Tzahor Lab

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About us

Our lab forms a bridge between developmental biology and regenerative medicine aiming to develop novel approaches for mammalian heart regeneration

Selected Publications

Tzahor, E; Poss, K (2017). Cardiac regeneration strategies: Staying young at heart..  SCIENCE. 2017, 356 (6342):1035-1039.

Research

Cardiomyocyte cell-cycle control and dedifferentiation

Ischemic heart disease is the most common cardiac ailment, and the leading cause of death in the Western world today. We combine novel approaches to study cardiomyocyte (CM) renewal by promoting CM cell division and dedifferentiation, as a potential therapeutic strategy to cure the injured heart. We focus on various signaling strategies (e.g., NRG/ERBB signaling pathway), combined with attention to the microenvironment. We focus on the biophysical properties (e.g., matrix rigidity) of the heart microenvironment as well on biochemical contents of the ECM and ECM- associated molecules. Finally, we employ a novel state-of-the-art high-throughput screening platform to identify molecules that promote CM proliferation and to study their effects on cardiac regeneration in mice. We have identified several novel compounds which significantly increase the proliferation of adult CMs. Understanding how mature CMs can disassemble their sarcomeric architecture and re-enter the cell cycle, combined with the development of novel procedures that can facilitate CM dedifferentiation and proliferation, are major challenges facing current biomedical research. Our research into myogenesis and cardiogenesis in chick embryos demonstrates that the FGF-ERK signaling pathway plays an inhibitory role in myogenic differentiation. We now seek to understand the molecular and cellular underpinnings of this phenomenon using adult muscle stem cells.

Cardiac and craniofacial development

We are interested in learning how the heart is formed during embryogenesis and, more specifically, the cellular origins of distinct heart progenitor populations. We use both chick and mouse embryonic models to address these questions. In the process, we have revealed novel developmental roles of vascular endothelial cells during heart and craniofacial development. Our search for the developmental mechanisms driving organogenesis led to identification of a gene regulatory network that orchestrates heart and craniofacial morphogenesis, findings that could pave the way toward a deeper understanding of certain birth defects (e.g., DiGeorge syndrome). We are also using a novel electroporation technique in chick embryos to follow the dynamics of cardiovascular lineage diversification.

Manipulating tumorigenic processes to stimulate heart regeneration

Perhaps one of the most surprising and interesting aspects of the adult heart is the fact that cardiac tumors rarely develop. This implies that some factor/s within the heart, which we are keen to identify, resists tumorigenesis. Inducing oncogenic transformation of cardiac cells may help to understand the heart resistance to cancer. Unleashing cell cycle control is a hallmark of cancer; on the other hand, these same mechanisms could be very useful in promoting heart regeneration. Hence, another angle of our research focus on the pros and cons of cell-cycle re-entry, finding just the right balance between these two processes (regeneration and tumorigenesis).

