Yaron Emanuel Antebi

Signal processing in cellular decision making

  • Developing a systems-level framework to characterize signal integration at the single cell level
  • Defining the role of perception and integration of complex stimuli in determining cellular fate
  • Analyzing multi-ligand information processing in the BMP/TGFβ pathway and its effect on mesenchymal stem cell differentiation
  • Studying signal processing in the JAK/STAT pathway during hematopoiesis and immune response
Yaron Emanuel Antebi research image

Lior Dayan

MSc student

Inbal Eizenberg Magar

Senior Intern

Omer Erez

PhD student

Guy Ilan

MSc student

Priel Siman-Tov

MSc student

Elizabeth Stoops

PhD student

Adi Wider

Dekel Yahav Har-Shai

PhD student

Omer Zachar

MSc student

Eli Arama

Programmed Cell Death and Cellular Destruction Mechanisms in Development

  1. Caspase-dependent non-lethal cellular processes (CDPs) in Drosophila:
    • Sperm terminal differentiation
    • Inhibition of unwanted cell migration and invasion
  2. Caspase-independent alternative cell death pathways (ACDs) in Drosophila development
    • Germ Cell Death (GCD) during premeiotic germ cell formation in the adult males
    • Primordial Germ Cell (PGC) death during germ cell specification in the embryo
  3. Structural organization of the Drosophila sperm mitochondria (Nebenkern)
  4. Paternal Mitochondrial Destruction after fertilization in Drosophila
Eli Arama research image

Sara Afar

Lab Technician

Naama Afgin

Lab Technician

Sharon Ben-Hur

Postdoctoral fellow

Tslil Braun

Postdoctoral fellow

Guy Hadary

PhD student

Alina Kolpakova

Research Associate

Zohar Mor-Rashti

PhD student

Rela Oved

PhD student

Adriana Reuveny

Associate Staff Scientist

Shoshana Sernik

PhD student

Keren Yacobi-Sharon

Associate Staff Scientist

Naama Barkai

Principles of Biological Circuits

  • Biological circuits are the building blocks of cellular information processing: what are the principles guiding their design, function and evolution?
  • Basic biological processes such as gene expression rely on a small number and therefore vary in a stochastic, unpredictable way. What is the role of variability in information processing and what mechanisms ensure robustness of processes such as embryonic patterning?
  • Transcription and replication compete for the same DNA template, and rely on the combined action of general and specific regulatory factors. How are these processes coordinate and how do they communicate with each other?
Naama Barkai research image

Joshua Bugis

MSc student

Miri Carmi

Lab Technician

Aileen Cohen

PhD student

David Jan

Lab Technician

Tamar Jana

Felix Reinhard Helmut Jonas

Visiting Scientist

Sana Khatib

PhD student

Divya Krishna Kumar

PhD student

Jing Liu

MSc student

Wajd Manadre

PhD student

Vladimir Mindel

PhD student

Noam Plotkin

MSc student

Alma Carolina Sanchez Rocha

Postdoctoral fellow

Achinoam Shoham

MSc student

Joseph M Steinberger

PhD student

Dan Weinberg

MSc student

Gilad Yaakov

Associate Staff Scientist

Inbal Zigdon

PhD student

Ari Elson

Cell signaling in osteoclasts: bone in health and disease

  • We study how osteoclasts, the only cells in our bodies that can degrade bone, are formed and how they function
  • Our studies are directly connected to bone biology and to human disease, including osteoporosis, osteopetrosis, and bone loss in cancer
  • Our studies combine between the molecular, cellular, and whole-organism (mouse model) levels
  • Our goals are to explain how individual signaling molecules and processes regulate normal physiology, how they can contribute to disease, and how they can be used to treat disease
Ari Elson research image

Maayan Barnea Zohar

Research Associate

Sarah Agnes Elkaim

PhD student

Hilla Knobler

Consultant

Daniela Novick

Consultant

Nina Reuven

Senior Staff Scientist

Jeffrey Gerst

Intracellular and intercellular mRNA trafficking and protein localization

  • Labeling and live imaging of mRNAs in yeast and mammalian cells
  • Affinity purification of mRNAs and identification of RNA-binding proteins and co-trafficked mRNAs
  • Assessment of the role of RNA-binding proteins in protein localization and cell physiology
  • Genome-wide mapping of mRNA localization and RNA-RNA and RNA-protein interactions
Jeffrey Gerst research image

