Tzahor Lab

  • Yan R., Cigliola V., Oonk K. A., Petrover Z., DeLuca S., Wolfson D. W., Vekstein A., Mendiola M. A., Devlin G., Bishawi M., Gemberling M. P., Sinha T., Sargent M. A., York A. J., Shakked A., DeBenedittis P., Wendell D. C., Ou J., Kang J., Goldman J. A., Baht G. S., Karra R., Williams A. R., Bowles D. E., Asokan A., Tzahor E., Gersbach C. A., Molkentin J. D., Bursac N., Black B. L. & Poss K. D. (2023). An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.  Cell Stem Cell. 2023 Jan , 30 (1):96-111.e6.
  • Nguyen P. D., Gooijers I., Campostrini G., Verkerk A. O., Honkoop H., Bouwman M., de Bakker D. E. M., Koopmans T., Vink A., Lamers G. E. M., Shakked A., Mars J., Mulder A. A., Chocron S., Bartscherer K., Tzahor E., Mummery C. L., de Boer T. P., Bellin M. & Bakkers J. (2023). Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.  Science (American Association for the Advancement of Science). 2023 May , 380 (6646):758-764.
  • Nguyen P. D., Gooijers I., Campostrini G., Verkerk A. O., Honkoop H., Bouwman M., de Bakker D. E. M., Koopmans T., Vink A., Lamers G. E. M., Shakked A., Mars J., Mulder A. A., Chocron S., Bartscherer K., Tzahor E., Mummery C. L., de Boer T. P., Bellin M. & Bakkers J. (2023). Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.  Science (New York, N.Y.). 2023 May , 380 (6646):758-764.
  • Shakked A., Petrover Z., Aharonov A., Ghiringhelli M., Umansky K., Kain D., Elkahal J., Divinsky Y., Nguyen P. D., Miyara S., Friedlander G., Savidor A., Zhang L., Perez D. E., Sarig R., Lendengolts D., Bueno-Levy H., Kastan N., Levin Y., Bakkers J., Gepstein L. & Tzahor E. (2023). Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury.  Nature Cardiovascular Research. 2023 Apr , 2 (4):383-398.
  • Tzahor E. & Yaniv K. (2022). How many fish make a mouse?.  Nature Cardiovascular Research. 2022 Jan , 1 (1):2-3.
  • Tzahor E. & Dimmeler S. (2022). A coalition to heal—the impact of the cardiac microenvironment.  Science. 2022 Sept , 377 (6610).
  • Pianca N., Sacchi F., Umansky K. B., Chirivì M., Iommarini L., Da Pra S., Papa V., Bongiovanni C., Pontis F., Miano C., Braga L., Tassinari R., Pantano E., Patnala R. S., Mazzeschi M., Cenacchi G., Porcelli A. M., Lauriola M., Ventura C., Giacca M., Rizzi R., Tzahor E. & D’Uva G. (2022). Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration.  Nature Cardiovascular Research. 2022 Jul , 1 (7):617-633.
  • Sun X., Malandraki-Miller S., Kennedy T., Bassat E., Klaourakis K., Zhao J., Gamen E., Vieira J. M., Tzahor E. & Riley P. R. (2021). The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development.  Development (Cambridge). 2021 May , 148 (9).
  • Kastan N., Gnedeva K., Alisch T., Petelski A. A., Huggins D. J., Chiaravalli J., Aharanov A., Shakked A., Tzahor E., Nagiel A., Segil N. & Hudspeth A. J. (2021). Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues.  Nature Communications. 2021 May , 12 (1).
  • Eigler T., Zarfati G., Amzallag E., Sinha S., Segev N., Zabary Y., Zaritsky A., Shakked A., Umansky K., Schejter E. D., Millay D. P., Tzahor E. & Avinoam O. (2021). ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.  Developmental Cell. 2021 Dec , 56 (24):3349-3363.e6.
  • Bassat E., Perez D. E. & Tzahor E. (2021). Myocardial infarction techniques in adult mice.  . 2021, :3-21.
  • Baehr A., Umansky K. B., Bassat E., Jurisch V., Klett K., Bozoglu T., Hornaschewitz N., Solyanik O., Kain D., Ferraro B., Cohen-Rabi R., Krane M., Cyran C., Soehnlein O., Laugwitz K. L., Hinkel R., Kupatt C. & Tzahor E. (2020). Agrin promotes coordinated therapeutic processes leading to improved cardiac repair in pigs.  Circulation. 2020 Sept , 142 (9):868-881.
