Tzahor Lab

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About us

Our lab forms a bridge between developmental biology and regenerative medicine aiming to develop novel approaches for mammalian heart regeneration

Selected Publications

Elad Bassat; Yara Eid Mutlak; Alex Genzelinakh; Ilya Y. Shadrin; Kfir-Baruch Umansky; Oren Yifa; David Kain; Dana Rajchman; John Leach; Daria Riabov Bassat; Yael Udi; Rachel Sarig; Irit Sagi; James F. Martin; Nenad Bursac; Shenhav Cohen; Eldad Tzahor (2017). The extracellular matrix protein agrin promotes heart regeneration in mice.  Nature. 2017 Jul , 547 (7662):179-+.
Tzahor, E; Poss, K (2017). Cardiac regeneration strategies: Staying young at heart..  SCIENCE. 2017, 356 (6342):1035-1039.

Research

Cardiomyocyte cell-cycle control and dedifferentiation

Ischemic heart disease is the most common cardiac ailment, and the leading cause of death in the Western world today. We combine novel approaches to study cardiomyocyte (CM) renewal by promoting CM cell division and dedifferentiation, as a potential therapeutic strategy to cure the injured heart. We focus on various signaling strategies (e.g., NRG/ERBB signaling pathway), combined with attention to the microenvironment. We focus on the biophysical properties (e.g., matrix rigidity) of the heart microenvironment as well on biochemical contents of the ECM and ECM- associated molecules. Finally, we employ a novel state-of-the-art high-throughput screening platform to identify molecules that promote CM proliferation and to study their effects on cardiac regeneration in mice. We have identified several novel compounds which significantly increase the proliferation of adult CMs. Understanding how mature CMs can disassemble their sarcomeric architecture and re-enter the cell cycle, combined with the development of novel procedures that can facilitate CM dedifferentiation and proliferation, are major challenges facing current biomedical research. Our research into myogenesis and cardiogenesis in chick embryos demonstrates that the FGF-ERK signaling pathway plays an inhibitory role in myogenic differentiation. We now seek to understand the molecular and cellular underpinnings of this phenomenon using adult muscle stem cells.

Cardiac and craniofacial development

We are interested in learning how the heart is formed during embryogenesis and, more specifically, the cellular origins of distinct heart progenitor populations. We use both chick and mouse embryonic models to address these questions. In the process, we have revealed novel developmental roles of vascular endothelial cells during heart and craniofacial development. Our search for the developmental mechanisms driving organogenesis led to identification of a gene regulatory network that orchestrates heart and craniofacial morphogenesis, findings that could pave the way toward a deeper understanding of certain birth defects (e.g., DiGeorge syndrome). We are also using a novel electroporation technique in chick embryos to follow the dynamics of cardiovascular lineage diversification.

Manipulating tumorigenic processes to stimulate heart regeneration

Perhaps one of the most surprising and interesting aspects of the adult heart is the fact that cardiac tumors rarely develop. This implies that some factor/s within the heart, which we are keen to identify, resists tumorigenesis. Inducing oncogenic transformation of cardiac cells may help to understand the heart resistance to cancer. Unleashing cell cycle control is a hallmark of cancer; on the other hand, these same mechanisms could be very useful in promoting heart regeneration. Hence, another angle of our research focus on the pros and cons of cell-cycle re-entry, finding just the right balance between these two processes (regeneration and tumorigenesis).