Publications

  • Han Y., Chen A., Umansky K., Oonk K. A., Choi W., Dickson A. L., Ou J., Cigliola V., Yifa O., Cao J., Tornini V. A., Cox B. D., Tzahor E. & Poss K. D. (2019). Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.  Developmental Cell. 2019 Mar , 48 (6):853-863.e5.
  • Sarig R., Rimmer R., Bassat E., Zhang L., Umansky K. B., Lendengolts D., Perlmoter G., Yaniv K. & Tzahor E. (2019). Transient p53-Mediated Regenerative Senescence in the Injured Heart.  Circulation. 2019 May , 139 (21):2491-2494.
  • Yifa O., Weisinger K., Bassat E., Li H., Kain D., Barr H., Kozer N., Genzelinakh A., Rajchman D., Eigler T., Umansky K. B., Lendengolts D., Brener O., Bursac N. & Tzahor E. (2019). The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.  JCI insight. 2019 Nov , 4 (22).
  • del Monte-Nieto G., Ramialison M., Adam A. A. S., Wu B., Aharonov A., D'Uva G., Bourke L. M., Pitulescu M. E., Chen H., Luis de la Pompa J., Shou W., Adams R. H., Harten S. K., Tzahor E., Zhou B. & Harvey R. P. (2018). Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.  Nature. 2018 May , 557 (7705):439-+.
  • Tzahor, E; Poss, K (2017). Cardiac regeneration strategies: Staying young at heart..  SCIENCE. 2017, 356 (6342):1035-1039.
  • Tzahor E. & Poss K. D. (2017). Cardiac regeneration strategies: Staying young at heart.  Science. 2017 Jun , 356 (6342):1035-1039.
  • Bassat E., Mutlak Y. E., Genzelinakh A., Shadrin I. Y., Umansky K., Yifa O., Kain D., Rajchman D., Leach J., Bassat D. R., Udi Y., Sarig R., Sagi I., Martin J. F., Bursac N., Cohen S. & Tzahor E. (2017). The extracellular matrix protein agrin promotes heart regeneration in mice.  Nature. 2017 Jul , 547 (7662):179-+.
  • Zamir L., Singh R., Nathan E., Patrick R., Yifa O., Yahalom-Ronen Y., Arraf A. A., Schultheiss T. M., Suo S., Han J., Peng G., Jing N., Wang Y., Palpant N., Tam P. P., Harvey R. P. & Tzahor E. (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.  eLife. 2017 May , .
  • Tzahor E. & Sarig R. (2017). The cancer paradigms of mammalian regeneration: can mammals regenerate as amphibians?.  Carcinogenesis. 2017 Apr , 38 (4):359-366.
  • Aghajanian H., Cho Y. K., Manderfield L. J., Herling M. R., Gupta M., Ho V. C., Li L., Degenhardt K., Aharonov A., Tzahor E. & Epstein J. A. (2016). Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor.  Nature Communications. 2016 Jun , 7 .
  • Leinonen J. V., Korkus-Emanuelov A., Wolf Y., Milgrom-Hoffman M., Lichtstein D., Hoss S., Lotan C., Tzahor E., Jung S. & Beeri R. (2016). Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45-stem cell-like phenotype.  International Journal of Cardiology. 2016 Apr , 209 :296-306.
  • Buzaglo-Azriel L., Kuperman Y., Tsoory M., Zaltsman Y., Shachnai L., Levin-Zaidman S., Bassat E., Michailovici I., Sarver A., Tzahor E., Haran M., Vernochet C. & Gross A. (2016). Loss Of Muscle Mtch2 Increases Whole-Body Energy Utilization And Protects From Diet-Induced Obesity.  Cell Reports. 2016 Feb , 14 (7):1602-1610.
  • D'Uva G., Aharonov A., Lauriola M., Kain D., Yahalom-Ronen Y., Carvalho S., Weisinger K., Bassat E., Rajchman D., Yifa O., Lysenko M., Konfino T., Hegesh J., Brenner O., Neeman M., Yarden Y., Leor J., Sarig R., Harvey R. P. & Tzahor E. (2015). ERBB2 triggers mammalian heart regeneration by promoting cardiorlyocyte dedifferentiation and proliferation.  Nature Cell Biology. 2015 May , 17 (5):627-U207.
  • Diogo R., Kelly R. G., Christiaen L., Levine M., Ziermann J. M., Molnar J. L., Noden D. M. & Tzahor E. (2015). A new heart for a new head in vertebrate cardiopharyngeal evolution.  Nature. 2015 Apr , 520 (7548):466-473.
  • D'Uva G. & Tzahor E. (2015). The key roles of ERBB2 in cardiac regeneration.  Cell Cycle. 2015 Aug , 14 (15):2383-2384.
  • Yahalom-Ronen Y., Rajchman D., Sarig R., Geiger B. & Tzahor E. (2015). Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion..  eLife. 2015, 4 .
  • Michailovici I., Eigler T. & Tzahor E. (2015). Craniofacial Muscle Development.  . 2015, :3-30.
  • Milgrom-Hoffman M., Michailovici I., Ferrara N., Zelzer E. & Tzahor E. (2014). Endothelial cells regulate neural crest and second heart field morphogenesis.  Biology Open. 2014 Aug , 3 (8):679-688.
  • Michailovici I., Harrington H. A., Azogui H. H., Yahalom-Ronen Y., Plotnikov A., Ching S., Stumpf M. P. H., Klein O. D., Seger R. & Tzahor E. (2014). Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.  Development. 2014 Jul , 141 (13):2611-2620.
  • Vandoorne K., Vandsburger M. H., Raz T., Shalev M., Weisinger K., Biton I., Brumfeld V., Raanan C., Nevo N., Eilam R., Hemmings B. A., Tzahor E., Harmelin A., Gepstein L. & Neeman M. (2013). Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction.  Circulation-Cardiovascular Imaging. 2013 Nov , 6 (6):992-1000.
