Past events

Add the event Special Guest Seminar with Prof. Judith Frydman to calendar

Special Guest seminar with Dr. Raul Andino

Type: Lecture

Date: Aug 28, 2023

Time14:30 - 15:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Raul Andino

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Seminar for PhD thesis defense

Type: Lecture

Date: Aug 08, 2023

Time16:00 - 17:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOffir Lupo

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Jul 24, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special guest Seminar

Type: Lecture

Date: Jul 16, 2023

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Anton Zilman

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Jul 10, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Jun 26, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special guest seminar with Nadav Ahituv

Type: Lecture

Date: Jun 13, 2023

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nadav Ahituv

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Jun 12, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: May 29, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special Guest Seminar

Type: Lecture

Date: May 16, 2023

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Meissner & Prof. Paul Tesar

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Special Guest Seminar

Type: Lecture

Date: May 16, 2023

Time15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Meissner & Prof. Paul Tesar

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: May 15, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Systems Biology Seminar

Type: Lecture

Date: May 01, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: May 01, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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MSc Thesis Defense

Type: Lecture

Date: Apr 02, 2023

Time14:00

LecturerElisheva Berent-Barzel

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Mar 27, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special Guest Seminar

Type: Lecture

Date: Mar 14, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Leonid Chernomordik

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Mar 13, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special Guest Seminar

Type: Lecture

Date: Mar 09, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Danielle Grotjahn

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Special Guest Seminar

Type: Lecture

Date: Feb 16, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jennifer Lippincott-Schwartz

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Seminar for PhD Thesis Defense

Type: Lecture

Date: Feb 09, 2023

Time09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Finkel

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Seminar for thesis defense with Yaara Finkel

Type: Lecture

Date: Feb 09, 2023

Time09:30 - 10:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Finkel

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Seminar for MSc thesis defense

Type: Lecture

Date: Jan 22, 2023

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSivan Arad

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Special Guest Seminar

Type: Lecture

Date: Jan 19, 2023

Time15:30 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ritsuko K. Pooh

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Seminar for MSc Thesis Defense

Type: Lecture

Date: Jan 16, 2023

Time15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLior Peer

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Jan 16, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Seminar for Thesis Defense with Raman Singh

Type: Lecture

Date: Jan 16, 2023

Time09:00 - 10:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerRaman Singh

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Seminar for Thesis Defense with Svetlana Markman

Type: Lecture

Date: Jan 15, 2023

Time14:30 - 15:30

LocationGerhard M.J. Schmidt Lecture Hall

LecturerSvetlana Markman

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Systems Biology Seminar 2022-2023

Type: Lecture

Date: Jan 02, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special Guest Seminar

Type: Lecture

Date: Jan 01, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yaron Orenstein

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Seminar for Thesis defense

Type: Lecture

Date: Dec 12, 2022

Time15:30 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoa Aharon-Hefetz

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Special Guest Seminar

Type: Lecture

Date: Nov 24, 2022

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Florian Wilfling

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Special guest seminar, Dr Harry Burgess

Type: Lecture

Date: Aug 15, 2022

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Harry Burgess

OrganizerDevelopmental Club

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Seminar for Thesis Defense of Adi Millman

Type: Lecture

Date: Jul 24, 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

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Guest seminar with Prof. Utpal Banerjee

Type: Lecture

Date: Jul 20, 2022

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Utpal Banerjee

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Special guest semianr with Dr. Asaf Zviran

Type: Lecture

Date: Jul 17, 2022

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Asaf Zviran

OrganizerCancer Research Club

AbstractEarly detection of recurrence and monitoring of Molecular Residual Disease (MRD) post-surgery is critical for clinical decision-making to tailor personalized treatments across solid cancers. C2i Genomics has developed an ultra-sensitive whole-genome ctDNA test, allowing extremely accurate and sensitive monitoring of patients with solid tumors. Here we present results from applying whole-genome sequencing (WGS) and identification of ctDNA across a variety of adult and pediatric solid tumors. We integrate a genome-wide mutation and copy number monitoring approach coupled with advanced signal processing and Artificial Intelligence (AI) for measuring the tumor load from low-input blood samples (~1mL of plasma) with ultra-sensitive detection. The increased sensitivity allowed clinical detection of tumor fraction down to 5*10-5 and recurrence detection sensitivity achieving >65% at the first two months after definitive treatment, enabling earlier clinical intervention for high-risk patients.

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Seminar for PhD thesis defense

Type: Lecture

Date: Jul 12, 2022

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNir Cohen

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Special Guest Seminar

Type: Lecture

Date: Jul 11, 2022

Time10:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. David Reich

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Seminar for PhD thesis defense

Type: Lecture

Date: May 25, 2022

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGal Chaim Nuta

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Special guest semianr with Prof. Jin Billy Li

Type: Lecture

Date: May 25, 2022

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJin Billy Li

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Special Guest Seminar with Prof. Hervé Le Hir

Type: Lecture

Date: May 15, 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Hervé Le Hir

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Seminar for Thesis Defense

Type: Lecture

Date: May 11, 2022

Time14:00 - 15:00

LecturerKarin Broennimann

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Transcription Drive Development Minisymposium

Type: Lecture

Date: May 11, 2022

Time10:30 - 15:00

LocationDolfi and Lola Ebner Auditorium

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Molecular Genteics departmental retreat

Type: Lecture

Date: May 09, 2022

Time00:00

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Molecular Genetics Departmental seminar

Type: Lecture

Date: May 08, 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYehuda Danino & Tslil Braun

OrganizerDDP Seminar

ContactSandra.britton@weizmann.ac.il

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Special guest seminar with Prof. Kent Søe

Type: Lecture

Date: Apr 07, 2022

Time13:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Kent Søe

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Seminar for PhD thesis defense

Type: Lecture

Date: Mar 10, 2022

Time12:00 - 13:00

LecturerMira Rosenthal

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Department of Molecular Genetics departmental seminar

Type: Lecture

Date: Feb 20, 2022

Time13:00 - 14:00

LocationDolfi and Lola Ebner Auditorium

LecturerAssaf Biran

OrganizerDDP Seminar

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Special Guest Seminar

Type: Lecture

Date: Feb 15, 2022

Time13:00 - 14:00

LecturerDr. Lilach Sheiner

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Department of Molecular Genetics departmental seminar

Type: Lecture

Date: Feb 06, 2022

Time13:00 - 14:00

LecturerYury Bykov and Oldak Bernardo

OrganizerJoint Seminar

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Azrieli Institute for Systems Biology, guest seminar with Ahmed H. Badran

Type: Lecture

Date: Jan 18, 2022

Time17:00 - 18:00

LecturerAhmed H. Badran, PhD

OrganizerSystem Biology

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Seminar for PhD thesis defense

Type: Lecture

Date: Jan 17, 2022

Time13:30

LecturerSivan Kaminski Strauss

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Seminar for PhD thesis defense

Type: Lecture

Date: Jan 05, 2022

Time11:00

LecturerChen Eitan

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Guest seminar with Vered Shacham-Silverberg

Type: Lecture

Date: Dec 26, 2021

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Vered Shacham-Silverberg

OrganizerJoint Seminar

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Seminar for PhD thesis defense

Type: Lecture

Date: Dec 12, 2021

Time13:15

LecturerTom Shani

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MicroEco2 Microbial Ecology Symposium for Young Researchers

