Host-microbiome interactions in health and disease

We study the tumor microenvironment, and how it is transcriptionally rewired by stress to promote cancer

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.

Human evolution and disease

Characterization of the functions and mechanisms of long noncoding RNAs and of nuclear RNA export

Functional genomics and transcriptomics in mouse models and humans

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

Chromosome Catastrophes in Cancer