature12587)

    Rais Y., Zviran A., Geula S., Gafni O., Chomsky E., Viukov S., Mansour A. A., Caspi I., Krupalnik V., Zerbib M. , et al. , Maza I., Mor N., Baran D., Weinberger L., Jaitin D. A., Lara-Astiaso D., Blecher-Gonen R., Shipony Z., Mukamel Z., Hagai T., Gilad S., Amann-Zalcenstein D., Tanay A., Amit I., Novershtern N. & Hanna J. H. Nature | 2015
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  • April 28, 2015

    Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq

    Fuchs G., Voichek Y., Rabani M., Benjamin S., Gilad S., Amit I. & Oren M. Nature protocols | 2015
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  • April 22, 2015

    A day in the life of the meta-organism: Diurnal rhythms of the intestinal microbiome and its host

    Thaiss C. A., Zeevi D., Levy M., Segal E. & Elinav E. Gut Microbes | 2015
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  • April 21, 2015

    NF-κB Regulation by NLRs: T Cells Join the Club

    Thaiss C. A. & Elinav E. Immunity | 2015
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  • April 16, 2015

    High-resolution chromatin dynamics during a yeast stress response

    Weiner A., Hsieh T. S., Appleboim A., Chen H. V., Rahat A., Amit I., Rando O. J. & Friedman N. Molecular Cell | 2015
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  • April 01, 2015

    Non-caloric artificial sweeteners and the microbiome: Findings and challenges

    Suez J., Korem T., Zilberman-Schapira G., Segal E. & Elinav E. Gut Microbes | 2015
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  • March 31, 2015

    Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor

    Tian R., Wang H., Gish G. D., Petsalaki E., Pasculescu A., Shi Y., Mollenauer M., Bagshaw R. D., Yosef N., Hunter T. , et al. , Gingras A., Weiss A. & Pawson T. Proceedings of the National Academy of Sciences of the United States of America | 2015
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  • March 02, 2015

    MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis

    Murugaiyan G., da Cunha A. P., Ajay A. K., Joller N., Garo L. P., Kumaradevan S., Yosef N., Vaidya V. S. & Weiner H. L. Journal of Clinical Investigation | 2015
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  • February 28, 2015

    Taming the inflammasome

    Levy M., Thaiss C. A. & Elinav E. Nature Medicine | 2015
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  • February 27, 2015

    m<sup>6</sup>A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

    Geula S., Moshitch-Moshkovitz S., Dominissini D., Mansour A. A., Kol N., Salmon-Divon M., Hershkovitz V., Peer E., Mor N., Manor Y. S. , et al. , Ben-Haim M., Eyal E., Yunger S., Pinto Y., Jaitin D. A., Viukov S., Rais Y., Krupalnik V., Chomsky E., Zerbib M., Maza I., Rechavi Y., Massarwa R., Hanna S., Amit I., Levanon E. Y., Amariglio N., Stern-Ginossar N., Novershtern N., Rechavi G. & Hanna J. H. Science | 2015
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  • February 19, 2015

    Transcription factor binding dynamics during human ES cell differentiation

    Tsankov A. M., Gu H., Akopian V., Ziller M. J., Donaghey J., Amit I., Gnirke A. & Meissner A. Nature | 2015
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  • February 01, 2015

    Each cell counts: Hematopoiesis and immunity research in the era of single cell genomics

    Jaitin D. A., Keren-Shaul H., Elefant N. & Amit I. Seminars in Immunology | 2015
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  • January 20, 2015

    Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Ben Chetrit C. N., Chetrit D., Russell R., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J. , et al. , Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Lapidot T., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M. & Yarden Y. Science Signaling | 2015
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  • December 31, 2014

    Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion

    Shakya A., Callister C., Goren A., Yosef N., Garg N., Khoddami V., Nix D., Regev A. & Tantin D. Molecular and Cellular Biology | 2015
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  • December 31, 2014

    Chronobiomics: The Biological Clock as a New Principle in HostMicrobial Interactions

    Thaiss C. A., Levy M. & Elinav E. PLoS Pathogens | 2015
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  • December 31, 2014

    Inflammasomes and the microbiotapartners in the preservation of mucosal homeostasis

    Levy M., Thaiss C. A., Katz M. N., Suez J. & Elinav E. Seminars in Immunopathology | 2015
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  • December 31, 2014

    Inflammatory mechanisms of infection-associated cancer

    Suez J., Levy M., Thaiss C. A. & Elinav E. | 2015
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  • December 31, 2014

    Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota: Editorial comment

    Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A. , et al. , Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E. Obstetrical & Gynecological Survey | 2015
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  • December 18, 2014

    A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States

    Bornstein C., Winter D., Barnett Itzhaki I. Z., David E., Kadri S., Garber M. & Amit I. Molecular Cell | 2014
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  • December 18, 2014

    High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies

    Rabani M., Raychowdhury R., Jovanovic M., Rooney M., Stumpo D. J., Pauli A., Hacohen N., Schier A. F., Blackshear P. J., Friedman N. , et al. , Amit I. & Regev A. Cell | 2014
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  • December 17, 2014

    Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner

    Cohen M., Matcovitch O., David E., Barnett Itzhaki I. Z., Keren-Shaul H., Blecher-Gonen R., Jaitin D. A., Sica A., Amit I. & Schwartz M. EMBO Journal | 2014
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  • December 04, 2014

    Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment

    Lavin Y., Winter D., Blecher-Gonen R., David E., Keren-Shaul H., Merad M., Jung S. & Amit I. Cell | 2014
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  • October 23, 2014

    Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis

    Thaiss C. A., Zeevi D., Levy M., Zilberman-Schapira G., Suez J., Tengeler A. C., Abramson L., Katz M. N., Korem T., Zmora N. , et al. , Kuperman Y., Biton I., Gilad S., Harmelin A., Shapiro H., Halpern Z., Segal E. & Elinav E. Cell | 2014
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  • October 17, 2014

    Artificial sweeteners induce glucose intolerance by altering the gut microbiota

    Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A. , et al. , Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E. Nature | 2014
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  • October 03, 2014

    Aging-induced type I interferon response at the choroid plexus negatively affects brain function

    Baruch K., Deczkowska A., David E., Castellano J. M., Miller O., Kertser A., Berkutzki T., Barnett Itzhaki I. Z., Bezalel D., Wyss-Coray T. , et al. , Amit I. & Schwartz M. Science | 2014
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  • October 01, 2014

    A simple cage-autonomous method for the maintenance of the barrier status of germ-free mice during experimentation

    Hecht G., Bar-Nathan C., Milite G., Alon I., Moshe Y., Greenfeld L., Dotsenko N., Suez J., Levy M., Thaiss C. A. , et al. , Dafni H., Elinav E. & Harmelin A. Laboratory Animals | 2014
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  • September 30, 2014