Type: conference

Date: Dec 09, 2021

Time08:00

LocationThe David Lopatie Conference Centre

Websitehttps://www.weizmann.ac.il/conferences/MICREC2021/

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Molecular Genetics departmental seminar

Type: Lecture

Date: Nov 28, 2021

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmit Kahana (lancet lab) Gabriela Lobinska (Pilpel lab)

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Special Guest seminar

Type: Lecture

Date: Nov 24, 2021

Time11:00

LecturerProf. Gianni Liti

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“Computational Methods for Super-resolution Single Molecule Localization Microscopy”

Type: Lecture

Date: Nov 21, 2021

Time11:30 - 12:30

LecturerDr. Ismail M. Khater

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Special Guest Seminar

Type: Lecture

Date: Nov 02, 2021

Time10:00 - 11:00

LecturerDr. Eyal Karzbrun

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Seminar for Thesis Defense,

Type: Lecture

Date: Oct 19, 2021

Time09:00 - 10:00

LecturerLia Heinemann Yerushalmi

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Seminar for PhD thesis defense

Type: Lecture

Date: Oct 17, 2021

Time10:00

LecturerHagai Marmor - Kollet

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Special seminar with Dr. Yaara Oren

Type: Lecture

Date: Aug 16, 2021

Time15:00 - 16:00

LecturerDr. Yaara Oren

AbstractDespite favorable initial response to therapy, a third of cancer patients will develop recurrent disease and succumb to it within five years of diagnosis. While there has been much progress in characterizing the pathways that contribute to stable genetic drug resistance, the mechanisms underlying early reversible resistance, also known as persisters-driven resistance, remain largely unknown. It has long been believed that persisters represent a subset of cells that happen to be non-proliferating at the time of treatment, and therefore can survive drugs that preferentially kill rapidly proliferating cells. However, in my talk I will describe a rare persister population which, despite not harboring any resistance-conferring mutation, can maintain proliferative capacity in the presence of drug. To study this rare, transiently-resistant, cycling persister population, we developed Watermelon, a high-complexity expressed barcode lentiviral library for simultaneous tracing of each cell’s clonal origin and proliferative and transcriptional states. We combine single cell transcriptomics with imaging and metabolomics to show that cycling and non-cycling persisters arise from different cell lineages with distinct transcriptional and metabolic programs. Finally, I will describe how by studying persister cells we can gain critical insights on cellular memory, fate, and evolution, which can guide the development of better anti-cancer treatments.

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Special guest seminar with Dr. Inna Ricardo-Lax

Type: Lecture

Date: Jul 20, 2021

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Inna Ricardo-Lax

OrganizerGuest Lecture

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Molecular Genetics departmental seminar with Omri Gilhar

Type: Lecture

Date: Jun 27, 2021

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmri Gilhar

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Molecular Genetics Departmental seminar with Nancy Yacovzada

Type: Lecture

Date: Jun 20, 2021

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNancy Yacovzada

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Molecular Genetics Departmental seminar with Daoud Sheiban

Type: Lecture

Date: Jun 13, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDaoud Sheiban

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Molecular Genetics Departmental seminar with Yotam David

Type: Lecture

Date: Jun 06, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYotam David

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Molecular Genetics Departmental seminar with Sveta Markman

Type: Lecture

Date: May 30, 2021

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSvetlana Markman

OrganizerDDP Seminar

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Departmental seminar with Michal Schwartz

Type: Lecture

Date: May 23, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michal Schwartz

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Seminar for PhD thesis defense - Aya Shkedy

Type: Lecture

Date: May 13, 2021

Time12:00 - 13:00

LecturerAya Shkedy

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Departmental Seminar with Lena Sapoznikov

Type: Lecture

Date: May 09, 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLena Sapoznikov

OrganizerStudent and Post-Doc Seminar

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Seminar for Thesis defense of Gat Krieger

Type: Lecture

Date: Apr 25, 2021

Time13:30 - 14:30

LecturerGat Krieger

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ILASOL 2021 Conference

Type: Lecture

Date: Apr 20, 2021

Time00:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contactamit.kahana@weizmann.ac.il

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Seminar for PhD thesis defense - Moran Shalev

Type: Lecture

Date: Apr 18, 2021

Time11:00

LecturerMoran Shalev

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Seminar for PhD thesis defense

Type: Lecture

Date: Apr 11, 2021

Time15:00 - 16:00

LecturerGal Ofir

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Molecular Genetics Departmental Seminar

Type: Lecture

Date: Apr 11, 2021

Time13:00 - 13:30

LecturerNadav Goldberg

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Departmental Seminar

Type: Lecture

Date: Apr 04, 2021

Time13:00 - 13:30

LecturerSivan Kaminski

OrganizerStudent and Post-Doc Seminar

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Seminar for MSc thesis defense - Nadav Goldberg

Type: Lecture

Date: Mar 22, 2021

Time10:00 - 11:00

LecturerNadav Goldberg

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Department of Molecular Genetics departmental seminar

Type: Lecture

Date: Mar 21, 2021

Time13:00 - 13:30

LecturerNir Cohen

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Department of Molecular Genetics departmental seminar

Type: Lecture

Date: Mar 14, 2021

Time13:00 - 13:30

LecturerSarah Rubin

OrganizerStudent and Post-Doc Seminar

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Department of Molecular Genetics department seminar

Type: Lecture

Date: Mar 07, 2021

Time13:00 - 13:30

LecturerJohannes Auth

OrganizerStudent and Post-Doc Seminar

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Seminar for PhD thesis defense - Lior Lasman

Type: Lecture

Date: Feb 24, 2021

Time10:00 - 11:00

LecturerLior Lasman

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Molecular Genetics Departmental Seminar

Type: Lecture

Date: Feb 14, 2021

Time13:00

LecturerTamar Gera

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Seminar for PhD thesis defense - Revital Ravid

Type: Lecture

Date: Feb 07, 2021

Time10:00

LecturerRevital Ravid

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PhD Thesis defense - Orel Mizrahi

Type: Lecture

Date: Jan 24, 2021

Time11:00 - 12:00

LecturerOrel Mizrahi

Websitehttps://weizmann.zoom.us/j/98492519654?pwd=a0lNd1ROc0kwTXBaUnI4M0R2aENOdz09

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Departmental seminar with Anna Uzonyi

Type: Lecture

Date: Jan 17, 2021

Time13:00 - 13:30

LecturerAnna Uzonyi

OrganizerStudent and Post-Doc Seminar

Websitehttps://weizmann.zoom.us/j/96260232296?pwd=ck16LzU2SjdWNU80eFZRWUNTbXpPUT09

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Departmental seminar with Nelly Frenkel

Type: Lecture

Date: Jan 10, 2021

Time13:00 - 13:30

LecturerNelly Frenkel

OrganizerStudent and Post-Doc Seminar

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Special zoom joint guest seminar

Type: Lecture

Date: Jan 07, 2021

Time11:00 - 12:00

LecturerDr. Anat Florentin

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Special Guest Seminar - David Gokhman

Type: Lecture

Date: Dec 27, 2020

Time10:00

LecturerDr. David Gokhman

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Molecular Genetics Departmental Seminar with Yaara Finkel