Publications

  • Gonzalo del Monte-Nieto; Mirana Ramialison; Arne A. S. Adam; Bingruo Wu; Alla Aharonov; Gabriele D'Uva; Lauren M. Bourke; Mara E. Pitulescu; Hanying Chen; Jose Luis de la Pompa; Weinian Shou; Ralf H. Adams; Sarah K. Harten; Eldad Tzahor; Bin Zhou; Richard P. Harvey (2018). Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.  Nature. 2018 May , 557 (7705):439-+.
  • Tzahor, E; Poss, K (2017). Cardiac regeneration strategies: Staying young at heart..  SCIENCE. 2017, 356 (6342):1035-1039.
  • Elad Bassat; Yara Eid Mutlak; Alex Genzelinakh; Ilya Y. Shadrin; Kfir-Baruch Umansky; Oren Yifa; David Kain; Dana Rajchman; John Leach; Daria Riabov Bassat; Yael Udi; Rachel Sarig; Irit Sagi; James F. Martin; Nenad Bursac; Shenhav Cohen; Eldad Tzahor (2017). The extracellular matrix protein agrin promotes heart regeneration in mice.  Nature. 2017 Jul , 547 (7662):179-+.
  • Lyad Zamir; Ratnakar Singh; Elisha Nathan; R Patrick; Oren Yifa; Y Yahalom-Ronen; A A Arraf; T M Schultheiss; S Suo; JJD Han; G Peng; Naihe Jing; Y Wang; N Palpant; P PL Tam; Richard P Harvey; Eldad Tzahor (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.  eLife. 2017 May , .
  • Eldad Tzahor; Kenneth D. Poss (2017). Cardiac regeneration strategies: Staying young at heart.  Science. 2017 Jun , 356 (6342):1035-1039.
  • Eldad Tzahor; Rachel Sarig (2017). The cancer paradigms of mammalian regeneration: can mammals regenerate as amphibians?.  Carcinogenesis. 2017 Apr , 38 (4):359-366.
  • Haig Aghajanian; Young Kuk Cho; Lauren J. Manderfield; Madison R. Herling; Mudit Gupta; Vivienne C. Ho; Li Li; Karl Degenhardt; Alla Aharonov; Eldad Tzahor; Jonathan A. Epstein (2016). Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor.  Nature Communications. 2016 Jun , 7 .
  • Liat Buzaglo-Azriel; Yael Kuperman; Michael Tsoory; Yehudit Zaltsman; Liat Shachnai; Smadar Levin-Zaidman; Elad Bassat; Inbal Michailovici; Alona Sarver; Eldad Tzahor; Michal Haran; Cecile Vernochet; Atan Gross (2016). Loss Of Muscle Mtch2 Increases Whole-Body Energy Utilization And Protects From Diet-Induced Obesity.  Cell Reports. 2016 Feb , 14 (7):1602-1610.
  • Jussi V. Leinonen; Avishag Korkus-Emanuelov; Yochai Wolf; Michal Milgrom-Hoffman; David Lichtstein; Sara Hoss; Chaim Lotan; Eldad Tzahor; Steffen Jung; Ronen Beeri (2016). Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45-stem cell-like phenotype.  International Journal of Cardiology. 2016 Apr , 209 :296-306.
  • Dana Rajchman; Rachel Sarig; Benjamin Geiger; Eldad Tzahor; Yfat Yahalom-Ronen (2015). Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion..  eLife. 2015, 4 .
  • Eldad Tzahor (2015). Cardiac and craniofacial development and regeneration.  FASEB Journal. 2015 Apr , 29 .
  • Inbal Michailovici; Tamar Eigler; Eldad Tzahor (2015). Craniofacial Muscle Development.  CRANIOFACIAL DEVELOPMENT. 2015, :3-30.
  • Gabriele D'Uva; Alla Aharonov; Mattia Lauriola; David Kain; Yfat Yahalom-Ronen; Silvia Carvalho; Karen Weisinger; Elad Bassat; Dana Rajchman; Oren Yifa; Marina Lysenko; Tal Konfino; Julius Hegesh; Ori Brenner; Michal Neeman; Yosef Yarden; Jonathan Leor; Rachel Sarig; Richard P. Harvey; Eldad Tzahor (2015). ERBB2 triggers mammalian heart regeneration by promoting cardiorlyocyte dedifferentiation and proliferation.  Nature Cell Biology. 2015 May , 17 (5):627-U207.
  • Rui Diogo; Robert G. Kelly; Lionel Christiaen; Michael Levine; Janine M. Ziermann; Julia L. Molnar; Drew M. Noden; Eldad Tzahor (2015). A new heart for a new head in vertebrate cardiopharyngeal evolution.  Nature. 2015 Apr , 520 (7548):466-473.
  • Gabriele D'Uva; Eldad Tzahor (2015). The key roles of ERBB2 in cardiac regeneration.  Cell Cycle. 2015 Aug , 14 (15):2383-2384.
