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Positions
Scientist | Description |
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Prof. Rivka Dikstein | 2 Years Phone:+972-8-934-2117 |
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases. |
Dr. Nir Fluman | 18 Months Phone:+972-8-934-6456 |
Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools. |
Prof. Michal Sharon | 2 Years Phone:+972-8-934-3947 |
<p>Developing a computational approach to assign mass spectrometry data - a theoretical project.</p> |
Prof. Michal Sharon | 2 Years Phone:+972-8-934-3947 |
<p>For a challenging and exciting project focusing on the regulation of the 20S proteasome we are seeking for a motivated MSc student. The study combines biochemical tools, native mass spectrometry and cell biology approaches.</p> |
Scientist | Description |
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Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
Studying circadian clock communication through exosomes mediated signaling |
Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
Investigating the effect of time of the day on exercise performance and related metabolic pathways. |
Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
Examining the metabolic consequences and disease states due to misalignment between feeding-activity and disrupted circadian clock |
Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
Establishing a system for studying the effect of dissolved gases (oxygen/carbon dioxide) on cyanobacteria clock |
Prof. Rivka Dikstein | 5 Years Phone:+972-8-934-2117 |
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases. |
Prof. Michael Fainzilber | 5 Years Phone:+972-8-934-4266 |
<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. |
Dr. Nir Fluman | 4.5 Years Phone:+972-8-934-6456 |
Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools. |
Prof. Gideon Schreiber | 5 Years Phone:+972-8-934-3249 |
<p>Type I interferons (IFNs) are proteins produced and secreted in all higher vertebrates as a result of viral and bacterial attacks. Secreted IFNs bind cell surface receptors initiating a cascade of signals that activate cellular protection machineries against pathogens. In addition, specific immune cells are activated to establish long-term defense of the organism. These properties have been successfully exploited for IFNs to serve as a drug for a variety of complex diseases including viral infections, cancer and multiple sclerosis. |
Prof. Michal Sharon | 4 Years Phone:+972-8-934-3947 |
<p>For a challenging and exciting project combining biology, chemistry and physics we are seeking for a motivated PhD student. The project involves the development of a new technology for bio-molecular analysis. This is a joint study of Ron Naaman's and Michal Sharon's lb.</p> |
Prof. Michal Sharon | 4 Years Phone:+972-8-934-3947 |
<p>Developing a computational approach to assign mass spectrometry data - a theoretical project.</p> |
Prof. Michal Sharon | 4 Years Phone:+972-8-934-3947 |
<p>For a challenging and exciting project combining biology, chemistry and physics we are seeking for a motivated PhD student. The project involves the development of a new technology for bio-molecular analysis. This is a joint study of Ron Naaman's and Michal Sharon's lb.</p> |
Prof. David Wallach | 5 Years Phone:+972-8-934-3941 |
Motivated and creative students with background in molecular biology are invited to join our studies of the mechanisms by which signaling by the TNF family contributes to immune defense, to chronic inflammatory and autoimmune diseases and to cancer, and our attempts to derive from this knowledge new ways of therapy. See our website and list of publications for the range of research subjects that we are exploring and for the range of experimental approaches that we are applying. (http://www.weizmann.ac.il/Biological_Chemistry/scientist/Wallach/home.html). |
Scientist | Description |
---|---|
Prof. Rivka Dikstein | 3 Years Phone:+972-8-934-2117 |
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases. |
Prof. Michael Fainzilber | 5 Years Phone:+972-8-934-4266 |
<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. |
Dr. Nir Fluman | 2 Years Phone:+972-8-934-6456 |
Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools. |
Prof. Anthony H. Futerman | 3 Years Phone:+972-8-934-2704 |
<p>See short description </p> |
Prof. Anthony H. Futerman | 3 Years Phone:+972-8-934-2704 |
<p>See short description </p> |
Dr. Neta Regev-Rudzki | 3 Years Phone:+972-8-934-3160 |
Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. Experience in microbiology, molecular genetics (including CRISPR/Cas9), advanced imaging platforms (including image analysis) or advanced protein chemistry is advantageous. This is a full-time position available from October 2020 for a period of two years with a possibility of a further extension subject to funding availability. Candidate should send a cover letter and CV (includes a publication list) to Dr. |
Dr. Neta Regev-Rudzki | 3 Years Phone:+972-8-934-3160 |
OPEN PhD and Post-Doc positions: Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. |
Prof. Ziv Reich | 3 Years Phone:+972-8-934-2982 |
We are looking for a postdoc to study microscopic and mesoscopic re-arrangements of photosynthetic complexes that govern the plant's response to high-light stress using high-end electron microscopy techniques. |
Prof. Gideon Schreiber | 5 Years Phone:+972-8-934-3249 |
<p>Type I interferons (IFNs) are proteins produced and secreted in all higher vertebrates as a result of viral and bacterial attacks. Secreted IFNs bind cell surface receptors initiating a cascade of signals that activate cellular protection machineries against pathogens. In addition, specific immune cells are activated to establish long-term defense of the organism. These properties have been successfully exploited for IFNs to serve as a drug for a variety of complex diseases including viral infections, cancer and multiple sclerosis. |
Prof. Michal Sharon | 4 Years Phone:+972-8-934-3947 |
<p>Developing a computational approach to assign mass spectrometry data - a theoretical project.</p> |