    Plasticity in the transcriptional and epigenetic circuits regulating dendritic cell lineage specification and function

    Paul F. & Amit I. Current Opinion in Immunology | 2014
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  • September 30, 2014

    The cross talk between microbiota and the immune system: Metabolites take center stage

    Shapiro H., Thaiss C. A., Levy M. & Elinav E. Current Opinion in Immunology | 2014
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  • September 30, 2014

    The central nervous system microenvironment imprints microglial inability to switch from pro- to anti-inflammatory phenotype

    Matcovitch O., Cohen M., David E., Barnettitzhaki Z., Keren-Shaul H., Blecher-gonen R., Jaitin D. A., Sica A., Amit I. & Schwartz M. Journal of Neuroimmunology | 2014
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  • August 31, 2014

    The role of chromatin dynamics in immune cell development

    Winter D. R. & Amit I. Immunological Reviews | 2014
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  • August 29, 2014

    Dynamic signaling by T follicular helper cells during germinal center B cell selection: Dynamic signaling by T follicular helper cells during germinal center B cell selection

    Shulman Z., Gitlin A. D., Weinstein J. S., Lainez B., Esplugues E., Flavell R. A., Craft J. E. & Nussenzweig M. C. Science | 2014
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  • August 22, 2014

    Chromatin state dynamics during blood formation

    Lara Astiaso A. D., Weiner A., Lorenzo Vivas V. E., Zaretsky I., Jaitin D. A., David E., Keren-Shaul H., Mildner A., Winter D., Jung S. , et al. , Friedman N. & Amit I. Science | 2014
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  • July 31, 2014

    Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

    Raza S., Barnett M. W., Barnett Itzhaki I. Z., Amit I., Hume D. A. & Freeman T. C. Journal of Leukocyte Biology | 2014
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  • July 31, 2014

    Type i and type II Fc receptors regulate innate and adaptive immunity

    Pincetic A., Bournazos S., Dilillo D. J., Maamary J., Wang T. T., Dahan R., Fiebiger B. M. & Ravetch J. V. Nature Immunology | 2014
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  • July 31, 2014

    Post-translational modification profiling-A high-content assay for identifying protein modifications in mammalian cellular systems

    Merbl Y. & Kirschner M. W. Current Protocols in Protein Science | 2014
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  • June 11, 2014

    Exploring new horizons in microbiome research

    Thaiss C. A. & Elinav E. Cell Host & Microbe | 2014
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  • June 01, 2014

    MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling

    Klasen C., Ohl K., Sternkopf M., Shachar I., Schmitz C., Heussen N., Hobeika E., Levit-Zerdoun E., Tenbrock K., Reth M. , et al. , Bernhagen J. & El Bounkari O. Journal of Immunology | 2014
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  • May 31, 2014

    Understanding Th17 cells through systematic genomic analyses

    Peters A. & Yosef N. Current Opinion in Immunology | 2014
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  • May 29, 2014

    Clonal selection in the germinal centre by regulated proliferation and hypermutation

    Gitlin A. D., Shulman Z. & Nussenzweig M. C. Nature | 2014
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  • May 08, 2014

    The fire within: Microbes inflame tumors

    Gagliani N., Hu B., Huber S., Elinav E. & Flavell R. A. Cell | 2014
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  • May 01, 2014

    HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis

    Meza-Romero R., Benedek G., Yu X., Mooney J. L., Dahan R., Duvshani N., Bucala R., Offner H., Reiter Y., Burrows G. G. & Vandenbark A. A. Journal of Immunology | 2014
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  • May 01, 2014

    The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis

    Bucala R. & Shachar I. Mini-Reviews in Medicinal Chemistry | 2014
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  • April 17, 2014

    Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

    Xiao S., Yosef N., Yang J., Wang Y., Zhou L., Zhu C., Wu C., Baloglu E., Schmidt D., Ramesh R. , et al. , Lobera M., Sundrud M. S., Tsai P., Xiang Z., Wang J., Xu Y., Lin X., Kretschmer K., Rahl P. B., Young R. A., Zhong Z., Hafler D. A., Regev A., Ghosh S., Marson A. & Kuchroo V. K. Immunity | 2014
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  • April 02, 2014

    Microarray discovery of new OGT substrates: The medulloblastoma oncogene OTX2 is O -GlcNAcylated

    Ortiz-Meoz R. F., Merbl Y., Kirschner M. W. & Walker S. Journal of the American Chemical Society | 2014
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  • March 31, 2014

    The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8 + T cells

    Kurachi M., Barnitz R. A., Yosef N., Odorizzi P. M., DiIorio M. A., Lemieux M. E., Yates K., Godec J., Klatt M. G., Regev A. , et al. , Wherry E. J. & Haining W. N. Nature Immunology | 2014
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  • February 27, 2014

    NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

    Wlodarska M., Thaiss C. A., Nowarski R., Henao-Mejia J., Zhang J. P., Brown E. M., Frankel G., Levy M., Katz M. N., Philbrick W. M. , et al. , Elinav E., Finlay B. B. & Flavell R. A. Cell | 2014
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  • February 20, 2014

    CD84 is a survival receptor for CLL cells

    Binsky-Ehrenreich I., Marom A., Sobotta M. C., Shvidel L., Berrebi A., Hazan-Halevy I., Kay S., Aloshin A., Sagi I., Goldenberg D. M. , et al. , Leng L., Bucala R., Herishanu Y., Haran M. & Shachar I. Oncogene | 2014
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  • February 01, 2014

    Digital cell quantification identifies global immune cell dynamics during influenza infection

    Altboum Z., Steuerman Y., David E., Barnett Itzhaki I. Z., Valadarsky L., Keren-Shaul H., Meningher T., Mendelson E., Mandelboim M., Gat-Viks I. & Amit I. Molecular Systems Biology | 2014
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  • January 31, 2014

    The interplay between the innate immune system and the microbiota

    Thaiss C. A., Levy M., Suez J. & Elinav E. Current Opinion in Immunology | 2014
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  • January 31, 2014

    Midkine as a regulator of B cell survival in health and disease

    Cohen S. & Shachar I. British Journal of Pharmacology | 2014
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  • December 31, 2013

    Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types

    Jaitin D. A., Kenigsberg E., Keren-Shaul H., Elefant N., Paul F., Zaretsky I., Mildner A., Cohen N., Jung S., Tanay A. & Amit I. Science | 2014
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  • December 31, 2013

    Inflammasomes and Metabolic Disease

    Henao-Mejia J., Elinav E., Thaiss C. A. & Flavell R. Annual Review of Physiology | 2014
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  • December 31, 2013

    4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

    Fuchs G., Voichek Y., Benjamin S., Gilad S., Amit I. & Oren M. GENOME BIOLOGY | 2014
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  • December 31, 2013

    Sequential feedback induction stabilizes the phosphate starvation response in budding yeast

