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2024

Special Guest Seminar with Prof. Eugene V. Koonin

Type: Lecture
Date: Mar 21, 2024

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eugene V. Koonin

Contactevi.ben-ami@weizmnn.ac.il

AbstractViruses and virus-like mobile genetic elements are ubiquitous parasites (and sometime symbionts) of all cellular life forms and the most abundant biological entities on earth. The recent, unprecedented advances of comparative genomics and metagenomics have led to the discovery of diverse novel groups of viruses and a rapid expansion of the chartered region of the virosphere. These discoveries provide for a vastly improved understanding of the evolutionary relationships within the virosphere. Arguably, we are approaching the point when the global architecture of the virus world can be outlined in its entirety, and the key evolutionary events in each of its domains can be reconstructed. I will present such an outline of the global organization of the virosphere and the corresponding megataxonomy, including 6 distinct virus realms, that has been recently approved by the International Committee on Taxonomy of Viruses, as well as some new candidates. The expansion of the prokaryotic virosphere that is being shown to include many groups of viruses, particularly, those with RNA genomes, previously thought to be eukaryote-specific, will be emphasized. I will further discuss the position of viruses within the wider space of replicators and the recent dramatic expansion of the “alternative virosphere” that includes viroids and diverse viroid-like viruses that seem to have evolved on multiple, independent occasions.

Seminar for PhD thesis defense

Type: Lecture
Date: Mar 12, 2024

Seminar for PhD thesis defense

Type: Lecture
Date: Feb 25, 2024

Seminar for PhD thesis defense

Type: Lecture
Date: Feb 22, 2024

Special Guest Seminar with Prof. Ziv Bar-Joseph

Type: Lecture
Date: Jan 18, 2024

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ziv Bar-Joseph

Contactevi.ben-ami@weizmnn.ac.il

AbstractAbstract: While research institutions including Weizmann are leading the way in cutting edge work in omics data analysis and modeling, biotechs and pharma are very advanced, and in some cases leading, in areas related to molecular design and clinical data analysis. I have been leading the AI / ML work for R&D at one of the largest pharma companies for almost two years and will share some of the methods we have been developing and using to address computational challenges across all stages of the drug discovery and development process. I Will also try to share some of the lessons I have learned over this period.

Special Guest Seminar with Prof. Yegor Bazykin

Type: Lecture
Date: Jan 04, 2024

2023

Seminar for PhD thesis defense

Type: Lecture
Date: Dec 06, 2023

Seminar for PhD thesis defense

Type: Lecture
Date: Nov 23, 2023

Special Guest Seminar with Prof. Judith Frydman

Type: Lecture
Date: Aug 29, 2023

Special Guest seminar with Dr. Raul Andino

Type: Lecture
Date: Aug 28, 2023

Seminar for PhD thesis defense

Type: Lecture
Date: Aug 08, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jul 24, 2023

Special guest Seminar

Type: Lecture
Date: Jul 16, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jul 10, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jun 26, 2023

Special guest seminar with Nadav Ahituv

Type: Lecture
Date: Jun 13, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jun 12, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: May 29, 2023

Special Guest Seminar

Type: Lecture
Date: May 16, 2023

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Meissner & Prof. Paul Tesar

Contactevi.ben-ami@weizmnn.ac.il

Special Guest Seminar

Type: Lecture
Date: May 16, 2023

Time15:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Meissner & Prof. Paul Tesar

Contactevi.ben-ami@weizmnn.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: May 15, 2023

Systems Biology Seminar

Type: Lecture
Date: May 01, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: May 01, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Mar 27, 2023

Special Guest Seminar

Type: Lecture
Date: Mar 14, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Mar 13, 2023

Special Guest Seminar

Type: Lecture
Date: Mar 09, 2023

Special Guest Seminar

Type: Lecture
Date: Feb 16, 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jennifer Lippincott-Schwartz

Contactevi.ben-ami@weizmnn.ac.il

Seminar for PhD Thesis Defense

Type: Lecture
Date: Feb 09, 2023

Seminar for thesis defense with Yaara Finkel

Type: Lecture
Date: Feb 09, 2023

Seminar for MSc thesis defense

Type: Lecture
Date: Jan 22, 2023

Special Guest Seminar

Type: Lecture
Date: Jan 19, 2023

Seminar for MSc Thesis Defense

Type: Lecture
Date: Jan 16, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jan 16, 2023