Type: Lecture

Date: Dec 06, 2020

Time13:00

LecturerYaara Finkel

OrganizerStudent and Post-Doc Seminar

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Seminar for thesis definse of Dvir Schirman

Type: Lecture

Date: Dec 03, 2020

Time11:00

LecturerDvir Schirman

OrganizerSeminar

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Seminar for thesis defense, Moria Weiss

Type: Lecture

Date: Dec 02, 2020

Time10:00 - 11:00

LecturerMoria Weiss

OrganizerSeminar

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Seminar for thesis defense - Shiri Kult

Type: Lecture

Date: Dec 01, 2020

Time16:00

LecturerShiri Kult

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Molecular Genetics departmental seminar with Sharon Ben-Hur

Type: Lecture

Date: Nov 29, 2020

Time13:00

LocationDolfi and Lola Ebner Auditorium

LecturerSharon Ben-Hur

OrganizerSeminar

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Molecular Genetics departmental seminar with Orel Mizrahi

Type: Lecture

Date: Nov 22, 2020

Time13:00

LocationDolfi and Lola Ebner Auditorium

LecturerOrel Mizrahi

OrganizerDDP Seminar

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Seminar for thesis defense

Type: Lecture

Date: Nov 18, 2020

Time13:00 - 14:00

LecturerNelly Frenkel

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seminar for thesis defense with Jonathan Bayerl

Type: Lecture

Date: Nov 17, 2020

Time13:00

LecturerJonathan Bayerl

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Special guest seminar with Dr. Yosef Kaplan Dor

Type: Lecture

Date: Nov 16, 2020

Time16:00

LecturerDr. Yosef Dor Kaplan

OrganizerGuest Lecture

AbstractSleep is ubiquitous in the animal kingdom, but its function has been a mystery. Besides its importance for the brain, sleep appears to play an essential physiological role, emphasized by the fact that severe sleep loss can be lethal. The cause of this lethality was unknown. We found that extreme sleep deprivation results in high levels of reactive oxygen species (ROS) that trigger oxidative stress specifically in the gut of flies and mice. Using flies, we show that neutralization of intestinal ROS prevents premature death of sleep-deprived animals, suggesting a causal link between ROS accumulation in the gut and lethality upon sleep loss. What may explain the observed phenomena? Could it teach us about the normal, daily function of sleep? In the second part of my talk, I will present our current attempts and preliminary data aiming at answering these questions.

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Seminar for thesis defense with Unnikannan CP

Type: Lecture

Date: Nov 16, 2020

Time10:00

LecturerUnnikannan CP

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Molecular Genetics departmental seminar

Type: Lecture

Date: Nov 15, 2020

Time13:00

LecturerNaama Zung

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Departmental seminar

Type: Lecture

Date: Nov 08, 2020

Time13:00

LecturerHagai Marmor

OrganizerStudent and Post-Doc Seminar

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Department seminar with Batsheva Rozman

Type: Lecture

Date: Oct 25, 2020

Time13:00 - 14:00

LecturerBatsheva Rozman

OrganizerStudent and Post-Doc Seminar

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Braginsky Center for the Interface between Science and the Humanities zoom lecture with Prof. Mario Livio

Type: Lecture

Date: Oct 19, 2020

Time16:00 - 17:00

LecturerProf. Mario Livio

OrganizerSpecial Guest Seminar

AbstractA fresh biography of Galileo Galilei which puts his scientific discoveries in context. Disturbed by rampant science denial in America—and around the world—that has only intensified in recent years, I began researching the life, ideas, and actions of this brilliant man who encountered similar pressures centuries ago. The result is a biography filled with lessons relevant for today—whether with respect to trusting the advice given by scientists in relation to COVID-19, the reality of climate change, the efficacy of vaccines, or the teaching of creationist theories in schools. I will discuss these topics in this talk.

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Special zoom Seminar with Dr. Dvir Gur

Type: Lecture

Date: Oct 14, 2020

Time10:00 - 11:00

LecturerDr. Dvir Gur

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Special zoom seminar with Dr. Dan Landau

Type: Lecture

Date: Sep 30, 2020

Time16:00 - 17:00

LecturerDr. Dan Landau

OrganizerGuest Lecture

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Departmental Seminar by Mira Rosenthal & Lia Yerushalmi

Type: Lecture

Date: Jul 05, 2020

Time13:00 - 14:00

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Departmental seminar by Miri Shnayder

Type: Lecture

Date: Jun 28, 2020

Time13:00 - 13:45

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Developmental Club Series 2019-20-cancelled

Type: Lecture

Date: Jun 24, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ori Avinoam

OrganizerDevelopmental Club

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Departmental Seminar by Romano Strobelt

Type: Lecture

Date: Jun 21, 2020

Time13:00 - 13:45

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Departmental Seminar by Aya Shkedy

Type: Lecture

Date: Jun 14, 2020

Time13:00 - 14:00

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Developmental Club Series 2019-20 - cancelled

Type: Lecture

Date: Jun 10, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Arama

OrganizerDevelopmental Club

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Departmental Seminar by Kamalesh Kumari

Type: Lecture

Date: Jun 07, 2020

Time13:00 - 13:45

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Departmental seminar by Aude Bernheim

Type: Lecture

Date: May 31, 2020

Time13:00 - 13:45

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Developmental Club Series 2019-20

Type: Lecture

Date: May 27, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

OrganizerDevelopmental Club

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POSTPONED: Braginsky Center for the interface between the Science and the Humanities

Type: Lecture

Date: May 25, 2020

Time14:00 - 15:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Menachem Fisch

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Departmental Seminar by Daria Amiad-Pavlov

Type: Lecture

Date: May 24, 2020

Time13:00 - 14:00

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Developmental Club Series 2019-20

Type: Lecture

Date: May 20, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yonatan Stelzer

OrganizerDevelopmental Club

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Developmental Club Series 2019-20

Type: Lecture

Date: May 13, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Efrat Shema

OrganizerDevelopmental Club

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Developmental Club Series

Type: Lecture

Date: May 06, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Amir Sapir

OrganizerDevelopmental Club

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Departmental Seminar by Lihi Ben Reuven & Miri Shnayder

Type: Lecture

Date: May 03, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Developmental Club Series 2019-20

Type: Lecture

Date: Apr 22, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

OrganizerDevelopmental Club

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Departmental Seminar by Nir Cohen & TBD

Type: Lecture

Date: Apr 19, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Decoding transcriptional regulation in Drosophila

Type: Lecture

Date: Apr 07, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Stark

OrganizerPhysics distinguished

Contactigor.ulitsky@weizmann.ac.il

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TBA - cancelled

Type: Lecture

Date: Apr 01, 2020

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Sperling

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POSTPONED: Departmental Seminar by Daria Amiad-Pavlov & Lia Yerushalmi

Type: Lecture

Date: Mar 29, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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POSTPONED: Developmental Club Series with Elazar Zelzer

Type: Lecture

Date: Mar 25, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerElazar Zelzer

OrganizerDevelopmental Club

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Seminar for Thesis Defense- Roni Winkler

Type: Lecture

Date: Mar 19, 2020

Time11:30 - 12:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRoni Winkler

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Departmental Seminar by Gat Krieger & Kamalesh Kumari

Type: Lecture

Date: Mar 15, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Azrieli Institute for Systems Biology