  • Buckingham M. & Tzahor E. (2020). In remembrance of David Yaffe.  Skeletal Muscle. 2020 Oct , 10 (1).
  • Aharonov A., Shakked A., Umansky K. B., Savidor A., Genzelinakh A., Kain D., Lendengolts D., Revach O. Y., Morikawa Y., Dong J., Levin Y., Geiger B., Martin J. F. & Tzahor E. (2020). ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration.  Nature Cell Biology. 2020 Nov , 22 (11):1346-1356.
  • Yifa O., Weisinger K., Bassat E., Li H., Kain D., Barr H., Kozer N., Genzelinakh A., Rajchman D., Eigler T., Umansky K. B., Lendengolts D., Brener O., Bursac N. & Tzahor E. (2019). The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.  JCI insight. 2019 Nov , 4 (22).
  • Fukuda R., Aharonov A., Ong Y. T., Stone O. A., El-Brolosy M., Maischein H., Potente M., Tzahor E. & Stainier D. Y. R. (2019). Metabolic modulation regulates cardiac wall morphogenesis in zebrafish.  eLife. 2019 Dec , 8 .
  • Han Y., Chen A., Umansky K., Oonk K. A., Choi W., Dickson A. L., Ou J., Cigliola V., Yifa O., Cao J., Tornini V. A., Cox B. D., Tzahor E. & Poss K. D. (2019). Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.  Developmental Cell. 2019 Mar , 48 (6):853-863.e5.
  • Sah J. P., Nguyen Thi Thu Hao, Kim Y., Eigler T., Tzahor E., Kim S., Hwang Y. & Yoon J. K. (2019). MBP-FGF2-Immobilized Matrix Maintains Self-Renewal and Myogenic Differentiation Potential of Skeletal Muscle Stem Cells.  International Journal of Stem Cells. 2019 Jul , 12 (2):360-366.
  • Sarig R., Rimmer R., Bassat E., Zhang L., Umansky K. B., Lendengolts D., Perlmoter G., Yaniv K. & Tzahor E. (2019). Transient p53-Mediated Regenerative Senescence in the Injured Heart.  Circulation. 2019 May , 139 (21):2491-2494.
  • Honkoop H., de Bakker D. E. M., Aharonov A., Kruse F., Shakked A., Nguyen P. D., de Heus C., Garric L., Muraro M. J., Shoffner A., Tessadori F., Peterson J. C., Noort W., Bertozzi A., Weidinger G., Posthuma G., Grun D., van der Laarse W. J., Klumperman J., Jaspers R. T., Poss K. D., van Oudenaarden A., Tzahor E. & Bakkers J. (2019). Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.  eLife. 2019 Dec , 8 .
  • del Monte-Nieto G., Ramialison M., Adam A. A. S., Wu B., Aharonov A., D'Uva G., Bourke L. M., Pitulescu M. E., Chen H., Luis de la Pompa J., Shou W., Adams R. H., Harten S. K., Tzahor E., Zhou B. & Harvey R. P. (2018). Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.  Nature. 2018 May , 557 (7705):439-+.
  • Tzahor E. & Sarig R. (2017). The cancer paradigms of mammalian regeneration: can mammals regenerate as amphibians?.  Carcinogenesis. 2017 Apr , 38 (4):359-366.
  • Tzahor E. & Poss K. D. (2017). Cardiac regeneration strategies: Staying young at heart.  Science. 2017 Jun , 356 (6342):1035-1039.
  • Bassat E., Mutlak Y. E., Genzelinakh A., Shadrin I. Y., Umansky K., Yifa O., Kain D., Rajchman D., Leach J., Bassat D. R., Udi Y., Sarig R., Sagi I., Martin J. F., Bursac N., Cohen S. & Tzahor E. (2017). The extracellular matrix protein agrin promotes heart regeneration in mice.  Nature. 2017 Jul , 547 (7662):179-+.
  • Tzahor, E; Poss, K (2017). Cardiac regeneration strategies: Staying young at heart..  SCIENCE. 2017, 356 (6342):1035-1039.
  • Zamir L., Singh R., Nathan E., Patrick R., Yifa O., Yahalom-Ronen Y., Arraf A. A., Schultheiss T. M., Suo S., Han J., Peng G., Jing N., Wang Y., Palpant N., Tam P. P., Harvey R. P. & Tzahor E. (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.  eLife. 2017 May , .