    Vardi N., Levy S., Gurvich Y., Polacheck T., Carmi M., Jaitin D., Amit I. & Barkai N. Cell Reports | 2014
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  • December 31, 2013

    Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

    Shalek A. K., Satija R., Shuga J., Trombetta J. J., Gennert D., Lu D., Chen P., Gertner R. S., Gaublomme J. T., Yosef N. , et al. , Schwartz S., Fowler B., Weaver S., Wang J., Wang X., Ding R., Raychowdhury R., Friedman N., Hacohen N., Park H., May A. P. & Regev A. Nature | 2014
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  • December 31, 2013

    Novel superactive leptin antagonists and their potential therapeutic applications

    Gertler A. & Elinav E. Current Pharmaceutical Design | 2014
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  • November 30, 2013

    Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope

    Dahan R., Gebe J. A., Preisinger A., James E. A., Tendler M., Nepom G. T. & Reiter Y. Journal of Autoimmunity | 2013
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  • October 25, 2013

    Semiconductor-based DNA sequencing of histone modification states

    Cheng C. S., Rai K., Garber M., Hollinger A., Robbins D., Anderson S., Macbeth A., Tzou A., Carneiro M. O., Raychowdhury R. , et al. , Russ C., Hacohen N., Gershenwald J. E., Lennon N., Nusbaum C., Chin L., Regev A. & Amit I. Nature Communications | 2013
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  • September 30, 2013

    Role of the intestinal microbiome in liver disease

    Henao-Mejia J., Elinav E., Thaiss C. A., Licona-Limon P. & Flavell R. A. Journal of Autoimmunity | 2013
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  • September 09, 2013

    SNP Detection in mRNA in Living Cells Using Allele Specific FRET Probes

    Dahan L., Huang L., Kedmi R., Behlke M. A. & Peer D. PLoS ONE | 2013
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  • August 09, 2013

    T Follicular Helper Cell Dynamics in Germinal Centers

    Shulman Z., Gitlin A. D., Targ S., Jankovic M., Pasqual G., Nussenzweig M. C. & Victora G. D. Science | 2013
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  • June 13, 2013

    Analysis of microbiota alterations in inflammasome-deficient mice

    Elinav E., Thaiss C. A. & Flavell R. A. | 2013
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  • June 11, 2013

    Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation

    Hu B., Elinav E., Huber S., Strowig T., Hao L., Hafemann A., Jin C., Eisenbarth S. C. & Flavell R. A. Proceedings of the National Academy of Sciences of the United States of America | 2013
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  • May 31, 2013

    Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

    Shalek A. K., Satija R., Adiconis X., Gertner R. S., Gaublomme J. T., Raychowdhury R., Schwartz S., Yosef N., Malboeuf C., Lu D. , et al. , Trombetta J. J., Gennert D., Gnirke A., Goren A., Hacohen N., Levin J. Z., Park H. & Regev A. Nature | 2013
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  • May 15, 2013

    IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic

    Zenewicz L. A., Yin X., Wang G., Elinav E., Hao L., Zhao L. & Flavell R. A. Journal of Immunology | 2013
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  • May 07, 2013

    Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation

    Wu C., Pot C., Apetoh L., Thalhamer T., Zhu B., Murugaiyan G., Xiao S., Lee Y., Rangachari M., Yosef N. & Kuchroo V. K. Proceedings of the National Academy of Sciences of the United States of America | 2013
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  • April 25, 2013

    Sodium chloride drives autoimmune disease by the induction of pathogenic T<sub>H</sub> 17 cells

    Kleinewietfeld M., Manzel A., Titze J., Kvakan H., Yosef N., Linker R. A., Muller D. N. & Hafler D. A. Nature | 2013
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  • April 25, 2013

    Dynamic regulatory network controlling T<sub>H</sub> 17 cell differentiation

    Yosef N., Shalek A. K., Gaublomme J. T., Jin H., Lee Y., Awasthi A., Wu C., Karwacz K., Xiao S., Jorgolli M. , et al. , Gennert D., Satija R., Shakya A., Lu D. Y., Trombetta J. J., Pillai M. R., Ratcliffe P. J., Coleman M. L., Bix M., Tantin D., Park H., Kuchroo V. K. & Regev A. Nature | 2013
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  • April 25, 2013

    Induction of pathogenic T<sub>H</sub> 17 cells by inducible salt-sensing kinase SGK1

    Wu C., Yosef N., Thalhamer T., Zhu C., Xiao S., Kishi Y., Regev A. & Kuchroo V. K. Nature | 2013
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  • April 23, 2013

    Harnessing nanomedicine for mucosal theranostics -A silver bullet at last?

    Elinav E. & Peer D. ACS Nano | 2013
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  • March 31, 2013

    Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli

    Gat-Viks I., Chevrier N., Wilentzik R., Eisenhaure T., Raychowdhury R., Steuerman Y., Shalek A. K., Hacohen N., Amit I. & Regev A. Nature biotechnology | 2013
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  • March 31, 2013

    Individual and meta-immune networks

    Bransburg-Zabary S., Kenett D. Y., Dar G., Madi A., Merbl Y., Quintana F. J., Tauber A. I., Cohen I. R. & Ben-Jacob E. Physical Biology | 2013
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  • February 28, 2013

    TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation

    Bahat A., Kedmi R., Gazit K., Richardo-Lax I., Ainbinder E. & Dikstein R. Genes to Cells | 2013
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  • February 28, 2013

    Profiling of ubiquitin-like modifications reveals features of mitotic control

    Merbl Y., Refour P., Patel H., Springer M. & Kirschner M. W. Cell | 2013
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  • February 07, 2013

    Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis

    Mildner A., Chapnik E., Manor O., Yona S., Kim K., Aychek T., Varol D., Beck G., Itzhaki Z. B., Feldmesser E. , et al. , Amit I., Hornstein E. & Jung S. Blood | 2013
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  • January 31, 2013

    High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states

    Blecher-Gonen R., Barnett Itzhaki Z., Jaitin D., Amann Zalcenstein D., Lara Astiaso D. & Amit I. Nature protocols | 2013
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  • January 31, 2013

    Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects

    Stepensky P., Keller B., Buchta M., Kienzler A. K., Elpeleg O., Somech R., Cohen S., Shachar I., Miosge L. A., Schlesier M. , et al. , Fuchs I., Enders A., Eibel H., Grimbacher B. & Warnatz K. Journal of Allergy and Clinical Immunology | 2013
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  • January 31, 2013

    A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

    Vandenbark A. A., Meza-Romero R., Benedek G., Andrew S., Huan J., Chou Y. K., Buenafe A. C., Dahan R., Reiter Y., Mooney J. L. , et al. , Offner H. & Burrows G. G. Journal of Autoimmunity | 2013
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  • December 31, 2012

    Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms

    Elinav E., Nowarski R., Thaiss C. A., Hu B., Jin C. & Flavell R. A. Nature Reviews Cancer | 2013
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  • December 31, 2012