Seminar for Thesis Defense with Raman Singh

Type: Lecture
Date: Jan 16, 2023

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jan 02, 2023

Special Guest Seminar

Type: Lecture
Date: Jan 01, 2023

2022

Seminar for Thesis defense

Type: Lecture
Date: Dec 12, 2022

Special Guest Seminar

Type: Lecture
Date: Nov 24, 2022

Special guest seminar, Dr Harry Burgess

Type: Lecture
Date: Aug 15, 2022

Seminar for Thesis Defense of Adi Millman

Type: Lecture
Date: Jul 24, 2022

Guest seminar with Prof. Utpal Banerjee

Type: Lecture
Date: Jul 20, 2022

Special guest semianr with Dr. Asaf Zviran

Type: Lecture
Date: Jul 17, 2022

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Asaf Zviran

OrganizerCancer Research Club

Contactsandra.britton@weizmann.ac.il

AbstractEarly detection of recurrence and monitoring of Molecular Residual Disease (MRD) post-surgery is critical for clinical decision-making to tailor personalized treatments across solid cancers. C2i Genomics has developed an ultra-sensitive whole-genome ctDNA test, allowing extremely accurate and sensitive monitoring of patients with solid tumors. Here we present results from applying whole-genome sequencing (WGS) and identification of ctDNA across a variety of adult and pediatric solid tumors. We integrate a genome-wide mutation and copy number monitoring approach coupled with advanced signal processing and Artificial Intelligence (AI) for measuring the tumor load from low-input blood samples (~1mL of plasma) with ultra-sensitive detection. The increased sensitivity allowed clinical detection of tumor fraction down to 5*10-5 and recurrence detection sensitivity achieving >65% at the first two months after definitive treatment, enabling earlier clinical intervention for high-risk patients.

Seminar for PhD thesis defense

Type: Lecture
Date: Jul 12, 2022

Special Guest Seminar

Type: Lecture
Date: Jul 11, 2022

Seminar for PhD thesis defense

Type: Lecture
Date: May 25, 2022

Special guest semianr with Prof. Jin Billy Li

Type: Lecture
Date: May 25, 2022

Special Guest Seminar with Prof. Hervé Le Hir

Type: Lecture
Date: May 15, 2022

Molecular Genetics Departmental seminar

Type: Lecture
Date: May 08, 2022

Special guest seminar with Prof. Kent Søe

Type: Lecture
Date: Apr 07, 2022

2021

Guest seminar with Vered Shacham-Silverberg

Type: Lecture
Date: Dec 26, 2021

Molecular Genetics departmental seminar

Type: Lecture
Date: Nov 28, 2021

Special seminar with Dr. Yaara Oren

Type: Lecture
Date: Aug 16, 2021

Time15:00 - 16:00

LecturerDr. Yaara Oren

Contactsandra.britton@weizmann.ac.il

AbstractDespite favorable initial response to therapy, a third of cancer patients will develop recurrent disease and succumb to it within five years of diagnosis. While there has been much progress in characterizing the pathways that contribute to stable genetic drug resistance, the mechanisms underlying early reversible resistance, also known as persisters-driven resistance, remain largely unknown. It has long been believed that persisters represent a subset of cells that happen to be non-proliferating at the time of treatment, and therefore can survive drugs that preferentially kill rapidly proliferating cells. However, in my talk I will describe a rare persister population which, despite not harboring any resistance-conferring mutation, can maintain proliferative capacity in the presence of drug. To study this rare, transiently-resistant, cycling persister population, we developed Watermelon, a high-complexity expressed barcode lentiviral library for simultaneous tracing of each cell’s clonal origin and proliferative and transcriptional states. We combine single cell transcriptomics with imaging and metabolomics to show that cycling and non-cycling persisters arise from different cell lineages with distinct transcriptional and metabolic programs. Finally, I will describe how by studying persister cells we can gain critical insights on cellular memory, fate, and evolution, which can guide the development of better anti-cancer treatments.