  • Inbal Michailovici; Heather A. Harrington; Hadar Hay Azogui; Yfat Yahalom-Ronen; Alexander Plotnikov; Saunders Ching; Michael P. H. Stumpf; Ophir D. Klein; Rony Seger; Eldad Tzahor (2014). Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.  Development. 2014 Jul , 141 (13):2611-2620.
  • Michal Milgrom-Hoffman; Inbal Michailovici; N Ferrara; Elazar Zelzer; Eldad Tzahor (2014). Endothelial cells regulate neural crest and second heart field morphogenesis.  Biology Open. 2014 Aug , 3 (8):679-688.
  • J. Leinonen; A. Korkus-Emanuelov; Michal Milgrom-Hoffman; S. Hoss; C. Lotan; Eldad Tzahor; R. Beeri (2013). Cardiac progenitor cells from the left atrial appendage may originate from a resident non-hematopoietic myeloid progenitor population.  European Heart Journal. 2013 Aug , 34 :280-280.
  • Katrien Vandoorne; Moriel H. Vandsburger; Tal Raz; Moran Shalev; Karen Weisinger; Inbal Biton; Vlad Brumfeld; Calanit Raanan; Nava Nevo; Raya Eilam; Brian A. Hemmings; Eldad Tzahor; Alon Harmelin; Lior Gepstein; Michal Neeman (2013). Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction.  Circulation-Cardiovascular Imaging. 2013 Nov , 6 (6):992-1000.
  • Itamar Harel; Yoshiro Maezawa; Roi Avraham; Ariel Rinon; Hsiao-Yen Ma; Joe W. Cross; Noam Leviatan; Julius Hegesh; Achira Roy; Jasmine Jacob-Hirsch; Gideon Rechavi; Jaime Carvajal; Shubha Tole; Chrissa Kioussi; Susan Quaggin; Eldad Tzahor (2012). Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov , 109 (46):18839-18844.
  • Yael Gruenbaum-Cohen; Itamar Harel; Kfir-Baruch Umansky; Eldad Tzahor; Scott B. Snapper; Ben-Zion Shilo; Eyal D. Schejter (2012). The actin regulator N-WASp is required for muscle-cell fusion in mice.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul , 109 (28):11211-11216.
  • Eldad Tzahor; Sylvia M. Evans (2011). Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis.  Cardiovascular Research. 2011 Jul , 91 (2):196-202.
  • Ariel Rinon; Alina Molchadsky; Elisha Nathan; Gili Yovel; Varda Rotter; Rachel Sarig; Eldad Tzahor (2011). p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.  Development. 2011 May , 138 (9):1827-1838.
  • Rachel Sarig; Eldad Tzahor (2011). p53 and epithelial-mesenchymal transition A linking thread between embryogenesis and cancer.  Cell Cycle. 2011 Sept , 10 (18):3036-3037.
  • Michal Milgrom-Hoffman; Zachary Harrelson; Napoleone Ferrara; Elazar Zelzer; Sylvia M. Evans; Eldad Tzahor (2011). The heart endocardium is derived from vascular endothelial progenitors.  Development. 2011 Nov , 138 (21):4777-4787.
  • Libbat Tirosh-Finkel; Amit Zeisel; Miriam Brodt-Ivenshitz; Ayelet Shamai; Zhong Yao; Rony Seger; Eytan Domany; Eldad Tzahor (2010). BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.  Development. 2010 Sept , 137 (18):2989-3000.
  • Susanne Theis; Ketan Patel; Petr Valasek; Anthony Otto; Qin Pu; Itamar Harel; Eldad Tzahor; Shahragim Tajbakhsh; Bodo Christ; Ruijin Huang (2010). The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature.  Development. 2010 Sept , 137 (17):2961-2971.
  • Jeremy Ben-Shoshan; Sofia Maysel-Auslender; Galia Luboshits; Iris Barshack; Sylvie Polak-Charcon; Eldad Tzahor; Gad Keren; Jacob George (2009). Hypoxia-Inducible Factor-1 alpha and-2 alpha Additively Promote Endothelial Vasculogenic Properties.  Journal of Vascular Research. 2009, 46 (4):299-310.
  • Jione Kang; Elisha Nathan; Shan-Mei Xu; Eldad Tzahor; Brian L. Black (2009). Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm.  Developmental Biology. 2009 Oct , 334 (2):513-522.
  • Elisha Nathan; Eldad Tzahor (2009). sFRPs: a declaration of (Wnt) independence.  Nature Cell Biology. 2009 Jan , 11 (1):13-14.
  • Ariel Rinon; Elisha Nathan; Eldad Tzahor (2009). p53 involvement in early cranial neural crest development in the chick.  Developmental Biology. 2009 Jul , 331 (2):430-430.