Type: Lecture

Date: Mar 04, 2020

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dieter Ebert

OrganizerSystem Biology

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Departmental Seminar by Rami Tshuva & Dvir Schirman

Type: Lecture

Date: Mar 01, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Molecular Genetics special guest seminar

Type: Lecture

Date: Feb 27, 2020

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gilad Barnea

OrganizerSeminar

AbstractI will present trans-Tango, a new technique for anterograde transsynaptic circuit tracing and manipulation that we have established in fruit flies. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell-surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined neurons, thereby activating the pathway in their postsynaptic partners. Activation of the pathway culminates in expression of a reporter that can be visualized. Because our system is modular, it can be easily adapted to experiments in which the properties of specific circuits are modified and the functional consequences are analyzed. We first validated trans-Tango in the Drosophila olfactory system and then implemented it in the gustatory system, where projections beyond the firstorder receptor neurons are not well characterized. We identified second-order neurons within the sweet and bitter circuits and revealed that they target brain areas involved in neuromodulation with similar but distinct projection patterns. I will also present experiments in which we use trans-Tango in functional analysis of the gustatory circuits. Using our studies in flies as proof of concept, we are currently establishing an equivalent technique for labeling circuits in vertebrate models, such as mice and zebrafish. These experiments establish trans-Tango as a flexible platform for comprehensive transsynaptic analysis of neural circuits.

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Developmental Club Series 2019-20

Type: Lecture

Date: Feb 26, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

OrganizerDevelopmental Club

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Departmental Seminar by Sagie Brodsky & Noa Novershtern

Type: Lecture

Date: Feb 16, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Seminar for thesis defense - Karen Fridman Talmon

Type: Lecture

Date: Feb 13, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKaren Fridman Talmon

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Special Guest Seminar with Prof. Detlef Wiegel

Type: Lecture

Date: Feb 12, 2020

Time11:30 - 12:30

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerProf. Detlef Wiegel

OrganizerJoint Seminar

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Developmental Club Series 2019-20

Type: Lecture

Date: Feb 12, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Takashi Kawashima

OrganizerDevelopmental Club

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Special Guest Seminar

Type: Lecture

Date: Feb 05, 2020

Time11:30 - 12:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. David Zeevi

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Developmental Club Series 2019-20

Type: Lecture

Date: Feb 05, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Meital Oren

OrganizerDevelopmental Club

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture

Date: Feb 02, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Next Gen Immunology 2020

Type: conference

Date: Feb 02, 2020

Time08:00

LocationMichael Sela Auditorium

Websitehttps://www.weizmann.ac.il/conferences/NGI2020/

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Developmental Club Series 2019-20

Type: Lecture

Date: Jan 29, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oren Schuldiner

OrganizerDevelopmental Club

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Department of Molecular Genetics Special guest seminar

Type: Lecture

Date: Jan 28, 2020

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Francesca Bartolini

OrganizerGuest Lecture

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Braginsky Center for the Interface between the Sciences and the Humanities

Type: Lecture

Date: Jan 27, 2020

Time11:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Oren Harman

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture

Date: Jan 19, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special Guest Seminar with Dr, Michael E. Ward

Type: Lecture

Date: Jan 16, 2020

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael E. Ward

OrganizerSpecial Guest Seminar

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Developmental Club Series 2019-20

Type: Lecture

Date: Jan 15, 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ido Amit

OrganizerDevelopmental Club

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture

Date: Jan 05, 2020

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Special Guest Seminar with Dr. Arbel Harpak

Type: Lecture

Date: Jan 02, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Arbel Harpak

OrganizerThe Azrieli Institute for Systems Biology

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Developmental Club Series 2019-20

Type: Lecture

Date: Jan 01, 2020

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Amnon Sharir, DVM, PhD.

OrganizerDevelopmental Club

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Special Guest Seminar with Dr. Onn Brandman

Type: Lecture

Date: Dec 30, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Onn Brandman

OrganizerGuest Lecture

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The Braginsky Center for the Interface between the Sciences and the Humanities

Type: Lecture

Date: Dec 30, 2019

Time11:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Reviel Netz

OrganizerFaculty of Mathematical Sciences Seminar

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Seminar for thesis defense, Nofar Mor

Type: Lecture

Date: Dec 29, 2019

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Mor

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Special guest seminar with Moran Dvela-Levitt

Type: Lecture

Date: Dec 22, 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMoran Dvela-Levitt

AbstractProtein homeostasis is critical for cellular function and survival. Dysregulation of the cellular protein homeostasis can lead to a build-up of misfolded proteins and facilitate the manifestation of a variety of pathological disorders including neurodegeneration, cancer and inflammation. Where and how the misfolded proteins accumulate, however, has remained a mystery. In studying MUC1 kidney disease (a rare kidney disorder), we have found that some of these pathologies may share a single, previously unrecognized cellular mechanism: a jam at a specific step in the secretory pathway involving a cargo receptor called TMED9. A small molecule called BRD4780 can break the jam and restore cells to normal function, providing a promising potential for therapeutic developments.

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Seminar for thesis defense, Maya Voichek

Type: Lecture

Date: Dec 19, 2019

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaya Voichek

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Special Guest Seminar

Type: Lecture

Date: Dec 18, 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Orly Laufman

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Developmental Club Series 2019-20

Type: Lecture

Date: Dec 18, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaron Antebi

OrganizerDevelopmental Club

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture

Date: Dec 15, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Developmental Club Series 2019-20

Type: Lecture

Date: Dec 11, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Avraham Yaron

OrganizerDevelopmental Club

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Seminar for thesis Defense - Zohar Erez

Type: Lecture

Date: Dec 08, 2019

Time15:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerZohar Erez

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Special Guest Seminar

Type: Lecture

Date: Dec 02, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNevan Krogan

OrganizerSystem Biology

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Braginsky Center for the Interface between the Sciences and the Humanities, special guest lecture with Daniel Matt

Type: Lecture

Date: Dec 01, 2019

Time16:00 - 17:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Daniel Matt

OrganizerGuest Lecture

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Departmental Seminar - Molecular Genetics Dept.

Type: Lecture

Date: Dec 01, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Seminar for thesis defense Naama Dekel

Type: Lecture

Date: Oct 30, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNaama Dekel

OrganizerSeminar

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Special Guest Seminar

Type: Lecture

Date: Oct 27, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Peter Tsvetkov

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Special Guest Seminar with Anat Zimmer

Type: Lecture

Date: Oct 03, 2019

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnat Zimmer

OrganizerThe Azrieli Institute for Systems Biology

AbstractIt is a challenge to answer questions like: why some people develop a disease, react to a specific treatment and/or develop severe side-effects while others don’t. In order to explain these occurrences, one has to take a holistic approach and study the body physiology from a systems level perspective. Longitudinal multi-omics measurements together with genetics, on a large population, can serve such a purpose and help in predicting, reasoning, and preventing diseases. In partnership with Arivale Inc., we have developed infrastructure to collect longitudinal Personalized Dense Dynamic Data clouds (PD3 clouds) on thousands of individuals, which include genetics and longitudinal measurements of clinical labs, microbiome, metabolome, proteome, and self-reported data. The value of these extremely high-dimensional data clouds is clear; however, it also comprises a challenge in data analysis and interpretation. One way to reduce data dimensionality is called Pareto Task Inference (PARTI, Hart et al. 2015). We used this method to analyze the clinical labs and found that the data falls on a significant tetrahedron. The 4 vertices are archetypes that specialize in a certain task. Using all other datatypes, we identified enriched traits next to every archetype and revealed the underline tradeoffs that shape the data. This distinctive analysis uncovers unexpected relationships between datasets such as metabolomics, proteomics and clinical labs, and helps in interconnecting the different datatypes to characterize different states of human health.