Prof. David Wallach | 4 Years Phone:+972-8-934-3941 |
Motivated and creative students with background in molecular biology are invited to join our studies of the mechanisms by which signaling by the TNF family contributes to immune defense, to chronic inflammatory and autoimmune diseases and to cancer, and our attempts to derive from this knowledge new ways of therapy. See our website and list of publications for the range of research subjects that we are exploring and for the range of experimental approaches that we are applying. (http://www.weizmann.ac.il/Biological_Chemistry/scientist/Wallach/home.html). |
Scientist | Description |
---|---|
Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
Biochemical identification of metabolic sensors |
Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
The relationship between hypoxia and the core circadian clock |
Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
Computational analyses of rhythmic outputs (e.g. metabolites, gases) |
Prof. Gad Asher | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 |
The interplay between circadian clocks and exercise performance |
Dr. Ori Avinoam | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3557 |
We are interested in the universal process of membrane remodeling, when subdomains of the membrane are reshaped into functional structures that allow cells to take up material, sense and communicate with the environment. We are particularly interested in understanding how membrane ultrastructure is established during muscle differentiation and homeostasis. |
Dr. Ori Avinoam | Rotation: 1st Phone:+972-8-934-3557 |
The student will apply a new analytical approach, super-resolution radial fluctuations (SRRF), to study vesicular trafficking in vivo. |
Prof. Ed Bayer | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2373 |
The research in our group involves the study of cohesin-dockerin interactions, the assembly of the cellulosome components, enzymatic activity and analysis, protein design and structural characterization of cellulosomal modules. The motivated individual that will join us can gain experience in the following methods: cloning, expression and purification methods, biochemical and biophysical protein-binding measurements, crystallization and X-ray crystallography, and enzymatic activity assays. Advantage: a good sense of humor. |
Prof. Rivka Dikstein | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2117 |
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases. |
Prof. Rivka Dikstein | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2117 |
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases. |
Prof. Michael Eisenbach | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3923 |
We are exploring signal transduction strategies using bacterial chemotaxis as a model. In chemotaxis of bacteria such as Escherichia coli or Salmonella typhimurium, the direction of rotation of the bacterial flagella is modulated so that the bacteria approach attractants and retreat from repellents. We are trying to understand how chemotactic signals are processed within less than a second, and how the response regulator of this system transmits this signal to the flagella. Of all the known signal transduction systems, this is the system that is best understood. |
Prof. Michael Eisenbach | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3923 |
Observations made in our laboratory suggest that in humans, the egg and sperm communicate prior to fertilization by way of chemotaxis. This process is mediated by a factor secreted from the egg or its surrounding cells and detected by the sperm cells. We are trying to identify and characterize the chemotactic factors and their receptors on the sperm and to understand the molecular and physiological mechanisms of this process. |
Prof. Zvulun Elazar | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3682 |
Study the role of autophagy in the regulation of different signaling pathways |
Prof. Zvulun Elazar | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3682 |
Study the role of TECOR2, a novel autophagic related factor. |
Prof. Zvulun Elazar | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3682 |
Study different aspects of the mechanism involved in the formation and maturation of an autophagosome. |
Prof. Michael Fainzilber | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-4266 |
<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. |
Dr. Nir Fluman | Rotation: 3rd Phone:+972-8-934-6456 |
Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools. |
Prof. Anthony H. Futerman | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2704 |
<p>See my web page</p> |
Prof. Anthony H. Futerman | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2704 |
<p>See my lab web page</p> |
Prof. Anthony H. Futerman | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2704 |
<p>See my web page for more details of our work http://www.weizmann.ac.il/Biological_Chemistry/scientist/futerman/ We are an active lab with at least one opening for a rotation/MSC student</p> |
Prof. Zvi Livneh | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3203 |
Current projects: (1) Principles of operation of mammalian error-prone DNA repair. (2) Analysis of novel genes involved in mammalian DNA damage tolerance. (3) Effect of nuclear architecture on DNA damage tolerance in mammalian cells. (4) Mechanisms and regulation of DNA repair in embryonic stem cells. (5) DNA repair in risk assessment and early detection of cancer. |
Dr. Neta Regev-Rudzki | Rotation: 2nd, 3rd Phone:+972-8-934-3160 |
Malaria laboratory, Weizmann Institute We are seeking for highly motivated, committed and curious students to join our team as rotation students. The projects center on different fascinating aspects of the cellular biology of the malaria parasite. Applicants with a strong background at the interfaces of molecular biology and/or biophysics are encouraged to apply. The chosen applicant will peruse wide spread of molecular biology technics, tissue-culture, microscopy, bioinformatics and more. Candidate should send a cover letter and CV (includes a publication list) to Dr. Neta Regev-Rudzki. |
