Systematic analysis of combinatorial signals during cellular fate determination processes

Proprioception and the the musculoskeletal system in development and disease

We study bacterial ecological interactions, diversity, stability and stress in communities from pre-Cambrian oceans

Our lab is a major driver in developing and applying cutting edge single-cell genomics technologies and advanced computational approaches. We apply these novel tools in animal models and human patients to uncover immune regulatory mechanisms and pathways

Human evolution and disease

Combining data analysis and experimental methods for understanding tissue function from single cells

We develop algorithms and utilize single cell genomics for studying the organization and function of immune cells in a tissue

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

Our studies proceed along three major lines: (1) Microbial population dynamics under stress, (2) Understanding drought resistance and engineering drought-resistant nutritious plants (3) The plant microbiome and its dynamics

We study interactions between peripheral circadian clocks and exercise physiology, hypoxia signaling and metabolic pathways

Biological circuits: design, function and evolution • Regulatory genome: transcription, replication and the chromatin as a communication platform • Developmental patterning: morphogen gradients, scaling, robustness

The interplay between viruses and their hosts

We study the functional roles of epigenetics during cell-fate decisions

Understanding epithelial, stem and immune cell interactions in the gut

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.

Why do some people succumb to infection - while others don't?