Special guest seminar with Dr. Inna Ricardo-Lax

Type: Lecture
Date: Jul 20, 2021

Molecular Genetics Departmental seminar with Sveta Markman

Type: Lecture
Date: May 30, 2021

Departmental seminar with Michal Schwartz

Type: Lecture
Date: May 23, 2021

Departmental Seminar with Lena Sapoznikov

Type: Lecture
Date: May 09, 2021

ILASOL 2021 Conference

Type: Lecture
Date: Apr 20, 2021

2020

Special guest seminar with Dr. Yosef Kaplan Dor

Type: Lecture
Date: Nov 16, 2020

Time16:00

LecturerDr. Yosef Dor Kaplan

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

AbstractSleep is ubiquitous in the animal kingdom, but its function has been a mystery. Besides its importance for the brain, sleep appears to play an essential physiological role, emphasized by the fact that severe sleep loss can be lethal. The cause of this lethality was unknown. We found that extreme sleep deprivation results in high levels of reactive oxygen species (ROS) that trigger oxidative stress specifically in the gut of flies and mice. Using flies, we show that neutralization of intestinal ROS prevents premature death of sleep-deprived animals, suggesting a causal link between ROS accumulation in the gut and lethality upon sleep loss. What may explain the observed phenomena? Could it teach us about the normal, daily function of sleep? In the second part of my talk, I will present our current attempts and preliminary data aiming at answering these questions.

Braginsky Center for the Interface between Science and the Humanities zoom lecture with Prof. Mario Livio

Type: Lecture
Date: Oct 19, 2020

Time16:00 - 17:00

LecturerProf. Mario Livio

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

AbstractA fresh biography of Galileo Galilei which puts his scientific discoveries in context. Disturbed by rampant science denial in America—and around the world—that has only intensified in recent years, I began researching the life, ideas, and actions of this brilliant man who encountered similar pressures centuries ago. The result is a biography filled with lessons relevant for today—whether with respect to trusting the advice given by scientists in relation to COVID-19, the reality of climate change, the efficacy of vaccines, or the teaching of creationist theories in schools. I will discuss these topics in this talk.

Developmental Club Series 2019-20-cancelled

Type: Lecture
Date: Jun 24, 2020

Developmental Club Series 2019-20 - cancelled

Type: Lecture
Date: Jun 10, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: May 27, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: May 20, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: May 13, 2020

Developmental Club Series

Type: Lecture
Date: May 06, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: Apr 22, 2020

Decoding transcriptional regulation in Drosophila

Type: Lecture
Date: Apr 07, 2020

TBA - cancelled

Type: Lecture
Date: Apr 01, 2020

POSTPONED: Developmental Club Series with Elazar Zelzer

Type: Lecture
Date: Mar 25, 2020

Seminar for Thesis Defense- Roni Winkler

Type: Lecture
Date: Mar 19, 2020

Azrieli Institute for Systems Biology

Type: Lecture
Date: Mar 04, 2020

Molecular Genetics special guest seminar

Type: Lecture
Date: Feb 27, 2020

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gilad Barnea

OrganizerSeminar

Contactsandra.britton@weizmann.ac.il

AbstractI will present trans-Tango, a new technique for anterograde transsynaptic circuit tracing and manipulation that we have established in fruit flies. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell-surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined neurons, thereby activating the pathway in their postsynaptic partners. Activation of the pathway culminates in expression of a reporter that can be visualized. Because our system is modular, it can be easily adapted to experiments in which the properties of specific circuits are modified and the functional consequences are analyzed. We first validated trans-Tango in the Drosophila olfactory system and then implemented it in the gustatory system, where projections beyond the firstorder receptor neurons are not well characterized. We identified second-order neurons within the sweet and bitter circuits and revealed that they target brain areas involved in neuromodulation with similar but distinct projection patterns. I will also present experiments in which we use trans-Tango in functional analysis of the gustatory circuits. Using our studies in flies as proof of concept, we are currently establishing an equivalent technique for labeling circuits in vertebrate models, such as mice and zebrafish. These experiments establish trans-Tango as a flexible platform for comprehensive transsynaptic analysis of neural circuits.

