Publications

2025

Cold and hot fibrosis define clinically distinct cardiac pathologies

Miyara S., Adler M., Umansky K. B., Häußler D., Bassat E., Divinsky Y., Elkahal J., Kain D., Lendengolts D., Ramirez Flores R. O., Bueno-Levy H., Golani O., Shalit T., Gershovits M., Weizman E., Genzelinakh A., Kimchi D. M., Shakked A., Zhang L., Wang J., Baehr A., Petrover Z., Sarig R., Dorn T., Moretti A., Saez-Rodriguez J., Kupatt C., Tanaka E. M., Medzhitov R., Krüger A., Mayo A., Alon U. & Tzahor E. (2025) Cell Systems. 16, 3, 101198.

2024

Multidirectional Filamented Light Biofabrication Creates Aligned and Contractile Cardiac Tissues

Jones L. S., Filippi M., Michelis M. Y., Balciunaite A., Yasa O., Aviel G., Narciso M., Freedrich S., Generali M., Tzahor E. & Katzschmann R. K. (2024) Advanced Science. 11, 47, 2404509.

Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

Aviel G., Elkahal J., Umansky K. B., Bueno-Levy H., Petrover Z., Kotlovski Y., Lendengolts D., Kain D., Shalit T., Zhang L., Miyara S., Kramer M. P., Merbl Y., Kozlovski S., Alon R., Aharoni R., Arnon R., Mishali D., Katz U., Nachman D., Asleh R., Amir O., Tzahor E. & Sarig R. (2024) Nature Cardiovascular Research. 3, 9, p. 1049-1066

Egr1 regulates regenerative senescence and cardiac repair

Zhang L., Elkahal J., Wang T., Rimmer R., Genzelinakh A., Bassat E., Wang J., Perez D., Kain D., Lendengolts D., Winkler R., Bueno-levy H., Umansky K. B., Mishaly D., Shakked A., Miyara S., Sarusi-Portuguez A., Goldfinger N., Prior A., Morgenstern D., Levin Y., Addadi Y., Li B., Rotter V., Katz U., Tanaka E. M., Krizhanovsky V., Sarig R. & Tzahor E. (2024) Nature Cardiovascular Research. 3, 8, p. 915-932

BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice

Bongiovanni C., Bueno-Levy H., Posadas Pena D., Del Bono I., Miano C., Boriati S., Da Pra S., Sacchi F., Redaelli S., Bergen M., Romaniello D., Pontis F., Tassinari R., Kellerer L., Petraroia I., Mazzeschi M., Lauriola M., Ventura C., Heermann S., Weidinger G., Tzahor E. & D'Uva G. (2024) Cell Reports. 43, 5, 114162.

How Can Young Extracellular Matrix Promote Cardiac Regeneration? Versi-Can!

Bassat E. & Tzahor E. (2024) Circulation. 149, 13, p. 1016-1018

2023

The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts

Mayer S., Milo T., Isaacson A., Halperin C., Miyara S., Stein Y., Lior C., Pevsner-Fischer M., Tzahor E., Mayo A., Alon U. & Scherz-Shouval R. (2023) Nature Communications. 14, 1, 5810.

Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Nguyen P. D., Gooijers I., Campostrini G., Verkerk A. O., Honkoop H., Bouwman M., de Bakker D. E. M., Koopmans T., Vink A., Lamers G. E. M., Shakked A., Mars J., Mulder A. A., Chocron S., Bartscherer K., Tzahor E., Mummery C. L., de Boer T. P., Bellin M. & Bakkers J. (2023) Science (New York, N.Y.). 380, 6646, p. 758-764

Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

Shakked A., Petrover Z., Aharonov A., Ghiringhelli M., Umansky K., Kain D., Elkahal J., Divinsky Y., Nguyen P. D., Miyara S., Friedlander G., Savidor A., Zhang L., Perez D. E., Sarig R., Lendengolts D., Bueno-Levy H., Kastan N., Levin Y., Bakkers J., Gepstein L. & Tzahor E. (2023) Nature Cardiovascular Research. 2, 4, p. 383-398