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Special Guest Seminar with Dr. Johnathan Cooper-Knock

Type: Lecture

Date: Sep 05, 2019

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Johnathan Cooper-Knock

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Special Guest Seminar with Ophir Shalem

Type: Lecture

Date: Aug 22, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOphir Shalem, Ph.D

OrganizerThe Azrieli Institute for Systems Biology

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Developmental Club Series 2018-2019

Type: Lecture

Date: Jul 31, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ori Avinoam

OrganizerDevelopmental Club

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Special Guest Seminar

Type: Lecture

Date: Jul 21, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerClaire Thomas

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Shoulder Injury Seminar Department of Molecular Genetics

Type: Lecture

Date: Jul 18, 2019

Time09:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Louis J. Soslowsky, Ph.D

OrganizerDevelopmental Club

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Special Guest Seminar

Type: Lecture

Date: Jul 16, 2019

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yael Weiss

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Developmental Club Series 2018-2019

Type: Lecture

Date: Jul 03, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Amrutha Swaminathan

OrganizerDevelopmental Club

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Departmental Seminar

Type: Lecture

Date: Jun 30, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Barshir

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Developmental Club Series 2018-2019

Type: Lecture

Date: Jun 26, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nadav Ahituv

OrganizerDevelopmental Club

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Developmental Club

Type: Lecture

Date: Jun 19, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Hornstein

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Departmental Seminar

Type: Lecture

Date: Jun 16, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAldema Sas Chen

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Developmental Club Series 2018-2019

Type: Lecture

Date: Jun 12, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEfrat Shema

OrganizerDevelopmental Club

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Developmental Club Series 2018-2019

Type: Lecture

Date: Jun 12, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEfrat Shema

OrganizerDevelopmental Club

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Departmental Seminar

Type: Lecture

Date: Jun 02, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHarsh Maan

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Developmental Club

Type: Lecture

Date: May 29, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Shalev Itzkovitz

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Departmental Seminar

Type: Lecture

Date: May 26, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Finkel

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Departmental Seminar

Type: Lecture

Date: May 19, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerQihui Hou

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Polymerizing the Fiber Between Bacterial Biofilms and Human Amyloids

Type: Lecture

Date: May 16, 2019

Time10:00 - 11:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerProf. Matthew Chapman

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Molecular Genetics Departmental Retreat

Type: Lecture

Date: May 14, 2019

Time00:00

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Cross regulation between the apoptotic cascade and the unfolded protein response

Type: Lecture

Date: May 13, 2019

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvi Ashkenazi

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Departmental Seminar

Type: Lecture

Date: May 12, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHagai Marmor

OrganizerDDP Seminar

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Developmental Club Series 2018-2019

Type: Lecture

Date: May 07, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOphir Klein

OrganizerDevelopmental Club

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Seminar for thesis defense

Type: Lecture

Date: May 05, 2019

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Felsenthal

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Developmental Club Series 2018-2019

Type: Lecture

Date: May 01, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Benny Shilo

OrganizerDevelopmental Club

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Departmental Seminar

Type: Lecture

Date: Apr 28, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInes Castro

OrganizerDDP Seminar

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Developmental Club Series 2018-2019

Type: Lecture

Date: Apr 17, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYonatan Stelzer

OrganizerDevelopmental Club

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Special Guest Seminar with Dr. Markus Mund

Type: Lecture

Date: Apr 16, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Markus Mund

OrganizerGuest Lecture

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Special Guest Seminar with prof. Johannes Herrmann

Type: Lecture

Date: Apr 11, 2019

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dr. Johannes Herrmann

OrganizerGuest Lecture

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Special guest seminar

Type: Lecture

Date: Apr 04, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrea Pauli

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Developmental Club Series 2018-2019

Type: Lecture

Date: Apr 03, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrea Pauli

OrganizerDevelopmental Club

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture

Date: Mar 26, 2019

Time13:00

LecturerYael Cohen Sharir

OrganizerSeminar

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Developmental Club Series 2018-2019

Type: Lecture

Date: Mar 20, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Hornstein

OrganizerDevelopmental Club

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Developmental Club Series 2018-2019

Type: Lecture

Date: Mar 20, 2019

Time10:00 - 11:00

LocationCamelia Botnar Building

LecturerHannes Buelow

OrganizerDevelopmental Club

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture

Date: Mar 19, 2019

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Metzl Raz

OrganizerSeminar

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture

Date: Mar 17, 2019

Time09:00 - 10:00

LecturerMarianna Riutin

OrganizerSeminar

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Developmental Club Series 2018-2019

Type: Lecture

Date: Mar 13, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

OrganizerDevelopmental Club

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Developmental Club Series 2018-2019

Type: Lecture

Date: Mar 06, 2019

Time09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMeital Oren

OrganizerDevelopmental Club

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Feb 24, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEden Yifrach

OrganizerStudent and Post-Doc Seminar

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Seminar for thesis defense

Type: Lecture

Date: Feb 20, 2019

Time14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Noiman

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Developmental Club Series 2018-2019

Type: Lecture

Date: Feb 06, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oren Schuldiner

OrganizerDevelopmental Club

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"Mechanisms of asymmetric cell division"

Type: Lecture

Date: Jan 28, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yves Barral

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Jan 27, 2019

Time00:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaayan Barnea

OrganizerDDP Seminar

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Special Guest Seminar with Prof. Meytal Landau

Type: Lecture

Date: Jan 22, 2019

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Meytal Landau

OrganizerGuest Lecture

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Special Guest Seminar with Dan Bracha

Type: Lecture

Date: Jan 17, 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDan Bracha

OrganizerSpecial Guest Seminar

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Special Guest Seminar with Ariel Schwartz

Type: Lecture

Date: Jan 17, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ariel Schwartz

OrganizerGuest Lecture

AbstractComputational assignment of function to proteins with no known homologs is still an unsolved problem. We have created a novel, function-based approach to protein annotation and discovery called D-SPACE (Deep Semantic Protein Annotation Classification and Exploration), comprised of a multi-task, multi-label deep neural network trained on over 70 million proteins. Distinct from homology and motif-based methods, D-SPACE encodes proteins in high-dimensional representations (embeddings), allowing the accurate assignment of over 180,000 labels for 13 distinct tasks. The embedding representation enables fast searches for functionally related proteins, including homologs undetectable by traditional approaches. D-SPACE annotates all 109 million proteins in UniProt in under 35 hours on a single computer and searches the entirety of these in seconds. D-SPACE further quantifies the relative functional effect of mutations, facilitating rapid in-silico mutagenesis for protein engineering applications. D-SPACE incorporates protein annotation, search, and other exploratory efforts into a single cohesive model. We have recently extended this work from protein to DNA, enabling assignment of function to whole genomes and metagenomic contigs in seconds. Conserved genomic motifs as well as the functional impact of mutations in coding as well as non-coding genomic regions can be predicted directly from raw DNA sequence without the use of traditional comparative genomics approaches for motif detection, such as multiple sequence alignments, PSSMs, and profile HMMs.