  • Aghajanian H., Cho Y. K., Manderfield L. J., Herling M. R., Gupta M., Ho V. C., Li L., Degenhardt K., Aharonov A., Tzahor E. & Epstein J. A. (2016). Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor.  Nature Communications. 2016 Jun , 7 .
  • Leinonen J. V., Korkus-Emanuelov A., Wolf Y., Milgrom-Hoffman M., Lichtstein D., Hoss S., Lotan C., Tzahor E., Jung S. & Beeri R. (2016). Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45-stem cell-like phenotype.  International Journal of Cardiology. 2016 Apr , 209 :296-306.
  • Buzaglo-Azriel L., Kuperman Y., Tsoory M., Zaltsman Y., Shachnai L., Levin-Zaidman S., Bassat E., Michailovici I., Sarver A., Tzahor E., Haran M., Vernochet C. & Gross A. (2016). Loss Of Muscle Mtch2 Increases Whole-Body Energy Utilization And Protects From Diet-Induced Obesity.  Cell Reports. 2016 Feb , 14 (7):1602-1610.
  • D'Uva G. & Tzahor E. (2015). The key roles of ERBB2 in cardiac regeneration.  Cell Cycle. 2015 Aug , 14 (15):2383-2384.
  • Michailovici I., Eigler T. & Tzahor E. (2015). Craniofacial Muscle Development.  . 2015, :3-30.
  • Diogo R., Kelly R. G., Christiaen L., Levine M., Ziermann J. M., Molnar J. L., Noden D. M. & Tzahor E. (2015). A new heart for a new head in vertebrate cardiopharyngeal evolution.  Nature. 2015 Apr , 520 (7548):466-473.
  • Tzahor E. (2015). Head Muscle Development.  . 2015, :123-142.
  • D'Uva G., Aharonov A., Lauriola M., Kain D., Yahalom-Ronen Y., Carvalho S., Weisinger K., Bassat E., Rajchman D., Yifa O., Lysenko M., Konfino T., Hegesh J., Brenner O., Neeman M., Yarden Y., Leor J., Sarig R., Harvey R. P. & Tzahor E. (2015). ERBB2 triggers mammalian heart regeneration by promoting cardiorlyocyte dedifferentiation and proliferation.  Nature Cell Biology. 2015 May , 17 (5):627-U207.
  • Yahalom-Ronen Y., Rajchman D., Sarig R., Geiger B. & Tzahor E. (2015). Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion..  eLife. 2015, 4 .
  • Milgrom-Hoffman M., Michailovici I., Ferrara N., Zelzer E. & Tzahor E. (2014). Endothelial cells regulate neural crest and second heart field morphogenesis.  Biology Open. 2014 Aug , 3 (8):679-688.
  • Michailovici I., Harrington H. A., Azogui H. H., Yahalom-Ronen Y., Plotnikov A., Ching S., Stumpf M. P. H., Klein O. D., Seger R. & Tzahor E. (2014). Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.  Development. 2014 Jul , 141 (13):2611-2620.
  • Vandoorne K., Vandsburger M. H., Raz T., Shalev M., Weisinger K., Biton I., Brumfeld V., Raanan C., Nevo N., Eilam R., Hemmings B. A., Tzahor E., Harmelin A., Gepstein L. & Neeman M. (2013). Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction.  Circulation-Cardiovascular Imaging. 2013 Nov , 6 (6):992-1000.
  • Harel I., Maezawa Y., Avraham R., Rinon A., Ma H., Cross J. W., Leviatan N., Hegesh J., Roy A., Jacob-Hirsch J., Rechavi G., Carvajal J., Tole S., Kioussi C., Quaggin S. & Tzahor E. (2012). Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov , 109 (46):18839-18844.
  • Gruenbaum-Cohen Y., Harel I., Umansky K., Tzahor E., Snapper S. B., Shilo B. & Schejter E. D. (2012). The actin regulator N-WASp is required for muscle-cell fusion in mice.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul , 109 (28):11211-11216.
  • Tzahor E. & Evans S. M. (2011). Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis.  Cardiovascular Research. 2011 Jul , 91 (2):196-202.
  • Sarig R. & Tzahor E. (2011). p53 and epithelial-mesenchymal transition A linking thread between embryogenesis and cancer.  Cell Cycle. 2011 Sept , 10 (18):3036-3037.
  • Rinon A., Molchadsky A., Nathan E., Yovel G., Rotter V., Sarig R. & Tzahor E. (2011). p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.  Development. 2011 May , 138 (9):1827-1838.
