Cardiac Fibrosis

Cardiac fibrosis is a key pathological process in many heart diseases, characterized by excessive extracellular matrix deposition that leads to stiffening of the heart muscle and impaired cardiac function. Our lab focuses on unraveling the complexities of fibrosis to identify novel therapeutic targets that can prevent or reverse disease progression.

We explore the emerging concept of hot and cold fibrosis, representing distinct fibrotic microenvironments. Hot fibrosisis an active, inflammatory-driven state with high cellular activity, immune infiltration, and dynamic remodeling, often seen in acute cardiac injury. In contrast, cold fibrosis is a more stable, fibrotic state with minimal inflammation, increased matrix deposition, and reduced regenerative potential, commonly associated with chronic heart failure.

By leveraging cutting-edge molecular and cellular techniques, we investigate how different fibrosis states impact disease progression and response to treatment. Our research aims to develop targeted therapies that modulate the fibrotic environment, promoting cardiac repair and functional recovery.

Through interdisciplinary collaborations and innovative approaches, our lab is at the forefront of discovering new strategies to combat cardiac fibrosis and improve patient outcomes.