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Special Guest Seminar with Dr. Shai Carmi

Type: Lecture

Date: Jan 16, 2019

Time11:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Shai Carmi

AbstractIn this talk, I will review recent work by myself and others on Jewish population and medical genetics, focusing on Ashkenazi Jews (AJ). I will describe the mixture events of AJ in Europe, the founder event they have experienced in the late Middle Ages, and their connections to ancient populations of the Levant. I will then describe large-scale genomic databases that we have recently generated for AJ, and the opportunities they open in medical genetics given the unique AJ demographic history. I will describe a few medical genetics projects including carrier screening, genome-wide association studies of microbiome composition and other traits, and preimplantation genetic diagnosis.

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Jan 13, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJulie Tai

OrganizerDDP Seminar

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Developmental Club Series 2018-2019

Type: Lecture

Date: Jan 09, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBruno Lemaitre

OrganizerDevelopmental Club

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“The Foreign within: Drosophilia-Spiroplasma interaction as a model of insect endosymbiosis”

Type: Lecture

Date: Jan 09, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBruno Lemaitre

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Large-scale genomic investigations of psychiatric and neurodevelopmental disorders and their connection to somatic disease in the Danish population

Type: Lecture

Date: Jan 07, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRon Nudel

ContactSimon.Fishilevich@weizmann.ac.il

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Jan 06, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

OrganizerDDP Seminar

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Jan 06, 2019

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

OrganizerDDP Seminar

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Smaller is better

Type: Lecture

Date: Jan 03, 2019

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Klaus Herick

ContactMoran.Shalev@weizmann.ac.il

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Developmental Club Series 2018-19

Type: Lecture

Date: Dec 26, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Lecturer Eldad Tzahor

OrganizerDevelopmental Club

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Dec 16, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInna Averbukh

OrganizerDDP Seminar

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Joint mini-symposium

Type: Lecture

Date: Dec 13, 2018

Time11:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Joel Richter

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Developmental Club Series 2018-19

Type: Lecture

Date: Dec 12, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Elazar Zelzer

OrganizerDevelopmental Club

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one2many2018 - A System View of Biology

Type: conference

Date: Dec 09, 2018

Time08:00

LocationThe David Lopatie Conference Centre

Websitehttp://www.weizmann.ac.il/conferences/one2many2018/

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Developmental Club Series 2018-2019, special guest seminar

Type: Lecture

Date: Dec 05, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Naihe Jing

OrganizerDevelopmental Club

AbstractDuring postimplantation development of the mouse embryo, descendants of the inner cell mass cells in the early epiblast transit from the naïve pluripotent state to the primed pluripotent state. Concurrent with the transition of the pluripotency states is the specification of cell lineages and formation of germ layers in the embryos that serves as the blueprint for embryogenesis. Fate mapping and lineage analysis studies have revealed that cells in different regions of the germ layers acquire location-specific cell fates during gastrulation. The regionalization of cell fates heralding the formation of the basic body plan is conserved in vertebrate embryos at a common phylotypic stage of development. Knowledge of the molecular regulation that underpins the lineage specification and tissue patterning is instrumental for understanding embryonic programming and stem cell-based translational study. However, a genome-wide molecular annotation of lineage segregation and tissue architecture of post-implantation embryo has yet to be undertaken. Here, we reported a spatially resolved transcriptome of cell populations at defined positions in the germ layers over the period of pre- to late gastrulation development. This spatio-temporal transcriptome provides high resolution digitized in situ gene expression profiles and defines the molecular attribute of the genealogy of lineages and continuum of pluripotency states in time and space. The transcriptome further identifies the networks of molecular determinants that drive lineage specification and tissue patterning in the early postimplantation mouse embryo.

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Dec 02, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Gabzi

OrganizerStudent and Post-Doc Seminar

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Developmental Club Series 2018-2019

Type: Lecture

Date: Nov 28, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nathan Lawson

OrganizerDevelopmental Club

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture

Date: Nov 26, 2018

Time13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRivi Halimi

OrganizerSeminar

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Nuclear Genome Nanostructure Imaging at Single Molecule Resolution

Type: Lecture

Date: Nov 20, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Christoph Cremer

OrganizerDevelopmental Club

AbstractSuper-resolution fluorescence microscopy allows quantitative studies of nuclear genome organization on the nanoscale1. Here we report on results obtained by single molecule localization microscopy (SMLM). SMLM has made possible to explore chromatin nanostructure down to the imaging of single histones, of short oligosequences, or single DNA sites; presently, an intranuclear optical resolution down to the 5 nm range has been achieved. Applying a novel SMLM technique (fBALM)2, the DNA distribution across entire nuclei at nanoscale resolution was quantitatively determined, localizing in individual nuclear optical sections up to ~4 million individual DNA bound single fluorophore molecule positions, corresponding to about one position per nucleosome. Intensity profile analyses of the intranuclear DNA distributions indicated sharp transitions between high-density domains and low-density compartments, with differences up to almost two orders of magnitude; compacted regions had a minimum diameter down to ca. 50 nm diameter. In contrast to these results, conventional resolution imaging of the same nuclear sites indicated only small differences in the compaction of different regions, combined with very smooth density transitions. Taken together, the quantitative compaction estimates support models of a nuclear organization based on highly compartmentalized chromatin nanostructures3.

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Special Guest Seminar

Type: Lecture

Date: Nov 19, 2018

Time10:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerDr. Nadav Sharon

OrganizerSpecial Guest Seminar

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Nov 18, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Rahimi

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture

Date: Nov 18, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Rahimi

OrganizerStudent and Post-Doc Seminar

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Special Guest Seminar

Type: Lecture

Date: Nov 08, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eugene Rosenberg

OrganizerSpecial Guest Seminar

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Developmental Club Series 2018-2019

Type: Lecture

Date: Oct 31, 2018

Time10:00

LocationCamelia Botnar Building

LecturerKarina Yaniv

OrganizerDevelopmental Club

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Seminar for thesis defense

Type: Lecture

Date: Oct 11, 2018

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerUri Weill

OrganizerSeminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: Jul 18, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Arama

OrganizerDevelopmental Club

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture

Date: Jul 04, 2018

Time15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDoreen Ben-Zvi

OrganizerSeminar

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Jul 01, 2018

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKarin Broennimann

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Jun 24, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLihi Ben-Reuven

OrganizerStudent and Post-Doc Seminar

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Special Guest Seminar

Type: Lecture

Date: Jun 20, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNava Segev

OrganizerSpecial Guest Seminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: Jun 20, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOri Avinoam

OrganizerDevelopmental Club

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Jun 17, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRonit Suissa

OrganizerStudent and Post-Doc Seminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: Jun 06, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerCarmine Settembre, PhD

OrganizerDevelopmental Club

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Jun 03, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoa Dahan

OrganizerStudent and Post-Doc Seminar

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Contrary to Dogma: Tau is not a stabilizer of microtubules in the axon

Type: Lecture

Date: May 29, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Peter W. Baas

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Building the pathway for motion vision

Type: Lecture

Date: May 27, 2018

Time12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Claude Desplan

OrganizerDevelopmental Club

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Developmental Club Series 2017-2018

Type: Lecture

Date: May 23, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShalev Itzkovitz

OrganizerDevelopmental Club

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Developmental Club Series 2017-2018

Type: Lecture

Date: May 16, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jerome Gros

OrganizerDevelopmental Club

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Accelerating bio discovery with machine learning

Type: Lecture

Date: May 15, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerPhilip Nelson

OrganizerThe Azrieli Institute for Systems Biology

AbstractGoogle Accelerated Sciences is a translational research team that brings Google's technological expertise to the scientific community. Recent advances in machine learning have delivered incredible results in consumer applications (e.g. photo recognition, language translation), and is now beginning to play an important role in life sciences. Taking examples from active collaborations in the biochemical, biological, and biomedical fields, I will focus on how our team transforms science problems into data problems and applies Google's scaled computation, data-driven engineering, and machine learning to accelerate discovery.