  • Gruenbaum-Cohen Y., Harel I., Umansky K., Tzahor E., Snapper S. B., Shilo B. & Schejter E. D. (2012). The actin regulator N-WASp is required for muscle-cell fusion in mice.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul , 109 (28):11211-11216.
  • Harel I., Maezawa Y., Avraham R., Rinon A., Ma H., Cross J. W., Leviatan N., Hegesh J., Roy A., Jacob-Hirsch J., Rechavi G., Carvajal J., Tole S., Kioussi C., Quaggin S. & Tzahor E. (2012). Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov , 109 (46):18839-18844.
  • Milgrom-Hoffman M., Harrelson Z., Ferrara N., Zelzer E., Evans S. M. & Tzahor E. (2011). The heart endocardium is derived from vascular endothelial progenitors.  Development. 2011 Nov , 138 (21):4777-4787.
  • Rinon A., Molchadsky A., Nathan E., Yovel G., Rotter V., Sarig R. & Tzahor E. (2011). p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.  Development. 2011 May , 138 (9):1827-1838.
  • Sarig R. & Tzahor E. (2011). p53 and epithelial-mesenchymal transition A linking thread between embryogenesis and cancer.  Cell Cycle. 2011 Sept , 10 (18):3036-3037.
  • Tzahor E. & Evans S. M. (2011). Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis.  Cardiovascular Research. 2011 Jul , 91 (2):196-202.
  • Theis S., Patel K., Valasek P., Otto A., Pu Q., Harel I., Tzahor E., Tajbakhsh S., Christ B. & Huang R. (2010). The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature.  Development. 2010 Sept , 137 (17):2961-2971.
  • Tirosh-Finkel L., Zeisel A., Brodt-Ivenshitz M., Shamai A., Yao Z., Seger R., Domany E. & Tzahor E. (2010). BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.  Development. 2010 Sept , 137 (18):2989-3000.
  • Ben-Shoshan J., Maysel-Auslender S., Luboshits G., Barshack I., Polak-Charcon S., Tzahor E., Keren G. & George J. (2009). Hypoxia-Inducible Factor-1 alpha and-2 alpha Additively Promote Endothelial Vasculogenic Properties.  Journal of Vascular Research. 2009, 46 (4):299-310.
  • Nathan E. & Tzahor E. (2009). sFRPs: a declaration of (Wnt) independence.  Nature Cell Biology. 2009 Jan , 11 (1):13-14.
  • Tzahor E. (2009). Heart and craniofacial muscle development: A new developmental theme of distinct myogenic fields.  Developmental Biology. 2009 Mar , 327 (2):273-279.
  • Harel I., Nathan E., Tirosh-Finkel L., Zigdon H., Guimaraes-Camboa N., Evans S. M. & Tzahor E. (2009). Distinct Origins and Genetic Programs of Head Muscle Satellite Cells.  Developmental Cell. 2009 Jun , 16 (6):822-832.
  • Kang J., Nathan E., Xu S., Tzahor E. & Black B. L. (2009). Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm.  Developmental Biology. 2009 Oct , 334 (2):513-522.
  • Rinon A., Nathan E. & Tzahor E. (2009). p53 involvement in early cranial neural crest development in the chick.  Developmental Biology. 2009 Jul , 331 (2):430-430.
  • Ben-Shoshan J., Schwartz S., Luboshits G., Maysel-Auslender S., Barzelay A., Polak-Charcon S., Tzahor E., Barshack I., Barak A., Levkovitch-Verbin H., Keren G. & George J. (2008). Constitutive Expression of HIF-1 alpha and HIF-2 alpha in Bone Marrow Stromal Cells Differentially Promotes Their Proangiogenic Properties.  Stem Cells. 2008, 26 (10):2634-2643.
  • Molchadsky A., Shats I., Goldfinger N., Pevsner-Fischer M., Olson M., Rinon A., Tzahor E., Lozano G., Zipori D., Sarig R. & Rotter V. (2008). p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner.  PLoS One. 2008 Nov , 3 (11):1-15.
  • Nathan E., Monovich A., Tirosh-Finkel L., Harrelson Z., Rousso T., Rinon A., Harel I., Evans S. M. & Tzahor E. (2008). The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development.  Development. 2008 Feb , 135 (4):647-657.
  • Wasserstrom A., Adar R., Shefer G., Frumkin D., Itzkovitz S., Stern T., Shur I., Zangi L., Kaplan S., Harmelin A., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008). Reconstruction of Cell Lineage Trees in Mice.  PLoS One. 2008 Apr , 3 (4).
  • Wasserstrom A., Frumkin D., Adar R., Itzkovitz S., Stern T., Kaplan S., Shefer G., Shur I., Zangi L., Reizel Y., Harmelin A., Dor Y., Dekel N., Reisner Y., Benayahu D., Tzahor E., Segal E. & Shapiro E. (2008). Estimating cell depth from somatic mutations.  PLoS Computational Biology. 2008 May , 4 (5).
  • Klaus A., Saga Y., Taketo M. M., Tzahor E. & Birchmeier W. (2007). Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.  Proceedings of the National Academy of Sciences of the United States of America. 2007 Nov , 104 (47):18531-18536.
  • Rinon A., Lazar S., Marshall H., Buechmann-Moller S., Neufeld A., Elhanany-Tamir H., Taketo M. M., Sommer L., Krumlauf R. & Tzahor E. (2007). Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.  Development. 2007 Sept , 134 (17):3065-3075.
  • Tzahor E. (2007). Wnt/beta-catenin signaling and cardiogenesis: Timing does matter.  Developmental Cell. 2007 Jul , 13 (1):10-13.
  • Tirosh-Finkel L., Elhanany H., Rinon A. & Tzahor E. (2006). Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract.  Development. 2006 May , 133 (10):1943-1953.