    Derivation of novel human ground state naive pluripotent stem cells

    Gafni O., Weinberger L., Mansour A. A., Manor Y. S., Chomsky E., Ben-Yosef D., Kalma Y., Viukov S., Maza I., Zviran A. , et al. , Rais Y., Shipony Z., Mukamel Z., Krupalnik V., Zerbib M., Geula S., Caspi I., Schneir D., Shwartz T., Gilad S., Amann Zalcenstein D., Benjamin S., Amit I., Tanay A., Massarwa R., Novershtern N. & Hanna J. (. Nature | 2013
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  • December 31, 2012

    The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications

    Shachar I. & Karin N. Journal of Leukocyte Biology | 2013
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  • December 31, 2012

    Deterministic direct reprogramming of somatic cells to pluripotency

    Rais Y., Zviran A., Geula S., Gafni O., Chomsky E., Viukov S., Mansour A. A., Caspi I., Krupalnik V., Zerbib M. , et al. , Maza I., Mor N., Baran D., Weinberger L., Jaitin D. A., Lara Astiaso A. D., Blecher-Gonen R., Shipony Z., Mukamel Z., Hagai T., Gilad S., Amann Zalcenstein D., Tanay A., Amit I., Novershtern N. & Hanna J. (. Nature | 2013
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  • December 31, 2012

    The Intestinal Microbiota in Chronic Liver Disease

    Henao-Mejia J., Elinav E., Thaiss C. A. & Flavell R. A. | 2013
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  • December 12, 2012

    Nanowire-mediated delivery enables functional interrogation of primary immune cells: Application to the analysis of chronic lymphocytic leukemia

    Shalek A. K., Gaublomme J. T., Wang L., Yosef N., Chevrier N., Andersen M. S., Robinson J. T., Pochet N., Neuberg D., Gertner R. S. , et al. , Amit I., Brown J. R., Hacohen N., Regev A., Wu C. J. & Park H. Nano Letters | 2012
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  • September 30, 2012

    Induction and molecular signature of pathogenic T H 17 cells

    Lee Y., Awasthi A., Yosef N., Quintana F. J., Xiao S., Peters A., Wu C., Kleinewietfeld M., Kunder S., Hafler D. A. , et al. , Sobel R. A., Regev A. & Kuchroo V. K. Nature Immunology | 2012
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  • September 30, 2012

    Cytokines as regulators of proliferation and survival of healthy and malignant peripheral B cells

    Cohen S. & Shachar I. Cytokine | 2012
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  • September 25, 2012

    Met Kinetic Signature Derived from the Response to HGF/SF in a Cellular Model Predicts Breast Cancer Patient Survival

    Stein G. Y., Yosef N., Reichman H., Horev J., Laser-Azogui A., Berens A., Resau J., Ruppin E., Sharan R. & Tsarfaty I. PLoS ONE | 2012
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  • September 14, 2012

    A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

    Garber M., Yosef N., Goren A., Raychowdhury R., Thielke A., Guttman M., Robinson J., Minie B., Chevrier N., Itzhaki Z. , et al. , Blecher-Gonen R., Bornstein C., Amann Zalcenstein D., Weiner A., Friedrich D., Meldrim J., Ram O., Cheng C., Gnirke A., Fisher S., Friedmann N., Wong B., Bernstein B. E., Nusbaum C., Hacohen N., Regev A. & Amit I. Molecular Cell | 2012
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  • August 31, 2012

    Regulation of CLL survival by hypoxia-inducible factor and its target genes

    Shachar I., Cohen S., Marom A. & Becker Herman S. FEBS Letters | 2012
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  • August 16, 2012

    The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

    Mansour A. A., Gafni O., Weinberger L., Zviran A., Ayyash M., Rais Y., Krupalnik V., Zerbib M., Amann Zalcenstein D., Maza I. , et al. , Geula S., Viukov S., Holtzman L., Pribluda A., Canaani E., Horn-Saban S., Amit I., Novershtern N. & Hanna J. H. Nature | 2012
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  • July 27, 2012

    Expression Noise and Acetylation Profiles Distinguish HDAC Functions

    Weinberger L., Voichek Y., Tirosh I., Hornung G., Amit I. & Barkai N. Molecular Cell | 2012
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  • April 20, 2012

    M(odu)LLating the Innate Response

    Blecher-Gonen R. & Amit I. Immunity | 2012
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  • March 31, 2012

    Systematic identification of gene annotation errors in the widely used yeast mutation collections

    Ben-Shitrit T., Yosef N., Shemesh K., Sharan R., Ruppin E. & Kupiec M. Nature Methods | 2012
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  • March 31, 2012

    EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF

    Tarcic G., Avraham R., Pines G., Amit I., Shay T., Lu Y., Zwang Y., Katz M., Ben Chetrit C. N., Jacob-Hirsch J. , et al. , Virgilio L., Rechavi G., Mavrothalassitis G., Mills G. B., Domany E. & Yarden Y. FASEB Journal | 2012
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  • January 01, 2012

    The cytokine midkine and its receptor RPTPζ regulate b cell survival in a pathway induced by CD74

    Cohen S., Shoshana O., Zelman-Toister E., Maharshak N., Binsky-Ehrenreich I., Gordin M., Hazan-Halevy I., Herishanu Y., Shvidel L., Haran M. , et al. , Leng L., Bucala R., Harroch S. & Shachar I. Journal of Immunology | 2012
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  • December 31, 2011

    T-cell-receptor-like antibodies - Generation, function and applications

    Dahan R. & Reiter Y. Expert Reviews in Molecular Medicine | 2012
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  • December 31, 2011

    CD74, the natural receptor for MIF, regulate cell survival in health and disease

    Idit S., Gordin M., Cohen S., Binsky I., Marom A. & Becker-Herman S. | 2012
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  • December 31, 2011

    Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots

    Shulman Z., Cohen S. J., Roediger B., Kalchenko V., Jain R., Grabovsky V., Klein E., Shinder V., Stoler-Barak L., Feigelson S. , et al. , Meshel T., Nurmi S. M., Goldstein I., Hartley O., Gahmberg C. G., Etzioni A., Weninger W., Ben-Baruch A. & Alon R. Nature Immunology | 2012
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  • December 23, 2011

    Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

    Ram O., Goren A., Amit I., Shoresh N., Yosef N., Ernst J., Kellis M., Gymrek M., Issner R., Coyne M. , et al. , Durham T., Zhang X., Donaghey J., Epstein C. B., Regev A. & Bernstein B. E. Cell | 2011
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  • November 30, 2011

    Strategies to discover regulatory circuits of the mammalian immune system

    Amit I., Regev A. & Hacohen N. Nature Reviews Immunology | 2011
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  • November 11, 2011

    Systematic discovery of TLR signaling components delineates viral-sensing circuits