  • Eldad Tzahor (2009). Heart and craniofacial muscle development: A new developmental theme of distinct myogenic fields.  Developmental Biology. 2009 Mar , 327 (2):273-279.
  • Itamar Harel; Elisha Nathan; Libbat Tirosh-Finkel; Hila Zigdon; Nuno Guimaraes-Camboa; Sylvia M. Evans; Eldad Tzahor (2009). Distinct Origins and Genetic Programs of Head Muscle Satellite Cells.  Developmental Cell. 2009 Jun , 16 (6):822-832.
  • Alexandra Klaus; Eldad Tzahor; Walter Birchmeier (2008). Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.  European Journal of Cell Biology. 2008 Jul , 87 (7):435-435.
  • Alina Molchadsky; Igor Shats; Naomi Goldfinger; Meirav Pevsner-Fischer; Melissa Olson; Ariel Rinon; Eldad Tzahor; Guillermina Lozano; Dov Zipori; Rachel Sarig; Varda Rotter (2008). p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner.  PLoS One. 2008 Nov , 3 (11).
  • Elisha Nathan; Amir Monovich; Libbat Tirosh-Finkel; Zachary Harrelson; Tal Rousso; Ariel Rinon; Itamar Harel; Sylvia M. Evans; Eldad Tzahor (2008). The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development.  Development. 2008 Feb , 135 (4):647-657.
  • Adam Wasserstrom; Rivka Adar; Gabi Shefer; Dan Frumkin; Shalev Itzkovitz; Tomer Stern; Irena Shur; Lior Zangi; Shai Kaplan; Alon Harmelin; Yair Reisner; Dafna Benayahu; Eldad Tzahor; Eran Segal; Ehud Shapiro (2008). Reconstruction of Cell Lineage Trees in Mice.  PLoS One. 2008 Apr , 3 (4).
  • Adam Wasserstrom; Dan Frumkin; Rivka Adar; Shalev Itzkovitz; Tomer Stern; Shai Kaplan; Gabi Shefer; Irena Shur; Lior Zangi; Yitzhak Reizel; Alon Harmelin; Yuval Dor; Nava Dekel; Yair Reisner; Dafna Benayahu; Eldad Tzahor; Eran Segal; Ehud Shapiro (2008). Estimating cell depth from somatic mutations.  PLoS Computational Biology. 2008 May , 4 (5).
  • Jeremy Ben-Shoshan; Shulamit Schwartz; Galia Luboshits; Sofia Maysel-Auslender; Aya Barzelay; Sylvie Polak-Charcon; Iris Barshack; Eldad Tzahor; Adiel Barak; Hani Levkovitch-Verbin; Gad Keren; Jacob George (2008). Constitutive expression of HIF-1 alpha and HIF-2 alpha in bone marrow stromal cells differentially promote their pro-angiogenic properties.  Human Gene Therapy. 2008 Oct , 19 (10):1180-1180.
  • Jeremy Ben-Shoshan; Sofia Maysel-Auslender; Galia Luboshits; Iris Barshack; Sylvie Polak-Charcon; Eldad Tzahor; Gad Keren; Jacob George (2008). Hypoxia inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha additively promote endothelial vasculogenic properties.  Human Gene Therapy. 2008 Oct , 19 (10):1111-1111.
  • Jeremy Ben-Shoshan; Shulamit Schwartz; Galia Luboshits; Sofia Maysel-Auslender; Aya Barzelay; Sylvie Polak-Charcon; Eldad Tzahor; Iris Barshack; Adiel Barak; Hani Levkovitch-Verbin; Gad Keren; Jacob George (2008). Constitutive Expression of HIF-1 alpha and HIF-2 alpha in Bone Marrow Stromal Cells Differentially Promotes Their Proangiogenic Properties.  Stem Cells. 2008, 26 (10):2634-2643.
  • Ariel Rinon; Shlomi Lazar; Heather Marshall; Stine Buechmann-Moller; Adi Neufeld; Hadas Elhanany-Tamir; Makoto M. Taketo; Lukas Sommer; Robb Krumlauf; Eldad Tzahor (2007). Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.  Development. 2007 Sept , 134 (17):3065-3075.
  • Eldad Tzahor (2007). Wnt/beta-catenin signaling and cardiogenesis: Timing does matter.  Developmental Cell. 2007 Jul , 13 (1):10-13.
  • Eldad Tzahor (2007). The contribution of second heart field cells to the jaw muscle reveals the multipotential nature of the cardio-craniofacial mesoderm.  Circulation Research. 2007 Aug , 101 (5):E69-E69.
  • Alexandra Klaus; Yumiko Saga; Makoto M. Taketo; Eldad Tzahor; Walter Birchmeier (2007). Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2007 Nov , 104 (47):18531-18536.
  • L Tirosh-Finkel; H Elhanany; Ariel Rinon; Eldad Tzahor (2006). Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract.  Development. 2006 May , 133 (10):1943-1953.