Prof. Ziv Reich | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2982 |
Our group is interested in the changes that occur in photosynthetic organisms when faced with varying conditions. Whereas organisms are usually grown in the lab under constant, well controlled conditions, real life organisms face vast changes in their environment that occur at time scales ranging from seconds to months. The ability of photosynthetic organisms to efficiently utilize a capricious energy source such as ambient light is remarkable. Even more impressive is their ability to withstand stress conditions. |
Prof. Eitan Reuveny | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3243 |
We are interested in signaling in excitable cells. Ion channels physiology. G protein coupled receptors signaling and regulation. Ca signaling and homeostasis. |
Prof. Eitan Reuveny | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3243 |
We are interested in signaling in excitable cells. Ion channels physiology. G protein coupled receptors signaling and regulation. Ca signaling and homeostasis. |
Dr. Ruth Scherz-Shouval | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2299 |
Transcriptional reprogramming and stress responses in the tumor microenvironment |
Prof. Gideon Schreiber | Rotation: 2nd, 3rd Phone:+972-8-934-3249 |
Investigating protein-protein interactions and interferon actions |
Prof. Gideon Schreiber | Rotation: 2nd, 3rd Phone:+972-8-934-3249 |
Molecular Biology, protein biophysics and bioinformatics |
Prof. Gideon Schreiber | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3249 |
Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. |
Prof. Gideon Schreiber | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3249 |
Nerve axons are extremely long in cellular terms, extending many orders of magnitude longer than the diameters of their parent cell bodies. How then is the cell body informed of an injury in distant portions of the axon? We are working on the molecular mechanisms of long distance communication within neurons, and their implications for neuronal growth and regeneration. People can integrate to a range of projects within this theme. For an overview of our research topics please visit the group home page at http://www.weizmann.ac.il/Biomolecular_Sciences/Fainzilber/ . |
Prof. Yechiel Shai | Rotation: 1st, 2nd, 3rd Phone:+972-8-934- |
(i) Antibacterial and antifungal peptides - Living organisms of all types produce a large repertoire of gene-encoded antimicrobial peptides that serve as part of the innate immunity. Since 1991 we have established the ??carpet?? mechanism as an efficient model describing membrane permeation by many antimicrobial peptides. Most importantly, we disproved accepted dogmas on the role of specific structure, sequence or chirality in biological function. Furthermore, we found parameter controlling target cell specificity. |
Prof. Yechiel Shai | Rotation: 1st, 2nd, 3rd Phone:+972-8-934- |
Within the systems described, we study self- and hetero-assembly of membrane-bound peptides derived from membrane proteins. Interestingly, although it is generally accepted that the chiral nature of most biologically relevant macromolecules restricts specific interactions to ??chiral partners??, we found that the lipid bilayer environment allows the interaction of two transmembrane (TM) domains with opposite chiralities, and between an all L-amino acid TM and its D,L-amino acid analog (diastereomer). |
Prof. Yechiel Shai | Rotation: 1st, 2nd, 3rd Phone:+972-8-934- |
The mammalian innate immune response is responsible for the early stages of defense against invading pathogens. One of the major receptor families facilitating innate immune activation is the Toll-like receptor (TLR) family, type I membrane proteins. All TLRs form homo- and hetero-dimers within membranes and we showed that the single transmembrane domain (TMD) of some of these receptors is involved in their dimerization and signaling regulation. |
Prof. Michal Sharon | Rotation: 2nd, 3rd Phone:+972-8-934-3947 |
Studying the structure function relationship of protein complexes involved the protein degradation pathway |
Prof. Michal Sharon | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3947 |
<p>Studying large protein complexes involved in the protein degradation pathway using a novel mass spectrometry approach.</p> |
Prof. Michael Walker | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3597 |
We focus on 1) the mechanisms underlying the embryonic development of beta cells both in vivo and in vitro and 2) the transcriptional and post-transcriptional mechanisms that permit beta cells to fulfill their role of releasing insulin in response to physiological needs. |
Prof. David Wallach | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3941 |
Caspase-8, a cysteine protease discovered in our laboratory, is the main proximal signaling enzyme in the activation of the extrinsic cell-death pathway by receptors of the TNF/NGF family. In certain cells it also participates in the regulation of cell growth, differentiation and survival. A number of different human tumors, including small cell lung carcinoma, neuroblastoma, hepatocellular carcinoma, and others, are frequently deficient of caspase-8. |
Prof. David Wallach | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3941 |
Transgenic and conditional-knockout mouse models are applied to gain better knowledge of the physiological and pathophysiological function of the following signaling proteins that were discovered in our laboratory: (a) Caspase-8, a cysteine protease that we have initially found to serve as the main proximal signaling protein in the initiation of death induction by the receptors (the extrinsic cell-death pathway), yet has more recently found also to serve various non-apoptotic roles. |
Prof. Avraham Yaron | Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6240 |
Positions are available joining the work on exciting ongoing projects in the lab: 1. The role of axonal mRNA translation during development. 2. Signaling mechanisms of axon guidance receptors. 3. Mechanisms of axonal degeneration |
We do not currently have open positions