    Chevrier N., Mertins P., Artyomov M. N., Shalek A. K., Iannacone M., Ciaccio M. F., Gat-Viks I., Tonti E., DeGrace M. M., Clauser K. R. , et al. , Garber M., Eisenhaure T. M., Yosef N., Robinson J., Sutton A., Andersen M. S., Root D. E., von Andrian U., Jones R. B., Park H., Carr S. A., Regev A., Amit I. & Hacohen N. Cell | 2011
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  • October 25, 2011

    ANAT: A tool for constructing and analyzing functional protein networks

    Yosef N., Zalckvar E., Rubinstein A. D., Homilius M., Atias N., Vardi L., Berman I., Zur H., Kimchi A., Ruppin E. & Sharan R. Science Signaling | 2011
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  • July 31, 2011

    The secret second life of an innocent chaperone: The story of CD74 and B cell/chronic lymphocytic leukemia cell survival

    Shachar I. & Haran M. Leukemia & Lymphoma | 2011
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  • June 30, 2011

    Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells

    Feigelson S., Grabovsky V., Manevich-Mendelson E., Pasvolsky R., Shulman Z., Shinder V., Klein E., Etzioni A., Aker M. & Alon R. Blood | 2011
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  • June 08, 2011

    Real-time analysis of integrin-dependent transendothelial migration and integrin-independent interstitial motility of leukocytes

    Shulman Z. & Alon R. | 2011
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  • April 30, 2011

    TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II-peptide complexes

    Dahan R., Tabul M., Chou Y. K., Meza-Romero R., Andrew S., Ferro A. J., Burrows G. G., Offner H., Vandenbark A. A. & Reiter Y. European Journal of Immunology | 2011
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  • April 30, 2011

    Protein microarrays for genome-wide posttranslational modification analysis

    Merbl Y. & Kirschner M. W. Wiley Interdisciplinary Reviews: Systems Biology and Medicine | 2011
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  • April 30, 2011

    CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions

    Schajnovitz A., Itkin T., D'Uva G., Kalinkovich A., Golan K., Ludin A., Cohen D., Shulman Z., Avigdor A., Nagler A. , et al. , Kollet O., Seger R. & Lapidot T. Nature Immunology | 2011
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  • March 18, 2011

    Impulse control: Temporal dynamics in gene transcription

    Yosef N. & Regev A. Cell | 2011
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  • March 10, 2011

    Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers

    Alon R. & Shulman Z. Experimental Cell Research | 2011
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  • February 04, 2011

    Analyses of antigen dependency networks unveil immune system reorganization between birth and adulthood

    Madi A., Kenett D. Y., Bransburg-Zabary S., Merbl Y., Quintana F. J., Boccaletti S., Tauber A. I., Cohen I. R. & Ben-Jacob E. Chaos | 2011
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  • January 21, 2011

    Densely interconnected transcriptional circuits control cell states in human hematopoiesis

    Novershtern N., Subramanian A., Lawton L. N., Mak R. H., Haining W. N., McConkey M. E., Habib N., Yosef N., Chang C. Y., Shay T. , et al. , Frampton G. M., Drake A. C. B., Leskov I., Nilsson B., Preffer F., Dombkowski D., Evans J. W., Liefeld T., Smutko J. S., Chen J., Friedman N., Young R. A., Golub T. R., Regev A. & Ebert B. L. Cell | 2011
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  • December 31, 2010

    Network theory analysis of antibody-antigen reactivity data: The immune trees at birth and adulthood

    Madi A., Kenett D. Y., Bransburg-Zabary S., Merbl Y., Quintana F. J., Tauber A. I., Cohen I. R. & Ben-Jacob E. PLoS ONE | 2011
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  • December 31, 2010

    A role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide

    Lapter S., Ben David D. H., Sharabi A., Zinger H., Telerman A., Gordin M., Leng L., Bucala R., Shachar I. & Mozes E. Immunology | 2011
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  • December 31, 2010

    Utilization of murine colonoscopy for orthotopic implantation of colorectal cancer

    Zigmond E., Halpern Z., Elinav E., Brazowski E., Jung S. & Varol C. PLoS ONE | 2011
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  • December 31, 2010

    Integrin-targeted nanoparticles for siRNA delivery

    Ben-Arie N., Kedmi R. & Peer D. | 2011
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  • December 31, 2010

    Genetic engineering of antigen-specific regulatory T cells

    Elinav E. & Eshhar Z. | 2011
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  • December 23, 2010

    Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen

    Manevich-Mendelson E., Grabovsky V., Feigelson S., Cinamon G., Gore Y., Goverse G., Monkley S. J., Margalit R., Melamed D., Mebius R. E. , et al. , Critchley D. R., Shachar I. & Alon R. Blood | 2010
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  • December 15, 2010

    Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR-but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state

    Feigelson S. W., Pasvolsky R., Cemerski S., Shulman Z., Grabovsky V., Ilani T., Sagiv A., Lemaitre F., Laudanna C., Shaw A. S. & Alon R. Journal of Immunology | 2010
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  • August 31, 2010

    The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

    Kedmi R., Ben-Arie N. & Peer D. Biomaterials | 2010
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  • August 31, 2010

    CCL2 (pM levels) as a therapeutic agent in inflammatory bowel disease models in mice

    Maharshak N., Hart G., Ron E., Zelman E., Sagiv A., Arber N., Brazowski E., Margolit R., Elinav E. & Shachar I. Inflammatory Bowel Diseases | 2010
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  • July 31, 2010

    A systems level strategy for analyzing the cell death network: Implication in exploring the apoptosisautophagy connection

    Zalckvar E., Yosef N., Reef S., Ber Y., Rubinstein A. D., Mor I., Sharan R., Ruppin E. & Kimchi A. Cell Death and Differentiation | 2010
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  • July 31, 2010

    Transcriptional regulation by CHIP/LDB complexes

    Bronstein R., Levkovitz L., Yosef N., Yanku M., Ruppin E., Sharan R., Westphal H., Oliver B. & Segal D. PLoS Genetics | 2010
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  • July 14, 2010

    CD74 is a survival receptor on colon epithelial cells

    Maharshak N., Cohen S., Lantner F., Hart G., Leng L., Bucala R. & Shachar I. World Journal of Gastroenterology | 2010
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  • June 01, 2010

    Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression

    Gore Y., Lantner F., Hart G. & Shachar I. Molecular Biology of the Cell | 2010
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  • June 01, 2010

    EGF decreases the abundance of MicroRNAs that restrain oncogenic transcription factors

    Avraham R., Sas-Chen A., Manor O., Steinfeld I., Shalgi R., Tarcic G., Bossel N., Zeisel A., Amit I., Zwang Y. , et al. , Enerly E., Russnes H. G., Biagioni F., Mottolese M., Strano S., Blandino G., Borresen-Dale A., Pilpel Y. & Yakhini Z. Science Signaling | 2010
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  • May 01, 2010

    TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner

    Binsky I., Lantner F., Grabovsky V., Harpaz N., Shvidel L., Berrebi A., Goldenberg D. M., Leng L., Bucala R., Alon R. , et al. , Haran M. & Shachar I. Journal of Immunology | 2010
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  • February 28, 2010

    Prediction of Phenotype Information from Genotype Data

    Yosef N., Gramm J., Wang Q., Noble W. S., Karp R. M. & Sharan R. Communications in Information and Systems | 2010
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  • January 26, 2010

    UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex

    Wu T., Merbl Y., Huo Y., Gallop J. L., Tzur A. & Kirschner M. W. Proceedings of the National Academy of Sciences of the United States of America | 2010
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  • December 31, 2009

    A novel HMM-based method for detecting enriched transcription factor binding sites reveals RUNX3 as a potential target in pancreatic cancer biology

    Levkovitz L., Yosef N., Gershengorn M. C., Ruppin E., Sharan R. & Oron Y. PLoS ONE | 2010
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  • December 31, 2009

    Network-free inference of knockout effects in yeast

    Peleg T., Yosef N., Ruppin E. & Sharan R. PLoS Computational Biology | 2010
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  • November 30, 2009

    RNAi nanoparticles in the service of personalized medicine

    Kedmi R. & Peer D. Nanomedicine (London, England) | 2009
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  • September 18, 2009

    Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

    Varol C., Vallon-Eberhard A., Elinav E., Aychek T., Shapira Y., Luche H., Fehling H. J., Hardt W. D., Shakhar G. & Jung S. Immunity | 2009
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  • August 25, 2009

    Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data

    Madi A., Hecht I., Bransburg-Zabary S., Merbl Y., Pick A., Zucker-Toledano M., Quintana F. J., Tauber A. I., Cohen I. R. & Ben-Jacob E. Proceedings of the National Academy of Sciences of the United States of America | 2009
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  • June 25, 2009

    A systems immunology approach to the host-tumor interaction: Large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice

    Merbl Y., Itzchak R., Vider-Shalit T., Louzoun Y., Quintana F. J., Vadai E., Eisenbach L. & Cohen I. R. PLoS ONE | 2009
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  • June 05, 2009

    Metabolic-network-driven analysis of bacterial ecological strategies

    Freilich S., Kreimer A., Borenstein E., Yosef N., Sharan R., Gophna U. & Ruppin E. GENOME BIOLOGY | 2009
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  • April 30, 2009

    Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor

    Elinav E., Adam N., Waks T. & Eshhar Z. Gastroenterology | 2009
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  • April 01, 2009

    Circulating B-ceII chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow

    Hartmann T. N., Grabovsky V., Wang W., Desch P., Rubenzer G., Wollner S., Binsky I., Vallon-Eberhard A., Sapoznikov A., Burger M. , et al. , Shachar I., Haran M., Honczarenko M., Greil R. & Alon R. Cancer Research | 2009
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  • March 20, 2009

    Lymphocyte Crawling and Transendothelial Migration Require Chemokine Triggering of High-Affinity LFA-1 Integrin

    Shulman Z., Shinder V., Klein E., Grabovsky V., Yeger O., Geron E., Montresor A., Bolomini-Vittori M., Feigelson S., Kirchhausen T. , et al. , Laudanna C., Shakhar G. & Alon R. Immunity | 2009
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  • February 24, 2009

    Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays

    Merbl Y. & Kirschner M. W. Proceedings of the National Academy of Sciences of the United States of America | 2009
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  • January 20, 2009

    Toward accurate reconstruction of functional protein networks

    Yosef N., Ungar L., Zalckvar E., Kimchi A., Kupiec M., Ruppin E. & Sharan R. Molecular Systems Biology | 2009
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  • December 31, 2008

    A genome-wide screen for essential yeast genes that affect telomere length maintenance

    Ungar L., Yosef N., Sela Y., Sharan R., Ruppin E. & Kupiec M. Nucleic Acids Research | 2009
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  • December 31, 2008

    A complex-centric view of protein network evolution

    Yosef N., Kupiec M., Ruppin E. & Sharan R. Nucleic Acids Research | 2009
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  • December 31, 2008

    RealTime In Vitro Assays For Studying the Role of Chemokines in Lymphocyte Transendothelial Migration Under Physiologic Flow Conditions

    Shulman Z. & Alon R. | 2009
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  • December 31, 2008

    Loss of kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions

    Manevich-Mendelson E., Feigelson S., Pasvolsky R., Aker M., Grabovsky V., Shulman Z., Kilic S. S., Rosenthal-Allieri M. A., Ben-Dor S., Mory A. , et al. , Bernard A., Moser M., Etzioni A. & Alon R. Blood | 2009
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  • December 31, 2008

    CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia

    Berrih-Aknin S., Ruhlmann N., Bismuth J., Cizeron-Clairac G., Zelman E., Shachar I., Dartevelle P., de Rosbo R. N. K. & Le Panse P. R. Annals of Neurology | 2009
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  • December 15, 2008

    Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions

    Flaishon L., Hart G., Zelman E., Moussion C., Grabovsky V., Tal G. L., Feigelson S., Margalit R., Harmelin A., Avin-Wittenberg T. , et al. , Shoseyov D., Alon R., Girard J. & Shachar I. Blood | 2008
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  • December 02, 2008

    Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis

    Quintana F. J., Farez M. F., Viglietta V., Iglesias A. H., Merbl Y., Izquierdo G., Lucas M., Basso A. S., Khoury S. J., Lucchinetti C. F. , et al. , Cohen I. R. & Weiner H. L. Proceedings of the National Academy of Sciences of the United States of America | 2008
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  • October 01, 2008

    A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34<sup>+</sup> cells

    Hartmann T. N., Grabovsky V., Pasvolsky R., Shulman Z., Buss E. C., Spiegel A., Nagler A., Thelen M. & Alon R. Journal of Leukocyte Biology | 2008
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  • September 12, 2008

    Analysis of Strand Transfer and Template Switching Mechanisms of DNA Gap Repair by Homologous Recombination in Escherichia coli: Predominance of Strand Transfer

    Izhar L., Goldsmith M., Dahan R., Geacintov N., Lloyd R. G. & Livneh Z. Journal of Molecular Biology | 2008
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  • July 31, 2008

    Improved network-based identification of protein orthologs

    Yosef N., Sharan R. & Noble W. S. Bioinformatics | 2008
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  • May 31, 2008

    Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

    Elinav E., Waks T. & Eshhar Z. Gastroenterology | 2008
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  • March 31, 2008

    Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches

    Sapoznikov A., Pewzner-Jung Y., Kalchenko V., Krauthgamer R., Shachar I. & Jung S. Nature Immunology | 2008
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  • March 01, 2008

    RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9

    Pasvolsky R., Grabovsky V., Giagulli C., Shulman Z., Shamri R., Feigelson S. W., Laudanna C. & Alon R. Journal of Immunology | 2008
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  • February 01, 2008

    Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

    Gore Y., Starlets D., Maharshak N., Becker Herman S., Kaneyuki U., Leng L., Bucala R. & Shachar I. Journal of Biological Chemistry | 2008
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  • January 01, 2008

    IL-15 regulates immature B-cell homing in an Ly49D-, IL-12-, and IL-18-dependent manner

    Hart G., Avin-Wittenberg T. & Shachar I. Blood | 2008
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  • December 31, 2007

    From sequence to structure to networks.

