Available Positions

We are looking for highly motivated, talented and hard working research students and postdoctoral scientists to join our lab. Applicants with strong research background at the intersection of molecular cell biology, bioinformatics, genomics and proteomics are encouraged to apply. Experience in molecular genetics (including CRISPR/Cas9), tissue culture or advanced proteomics is advantageous.

Potential candidates are encouraged to apply for MSc./ PhD / Postdoctoral fellowships and send a cover letter and academic CV (including a publication list) to Prof. Yardena Samuels.

For additional inquiries, please contact us by email at Yardena.Samuels@weizmann.ac.il

 

Immunotherapy has sparked new hope for oncology in recent years, due to its remarkable ability to induce durable response in patients with metastatic cancer. It is therefore essential to accurately delineate the interactions of cancer cells with the immune system. The project will use multiomic tools including whole exome sequencing , RNAseq, ribosome profiling, proteomic, HLA-peptidomics and systems biology to decipher the genetic, neo-antigenic and immune landscape in melanoma. Followup functional and immunological analysis of  relevant genes and neoantigens will be conducted using novel mouse models. 

Year(s)
Rotation: 
Area: 
Life Sciences
Sunday, September 26, 2021

 

Within the past decade, major advances have been made in the treatment of melanoma through the use of targeted therapy and immunotherapy, however responses are not universal and are not always durable. The project aims to further delineate the interactions of melanoma cells with the immune system to better understand molecular and immune mechanisms of therapeutic response and resistance. Our lab combines genomic tools, systems biology tools, advanced somatic cell knockout and knock-in techniques and various comprehensive mouse model approaches to study melanoma immune-genetics. Our studies link basic biology, computational biology and clinical studies. Trainees will learn sophisticated technologies such as whole exome sequencing, Riboseq, HLA-peptidomics,  somatic cell knockouts and expression and proteomic analyses. Candidates who wish to join the group may contact me at: Yardena.samuels@weizmann.ac.il