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair

Yan R., Cigliola V., Oonk K. A., Petrover Z., DeLuca S., Wolfson D. W., Vekstein A., Mendiola M. A., Devlin G., Bishawi M., Gemberling M. P., Sinha T., Sargent M. A., York A. J., Shakked A., DeBenedittis P., Wendell D. C., Ou J., Kang J., Goldman J. A., Baht G. S., Karra R., Williams A. R., Bowles D. E., Asokan A., Tzahor E., Gersbach C. A., Molkentin J. D., Bursac N., Black B. L. & Poss K. D. (2023) Cell Stem Cell. 30, 1, p. 96-111.e6

2022

A coalition to healthe impact of the cardiac microenvironment

Tzahor E. & Dimmeler S. (2022) Science. 377, 6610, eabm4443.

Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration

Pianca N., Sacchi F., Umansky K. B., Chirivì M., Iommarini L., Da Pra S., Papa V., Bongiovanni C., Pontis F., Miano C., Braga L., Tassinari R., Pantano E., Patnala R. S., Mazzeschi M., Cenacchi G., Porcelli A. M., Lauriola M., Ventura C., Giacca M., Rizzi R., Tzahor E. & DUva G. (2022) Nature Cardiovascular Research. 1, 7, p. 617-633

How many fish make a mouse?

Tzahor E. & Yaniv K. (2022) Nature Cardiovascular Research. 1, p. 2-3

2021

ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion

Eigler T., Zarfati G., Amzallag E., Sinha S., Segev N., Zabary Y., Zaritsky A., Shakked A., Umansky K., Schejter E. D., Millay D. P., Tzahor E. & Avinoam O. (2021) Developmental Cell. 56, 24, p. 3349-3363.e6

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

Kastan N., Gnedeva K., Alisch T., Petelski A. A., Huggins D. J., Chiaravalli J., Aharanov A., Shakked A., Tzahor E., Nagiel A., Segil N. & Hudspeth A. J. (2021) Nature Communications. 12, 1, 3100.

The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development

Sun X., Malandraki-Miller S., Kennedy T., Bassat E., Klaourakis K., Zhao J., Gamen E., Vieira J. M., Tzahor E. & Riley P. R. (2021) Development (Cambridge). 148, 9, dev197525.

Myocardial infarction techniques in adult mice

Bassat E., Perez D. E. & Tzahor E. (2021) Cardiac Regeneration : Methods and Protocols . Kühn B. & Poss K. D.(eds.). p. 3-21

2020

ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

Aharonov A., Shakked A., Umansky K. B., Savidor A., Genzelinakh A., Kain D., Lendengolts D., Revach O. Y., Morikawa Y., Dong J., Levin Y., Geiger B., Martin J. F. & Tzahor E. (2020) Nature Cell Biology. 22, 11, p. 1346-1356

In remembrance of David Yaffe

Buckingham M. & Tzahor E. (2020) Skeletal Muscle. 10, 1, 31.

Agrin promotes coordinated therapeutic processes leading to improved cardiac repair in pigs

Baehr A., Umansky K. B., Bassat E., Jurisch V., Klett K., Bozoglu T., Hornaschewitz N., Solyanik O., Kain D., Ferraro B., Cohen-Rabi R., Krane M., Cyran C., Soehnlein O., Laugwitz K. L., Hinkel R., Kupatt C. & Tzahor E. (2020) Circulation. 142, 9, p. 868-881

2019

Metabolic modulation regulates cardiac wall morphogenesis in zebrafish

Fukuda R., Aharonov A., Ong Y. T., Stone O. A., El-Brolosy M., Maischein H., Potente M., Tzahor E. & Stainier D. Y. R. (2019) eLife. 8, 50161.