Members

Members

Eldad Tzahor

Prof. Eldad Tzahor

יועץ לנשיא,Center Head,Department Head,ראש מחלקה,ראש מרכז,Professor
Wolfson, room: 608
Phone+972-8-934-3715
Rachel Sarig

Dr. Rachel Sarig

Associate Staff Scientist
Wolfson, room: 610
Phone+972-8-934-2913
Kfir-Baruch Umansky

Dr. Kfir-Baruch Umansky

Senior Intern
Wolfson, room: 610
Tamar Eigler

Dr. Tamar Eigler

Postdoctoral fellow
Wolfson, room: 610
Phone+972-8-934-2762
Alla Aharonov

Alla Aharonov

PhD student
Wolfson, room: 610
Phone+972-8-934-2762
Elad Bassat

Dr. Elad Bassat

Postdoctoral fellow
Wolfson, room: 610
Phone+972-8-934-2762
Oren Yifa

Oren Yifa

PhD student
Candiotty, room: 206
Phone+972-8-934-2762
Rachel Rimmer

Rachel Rimmer

MSc student
Wolfson, room: 610
Phone+972-8-934-2762
Renee Cohen Rabi

Renee Cohen Rabi

MSc student
Wolfson
Doran Gal

Doran Gal

עובד מעבדה
Wolfson, room: 609
Phone+972-8-934-2762
Emmanuel Amzallag

Emmanuel Amzallag

MSc student
Wolfson
Alexander Genzelinakh

Alexander Genzelinakh

PhD student
Wolfson, room: 206
Daria Lendengolts

Dr. Daria Lendengolts

Consultant
Wolfson
Dahlia Perez

Dr. Dahlia Perez

Postdoctoral fellow
Wolfson
Phone+972-8-934-2762
Shoval Ochana

Shoval Ochana

עובד מעבדה
Wolfson, room: 610
Phone+972-8-934-2762
Jini Simon

Jini Simon

MSc student
Wolfson, room: 610
Gali Attias

Gali Attias

עובד מעבדה
Wolfson
David Kain

Dr. David Kain

Consultant
Candiotty
Uri Nudel

Prof. Uri Nudel

Consultant
Wolfson, room: 117
Phone+972-8-934-2815
Divya Dasagrandhi

Dr. Divya Dasagrandhi

Consultant
Lingling Zhang

Lingling Zhang

PhD student
Wolfson
Avraham Shakked

Avraham Shakked

PhD student
Wolfson, room: 610

Postdoc
Karen Weisinger - kweisinger2@gmail.com
Gabriele D'uva - duva.gabriele@gmail.com
Miriam Ivenshitz - miriam.ivenshitz@gmail.com
Vardina Bensoussan Trigano - vardina.trigano@gmail.com

PhD
Michal Milgrom-Hoffman - michalmilgrom@yahoo.com
Libbat Tirosh - libbatt@gmail.com
Itamar Harel - itamarharel1980@gmail.com
Inbal Michailovici - inbalit11@gmail.com
Arial Rinon - ariel.rinon@gmail.com
Elisha Natan - elishanatan@gmail.com
Adam Wasserstrom - adam.wasserstrom@gmail.com

MSc
Ayelet Levit - ayeletshamai@gmail.com
Elik Chapnik - elikcha@gmail.com
Hadar Hay - hadar.hay2@gmail.com
Roni Winkler - roni.winkler@weizmann.ac.il
Adi Neufeld - adi.neufeld@yahoo.com
Amir Monovich
Hadas Elhanany-Tamir
Shlomi Lazar

Galleries

Contact

 

Prof. Eldad Tzahor

Weizmann Institute of Science
Department of Molecular Cell Biology
Wolfson Building
Rehovot, 76100, Israel

Office: +972-8-934-3715
Mobile: +972-50-510-9606
Email: eldad.tzahor@weizmann.ac.il

 

Find us on campus, Building 33.