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Leica Biosystems

Type: Lecture

Date: May 15, 2018

Time10:00 - 11:30

LocationRaoul and Graziella de Picciotto Building for Scientific and Technical Support

LecturerDr. Dorothee Lasrich

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Cyagen technologies

Type: Lecture

Date: May 14, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Matthew Wheeler

OrganizerThe Arthur & Rochelle Belfer Institute of Mathematics and Computer Science

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: May 13, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRoni Winkler

OrganizerStudent and Post-Doc Seminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: May 09, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. James Sharpe

OrganizerDevelopmental Club

AbstractThe vertebrate limb bud is a classical model system for developmental biology – with the advantage of having been studied for many decades. Despite this, and despite its relatively simple shape, a consensus model of its physical morphogenesis has not been reached. I will introduce our own hypothesis on limb bud morphogenesis – convergent-extension coupled with tissue growth – and contrast it to previous ideas. I will introduce a 3D dynamical model which captures this hypothesis (a Cellular Potts Model) and also discuss our ongoing improvements to these simulations.

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Atlases of structure-function relationships in small motifs: the limits of modularity

Type: Lecture

Date: May 08, 2018

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. James Sharpe

OrganizerSystem Biology

AbstractAbstract: I will discuss our work on visualizing “topology atlases” which act as a map of possible circuit designs for small 3-node regulatory motifs. These can help in understanding the relationship between a circuit's structure and its function, but how is this relationship affected if the circuit must perform multiple distinct functions within the same organism? In particular, to what extent do multi‐functional circuits contain modules which reflect the different functions? We computationally surveyed a range of bi‐functional circuits which show no simple structural modularity: They can switch between two qualitatively distinct functions, while both functions depend on all genes of the circuit. Our analysis revealed two distinct classes: hybrid circuits which overlay two simpler mono‐functional sub‐circuits within their circuitry, and emergent circuits, which do not. In this second class, the bi‐functionality emerges from more complex designs which are not fully decomposable into distinct modules and are consequently less intuitive to predict or understand. These non‐intuitive emergent circuits are just as robust as their hybrid counterparts, and we therefore suggest that the common bias toward studying modular systems may hinder our understanding of real biological circuits. Relevant papers: 1. A spectrum of modularity in multi-functional gene circuits. Jiménez A, Cotterell J, Munteanu A, Sharpe J. (2017) Mol Syst Biol 13(4):925. doi: 10.15252/msb.20167347 http://msb.embopress.org/content/13/4/925 2. An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients. Cotterell J, Sharpe J. (2010) Mol Syst Biol 6:425. doi: 10.1038/msb.2010.74 http://msb.embopress.org/content/6/1/425 Bio: James Sharpe was originally captivated by computer programming, but upon learning about the digital nature of the genetic code, chose to study Biology for his undergraduate degree at Oxford University (1988-1991). He then did his PhD on the genetic control of embryo development at NIMR, London (1992-1997) and in parallel started writing computer simulations of multicellular development. During his post-doc in Edinburgh, he began modelling the dynamics of limb development, and also invented a new optical imaging technology called Optical Projection Tomography (OPT), which is dedicated to imaging specimens too large for microscopy - tissues and organs. In 2006 he moved to Barcelona, becoming a senior group leader at the Centre for Genomic Regulation, and focusing on a systems biology approach to modelling limb development – combining experimentation with computer modelling. In this way the group demonstrated that the signalling proteins which pattern the fingers during embryogenesis, act as a Turing reaction-diffusion system. In 2011 he became the coordinator of the Systems Biology Program, and in 2017 was recruited to EMBL as Head of the new Barcelona outstation on Tissue Biology and Disease Modelling.

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Molecular Genetics Departmental Seminar

Type: Lecture

Date: Apr 29, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvigail Stokar

OrganizerStudent and Post-Doc Seminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: Apr 25, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ben-Zion Shilo

OrganizerDevelopmental Club

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Developmental Club Series 2017-2018

Type: Lecture

Date: Apr 25, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBenny Shilo

OrganizerDevelopmental Club

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Apr 22, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAlona keren-Paz

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Apr 15, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRivi Halimi

OrganizerStudent and Post-Doc Seminar

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Special Guest Seminar

Type: Lecture

Date: Apr 11, 2018

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvi Ashkenazi, PhD

OrganizerSpecial Guest Seminar

AbstractPrecise protein folding by the endoplasmic reticulum (ER) supports homeostasis, while cumulative protein misfolding causes ER stress and promotes disease. The kinases PERK and IRE1 help orchestrate the unfolded protein response (UPR) to alleviate ER stress; however, if stress persists, the UPR activates apoptosis to eliminate the damaged cell. We have previously shown that PERK drives cell death via transcriptional up-regulation of the pro-apoptotic death receptor DR5; we further showed that IRE1—which harbors both kinase and RNase modules—blocks apoptosis through regulated IRE1-dependent mRNA decay (RIDD) of DR5 (Lu et al, Science 2014). Recently, we turned to investigate the paradoxical observation that under irresolvable ER stress PERK activity persists, while IRE1 function attenuates. We discovered that PERK governs the attenuation of IRE1, through a phosphatase called RNA polymerase II-associated protein 2 (RPAP2). RPAP2 reverses IRE1 phosphorylation, inhibiting IRE1 RNase activation. This disrupts IRE1-dependent generation of the cytoprotective transcription factor XBP1s and dampens ER-associated degradation of misfolded proteins. Furthermore, it inhibits RIDD, thereby licensing DR5-mediated caspase activation and apoptotic cell death. Thus, under excessive ER stress, PERK attenuates IRE1 via RPAP2 to abort failed adaptation and trigger an apoptotic cell fate.

