• Our research group (est. Jan 2011) is broadly interested in understanding how immunological tolerance to self is established in the thymus and how breakdown of this process results in autoimmunity.

    Location: Wolfson Building for Biological Research, Room 228/229 Phone: +972-8-934-2776 Group Members of Prof. Jakub Abramson
  • Immune cells exit blood vessels near sites of inflammation using specific combinations of traffic signals. Using chambers which simulate blood flow and different in vivo microscopy approaches in genetically manipulated mice, we dissect how trafficking molecules promote leukocyte exit and which of these signals are used by circulating tumor cells during metastasis.

    Location: Wolfson Building for Biological Research, Room 330 Phone: +972-8-934-2482 Group Members of Prof. Ronen Alon
  • The Amit lab studies the genomic code enabling immune cells to differentiate to specific subtypes and devise a specific response to invading pathogens. Our main focus is to understand how gene regulatory networks activate this code. We develop and apply state of the art high throughput genomic tools and interdisciplinary approaches to address these critical biological and therapeutic questions.

    Location: Wolfson Building for Biological Research, Room 252 Phone: +972-8-934-3338 Group Members of Prof. Ido Amit
  • Prof. Ruth Arnon (Institute Professor)

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    Location: Wolfson Building for Biological Research, Room 431A Phone: +972-8-934-4017 Group Members of Prof. Ruth Arnon
  • Our group studies how antibodies mediate diverse immune responses. Specifically, we investigate the role of the interaction of antibodies with their receptors for mediating their effector functions. We exploit our findings to improve the activity of antibody-based immunotherapies focusing mainly on strategies to enhance immunity against tumors.

    Location: Wolfson Building for Biological Research, Room 339 Phone: +972-8-952-9025 Group Members of Dr. Rony Dahan
  • At the Elinav Lab, we study the interactions between the mammalian host, its intestinal microbiota, the immune system and their effects on health and disease. We strive to develop human personalized medicine.

    Location: Wolfson Building for Biological Research, Room 211 Phone: +972-8-934-4014 Group Members of Prof. Eran Elinav
  • We combine advanced experimental and mathematical approaches to study intercellular communication, T cell activation and differentiation and TCR repertoires.

    Location: Isaac Wolfson Building, Room 253 Phone: +972-8-934-6294 Group Members of Prof. Nir Friedman
  • Prof. Steffen Jung (Professor, Center Head, Department Head)

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    Mononuclear phagocytes are critical players devoted to maintenance of health and immune defense of the organism. We study these monocytes, dendritic cells and macrophages in physiology and pathophysiology using gene expression and epigenome profiling, as well as a combination of conditional mutagenesis, in vivo cell imaging, cell ablation and transfer strategies.

    Location: Wolfson Building for Biological Research, Room 320 Phone: +972-8-934-2787 Group Members of Prof. Steffen Jung
  • Metabolic regulation of hematopoietic stem cell migration and development by their dynamic bone marrow (BM) microenvironment and BM neutrophil activation and recruitment. The role of  daily circadian light and darkness onset, ROS, nitric oxide, lactate, mitochondria transfer, the endothelial BM/Blood barrier, TNF, Norepinephrine, Melatonin, CXCL12/CXCR4 interactions,  proinflammatory Thrombin/PAR1 interactions, anti-inflammatory aPC/EPCR/PAR1 stem cell regulation, clinical stem cell mobilization, homing and repopulation are currently investigated.

    Location: Wolfson Building for Biological Research, Room 301 Phone: +972-8-934-2481 Group Members of Prof. Tsvee Lapidot
  • Standing at the intersection of Biochemistry, Proteomics, and Immunology, our lab studies proteostasis regulation in cancer and immunity. We focus primarily on two aspects of proteostasis control namely, regulatory mechanisms of protein post-translational modifications (PTMs) and degradation in health and disease.

    Location: Wolfson Building for Biological Research, Room 215 Phone: +972-8-934-3335 Group Members of Dr. Yifat Merbl
  • Prof. Michael Sela (Institute Professor)

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    Continues his pioneering work on molecular quantitative immunology with accent on antigens, as well as continues studies on antibody combinations for fighting pancreatic cancer.

    Location: Wolfson Building for Biological Research, Room 708 Phone: +972-8-934-4022 Group Members of Prof. Michael Sela
  • Adaptive immunity depends on the production and maintenance throughout life of a constant size pool of mature peripheral lymphocytes. Lymphoid homeostasis is the result of a fine balance between lymphocyte production, differentiation, homing to their specific niches and organs, proliferation and survival. Our lab studies these process and pathways mainly in B cells and their micro-environment during health and disease.