Developmental Club Series 2019-20

Type: Lecture
Date: Feb 26, 2020

Seminar for thesis defense - Karen Fridman Talmon

Type: Lecture
Date: Feb 13, 2020

Special Guest Seminar with Prof. Detlef Wiegel

Type: Lecture
Date: Feb 12, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: Feb 12, 2020

Special Guest Seminar

Type: Lecture
Date: Feb 05, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: Feb 05, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: Jan 29, 2020

Department of Molecular Genetics Special guest seminar

Type: Lecture
Date: Jan 28, 2020

Special Guest Seminar with Dr, Michael E. Ward

Type: Lecture
Date: Jan 16, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: Jan 15, 2020

Special Guest Seminar with Dr. Arbel Harpak

Type: Lecture
Date: Jan 02, 2020

Developmental Club Series 2019-20

Type: Lecture
Date: Jan 01, 2020

2019

Special Guest Seminar with Dr. Onn Brandman

Type: Lecture
Date: Dec 30, 2019

Seminar for thesis defense, Nofar Mor

Type: Lecture
Date: Dec 29, 2019

Special guest seminar with Moran Dvela-Levitt

Type: Lecture
Date: Dec 22, 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMoran Dvela-Levitt

Contactsandra.britton@weizmann.ac.il

AbstractProtein homeostasis is critical for cellular function and survival. Dysregulation of the cellular protein homeostasis can lead to a build-up of misfolded proteins and facilitate the manifestation of a variety of pathological disorders including neurodegeneration, cancer and inflammation. Where and how the misfolded proteins accumulate, however, has remained a mystery. In studying MUC1 kidney disease (a rare kidney disorder), we have found that some of these pathologies may share a single, previously unrecognized cellular mechanism: a jam at a specific step in the secretory pathway involving a cargo receptor called TMED9. A small molecule called BRD4780 can break the jam and restore cells to normal function, providing a promising potential for therapeutic developments.

Seminar for thesis defense, Maya Voichek

Type: Lecture
Date: Dec 19, 2019

Special Guest Seminar

Type: Lecture
Date: Dec 18, 2019

Developmental Club Series 2019-20

Type: Lecture
Date: Dec 18, 2019

Developmental Club Series 2019-20

Type: Lecture
Date: Dec 11, 2019

Seminar for thesis Defense - Zohar Erez

Type: Lecture
Date: Dec 08, 2019

Special Guest Seminar

Type: Lecture
Date: Dec 02, 2019

Seminar for thesis defense Naama Dekel

Type: Lecture
Date: Oct 30, 2019

Special Guest Seminar

Type: Lecture
Date: Oct 27, 2019

Special Guest Seminar with Anat Zimmer

Type: Lecture
Date: Oct 03, 2019

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnat Zimmer

OrganizerThe Azrieli Institute for Systems Biology

Contactsandra.britton@weizmann.ac.il

AbstractIt is a challenge to answer questions like: why some people develop a disease, react to a specific treatment and/or develop severe side-effects while others don’t. In order to explain these occurrences, one has to take a holistic approach and study the body physiology from a systems level perspective. Longitudinal multi-omics measurements together with genetics, on a large population, can serve such a purpose and help in predicting, reasoning, and preventing diseases. In partnership with Arivale Inc., we have developed infrastructure to collect longitudinal Personalized Dense Dynamic Data clouds (PD3 clouds) on thousands of individuals, which include genetics and longitudinal measurements of clinical labs, microbiome, metabolome, proteome, and self-reported data. The value of these extremely high-dimensional data clouds is clear; however, it also comprises a challenge in data analysis and interpretation. One way to reduce data dimensionality is called Pareto Task Inference (PARTI, Hart et al. 2015). We used this method to analyze the clinical labs and found that the data falls on a significant tetrahedron. The 4 vertices are archetypes that specialize in a certain task. Using all other datatypes, we identified enriched traits next to every archetype and revealed the underline tradeoffs that shape the data. This distinctive analysis uncovers unexpected relationships between datasets such as metabolomics, proteomics and clinical labs, and helps in interconnecting the different datatypes to characterize different states of human health.