    Yosef N. & Käll L. GenomeBiology.com | 2008
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  • December 31, 2007

    Cross-Species Analysis of Protein-protein Interaction Networks

    Yosef N., Ruppin E. & Sharan R. | 2008
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  • December 15, 2007

    CD74 induces TAp63 expression leading to B-cell survival

    Lantner F., Starlets D., Gore Y., Flaishon L., Yamit-Hezi A., Dikstein R., Leng L., Bucala R., Machluf Y., Oren M. & Shachar I. Blood | 2007
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  • November 14, 2007

    A promising therapeutic approach for multiple sclerosis: Recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS

    Sinha S., Subramanian S., Proctor T. M., Kaler L. J., Grafe M., Dahan R., Huan J., Vandenbark A. A., Burrows G. G. & Offner H. Journal of Neuroscience | 2007
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  • September 30, 2007

    Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

    Woolf E., Grigorova I., Sagiv A., Grabovsky V., Feigelson S., Shulman Z., Hartmann T., Sixt M., Cyster J. G. & Alon R. Nature Immunology | 2007
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  • August 31, 2007

    Systems approach to growth factor signaling and to therapeutic intervention

    Yarden Y. & Amit I. Ejc Supplements | 2007
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  • August 14, 2007

    IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival

    Binsky I., Haran M., Starlets D., Gore Y., Lantner F., Harpaz N., Leng L., Goldenberg D. M., Shvidel L., Berrebi A. , et al. , Bucala R. & Shachar I. Proceedings of the National Academy of Sciences of the United States of America | 2007
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  • July 31, 2007

    A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

    Katz M., Amit I., Citri A., Shay T., Carvalho S., Lavi S., Milanezi F., Lyass L., Amariglio N., Jacob-Hirsch J. , et al. , Ben Chetrit C. N., Tarcic G., Lindzen M., Avraham R., Liao Y., Trusk P., Lyass A., Rechavi G. & Spector N. L. Nature Cell Biology | 2007
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  • July 31, 2007

    Regulation of MAPKs by growth factors and receptor tyrosine kinases

    Katz M., Amit I. & Yarden Y. Biochimica et Biophysica Acta - Molecular Cell Research | 2007
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  • June 30, 2007

    IL-12 and IL-18 down-regulate B cell migration in an Ly49D-dependent manner

    Hart G., Flaishon L. & Shachar I. European Journal of Immunology | 2007
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  • June 30, 2007

    Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication

    Greenbaum L., Strous R. D., Kanyas K., Merbl Y., Horowitz A., Karni O., Katz E., Kotler M., Olender T., Deshpande S. N. , et al. , Lancet D., Ben-Asher E. & Lerer B. Pharmacogenetics and Genomics | 2007
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  • May 31, 2007

    Association of the dopamine receptor interacting protein gene, NEF3, with early response to antipsychotic medication

    Strous R. D., Greenbaum L., Kanyas K., Merbl Y., Horowitz A., Karni O., Viglin D., Olender T., Deshpande S. N., Lancet D. , et al. , Ben-Asher E. & Lerer B. International Journal of Neuropsychopharmacology | 2007
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  • March 31, 2007

    A module of negative feedback regulators defines growth factor signaling

    Amit I., Citri A., Shay T., Lu Y., Katz M., Zhang F., Tarcic G., Siwak D., Lahad J., Jacob-Hirsch J. , et al. , Amariglio N., Vaisman N., Segal E., Rechavi G., Alon U., Mills G. B., Domany E. & Yarden Y. Nature Genetics | 2007
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  • March 31, 2007

    Medical sequencing at the extremes of human body mass

    Ahituv N., Kavaslar N., Schackwitz W., Ustaszewska A., Martin J., Hébert S., Doelle H., Ersoy B., Kryukov G., Schmidt S. , et al. , Yosef N., Ruppin E., Sharan R., Vaisse C., Sunyaev S., Dent R., Cohen J., McPherson R. & Pennacchio L. American Journal of Human Genetics | 2007
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  • March 01, 2007

    Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics

    Merbl Y., Zucker-Toledano M., Quintana F. J. & Cohen I. R. Journal of Clinical Investigation | 2007
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  • January 01, 2007

    Genetic manipulation of CD74 in mouse strains of different backgrounds can result in opposite responses to central nervous system injury

    Schori H., Shechter R., Shachar I. & Schwartz M. Journal of Immunology | 2007
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  • December 31, 2006

    A supervised approach for identifying discriminating genotype patterns and its application to breast cancer data

    Yosef N., Yakhini Z., Tsalenko A., Kristensen V., Børresen-Dale A., Ruppin E. & Sharan R. Bioinformatics | 2007
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  • December 31, 2006

    Evolvable signaling networks of receptor tyrosine kinases: Relevance of robustness to malignancy and to cancer therapy

    Amit I., Wides R. & Yarden Y. Molecular Systems Biology | 2007
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  • October 01, 2006

    DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration

    Shulman Z., Pasvolsky R., Woolf E., Grabovsky V., Feigelson S. W., Erez N., Fukui Y. & Alon R. Blood | 2006
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  • July 15, 2006

    Inferring functional pathways from multi-perturbation data

    Yosef N., Kaufman A. & Ruppin E. Bioinformatics | 2006
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  • June 15, 2006

    Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival

    Starlets D., Gore Y., Binsky I., Haran M., Harpaz N., Shvidel L., Becker Herman S., Berrebi A. & Shachar I. Blood | 2006
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  • April 15, 2006

    IFN-γ acts on T cells to induce NK cell mobilization and accumulation in target organs

    Wald O., Weiss I., Wald H., Shoham H., Bar-Shavit Y., Beider K., Galun E., Weiss L., Flaishon L., Shachar I. , et al. , Nagler A., Lu B., Gerard C., Gao J., Mishani E., Farber J. & Peled A. Journal of Immunology | 2006
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  • February 28, 2006

    Response to Dr. Padda [2]

    Elinav E. American Journal of Gastroenterology | 2006
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  • February 28, 2006

    Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes

    Greenbaum L., Kanyas K., Karni O., Merbl Y., Olender T., Horowitz A., Yakir A., Lancet D., Ben-Asher E. & Lerer B. Molecular Psychiatry | 2006
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  • December 31, 2005