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Special Guest Seminar

Type: Lecture

Date: Apr 11, 2018

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Avi Ashkenazi

OrganizerSpecial Guest Seminar

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Apr 08, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Chapal

OrganizerStudent and Post-Doc Seminar

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Barcoding evolution

Type: Lecture

Date: Mar 27, 2018

Time13:00

LocationCamelia Botnar Building

LecturerProf. Dmitri Petrov

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Mar 25, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRon Weiss

OrganizerStudent and Post-Doc Seminar

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Department of Molecular Genetics seminar for thesis defense

Type: Lecture

Date: Mar 25, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiraz Keidar

OrganizerSeminar

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Mini-Symposium on Genome, Transcriptome and Proteome

Type: Lecture

Date: Mar 11, 2018

Time14:30 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Mar 11, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Metzl-Raz

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Mar 11, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDaoud Sheban

OrganizerStudent and Post-Doc Seminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: Mar 07, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Orly Reiner

OrganizerDevelopmental Club

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Developmental Club Series 2017-2018

Type: Lecture

Date: Mar 07, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Orly Reiner

OrganizerDevelopmental Club

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Predator-prey interactions of nematophagous fungi and C. elegans

Type: Lecture

Date: Mar 01, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yen-Ping Hsueh

OrganizerDevelopmental Club

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Feb 25, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLia Yerushalmi

OrganizerStudent and Post-Doc Seminar

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Optimizations and trade-offs in cellular growth and survial

Type: conference

Date: Feb 25, 2018

Time08:00

LocationThe David Lopatie Conference Centre

Websitehttp://www.weizmann.ac.il/conferences/OTCGS2018/

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Developmental Club Series 2017-2018

Type: Lecture

Date: Feb 07, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

OrganizerDevelopmental Club

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Noncoding RNA in Health and Disease

Type: Lecture

Date: Jan 30, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nikolaus Rajewsky

OrganizerSystem Biology

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Jan 28, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShiran Maskit

OrganizerStudent and Post-Doc Seminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: Jan 24, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

OrganizerDevelopmental Club

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Functions and regulation of 3D genome organisation in development and disease

Type: Lecture

Date: Jan 23, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Francois Spitz

OrganizerSystem Biology

AbstractThe complex hierarchy of three-dimensional patterns that characterize the 3D folding of mammalian chromosomes appears as an important element in controlling gene expression. At the megabase scale, chromosomes are partitioned into domains that define two main compartments, corresponding to transcriptionally active and inactive regions, respectively. Each compartment domain is itself composed of distinct domains characterized by increased self-interactions called topological domains (TADs). Recent high-resolution Hi-C approaches revealed a finer-scale organisation of the genome in smaller “contact domains”, often associated with loops linking specific points. At these different scales, the spatial organisation of the genome shows tight correlation with its chromatin structure and its transcriptional activity. However, while steady progress is being made in describing the 3D folding of the genome at increased resolution, the mechanisms that determine this folding, its dynamic properties and the functional implications of these emerging features are still poorly understood. We use advanced genome tagging and engineering strategies, as well as targeted inactivation of factors involved in chromosomal folding to unravel the elements and mechanisms that drive the folding of large loci in specific yet dynamic conformations and their influence on gene expression. Our recent results show that the complex patterns of vertebrate HiC maps result from the superimposition of two distinct mechanisms: 1) a cohesin-independent mechanism which brings together regions of similar chromatin states 2) a cohesin-dependent folding that associate different small compartments into TADs. Within TADS, we show as well that enhancers are not acting in a homogeneous manner, but that their influence is distributed in complex patterns, partially guided by the underlying structure. I will discuss the different implications of these findings for our views of genome organisation.

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Molecular Genetics Departmental Seminar

Type: Lecture

Date: Jan 21, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Yanowski

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Special Guest Seminar

Type: Lecture

Date: Jan 21, 2018

Time10:00 - 11:00

LecturerDr. Nicolas Plachta

OrganizerGuest Lecture

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Frontiers in Systems Biology: Prof. Anshule Kundaje

Type: Lecture

Date: Jan 16, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Anshule Kundaje

OrganizerSystem Biology

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Jan 14, 2018

Time13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIdan Frumkin

OrganizerStudent and Post-Doc Seminar

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Molecular Genetics Special Guest Seminar

Type: Lecture

Date: Jan 10, 2018

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yoav Ram

OrganizerGuest Lecture

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Developmental Club Series 2017-2018

Type: Lecture

Date: Jan 10, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

OrganizerDevelopmental Club

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Perception and computation in cellular signaling pathways

Type: Lecture

Date: Jan 09, 2018

Time13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaron Antebi

OrganizerAdvancing Women in Science Office

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Single cell analysis of rare events in cancer

Type: Lecture

Date: Jan 09, 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Arjun Raj

OrganizerSystem Biology

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Molecular Genetics Departmental Seminar

Type: Lecture

Date: Jan 07, 2018

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDana Lorber

OrganizerSeminar

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Special Guest Seminar

Type: Lecture

Date: Dec 28, 2017

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRavit Boger, MD

OrganizerGuest Lecture

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Developmental Club Series 2017-2018

Type: Lecture

Date: Dec 27, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerElla Preger-Ben Noon

OrganizerDevelopmental Club

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Revealing the structural basis for membrane transport and GPCR signaling through atomic-level simulation

Type: Lecture

Date: Dec 26, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ron Dror

OrganizerSystem Biology

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Departmental Seminar

Type: Lecture

Date: Dec 24, 2017

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Lecturer Gal Nuta

OrganizerStudent and Post-Doc Seminar

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Developmental Club Series 2017-2018

Type: Lecture

Date: Dec 20, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGil Levkowitz

OrganizerDevelopmental Club

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Frontiers in Systems Biology

Type: Lecture

Date: Dec 19, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Mihaela Zavolan

OrganizerSystem Biology

AbstractIn yeast, the knock out of individual ribosomal protein (RP) genes leads to a wide range of life span phenotypes, some mutants having significantly increased, other significantly decreased life span. In this talk I would like to present our efforts in characterizing the regulation of mRNA translation in relation to cellular states, from yeast to man. I will describe our work on inferring determinants of protein synthesis rates in yeast, where we found that the Gcn4 transcription factor, which is induced in many conditions that enhance yeast lifespan (RP gene knockout, calorie restriction, mTOR inhibition) not only activates transcription of amino acid biosynthesis genes, but also represses protein biosynthesis. How much variation in RP expression is expected in human tissues has been largely unknown, but RP gene mutations have been described in association with hematological disorders. Through a comprehensive analysis of human RP mRNAs expression pattern across 28 tissues, over 300 primary cells and 16 tumor types, we identified many RPs which exhibit tissue-specific expression. In the hematopoietic system, a small number of RP genes, possible regulated by transcription factors with tissue-specific expression, unequivocally discriminate cells of distinct lineages and developmental stages. Different cancer types also show dysregulated expression of individual RPs, some RPs having a relative increase and other decrease in expression. Finally, I will discuss our efforts in mapping sites of snoRNA-guided RNA modifications.

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Unexpected Adventures with Human Endogenous Retroviruses and Centromeres

Type: Lecture

Date: Dec 18, 2017

Time14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. David Markovitz

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Accessing the genome: transcription factors as sensors and modifiers of chromatin

Type: Lecture

Date: Dec 12, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dirk Schubeler

OrganizerSystem Biology

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(Re)Constructing the Vertebrate Neural Tube

Type: Lecture

Date: Dec 07, 2017

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. James Briscoe

OrganizerThe Azrieli Institute for Systems Biology

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Developmental Club Series 2017-2018

Type: Lecture

Date: Dec 06, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr.Meital Oren

OrganizerDevelopmental Club

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Frontiers in Systems Biology: Prof. Jörg Vogel

Type: Lecture

Date: Dec 05, 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jörg Vogel

OrganizerSystem Biology

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Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture

Date: Dec 03, 2017

Time13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Mor

OrganizerSeminar

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Population as Distributed Memory System

Type: Lecture

Date: Nov 29, 2017

Time11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ehud Lamm