Special Guest Seminar with Dr. Johnathan Cooper-Knock

Type: Lecture
Date: Sep 05, 2019

Special Guest Seminar with Ophir Shalem

Type: Lecture
Date: Aug 22, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Jul 31, 2019

Special Guest Seminar

Type: Lecture
Date: Jul 21, 2019

Shoulder Injury Seminar Department of Molecular Genetics

Type: Lecture
Date: Jul 18, 2019

Special Guest Seminar

Type: Lecture
Date: Jul 16, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Jul 03, 2019

Departmental Seminar

Type: Lecture
Date: Jun 30, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 26, 2019

Developmental Club

Type: Lecture
Date: Jun 19, 2019

Departmental Seminar

Type: Lecture
Date: Jun 16, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 12, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 12, 2019

Departmental Seminar

Type: Lecture
Date: Jun 02, 2019

Developmental Club

Type: Lecture
Date: May 29, 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Shalev Itzkovitz

Contactevi.ben-ami@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: May 26, 2019

Departmental Seminar

Type: Lecture
Date: May 19, 2019

Departmental Seminar

Type: Lecture
Date: May 12, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHagai Marmor

OrganizerDDP Seminar

Contactevi@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: May 07, 2019

Seminar for thesis defense

Type: Lecture
Date: May 05, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: May 01, 2019

Departmental Seminar

Type: Lecture
Date: Apr 28, 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInes Castro

OrganizerDDP Seminar

Contactsandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Apr 17, 2019

Special Guest Seminar with Dr. Markus Mund

Type: Lecture
Date: Apr 16, 2019

Special Guest Seminar with prof. Johannes Herrmann

Type: Lecture
Date: Apr 11, 2019

Special guest seminar

Type: Lecture
Date: Apr 04, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Apr 03, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 20, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 20, 2019

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 19, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 13, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 06, 2019

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Feb 24, 2019

Seminar for thesis defense

Type: Lecture
Date: Feb 20, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Feb 06, 2019

"Mechanisms of asymmetric cell division"

Type: Lecture
Date: Jan 28, 2019

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 27, 2019

Special Guest Seminar with Prof. Meytal Landau

Type: Lecture
Date: Jan 22, 2019

Special Guest Seminar with Dan Bracha

Type: Lecture
Date: Jan 17, 2019

Special Guest Seminar with Ariel Schwartz

Type: Lecture
Date: Jan 17, 2019

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ariel Schwartz

OrganizerGuest Lecture

Contactsandra.britton@weizmann.ac.il

AbstractComputational assignment of function to proteins with no known homologs is still an unsolved problem. We have created a novel, function-based approach to protein annotation and discovery called D-SPACE (Deep Semantic Protein Annotation Classification and Exploration), comprised of a multi-task, multi-label deep neural network trained on over 70 million proteins. Distinct from homology and motif-based methods, D-SPACE encodes proteins in high-dimensional representations (embeddings), allowing the accurate assignment of over 180,000 labels for 13 distinct tasks. The embedding representation enables fast searches for functionally related proteins, including homologs undetectable by traditional approaches. D-SPACE annotates all 109 million proteins in UniProt in under 35 hours on a single computer and searches the entirety of these in seconds. D-SPACE further quantifies the relative functional effect of mutations, facilitating rapid in-silico mutagenesis for protein engineering applications. D-SPACE incorporates protein annotation, search, and other exploratory efforts into a single cohesive model. We have recently extended this work from protein to DNA, enabling assignment of function to whole genomes and metagenomic contigs in seconds. Conserved genomic motifs as well as the functional impact of mutations in coding as well as non-coding genomic regions can be predicted directly from raw DNA sequence without the use of traditional comparative genomics approaches for motif detection, such as multiple sequence alignments, PSSMs, and profile HMMs.

Special Guest Seminar with Dr. Shai Carmi

Type: Lecture
Date: Jan 16, 2019

Time11:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Shai Carmi

Contactilona.kalderon@weizmann.ac.il

AbstractIn this talk, I will review recent work by myself and others on Jewish population and medical genetics, focusing on Ashkenazi Jews (AJ). I will describe the mixture events of AJ in Europe, the founder event they have experienced in the late Middle Ages, and their connections to ancient populations of the Levant. I will then describe large-scale genomic databases that we have recently generated for AJ, and the opportunities they open in medical genetics given the unique AJ demographic history. I will describe a few medical genetics projects including carrier screening, genome-wide association studies of microbiome composition and other traits, and preimplantation genetic diagnosis.