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Honkoop H., de Bakker D. E. M., Aharonov A., Kruse F., Shakked A., Nguyen P. D., de Heus C., Garric L., Muraro M. J., Shoffner A., Tessadori F., Peterson J. C., Noort W., Bertozzi A., Weidinger G., Posthuma G., Grun D., van der Laarse W. J., Klumperman J., Jaspers R. T., Poss K. D., van Oudenaarden A., Tzahor E. & Bakkers J. (2019) eLife. 8, 50163.

The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice

Yifa O., Weisinger K., Bassat E., Li H., Kain D., Barr H., Kozer N., Genzelinakh A., Rajchman D., Eigler T., Umansky K. B., Lendengolts D., Brenner O., Bursac N. & Tzahor E. (2019) JCI insight. 4, 22, e128025.

MBP-FGF2-Immobilized Matrix Maintains Self-Renewal and Myogenic Differentiation Potential of Skeletal Muscle Stem Cells

Sah J. P., Nguyen Thi Thu Hao, Kim Y., Eigler T., Tzahor E., Kim S., Hwang Y. & Yoon J. K. (2019) International Journal of Stem Cells. 12, 2, p. 360-366

Transient p53-Mediated Regenerative Senescence in the Injured Heart

Sarig R., Rimmer R., Bassat E., Zhang L., Umansky K. B., Lendengolts D., Perlmoter G., Yaniv K. & Tzahor E. (2019) Circulation. 139, 21, p. 2491-2494

Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish

Han Y., Chen A., Umansky K., Oonk K. A., Choi W., Dickson A. L., Ou J., Cigliola V., Yifa O., Cao J., Tornini V. A., Cox B. D., Tzahor E. & Poss K. D. (2019) Developmental Cell. 48, 6, p. 853-863.e5

2018

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation

del Monte-Nieto G., Ramialison M., Adam A. A. S., Wu B., Aharonov A., D'Uva G., Bourke L. M., Pitulescu M. E., Chen H., Luis de la Pompa J., Shou W., Adams R. H., Harten S. K., Tzahor E., Zhou B. & Harvey R. P. (2018) Nature. 557, 7705, p. 439-+

2017

The extracellular matrix protein agrin promotes heart regeneration in mice

Bassat E., Mutlak Y. E., Genzelinakh A., Shadrin I. Y., Umansky K., Yifa O., Kain D., Rajchman D., Leach J., Bassat D. R., Udi Y., Sarig R., Sagi I., Martin J. F., Bursac N., Cohen S. & Tzahor E. (2017) Nature. 547, 7662, p. 179-184

Cardiac regeneration strategies: Staying young at heart

Tzahor E. & Poss K. D. (2017) Science. 356, 6342, p. 1035-1039

The cancer paradigms of mammalian regeneration: Can mammals regenerate as amphibians?

Sarig R. & Tzahor E. (2017) Carcinogenesis. 38, 4, p. 359-366

Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta

Zamir L., Singh R., Nathan E., Patrick R., Yifa O., Yahalom-Ronen Y., Arraf A. A., Schultheiss T. M., Suo S., Han J., Peng G., Jing N., Wang Y., Palpant N., Tam P. P., Harvey R. P. & Tzahor E. (2017) eLife. 6, e20994.

2016

Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor

Aghajanian H., Cho Y. K., Manderfield L. J., Herling M. R., Gupta M., Ho V. C., Li L., Degenhardt K., Aharonov A., Tzahor E. & Epstein J. A. (2016) Nature Communications. 7, 12038.

Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45 - Stem cell-like phenotype

Leinonen J. V., Korkus-Emanuelov A., Wolf Y., Milgrom-Hoffman M., Lichtstein D., Hoss S., Lotan C., Tzahor E., Jung S. & Beeri R. (2016) International Journal of Cardiology. 209, p. 296-306

Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity

Buzaglo-Azriel L., Kuperman Y., Tsoory M., Zaltsman Y., Shachnai L., Levin-Zaidman S., Bassat E., Michailovici I., Sarver A., Tzahor E., Haran M., Vernochet C. & Gross A. (2016) Cell Reports. 14, 7, p. 1602-1610

Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling

Harvey R. P., Wystub-Lis K., del Monte-Nieto G., Graham R. M. & Tzahor E. (2016) Heart Lung and Circulation. 25, 1, p. 4-7

2015

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

D'Uva G., Aharonov A., Lauriola M., Kain D., Yahalom-Ronen Y., Carvalho S., Weisinger K., Bassat E., Rajchman D., Yifa O., Lysenko M., Konfino T., Hegesh J., Brenner O., Neeman M., Yarden Y., Leor J., Sarig R., Harvey R. P. & Tzahor E. (2015) Nature Cell Biology. 17, 5, p. 627-638

A new heart for a new head in vertebrate cardiopharyngeal evolution

Diogo R., Kelly R. G., Christiaen L., Levine M., Ziermann J. M., Molnar J. L., Noden D. M. & Tzahor E. (2015) Nature. 520, 7548, p. 466-473

The key roles of ERBB2 in cardiac regeneration

D'Uva G. & Tzahor E. (2015) Cell Cycle. 14, 15, p. 2383-2384

Head Muscle Development

Tzahor E. (2015) Vertebrate Myogenesis . p. 123-142

Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion.

Yahalom-Ronen Y., Rajchman D., Sarig R., Geiger B. & Tzahor E. (2015) eLife. 4,

Craniofacial Muscle Development

Michailovici I., Eigler T. & Tzahor E. (2015) CRANIOFACIAL DEVELOPMENT . p. 3-30 (trueCurrent Topics in Developmental Biology).

2014

Endothelial cells regulate neural crest and second heart field morphogenesis

Milgrom-Hoffman M., Michailovici I., Ferrara N., Zelzer E. & Tzahor E. (2014) Biology Open. 3, 8, p. 679-688

Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells

Michailovici I., Harrington H. A., Azogui H. H., Yahalom-Ronen Y., Plotnikov A., Ching S., Stumpf M. P., Klein O. D., Seger R. & Tzahor E. (2014) Development (Cambridge). 141, 13, p. 2611-2620

2013

Chronic Akt1 deficiency attenuates adverse remodeling and enhances angiogenesis after myocardial infarction

Vandoorne K., Vandsburger M. H., Raz T., Shalev M., Weisinger K., Biton I., Brumfeld V., Raanan C., Nevo N., Eilam R., Hemmings B. A., Tzahor E., Harmelin A., Gepstein L. & Neeman M. (2013) Circulation-Cardiovascular Imaging. 6, 6, p. 992-1000

2012

Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis

Harel I., Maezawa Y., Avraham R., Rinon A., Ma H. Y., Cross J. W., Leviatan N., Hegesh J., Roy A., Jacob-Hirsch J., Rechavi G., Carvajal J., Tole S., Kioussi C., Quaggin S. & Tzahor E. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109, 46, p. 18839-18844

Head muscle development

Harel I. & Tzahor E. (2012) Craniofacial Muscles : A New Framework for Understanding the Effector Side of Craniofacial Muscle Control . Andrade F. & K. McLoon L.(eds.). p. 11-28

The actin regulator N-WASp is required for muscle-cell fusion in mice

Gruenbaum-Cohen Y., Harel I., Umansky K. B., Tzahor E., Snapper S. B., Shilo B. Z. & Schejter E. D. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11211-11216

2011

The heart endocardium is derived from vascular endothelial progenitors

Milgrom-Hoffman M., Harrelson Z., Ferrara N., Zelzer E., Evans S. M. & Tzahor E. (2011) Development. 138, 21, p. 4777-4787

Pharyngeal mesoderm development during embryogenesis: Implications for both heart and head myogenesis

Tzahor E. & Evans S. M. (2011) Cardiovascular Research. 91, 2, p. 196-202

P53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes

Rinon A., Molchadsky A., Nathan E., Yovel G., Rotter V., Sarig R. & Tzahor E. (2011) Development. 138, 9, p. 1827-1838

2010

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors

Tirosh-Finkel L., Zeisel A., Brodt-Ivenshitz M., Shamai A., Yao Z., Seger R., Domany E. & Tzahor E. (2010) Development. 137, 18, p. 2989-3000