    Location: Wolfson Building for Biological Research, Room 427 Phone: +972-8-934-4257 Group Members of Prof. Idit Shachar
  • We study the aging of the human hematopoietic system and how age related clonal hematopoiesis associates with inflammation and aging. We study leukemia in its early staged and looking for new strategies to target preleukemia. We try to understand how the aging of the human bone marrow environment influences the blood system.

    Location: Weizmann UK Building for Biocomplexity Research, Room 24 Phone: +972-8-934-4441 Group Members of Dr. Liran Shlush
  • Dr. Ziv Shulman (Senior Scientist, Representative to Scientific Council)

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    In our lab we examine how interactions between immune cells promote antibody affinity maturation and differentiation of B cells into long lived memory and antibody forming cells.

    Location: Wolfson Building for Biological Research, Room 437 Phone: +972-8-934-2484 Group Members of Dr. Ziv Shulman
  • Prof. Gideon Berke (Emeritus)

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    Location: Wolfson Building for Biological Research, Room 319 Phone: +972-8-934-3975
  • As a Professor Emeritus my activities related to research are three:  1. I shepherd clinical applications arising from my basic research: T cell vaccination is used to treat MS, RA, and SLE; antigen micro-array profiling of antibody repertoires (ImmunArray Ltd) is used clinically for autoimmune diseases and cancer; HSP DNA treatments are under development for inflammatory bowel disease and arthritis (Alma Bio Therapuetics); peptide therapy for ALS (Immunity Pharma) has now entered early clinical trials.  2. I write on modelling the immune system and on evolution.  3.

    Location: Wolfson Building for Biological Research, Room 16 Phone: +972-8-934-2911
  • Cancer, Metastasis and Immunotherapy: Identification of tumor associated antigens, vaccination strategies, mechanisms of anti-tumor immunity, tumor escape and tolerance, cryoimmunotherapy, the role of small interferon induced genes in tumorigenicity and apoptosis, TCR evolution.

    Location: Wolfson Building for Biological Research, Room 414 Phone: +972-8-934-4555 Group Members of Prof. Lea Eisenbach
  • Prof. Zelig Eshhar (Emeritus)

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    The specificity of the cognitive immune system is dictated by similar groups of molecules: antibodies and T cell receptors, both belong to the immunoglobulin gene family. The group of Prof Zelig Eshhar took advantage of genetic engineering to design and construct T cells with antibody specificity. Effector T cells expressing these chimeric antigen receptors (CARs) could kill cancers, and on the other hand, regulatory CAR T cells suppress inflammatory responses and graft rejection.

    Location: Wolfson Building for Biological Research, Room 14 Phone: +972-8-934-3965 Group Members of Prof. Zelig Eshhar
  • Prof. Sara Fuchs (Emeritus)

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    Location: Wolfson Building for Biological Research, Room 426 Phone: +972-8-934-2618
  • Prof. Edna Mozes (Emeritus)

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    We are interested in the immunomodulation of the autoimmune diseases, systemic lupus erythematosus and Sjogren Syndrome. A peptide, that we developed, induces a physiological cascade of events by affecting various cell types and pathways. These effects, studied in vitro and in vivo, result in disease specific amelioration of autoreactive responses.

    Location: Wolfson Building for Biological Research, Room 526 Phone: +972-8-934-3646 Group Members of Prof. Edna Mozes
  • Prof. Roald Nezlin (Emeritus)

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    Location: Wolfson Building for Biological Research, Room 716 Phone: +972-8-934-3652
  • We study the recognition processes performed by immunoreceptors, from antibodies to those of T-cells, and their coupling, by transmembrane signaling to activation of different cellular responses, as illustrated by mast cells secretion.

    In parallel, electron transfer and transport via proteins are investigated.

    Location: Wolfson Building for Biological Research, Room 709A Phone: +972-8-934-4020 Group Members of Prof. Israel Pecht
  • Our research has been involved, for more than thirty years, with the subject of transplantation immunology and, more specifically, with questions relating to stem cell transplantation. As of March 2018, Prof. Reisner has been recruited to the University of Texas, MD Anderson Cancer Center where he currently serves as the head of Stem Cell Research in the department of Stem Cell Transplantation and Cellular Therapy.

    Location: Wolfson Building for Biological Research, Room 420 Phone: +972-8-934-4023 Group Members of Prof. Yair Reisner