    Antigen-chip technology for accessing global information about the state of the body

    Quintana F. J., Merbl Y., Sahar E., Domany E. & Cohen I. R. Lupus | 2006
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  • October 31, 2005

    Erratum: POEMS syndrome: Failure of newly suggested diagnostic criteria to anticipate the development of the syndrome (American Journal of Hematology (2005) 79, 4 (316-318))

    Ofran Y. & Elinav E. American Journal of Hematology | 2005
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  • October 31, 2005

    CD74 is a member of the regulated intramembrane proteolysis-processed protein family

    Becker Herman S., Arie G., Medvedovsky H., Kerem A. & Shachar I. Molecular Biology of the Cell | 2005
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  • October 15, 2005

    Tight regulation of IFN-γ transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2

    Hart G., Flaishon L., Becker Herman S. & Shachar I. Journal of Immunology | 2005
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  • February 25, 2005

    Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

    Kario E., Marmor M., Adamsky K., Citri A., Amit I., Amariglio N., Rechavi G. & Yarden Y. Journal of Biological Chemistry | 2005
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  • December 31, 2004

    Vessel maturation effects on tumour growth: validation of a computer model in implanted human ovarian carcinoma spheroids

    Arakelyan L., Merbl Y. & Agur Z. European Journal of Cancer | 2005
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  • December 31, 2004

    Thermal stability of a slab waveguide implemented by α particles implantation in potassium lithium tantalate niobate

    Gumennik A., Agranat A., Shachar I. & Hass M. Applied Physics Letters | 2005
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  • November 30, 2004

    Grb7 expression and cellular migration in chronic lymphocytic leukemia: A comparative study of early and advanced stage disease

    Haran M., Chebatco S., Flaishon L., Lantner F., Harpaz N., Valinsky L., Berrebi A. & Shachar I. Leukemia | 2004
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  • October 05, 2004

    Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of mice to indunced diabetes

    Quintana F., Hagedorn P., Elizur G., Merbl Y., Domany E. & Cohen I. R. Proceedings of the National Academy of Sciences of the United States of America | 2004
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  • October 01, 2004

    HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes

    Finn T., Jones R., Rich C., Dahan R., Link J., David C., Chou Y., Offner H. & Vandenbark A. Journal of Neuroscience Research | 2004
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  • August 18, 2004

    LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

    Gur G., Rubin C., Katz M., Amit I., Citri A., Nilsson J., Amariglio N., Henriksson R., Rechavi G., Hedman H. , et al. , Wides R. & Yarden Y. EMBO Journal | 2004
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  • August 15, 2004

    Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration

    Flaishon L., Becker Herman S., Hart G., Levo Y., Kuziel W. & Shachar I. Blood | 2004
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  • July 15, 2004

    Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding

    Amit I., Yakir L., Katz M., Zwang Y., Marmor M., Citri A., Shtiegman K., Alroy I., Tuvia S., Reiss Y. , et al. , Roubini E., Cohen M., Wides R., Bacharach E., Schubert U. & Yarden Y. GENES & DEVELOPMENT | 2004
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  • March 31, 2004

    The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing

    Topilski I., Flaishon L., Naveh Y., Harmelin A., Levo Y. & Shachar I. European Journal of Immunology | 2004
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  • October 01, 2003

    Ly49D Receptor Expressed on Immature B Cells Regulates Their IFN-γ Secretion, Actin Polymerization, and Homing

    Hart G., Flaishon L., Becker Herman S. & Shachar I. Journal of Immunology | 2003
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  • May 31, 2003

    Licorice consumption causing severe hypokalemic paralysis

    Elinav E. & Chajek-Shaul T. Mayo Clinic Proceedings | 2003
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  • May 01, 2003

    Invariant chain, a chain of command

    Matza D., Kerem A. & Shachar I. Trends in Immunology | 2003
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  • December 31, 2002

    Multi-Scale Analysis of Angiogenic Dynamics and Therapy

    Arakelyan L., Merbl Y., Daugulis P., Ginosar Y., Vainstein V., Selitser V., Kogan Y., Harpak H. & Agur Z. | 2003
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  • November 01, 2002

    Invariant chain-induced B cell differentiation requires intramembrane proteolytic release of the cytosolic domain

    Matza D., Kerem A., Medvedovsky H., Lantner F. & Shachar I. Immunity | 2002
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  • September 15, 2002

    Severe immunodeficiency has opposite effects on neuronal survival in glutamate-susceptible and -resistant mice: Adverse effect of B cells

    Schori H., Lantner F., Shachar I. & Schwartz M. Journal of Immunology | 2002
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  • June 01, 2002

    Id2 negatively regulates B cell differentiation in the spleen

    Becker Herman S., Lantner F. & Shachar I. Journal of Immunology | 2002
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  • May 17, 2002

    Enhanced apoptosis of B and T lymphocytes in TAF<sub>II</sub>105 dominant-negative transgenic mice is linked to nuclear factor-κB

    Silkov A., Wolstein O., Shachar I. & Dikstein R. Journal of Biological Chemistry | 2002
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  • April 15, 2002

    Cutting edge: Anti-inflammatory properties of low levels of IFN-γ

    Flaishon L., Topilski I., Shoseyov D., Hershkoviz R., Fireman E., Levo Y., Marmor S. & Shachar I. Journal of Immunology | 2002
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  • March 05, 2002

    Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity

    Matza D., Lantner F., Bogoch Y., Flaishon L., Hershkoviz R. & Shachar I. Proceedings of the National Academy of Sciences of the United States of America | 2002
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  • February 15, 2002

    Preferential Th1 immune response in invariant chain-deficient mice

    Topilski I., Harmelin A., Flavell R., Levo Y. & Shachar I. Journal of Immunology | 2002
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  • December 14, 2001

    Low Levels of IFN-γ Down-regulate the Integrin-dependent Adhesion of B Cells by Activating a Pathway That Interferes with Cytoskeleton Rearrangement

    Flaishon L., Lantner F., Hershkoviz R., Levo Y. & Shachar I. Journal of Biological Chemistry | 2001
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  • July 20, 2001

    Invariant Chain Induces B Cell Maturation by Activating a TAF <sub>II</sub>105-NFκB-dependent Transcription Program

    Matza D., Wolstein O., Dikstein R. & Shachar I. Journal of Biological Chemistry | 2001
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  • November 06, 2000

    Autocrine secretion of interferon γ negatively regulates homing of immature B cells

    Flaishon L., Hershkoviz R., Lantner F., Lider O., Alon R., Levo Y., Flavell R. & Shachar I. Journal of Experimental Medicine | 2000
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  • March 20, 2000

    Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells

    Pierre P., Shachar I., Matza D., Gatti E., Flavell R. & Mellman I. Journal of Experimental Medicine | 2000
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Weizmann Institute of Science
Department of Systems Immunology

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