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 13, 2019

Developmental Club Series 2018-2019

Type: Lecture
Date: Jan 09, 2019

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 06, 2019

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 06, 2019

Smaller is better

Type: Lecture
Date: Jan 03, 2019

2018

Developmental Club Series 2018-19

Type: Lecture
Date: Dec 26, 2018

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Dec 16, 2018

Joint mini-symposium

Type: Lecture
Date: Dec 13, 2018

Developmental Club Series 2018-19

Type: Lecture
Date: Dec 12, 2018

Developmental Club Series 2018-2019, special guest seminar

Type: Lecture
Date: Dec 05, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Naihe Jing

OrganizerDevelopmental Club

Contactsandra.britton@weizmann.ac.il

AbstractDuring postimplantation development of the mouse embryo, descendants of the inner cell mass cells in the early epiblast transit from the naïve pluripotent state to the primed pluripotent state. Concurrent with the transition of the pluripotency states is the specification of cell lineages and formation of germ layers in the embryos that serves as the blueprint for embryogenesis. Fate mapping and lineage analysis studies have revealed that cells in different regions of the germ layers acquire location-specific cell fates during gastrulation. The regionalization of cell fates heralding the formation of the basic body plan is conserved in vertebrate embryos at a common phylotypic stage of development. Knowledge of the molecular regulation that underpins the lineage specification and tissue patterning is instrumental for understanding embryonic programming and stem cell-based translational study. However, a genome-wide molecular annotation of lineage segregation and tissue architecture of post-implantation embryo has yet to be undertaken. Here, we reported a spatially resolved transcriptome of cell populations at defined positions in the germ layers over the period of pre- to late gastrulation development. This spatio-temporal transcriptome provides high resolution digitized in situ gene expression profiles and defines the molecular attribute of the genealogy of lineages and continuum of pluripotency states in time and space. The transcriptome further identifies the networks of molecular determinants that drive lineage specification and tissue patterning in the early postimplantation mouse embryo.

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Dec 02, 2018

Developmental Club Series 2018-2019

Type: Lecture
Date: Nov 28, 2018

Nuclear Genome Nanostructure Imaging at Single Molecule Resolution

Type: Lecture
Date: Nov 20, 2018

Time10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Christoph Cremer

OrganizerDevelopmental Club

ContactIngrid.lehrer@weizmann.ac.il

AbstractSuper-resolution fluorescence microscopy allows quantitative studies of nuclear genome organization on the nanoscale1. Here we report on results obtained by single molecule localization microscopy (SMLM). SMLM has made possible to explore chromatin nanostructure down to the imaging of single histones, of short oligosequences, or single DNA sites; presently, an intranuclear optical resolution down to the 5 nm range has been achieved. Applying a novel SMLM technique (fBALM)2, the DNA distribution across entire nuclei at nanoscale resolution was quantitatively determined, localizing in individual nuclear optical sections up to ~4 million individual DNA bound single fluorophore molecule positions, corresponding to about one position per nucleosome. Intensity profile analyses of the intranuclear DNA distributions indicated sharp transitions between high-density domains and low-density compartments, with differences up to almost two orders of magnitude; compacted regions had a minimum diameter down to ca. 50 nm diameter. In contrast to these results, conventional resolution imaging of the same nuclear sites indicated only small differences in the compaction of different regions, combined with very smooth density transitions. Taken together, the quantitative compaction estimates support models of a nuclear organization based on highly compartmentalized chromatin nanostructures3.

Special Guest Seminar

Type: Lecture
Date: Nov 19, 2018

Time10:00 - 12:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerDr. Nadav Sharon

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Nov 18, 2018

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Nov 18, 2018

Special Guest Seminar

Type: Lecture
Date: Nov 08, 2018

Time10:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eugene Rosenberg

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Oct 31, 2018

Seminar for thesis defense

Type: Lecture
Date: Oct 11, 2018

Developmental Club Series 2017-2018

Type: Lecture
Date: Jul 18, 2018

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Jul 04, 2018

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jul 01, 2018

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 24, 2018

Special Guest Seminar

Type: Lecture
Date: Jun 20, 2018

Time14:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNava Segev

OrganizerSpecial Guest Seminar

Contactsandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Jun 20, 2018

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 17, 2018