Shahar Garin

PhD student

Gal Haimovich

Assistant Staff Scientist

Liav Levavi

PhD student

Dheerendra Pratap Mall

Postdoctoral fellow

Emese Pataki

Postdoctoral fellow

David Gokhman

Human evolution and gene regulation

  • What are the genetic changes that made us human?
  • What is the origin of human-specific diseases?
  • How can we computationally infer traits from genetic data?
  • ?What is the genetic basis of human adaptation

David Gokhman research image

Gal Bodek

Bioinformatician

Nachshon Egyes

MSc student

Yael Elboim

Lab Technician

Simon Fishilevich

Bioinformatics programmer

Nitzan Haim

PhD student

Nadav Mishol

MSc student

Noam Priel

PhD student

Adi Rozenblatt

Lab Technician

Yoram Groner

RUNX transcription factors in development and disease

  • Regulatory elements conferring time and tissue specific expression of RUNX transcription factors
  • Runx3 target genes in TrkC neurons
  • Function of Runx3 in gut macrophages and dendritic cells
  • Runx1 transcriptionally regulates megakaryocytic maturation and myoblast proliferation
Yoram Groner research image

Ditsa Levanon

Consultant

Dvir Gur

Biological Crystallization Mechanisms

  • Study the development and cell biology of crystal-forming cells in model organisms (zebrafish, medaka) and exotic species (Copepods, Chameleon, Geckos).
  • Study pathological crystallization (i.e. gout disease and kidney stones) and develop new therapeutic approaches.
  • Discover and characterize new bio-crystals.
  • Investigate novel crystal-based biological optical systems.
Dvir Gur research image

Avi Baram

Yuval Barzilay

PhD student

Sourabh Bera

Postdoctoral fellow

Dolev Brenman-Begin

PhD student

Rachael Lynn Deis

PhD student

Zohar Eyal

Senior Intern

May Glaser

Lab Technician

Anna Gorelick Ashkenazi

Postdoctoral fellow

Tali Lerer Goldshtein

Research Associate

Yael Noy

PhD student

Amit Oved

Lab Technician

Nahuel Hernan Ramos

Lab Technician

Anat Reuveni

MSc student

Rebecca Rotnemer

MSc student

Siddharth Sahoo

MSc student

Jacob (Yaqub) Hanna

Pluripotent Stem cells and Epigenetics

  • How do mature differentiated cells revert back to an embryonic pluripotent state?
  • How do different flavors of embryonic pluripotency influence differentiation potential of stem cells
  • What are the key epigenetic pathways regulating timely execution of lineage commitment programs during early development?
  • Why do totipotent or primordial germ cells retain only some of properties of embryonic stem cells?
Jacob (Yaqub) Hanna research image

Gaia Auerbach

PhD student

Roni Cohen

Lab Technician

Mehmet Yunus Comar

PhD student

Mert Gayretli

PhD student

Sergey Golenchenko

Lab Technician

Gulben Gurhan Sevinc

Postdoctoral fellow

Tae Won Ha

Postdoctoral fellow

Vladislav Krupalnik

Consultant

Nir Livnat

PhD student

Deborah Minz

Lab Technician

Aseel Mughrabi

MSc student

Noa Novershtern

Associate Staff Scientist

Bernardo Oldak Kovalsky

Postdoctoral fellow

Angel Polanco

PhD student

Leon Qarawani

Lab Technician

Shmuel Rozenblatt

Consultant

Gal Shwartz

MSc student

Luba Trakhtenbrot

Consultant

Sergey Viukov

Lab Technician

Alperen Yilmaz

PhD student

Eran Hornstein

Regulatory RNA in brain integrity and neurodegeneration

  • We are RNA biologists, seeking to understand RNA function in lifelong tissues: motor neurons and β cells.
  • A long-term interest is on neurodegeneration, focusing on ALS. Our research spans from basic molecular mechanisms to translational / clinical studies.
  • Human genomics, transcriptomics and proximity proteomics drive current projects:

(i) Specific non-coding RNAs and regulated pathways in lifelong cells

(ii) Decompensated microRNA biogenesis contribute to ALS pathogenesis

(iii) Hunting non-coding mutations, which drive ALS by human ALS genomics

(iv) Cell-free RNA biomarkers for neurodegeneration

(v) Silencing of disallowed genes in the endocrine pancreas

(vi) microRNA contribution to adult β-cell homeostasis and cellular plasticity

Eran Hornstein research image

Bar Abarbanel

Lab Technician

Emmanuel Amzallag

PhD student

Gal Aviram

Yahel Cohen

PhD student

Kobi Dabosh

Yehuda Matan Danino

Postdoctoral fellow

Guy Haim

PhD student

Hadar Klimovski

MSc student

Sagy Krispin

PhD student

Lior Lin

MSc student

Iddo Magen

Associate Staff Scientist

Thea Meimoun

PhD student

Oz Sharabi

Aviad Siany Levkovitch

PhD student

Joelle Welmoed Rachel Van Zuiden

PhD student

Gili Wolf

MSc student

Nancy - Sarah Yacovzada

Research Associate

Chaim Kahana

Role of polyamines in supporting cellular functions

  • Polyamines and cellular proliferation
  • Polyamines in regulating translation
  • Mechanism of degradation of proteins from the polyamine biosynthesis pathway
Chaim Kahana research image

Yulia Feiler

Lab Technician

Eyal Karzbrun

Self-organization in embryonic development:

  • Developing 3D human stem-cell systems as minimal quantitative models of embryonic organ formation.
  • Studying the physical principles of tissue morphogenesis.
  • Defining how geometry and morphogen gradients encode organ shape.
  • Understanding how genetic mutations drive organ shape malformations in disease.
Eyal Karzbrun research image

Mor Cohen

PhD student

Chen Davidyan

MSc student

Alon Gershkoviz

PhD student

Zohar Mukamel

Associate Staff Scientist

Iris Schodl

MSc student

Swati Singh

PhD student

David Zingerman

MSc student

Adi Kimchi

The Protein Interaction Map of Programmed Cell Death in Development and Disease

  • Monitoring the global profile of protein- protein interactions along the autophagic and apoptotic pathways, in cells in real time
  • Whole genome functional screens to identify drivers of alternative forms of programmed cell death
  • Non canonical modes of RNA translation in embryonal stem cell differentiation
  • Mechanisms of cell death in the developing mammalian embryo
  • Identifying the cell death signature of patient’s tumors and targeting point of vulnerability towards precision cancer therapy
Adi Kimchi research image

Shani Brown

Consultant

Nadav Goldberg

PhD student

Doron Lancet

Systems Biology, Medicine and Protobiology

  • A Systems Biology and Systems Medicine suite of databases: GeneCards, MalaCards and PathCards
  • GeneHancer: Integrated view of gene regulatory elements and their taget genes
  • Systems Protobiology: Origin of Life in lipid catalytic networks without RNA
  • Deciphering genetic diseases with VarElect, a whole genome sequence phenotype interpretation tool
Doron Lancet research image

Niv Dobzinski

Marilyn Safran

Marilyn Safran

Marilyn Safran

Marilyn Safran

Roy Yaniv

Lab Technician

Ofer Zelig

Orly Laufman

Molecular and Cell Biology of RNA viruses

  • RNA viruses including corona, zika and dengue are a major threat to human health. We study how RNA viruses interact with their host cells and transform them into viral manufactories.
  • Our main model is enteroviruses - common viral pathogens that cause severe medical complications in humans, with no available therapeutic treatments.
  • We investigate how enteroviruses remodel the structure and function of host organelles to generate an environment favorable to virus replication.
  • Another key question we tackle is how enteroviruses, that express only a small number of proteins, take control of human cells with complex protein machineries. We study the different roles of viral proteins and the mechanisms they use to hijack host machineries.
  • We aim to piece together the complete program of enterovirus replication. This could lead to the development of new antiviral therapeutics.
Orly Laufman research image

Nadav Ben Tsvi

MSc student

Etai Boichis

PhD student

Keren Eden

MSc student

Yana Lerner

PhD student

Maya Malka

PhD student

Noam Hugo Alexis Morris

MSc student

Rachel Sharan

Lab Technician

Shirel Steinberger

PhD student

Yael Yair

Postdoctoral fellow

Shmuel Pietrokovski

Computational Biology of Conservation and Change

  • Evolution, function, and activity of intein protein domains, intein-like protein-domains, and intein-associated homing endonucleases
  • Sex-specific gene expression and Human genetics
  • Computational genomics of predatory bacteria
  • Developing methods and procedures for analysing sequence and structure of proteins, genes and genomes
Shmuel Pietrokovski research image

