Stern-Ginossar lab

Profiling viral infections

Research

We study viruses and explore the creative strategies they use to maneuver their host cells. We are interested in deciphering the roles different viral elements play during infection, as well as how viruses interact with and commandeer cellular pathways to control gene expression. We study these complex interactions using mainly cytomegalovirus (CMV), a herpesvirus that infects most of the world's population, but also additional viruses, such as SARS-CoV2. Leveraging high-throughput technologies, we approach these complex questions with an unbiased perspective, and uncover new aspects of virus-host interactions, as well as reveal new cell biology principles.

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News

December 9, 2024

Noam receives an ERC consolidator grant

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Selected Publications

A virally encoded high-resolution screen of cytomegalovirus dependencies

Finkel Y., Nachshon A., Aharon E., Arazi T., Simonovsky E., Dobešová M., Saud Z., Gluck A., Fisher T., Stanton R. J., Schwartz M. & Stern-Ginossar N. (2024) Nature. 630, 8017, p. 712-719

Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics

Schwartz M., Shnayder M., Nachshon A., Arazi T., Kitsberg Y., Levi Samia R., Lavi M., Kuint R., Tsabari R. & Stern-Ginossar N. (2023) Nature Microbiology. 8, 3, p. 455-468

Parsing the role of NSP1 in SARS-CoV-2 infection

Fisher T., Gluck A., Narayanan K., Kuroda M., Nachshon A., Hsu J. C., Halfmann P. J., Yahalom-Ronen Y., Tamir H., Finkel Y., Schwartz M., Weiss S., Tseng C. K., Israely T., Paran N., Kawaoka Y., Makino S. & Stern-Ginossar N. (2022) Cell reports (Cambridge). 39, 11, 110954.
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