The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature

Theis S., Patel K., Valasek P., Otto A., Pu Q., Harel I., Tzahor E., Tajbakhsh S., Christ B. & Huang R. (2010) Development. 137, 17, p. 2961-2971

2009

Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm

Kang J., Nathan E., Xu S., Tzahor E. & Black B. L. (2009) Developmental Biology. 334, 2, p. 513-522

p53 involvement in early cranial neural crest development in the chick

Rinon A., Nathan E. & Tzahor E. (2009) Developmental Biology. 331, 2, p. 430-430

Distinct Origins and Genetic Programs of Head Muscle Satellite Cells

Harel I., Nathan E., Tirosh-Finkel L., Zigdon H., Guimaraes-Camboa N., Evans S. M. & Tzahor E. (2009) Developmental Cell. 16, 6, p. 822-832

Heart and craniofacial muscle development: A new developmental theme of distinct myogenic fields

Tzahor E. (2009) Developmental Biology. 327, 2, p. 273-279

Hypoxia-Inducible Factor-1 alpha and-2 alpha Additively Promote Endothelial Vasculogenic Properties

Ben-Shoshan J., Maysel-Auslender S., Luboshits G., Barshack I., Polak-Charcon S., Tzahor E., Keren G. & George J. (2009) Journal of Vascular Research. 46, 4, p. 299-310

sFRPs: A declaration of (Wnt) independence

Nathan E. & Tzahor E. (2009) Nature Cell Biology. 11, 1, p. 13-14

2008

P53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

Molchadsky A., Shats I., Goldfinger N., Pevsner-Fischer M., Olson M., Rinon A., Tzahor E., Lozano G., Zipori D., Sarig R. & Rotter V. (2008) PLoS ONE. 3, 11, p. 1-15 e3707.

Constitutive expression of HIF-1α and HIF-2α in bone marrow stromal cells differentially promotes their proangiogenic properties

Ben-Shoshan J., Schwartz S., Luboshits G., Maysel-Auslender S., Barzelay A., Polak-Charcon S., Tzahor E., Barshack I., Barak A., Levkovitch-Verbin H., Keren G. & George J. (2008) Stem Cells. 26, 10, p. 2634-2643

Estimating cell depth from somatic mutations

Wasserstrom A., Frumkin D., Adar R., Itzkovitz S., Stern T., Kaplan S., Shefer G., Shur I., Zangi L., Reizel Y., Harmelin A., Dor Y., Dekel N., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008) PLoS Computational Biology. 4, 5, 1000058.

Reconstruction of Cell Lineage Trees in Mice

Wasserstrom A., Adar R., Shefer G., Frumkin D., Itzkovitz S., Stern T., Shur I., Zangi L., Kaplan S., Harmelin A., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008) PLoS ONE. 3, 4, 1939.

The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development

Nathan E., Monovich A., Tirosh-Finkel L., Harrelson Z., Rousso T., Rinon A., Harel I., Evans S. M. & Tzahor E. (2008) Development. 135, 4, p. 647-657

2007

Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis

Klaus A., Saga Y., Taketo M. M., Tzahor E. & Birchmeier W. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18531-18536

Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis

Rinon A., Lazar S., Marshall H., Buechmann-Moller S., Neufeld A., Elhanany-Tamir H., Taketo M. M., Sommer L., Krumlauf R. & Tzahor E. (2007) Development. 134, 17, p. 3065-3075

Wnt/β-Catenin Signaling and Cardiogenesis: Timing Does Matter

Tzahor E. (2007) Developmental Cell. 13, 1, p. 10-13

2006

Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract

Tirosh-Finkel L., Elhanany H., Rinon A. & Tzahor E. (2006) Development. 133, 10, p. 1943-1953

2003

Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle

Tzahor E., Kempf H., Mootoosamy R. C., Poon A. C., Abzhanov A., Tabin C. J., Dietrich S. & Lassar A. B. (2003) Genes and Development. 17, 24, p. 3087-3099