Yitzhak Pilpel

Genome Evolution and Systems Biology

  • Evolution of genomes and gene expression regulatory networks
  • Cancer genome, transcriptome and proteome
  • Systems and genome biology of translation regulation
  • Physiology of cellular response to the environment
  • Evolution of human language
Yitzhak Pilpel research image

Omer Asraf

Lab Technician

Bar Cohen

MSc student

Orna Dahan

Senior Staff Scientist,Representative to Scientific Council

Ruthie Golomb

PhD student

Noam Hadar

Postdoctoral fellow

Noa Hefetz

Research Associate

Omer Kerner

PhD student

Donya Khoury

Lab Technician

Saurav Mallik

Research Associate

Ehud Sass

Research Associate

Sivan Struass

Consultant

Meir Sylman

MSc student

Vjaceslav Tretjacenko

Postdoctoral fellow

Esther Weindling

Lab Technician

Maayan Yoles

MSc student

Orly Reiner

Cortical Development in Health and Disease

  • Understanding the molecular and cellular events that shape the developing human cortex
  • Studying the functions of neurodevelopmental disease-causing genes
  • Developing mouse models for human neurodevelopmental disorders
  • Applying “Disease in a Dish” approach for studying human embryonic cells derived brain organoids
Orly Reiner research image

Shams Abu Rashed

Bidisha Bhattacharya

PhD student

Ruth Buber

Lab Technician

Zlil Dobrish

Lab Technician

Zlil Dobrish

Lab Technician

Shai Fuchs

PhD student

Anna Gorelik

Research Associate

Adva Hadar

Postdoctoral fellow

Ariel Roy Hochfeld

Yehonadav Komemy

MSc student

Nataly Korover

Mio Nonaka

Research Associate

Alfredo Isaac Ponce Arias

PhD student

Tamar Sapir

Senior Staff Scientist

Ophir Schwazbard

Miriam Shulman

PhD student

Varun Suresh

Itay Vaknin

PhD student

Boaz Yaari

PhD student

Noy Shir Zer

PhD student

Menachem Rubinstein

Leukotrienes link ER stress and oxidative stress

  • Endoplasmic reticulum (ER) stress and cytotoxic agents trigger biosynthesis of Leukotriene C4 (LTC4) by activating a biosynthetic pathway based on microsomal glutathione S transferase 2 (MGST2)
  • LTC4, in turn, triggers oxidative stress and DNA damage by nuclear translocation of NADPH oxidase 4 (NOX4)
  • LTC4 inhibitors, which serve as asthma drugs alleviated cytotoxicity of chemotherapeutic agents
Menachem Rubinstein research image

Diana Gataulin

Research Associate

Maya Schuldiner

Systematic Cell Biology of Organelles

  • Search for functions for unstudied proteins in yeast
  • Understand how organelles function
  • Study how proteins are targeted and translocated into the endoplasmic reticulum, mitochondria and peroxisomes
  • Uncover new contact sites, their tethering proteins and functions
  • Focus on peroxisomes, metabolic hubs of the cells
Maya Schuldiner research image

Mor Angel

PhD student

Sivan Arad

PhD student

Yeynit Asraf

Lab Technician

Reut Ester Avraham

Lab Technician

Din Baruch

PhD student

Olga Beresh

PhD student

Terry Debesh

Personal Administrative Coordinator

Benjamin Dubreuil

Dunya Edilbi

PhD student

Sarah Margarethe Hassdenteufel

Senior Intern

Ofir Klein

Senior Intern

Hadar Meyer

Lab Technician

Hanni Naor

Personal Administrative Coordinator

Lior Peer

PhD student

Noga Preminger

PhD student

Maria Del Rosario Valenti

PhD student

Einat Zalckvar

Naama Zung

Postdoctoral fellow

Schraga Schwartz

Cracking the epitranscriptome

  • Mapping and characterizing the growing repertoire of post-transcriptional modifications present on mRNA ('the epitranscriptome')
  • Deciphering the functions of post-transcriptional modifications in regulating mRNA fate (localization/stability/translation) and cellular physiology
  • Dissecting the mechanisms through which mRNA modifications act
  • Interdisciplinary integration of Molecular Biology, Genetics and Computational Biology
Schraga Schwartz research image