  • Milgrom-Hoffman M., Harrelson Z., Ferrara N., Zelzer E., Evans S. M. & Tzahor E. (2011). The heart endocardium is derived from vascular endothelial progenitors.  Development. 2011 Nov , 138 (21):4777-4787.
  • Tirosh-Finkel L., Zeisel A., Brodt-Ivenshitz M., Shamai A., Yao Z., Seger R., Domany E. & Tzahor E. (2010). BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.  Development. 2010 Sept , 137 (18):2989-3000.
  • Theis S., Patel K., Valasek P., Otto A., Pu Q., Harel I., Tzahor E., Tajbakhsh S., Christ B. & Huang R. (2010). The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature.  Development. 2010 Sept , 137 (17):2961-2971.
  • Rinon A., Nathan E. & Tzahor E. (2009). p53 involvement in early cranial neural crest development in the chick.  Developmental Biology. 2009 Jul , 331 (2):430-430.
  • Tzahor E. (2009). Heart and craniofacial muscle development: A new developmental theme of distinct myogenic fields.  Developmental Biology. 2009 Mar , 327 (2):273-279.
  • Kang J., Nathan E., Xu S., Tzahor E. & Black B. L. (2009). Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm.  Developmental Biology. 2009 Oct , 334 (2):513-522.
  • Harel I., Nathan E., Tirosh-Finkel L., Zigdon H., Guimaraes-Camboa N., Evans S. M. & Tzahor E. (2009). Distinct Origins and Genetic Programs of Head Muscle Satellite Cells.  Developmental Cell. 2009 Jun , 16 (6):822-832.
  • Ben-Shoshan J., Maysel-Auslender S., Luboshits G., Barshack I., Polak-Charcon S., Tzahor E., Keren G. & George J. (2009). Hypoxia-Inducible Factor-1 alpha and-2 alpha Additively Promote Endothelial Vasculogenic Properties.  Journal of Vascular Research. 2009, 46 (4):299-310.
  • Nathan E. & Tzahor E. (2009). sFRPs: a declaration of (Wnt) independence.  Nature Cell Biology. 2009 Jan , 11 (1):13-14.
  • Ben-Shoshan J., Schwartz S., Luboshits G., Maysel-Auslender S., Barzelay A., Polak-Charcon S., Tzahor E., Barshack I., Barak A., Levkovitch-Verbin H., Keren G. & George J. (2008). Constitutive Expression of HIF-1 alpha and HIF-2 alpha in Bone Marrow Stromal Cells Differentially Promotes Their Proangiogenic Properties.  Stem Cells. 2008, 26 (10):2634-2643.
  • Wasserstrom A., Frumkin D., Adar R., Itzkovitz S., Stern T., Kaplan S., Shefer G., Shur I., Zangi L., Reizel Y., Harmelin A., Dor Y., Dekel N., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008). Estimating cell depth from somatic mutations.  PLoS Computational Biology. 2008 May , 4 (5).
  • Nathan E., Monovich A., Tirosh-Finkel L., Harrelson Z., Rousso T., Rinon A., Harel I., Evans S. M. & Tzahor E. (2008). The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development.  Development. 2008 Feb , 135 (4):647-657.
  • Wasserstrom A., Adar R., Shefer G., Frumkin D., Itzkovitz S., Stern T., Shur I., Zangi L., Kaplan S., Harmelin A., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008). Reconstruction of Cell Lineage Trees in Mice.  PLoS ONE. 2008 Apr , 3 (4).
  • Molchadsky A., Shats I., Goldfinger N., Pevsner-Fischer M., Olson M., Rinon A., Tzahor E., Lozano G., Zipori D., Sarig R. & Rotter V. (2008). p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner.  PLoS ONE. 2008 Nov , 3 (11):1-15.
  • Klaus A., Saga Y., Taketo M. M., Tzahor E. & Birchmeier W. (2007). Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2007 Nov , 104 (47):18531-18536.
  • Tzahor E. (2007). Wnt/beta-catenin signaling and cardiogenesis: Timing does matter.  Developmental Cell. 2007 Jul , 13 (1):10-13.
  • Rinon A., Lazar S., Marshall H., Buechmann-Moller S., Neufeld A., Elhanany-Tamir H., Taketo M. M., Sommer L., Krumlauf R. & Tzahor E. (2007). Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.  Development. 2007 Sept , 134 (17):3065-3075.
  • Tirosh-Finkel L., Elhanany H., Rinon A. & Tzahor E. (2006). Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract.  Development. 2006 May , 133 (10):1943-1953.