Members

Members

Eldad Tzahor

Prof. Eldad Tzahor

יועץ לנשיא,Center Head,Department Head,ראש מחלקה,ראש מרכז,Professor
Wolfson, room: 608
Phone+972-8-934-3715
Rachel Sarig

Dr. Rachel Sarig

Associate Staff Scientist
Wolfson, room: 610
Phone+972-8-934-2913
Kfir-Baruch Umansky

Dr. Kfir-Baruch Umansky

Senior Intern
Wolfson, room: 610
Tamar Eigler

Dr. Tamar Eigler

עוזר מחקר
Wolfson, room: 610
Phone+972-8-934-2762
Alla Aharonov

Alla Aharonov

PhD student
Wolfson, room: 610
Phone+972-8-934-2762
Lingling Zhang

Lingling Zhang

PhD student
Wolfson
Phone+972-8-934-2762
Dov Zipori

Prof. Dov Zipori

Consultant
Wolfson, room: 118
William Sam Tobelaim

William Sam Tobelaim

Postdoctoral fellow
Wolfson
Emmanuel Amzallag

Emmanuel Amzallag

PhD student
Wolfson
Micha Yehudi

Micha Yehudi

עובד מעבדה
Wolfson, room: 610
Phone+972-8-934-2762
David Kain

Dr. David Kain

Consultant
Candiotty
Shoval Miyara

Shoval Miyara

MSc student
Wolfson
Nachum Nathan

Nachum Nathan

MSc student
Wolfson
Avraham Shakked

Avraham Shakked

PhD student
Wolfson, room: 610
Alexander Genzelinakh

Alexander Genzelinakh

PhD student
Wolfson, room: 206
Daria Lendengolts

Dr. Daria Lendengolts

Consultant
Wolfson
Dahlia Perez

Dr. Dahlia Perez

Postdoctoral fellow
Wolfson
Phone+972-8-934-2762
Shoval Ochana

Shoval Ochana

עובד מעבדה
Wolfson, room: 610
Phone+972-8-934-2762
Gali Attias

Gali Attias

עובד מעבדה
Wolfson, room: 610
Phone+972-8-934-2762
Uri Nudel

Prof. Uri Nudel

Consultant
Wolfson, room: 117
Phone+972-8-934-2815

Postdoc
Karen Weisinger - kweisinger2@gmail.com
Gabriele D'uva - duva.gabriele@gmail.com
Miriam Ivenshitz - miriam.ivenshitz@gmail.com
Vardina Bensoussan Trigano - vardina.trigano@gmail.com

PhD
Michal Milgrom-Hoffman - michalmilgrom@yahoo.com
Libbat Tirosh - libbatt@gmail.com
Itamar Harel - itamarharel1980@gmail.com
Inbal Michailovici - inbalit11@gmail.com
Arial Rinon - ariel.rinon@gmail.com
Elisha Natan - elishanatan@gmail.com
Adam Wasserstrom - adam.wasserstrom@gmail.com

MSc
Ayelet Levit - ayeletshamai@gmail.com
Elik Chapnik - elikcha@gmail.com
Hadar Hay - hadar.hay2@gmail.com
Roni Winkler - roni.winkler@weizmann.ac.il
Adi Neufeld - adi.neufeld@yahoo.com
Amir Monovich
Hadas Elhanany-Tamir
Shlomi Lazar

Galleries

Contact

 

Prof. Eldad Tzahor

Weizmann Institute of Science
Department of Molecular Cell Biology
Wolfson Building
Rehovot, 76100, Israel

Office: +972-8-934-3715
Mobile: +972-50-510-9606
Email: eldad.tzahor@weizmann.ac.il

 

Find us on campus, Building 33.