Shahd Ashouokhi

PhD student

Miguel Angel Garcia Campos

Shira Gelman

MSc student

Joseph Maxwell Georgeson

PhD student

Vinithra Iyer

Postdoctoral fellow

Anatoli Kustanovich

Research Associate

Alexander Maman

PhD student

Rotem Morag

Lab Technician

Ronit Nir

Research Associate

Hamish Nicholl Cathcart Pike

Postdoctoral fellow

Shani Rochell

MSc student

Anna Uzonyi

PhD student

Monika Witzenberger

Postdoctoral fellow

Yosef Shaul

Molecular virology and cell biology

  • Understanding the molecular basis of virus-host interaction using HBV and Py viruses as models
  • The role of non-receptor tyrosine kinases in DNA damage and Hippo pathways in cell fate determination
  • The process of proteasomal degradation of intrinsically disordered proteins (IDPs)
Yosef Shaul research image

Julia Adler

Lab Technician

Victoria Meltser

Consultant

Rotem Sorek

Microbial genomics and systems biology

  • CRISPR, the microbial anti-phage immune system
  • The arms-race between bacteria and phage
  • Communication between viruses
  • RNA-mediated regulation in microbes
  • Microbial genome evolution
Rotem Sorek research image

Gil Amitai

Senior Staff Scientist

Nathalie Bechon

Postdoctoral fellow

Jeremy Garb

PhD student

Romi Hadary

PhD student

Dina Hochhauser

PhD student

Bohdana Hurieva

MSc student

Azita Leavitt

Lab Technician

Sarah Melamed

Lab Technician

Shaked Nizan

MSc student

Ilya Osterman

Research Associate

Ohad Roth

Postdoctoral fellow

Hadar Samra

PhD student

Nitzan Tal

Postdoctoral fellow

Erez Yirmiya

PhD student

Noam Stern-Ginossar

Profiling viral infection

  • How viruses interface with and commandeer cellular pathways to control gene expression
  • Uncover new aspects of virus-host interactions, as well as reveal new cell biology principles
  • Deciphering the roles different viral elements are playing during infection
Noam Stern-Ginossar research image

Einav Aharon

Lab Technician

Tamar Arazi

Lab Technician

Orr Barak

MSc student

Tal Fisher

PhD student

Batsheva Frankel Rozman

PhD student

Avraham Gluck

PhD student

Faris Khateeb

PhD student

Yaarit Kitsberg

PhD student

Anna Lilja

PhD student

Aharon Nachshon

Bioinformatician

Michal Schwartz

Associate Staff Scientist

Shira Turgeman

PhD student

Talila Volk

The development and Cell biology of striated muscles

  • The architecture and epigenetics of muscle nuclei
  • Dynamics of myonuclei during muscle contraction
  • Mechanotransduction and cell cycle progression in myofibers
Talila Volk research image

Dana Lorber

Research Associate

Elazar Zelzer

Musculoskeletal development, regeneration and pathology

  • Our main goal is to understand the biological and biomechanical principles governing musculoskeletal development and function, maintenance and regeneration, as well as aging and pathology
  • We investigate musculoskeletal assembly, that is, the creation of physical attachments between components of the system, focusing on the unique transitional tissue of the enthesis, the attachment site between tendon and bone
  • We study the involvement of proprioceptive mechanosensors, which control muscle action, in musculoskeletal maintenance and disease, including scoliosis, developmental dysplasia of the hip (DDH) and fracture repair
  • By using advanced imaging modalities, high-throughput computer vision algorithms and computational models for analyzing temporal series of 3D images, we study the mechanisms that sculpt the distinctive and intricate three-dimensional morphology of each bone
Elazar Zelzer research image

Anat Abramov

MSc student

Daria Amiad Pavlov

Senior Intern

Elisheva Berent-Barzel

PhD student

Bavat Bornstein

Assistant Staff Scientist

Miriam Eisenstein

Consultant

Qingyuan Guo

PhD student

Nitzan Konstantin

Personal Administrative Coordinator

Sharon Krief

Lab Technician

Tsviya Olender

Senior Staff Scientist

Avital Rosner

MSc student

Eyal Schejter

Senior Research Fellow

Ron Carmel Vinestock

PhD student

Professor Emeritus

  • Prof. Ernest Winocour

  • Prof. Michel Revel

In Memorium

  • Prof. Al Kaye
  • Prof. Peter Lonai
  • Prof. Yossi Aloni
  • Prof. Leo Sachs